Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01973:Zzz3'

182608

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zzz3

Ensembl Gene

ENSMUSG00000039068

Gene Name

zinc finger, ZZ domain containing 3

Synonyms

3110065C23Rik, 6430567E01Rik

Accession Numbers

Is this an essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL01973

Quality Score

Status

Chromosome

Chromosomal Location

152395473-152462826 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 152428370 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 355 (V355A)

Ref Sequence

ENSEMBL: ENSMUSP00000101707 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089982] [ENSMUST00000106100] [ENSMUST00000106101] [ENSMUST00000106103] [ENSMUST00000200570]

AlphaFold

Q6KAQ7

Predicted Effect

probably benign
Transcript: ENSMUST00000089982
AA Change: V355A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000087428
Gene: ENSMUSG00000039068
AA Change: V355A

Domain	Start	End	E-Value	Type
SANT	657	711	1.42e-9	SMART
low complexity region	776	787	N/A	INTRINSIC
low complexity region	799	814	N/A	INTRINSIC
ZnF_ZZ	823	871	6.46e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000106100
AA Change: V355A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000101706
Gene: ENSMUSG00000039068
AA Change: V355A

Domain	Start	End	E-Value	Type
SANT	658	712	1.42e-9	SMART
low complexity region	777	788	N/A	INTRINSIC
low complexity region	800	815	N/A	INTRINSIC
ZnF_ZZ	824	872	6.46e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000106101
AA Change: V355A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000101707
Gene: ENSMUSG00000039068
AA Change: V355A

Domain	Start	End	E-Value	Type
SANT	658	712	1.42e-9	SMART
low complexity region	777	788	N/A	INTRINSIC
low complexity region	800	815	N/A	INTRINSIC
ZnF_ZZ	824	872	6.46e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000106103

SMART Domains

Protein: ENSMUSP00000101709
Gene: ENSMUSG00000039068

Domain	Start	End	E-Value	Type
SANT	157	211	1.42e-9	SMART
low complexity region	276	287	N/A	INTRINSIC
low complexity region	299	314	N/A	INTRINSIC
ZnF_ZZ	323	371	6.46e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138115

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150802

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000197987

Predicted Effect

probably benign
Transcript: ENSMUST00000200570

SMART Domains

Protein: ENSMUSP00000143693
Gene: ENSMUSG00000039068

Domain	Start	End	E-Value	Type
SANT	161	215	1.42e-9	SMART
low complexity region	280	291	N/A	INTRINSIC
low complexity region	303	318	N/A	INTRINSIC
ZnF_ZZ	327	375	6.46e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410004P03Rik	A	G	12: 17,011,171	W59R	probably damaging	Het
Adam17	C	T	12: 21,349,943	R154K	probably damaging	Het
Atp9b	A	T	18: 80,758,303	F791I	probably benign	Het
Atr	T	G	9: 95,871,674	S776R	probably damaging	Het
AW554918	A	T	18: 25,419,999	T487S	probably damaging	Het
Bckdhb	T	A	9: 83,991,736	F217Y	probably benign	Het
Cacna1i	G	A	15: 80,382,033	A1574T	probably damaging	Het
Ccdc150	G	A	1: 54,300,488		probably null	Het
Clca4c-ps	A	T	3: 144,879,832		noncoding transcript	Het
Clec4a1	T	C	6: 122,930,721	S123P	probably damaging	Het
Col6a4	T	C	9: 106,062,894	Y1279C	probably damaging	Het
Cox8c	T	A	12: 102,899,367	M1K	probably null	Het
Crat	G	T	2: 30,405,481	S370Y	probably damaging	Het
Cts7	A	T	13: 61,355,600	D183E	probably benign	Het
Cyp1a2	C	A	9: 57,682,395	W45C	probably damaging	Het
Eml5	T	A	12: 98,863,280	I492L	probably benign	Het
Fbxl4	T	G	4: 22,422,766	L456R	probably damaging	Het
Flt1	G	T	5: 147,683,889	H148Q	probably benign	Het
Galnt3	T	C	2: 66,084,262	M604V	probably benign	Het
Gatb	T	C	3: 85,611,424	V279A	probably damaging	Het
Gm6904	A	G	14: 59,251,129	V73A	probably benign	Het
Gm996	G	T	2: 25,579,572	S109*	probably null	Het
Heatr1	C	A	13: 12,429,799	H1543Q	probably benign	Het
Ighg2b	C	T	12: 113,307,685	V83I	unknown	Het
Jcad	A	G	18: 4,675,514	Q1092R	probably benign	Het
Kirrel3	A	G	9: 35,016,468	E6G	probably damaging	Het
Klhl22	A	G	16: 17,792,711	S609G	probably benign	Het
Kntc1	A	G	5: 123,765,958	Y346C	probably damaging	Het
Maneal	T	C	4: 124,859,155	D233G	probably benign	Het
Mcm3ap	T	C	10: 76,471,117	S355P	probably benign	Het
Mettl11b	A	G	1: 163,717,120	I98T	probably benign	Het
Mtus2	C	T	5: 148,303,476		probably benign	Het
Muc4	A	G	16: 32,754,265	T1380A	probably benign	Het
Nedd4	T	A	9: 72,736,934	M661K	possibly damaging	Het
Nomo1	T	C	7: 46,083,227		probably benign	Het
Ntsr2	T	A	12: 16,656,774	W268R	probably benign	Het
Nup188	A	C	2: 30,339,850	Q1360P	possibly damaging	Het
Olfr15	A	T	16: 3,839,777	Q268L	probably damaging	Het
Olfr231	A	G	1: 174,117,533	F161S	probably damaging	Het
Pabpc1	A	T	15: 36,599,275	V392E	probably benign	Het
Pcdhb11	C	A	18: 37,423,512	R632S	probably damaging	Het
Pnpla6	T	A	8: 3,517,619	M87K	probably damaging	Het
Prkd1	C	T	12: 50,366,379	G670R	probably damaging	Het
Raf1	G	A	6: 115,676,569		probably benign	Het
Rapgef2	T	A	3: 79,091,809		probably null	Het
Rnf215	A	T	11: 4,136,615	H164L	probably damaging	Het
Slc24a3	T	C	2: 145,245,027	V19A	probably benign	Het
Tbc1d16	A	T	11: 119,156,707	V396E	probably benign	Het
Tecpr1	T	C	5: 144,197,988		probably benign	Het
Thap12	T	A	7: 98,716,499	Y625N	possibly damaging	Het
Tshz2	A	T	2: 169,884,683	M400L	probably damaging	Het
Ttc28	A	G	5: 111,224,235	Y850C	possibly damaging	Het
Ugt1a7c	A	G	1: 88,095,134	D5G	probably benign	Het
Vmn2r10	C	T	5: 108,995,677	M802I	probably damaging	Het
Washc4	T	C	10: 83,556,109	Y220H	probably damaging	Het
Zfhx3	T	A	8: 108,947,193	M1625K	probably damaging	Het
Zfp677	T	A	17: 21,396,907	N75K	probably damaging	Het

