Incidental Mutation 'IGL01980:Or51a10'
ID 182706
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or51a10
Ensembl Gene ENSMUSG00000049797
Gene Name olfactory receptor family 51 subfamily A member 10
Synonyms MOR13-6, GA_x6K02T2PBJ9-6784380-6783436, Olfr642
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # IGL01980
Quality Score
Status
Chromosome 7
Chromosomal Location 103698615-103699559 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 103699300 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 87 (M87K)
Ref Sequence ENSEMBL: ENSMUSP00000148961 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052660] [ENSMUST00000074064] [ENSMUST00000138055] [ENSMUST00000214299]
AlphaFold Q924X8
Predicted Effect probably benign
Transcript: ENSMUST00000052660
AA Change: M87K

PolyPhen 2 Score 0.208 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000061462
Gene: ENSMUSG00000049797
AA Change: M87K

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 8.5e-119 PFAM
Pfam:7TM_GPCR_Srsx 37 309 1.7e-7 PFAM
Pfam:7tm_1 43 294 4.1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000074064
SMART Domains Protein: ENSMUSP00000073707
Gene: ENSMUSG00000090219

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 2.6e-124 PFAM
Pfam:7TM_GPCR_Srsx 37 255 3.1e-7 PFAM
Pfam:7tm_1 43 294 3.2e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138055
SMART Domains Protein: ENSMUSP00000139240
Gene: ENSMUSG00000109824

DomainStartEndE-ValueType
transmembrane domain 29 51 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000214299
AA Change: M87K

PolyPhen 2 Score 0.208 (Sensitivity: 0.92; Specificity: 0.88)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd60 C T 2: 173,412,996 (GRCm39) C164Y probably benign Het
Atp13a2 C T 4: 140,733,463 (GRCm39) A979V probably benign Het
Col5a2 C T 1: 45,421,393 (GRCm39) probably benign Het
Col6a6 T C 9: 105,658,184 (GRCm39) N676S probably damaging Het
Cpa1 T C 6: 30,641,581 (GRCm39) F192L possibly damaging Het
Entpd6 T A 2: 150,604,286 (GRCm39) probably null Het
Fam185a A G 5: 21,664,171 (GRCm39) K302E probably damaging Het
Il12rb2 T C 6: 67,337,519 (GRCm39) K121E probably benign Het
Impg2 G A 16: 56,041,890 (GRCm39) C178Y probably damaging Het
Kdm3b G T 18: 34,967,289 (GRCm39) C1698F probably damaging Het
Llgl2 A G 11: 115,740,851 (GRCm39) D451G probably damaging Het
Mgat4b T A 11: 50,121,540 (GRCm39) L52Q probably damaging Het
Mmp9 C A 2: 164,792,836 (GRCm39) S363R probably benign Het
Mtfmt A G 9: 65,344,356 (GRCm39) Y94C probably benign Het
Myo7b G A 18: 32,094,953 (GRCm39) L1881F possibly damaging Het
Or6c6 G T 10: 129,187,386 (GRCm39) probably benign Het
Pex5 T C 6: 124,375,339 (GRCm39) N524S probably damaging Het
Plppr1 A T 4: 49,319,992 (GRCm39) Y206F possibly damaging Het
Polr3e A G 7: 120,539,519 (GRCm39) probably benign Het
Rhbdd1 A G 1: 82,318,555 (GRCm39) probably benign Het
Rims4 A T 2: 163,707,702 (GRCm39) probably benign Het
Smarcal1 A T 1: 72,655,679 (GRCm39) K653* probably null Het
Stt3b C T 9: 115,105,767 (GRCm39) probably null Het
Syt8 C A 7: 141,993,877 (GRCm39) L343M probably damaging Het
Tbc1d23 G A 16: 57,009,615 (GRCm39) probably benign Het
Tfec T C 6: 16,845,465 (GRCm39) I65V probably damaging Het
Tmem236 A T 2: 14,223,716 (GRCm39) Q168H probably benign Het
Tmem25 G A 9: 44,709,568 (GRCm39) R78* probably null Het
Tnip2 A G 5: 34,654,212 (GRCm39) V288A probably benign Het
Ttc1 G A 11: 43,621,291 (GRCm39) probably benign Het
Tubb4b-ps1 A C 5: 7,229,843 (GRCm39) probably benign Het
Tut1 T C 19: 8,931,364 (GRCm39) C21R probably damaging Het
Ubr4 C A 4: 139,156,913 (GRCm39) Q2313K probably damaging Het
Unc5b T C 10: 60,615,966 (GRCm39) E119G probably damaging Het
Vmn1r23 T A 6: 57,903,475 (GRCm39) Q101L probably damaging Het
Vmn2r77 A G 7: 86,450,678 (GRCm39) D188G probably benign Het
Vmn2r79 A G 7: 86,686,290 (GRCm39) E557G possibly damaging Het
Zfp738 A G 13: 67,818,096 (GRCm39) F632L possibly damaging Het
Other mutations in Or51a10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01457:Or51a10 APN 7 103,699,376 (GRCm39) missense probably damaging 1.00
IGL01933:Or51a10 APN 7 103,699,021 (GRCm39) missense probably damaging 1.00
IGL02161:Or51a10 APN 7 103,698,797 (GRCm39) missense possibly damaging 0.66
IGL02639:Or51a10 APN 7 103,698,988 (GRCm39) missense probably damaging 0.99
I2289:Or51a10 UTSW 7 103,698,961 (GRCm39) missense probably damaging 1.00
R0418:Or51a10 UTSW 7 103,698,979 (GRCm39) missense probably benign 0.00
R1647:Or51a10 UTSW 7 103,699,376 (GRCm39) missense probably damaging 1.00
R1648:Or51a10 UTSW 7 103,699,376 (GRCm39) missense probably damaging 1.00
R1701:Or51a10 UTSW 7 103,699,402 (GRCm39) missense possibly damaging 0.95
R2142:Or51a10 UTSW 7 103,699,507 (GRCm39) missense probably damaging 1.00
R2165:Or51a10 UTSW 7 103,698,845 (GRCm39) missense probably benign 0.22
R2655:Or51a10 UTSW 7 103,698,638 (GRCm39) missense probably benign 0.03
R6216:Or51a10 UTSW 7 103,698,902 (GRCm39) missense probably damaging 1.00
R6759:Or51a10 UTSW 7 103,699,334 (GRCm39) missense probably damaging 1.00
R6925:Or51a10 UTSW 7 103,698,947 (GRCm39) missense probably benign 0.16
R7243:Or51a10 UTSW 7 103,698,962 (GRCm39) missense probably damaging 1.00
R7684:Or51a10 UTSW 7 103,698,667 (GRCm39) missense probably damaging 0.99
R7699:Or51a10 UTSW 7 103,699,800 (GRCm39) start gained probably benign
R8316:Or51a10 UTSW 7 103,698,829 (GRCm39) missense probably damaging 1.00
R8458:Or51a10 UTSW 7 103,698,875 (GRCm39) missense possibly damaging 0.93
R8836:Or51a10 UTSW 7 103,699,055 (GRCm39) missense probably benign 0.07
R9161:Or51a10 UTSW 7 103,699,725 (GRCm39) start gained probably benign
R9519:Or51a10 UTSW 7 103,698,636 (GRCm39) missense probably benign 0.00
Z1176:Or51a10 UTSW 7 103,699,480 (GRCm39) missense probably benign
Posted On 2014-05-07