Other mutations in Zzz3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00691:Zzz3	APN	3	152428514	missense	probably benign	0.16
IGL00707:Zzz3	APN	3	152449043	nonsense	probably null
IGL00983:Zzz3	APN	3	152455810	splice site	probably benign
IGL01586:Zzz3	APN	3	152455839	missense	possibly damaging	0.80
IGL02002:Zzz3	APN	3	152451369	missense	probably damaging	0.98
IGL02009:Zzz3	APN	3	152428115	missense	possibly damaging	0.80
IGL02260:Zzz3	APN	3	152452083	missense	probably benign	0.04
IGL02336:Zzz3	APN	3	152428059	missense	possibly damaging	0.74
IGL02454:Zzz3	APN	3	152428574	missense	probably benign	0.03
IGL02519:Zzz3	APN	3	152427390	missense	probably damaging	1.00
R0067:Zzz3	UTSW	3	152428403	missense	possibly damaging	0.88
R0067:Zzz3	UTSW	3	152428403	missense	possibly damaging	0.88
R0314:Zzz3	UTSW	3	152427448	missense	probably benign	0.00
R0536:Zzz3	UTSW	3	152448828	missense	probably damaging	1.00
R1706:Zzz3	UTSW	3	152449098	missense	probably damaging	1.00
R2869:Zzz3	UTSW	3	152446844	synonymous	silent
R2870:Zzz3	UTSW	3	152446844	synonymous	silent
R2871:Zzz3	UTSW	3	152446844	synonymous	silent
R2872:Zzz3	UTSW	3	152446844	synonymous	silent
R3927:Zzz3	UTSW	3	152455862	missense	probably damaging	1.00
R4195:Zzz3	UTSW	3	152428465	missense	probably benign	0.02
R4768:Zzz3	UTSW	3	152448783	missense	probably damaging	1.00
R5248:Zzz3	UTSW	3	152427545	missense	probably damaging	0.99
R5566:Zzz3	UTSW	3	152455824	missense	probably damaging	1.00
R5752:Zzz3	UTSW	3	152452122	missense	possibly damaging	0.48
R5782:Zzz3	UTSW	3	152428100	missense	possibly damaging	0.69
R5884:Zzz3	UTSW	3	152450658	missense	probably damaging	1.00
R6008:Zzz3	UTSW	3	152428151	missense	probably benign	0.01
R6155:Zzz3	UTSW	3	152427682	missense	possibly damaging	0.57
R6557:Zzz3	UTSW	3	152428460	missense	probably damaging	1.00
R6865:Zzz3	UTSW	3	152428053	missense	probably benign	0.01
R7344:Zzz3	UTSW	3	152452099	missense	probably damaging	0.98
R7588:Zzz3	UTSW	3	152422768	missense	possibly damaging	0.85
R7636:Zzz3	UTSW	3	152427652	missense	probably benign
R7732:Zzz3	UTSW	3	152448842	missense	probably damaging	1.00
R8157:Zzz3	UTSW	3	152449648	missense	probably null	0.71
R8490:Zzz3	UTSW	3	152428653	nonsense	probably null
R8926:Zzz3	UTSW	3	152427892	missense	possibly damaging	0.76
R9143:Zzz3	UTSW	3	152458271	missense	probably benign	0.04
R9243:Zzz3	UTSW	3	152428283	missense	probably damaging	1.00
X0018:Zzz3	UTSW	3	152428733	missense	possibly damaging	0.88
Z1176:Zzz3	UTSW	3	152449097	missense	possibly damaging	0.94

Posted On

2014-05-07