Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01980:Or6c6'

182719

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or6c6

Ensembl Gene

ENSMUSG00000095075

Gene Name

olfactory receptor family 6 subfamily C member 6

Synonyms

MOR110-8, GA_x6K02T2PULF-11031172-11032116, Olfr782

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

IGL01980

Quality Score

Status

Chromosome

Chromosomal Location

129186434-129187378 bp(+) (GRCm39)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

G to T at 129187386 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000150951 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077024] [ENSMUST00000213970]

AlphaFold

Q7TRI2

Predicted Effect

probably benign
Transcript: ENSMUST00000077024

SMART Domains

Protein: ENSMUSP00000076282
Gene: ENSMUSG00000095075

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	1e-48	PFAM
Pfam:7tm_1	39	288	8.5e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213970

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd60	C	T	2: 173,412,996 (GRCm39)	C164Y	probably benign	Het
Atp13a2	C	T	4: 140,733,463 (GRCm39)	A979V	probably benign	Het
Col5a2	C	T	1: 45,421,393 (GRCm39)		probably benign	Het
Col6a6	T	C	9: 105,658,184 (GRCm39)	N676S	probably damaging	Het
Cpa1	T	C	6: 30,641,581 (GRCm39)	F192L	possibly damaging	Het
Entpd6	T	A	2: 150,604,286 (GRCm39)		probably null	Het
Fam185a	A	G	5: 21,664,171 (GRCm39)	K302E	probably damaging	Het
Il12rb2	T	C	6: 67,337,519 (GRCm39)	K121E	probably benign	Het
Impg2	G	A	16: 56,041,890 (GRCm39)	C178Y	probably damaging	Het
Kdm3b	G	T	18: 34,967,289 (GRCm39)	C1698F	probably damaging	Het
Llgl2	A	G	11: 115,740,851 (GRCm39)	D451G	probably damaging	Het
Mgat4b	T	A	11: 50,121,540 (GRCm39)	L52Q	probably damaging	Het
Mmp9	C	A	2: 164,792,836 (GRCm39)	S363R	probably benign	Het
Mtfmt	A	G	9: 65,344,356 (GRCm39)	Y94C	probably benign	Het
Myo7b	G	A	18: 32,094,953 (GRCm39)	L1881F	possibly damaging	Het
Or51a10	A	T	7: 103,699,300 (GRCm39)	M87K	probably benign	Het
Pex5	T	C	6: 124,375,339 (GRCm39)	N524S	probably damaging	Het
Plppr1	A	T	4: 49,319,992 (GRCm39)	Y206F	possibly damaging	Het
Polr3e	A	G	7: 120,539,519 (GRCm39)		probably benign	Het
Rhbdd1	A	G	1: 82,318,555 (GRCm39)		probably benign	Het
Rims4	A	T	2: 163,707,702 (GRCm39)		probably benign	Het
Smarcal1	A	T	1: 72,655,679 (GRCm39)	K653*	probably null	Het
Stt3b	C	T	9: 115,105,767 (GRCm39)		probably null	Het
Syt8	C	A	7: 141,993,877 (GRCm39)	L343M	probably damaging	Het
Tbc1d23	G	A	16: 57,009,615 (GRCm39)		probably benign	Het
Tfec	T	C	6: 16,845,465 (GRCm39)	I65V	probably damaging	Het
Tmem236	A	T	2: 14,223,716 (GRCm39)	Q168H	probably benign	Het
Tmem25	G	A	9: 44,709,568 (GRCm39)	R78*	probably null	Het
Tnip2	A	G	5: 34,654,212 (GRCm39)	V288A	probably benign	Het
Ttc1	G	A	11: 43,621,291 (GRCm39)		probably benign	Het
Tubb4b-ps1	A	C	5: 7,229,843 (GRCm39)		probably benign	Het
Tut1	T	C	19: 8,931,364 (GRCm39)	C21R	probably damaging	Het
Ubr4	C	A	4: 139,156,913 (GRCm39)	Q2313K	probably damaging	Het
Unc5b	T	C	10: 60,615,966 (GRCm39)	E119G	probably damaging	Het
Vmn1r23	T	A	6: 57,903,475 (GRCm39)	Q101L	probably damaging	Het
Vmn2r77	A	G	7: 86,450,678 (GRCm39)	D188G	probably benign	Het
Vmn2r79	A	G	7: 86,686,290 (GRCm39)	E557G	possibly damaging	Het
Zfp738	A	G	13: 67,818,096 (GRCm39)	F632L	possibly damaging	Het

Other mutations in Or6c6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01286:Or6c6	APN	10	129,186,519 (GRCm39)	missense	probably damaging	1.00
IGL01469:Or6c6	APN	10	129,186,449 (GRCm39)	missense	probably benign
IGL03309:Or6c6	APN	10	129,187,178 (GRCm39)	missense	probably benign	0.01
R0449:Or6c6	UTSW	10	129,187,103 (GRCm39)	missense	probably benign	0.00
R1994:Or6c6	UTSW	10	129,186,561 (GRCm39)	missense	probably damaging	1.00
R3121:Or6c6	UTSW	10	129,186,552 (GRCm39)	missense	possibly damaging	0.74
R6421:Or6c6	UTSW	10	129,187,370 (GRCm39)	nonsense	probably null
R7268:Or6c6	UTSW	10	129,187,263 (GRCm39)	missense	possibly damaging	0.60
R7399:Or6c6	UTSW	10	129,186,426 (GRCm39)	start gained	probably benign
R7647:Or6c6	UTSW	10	129,187,326 (GRCm39)	missense	probably benign
R8384:Or6c6	UTSW	10	129,186,695 (GRCm39)	nonsense	probably null
R8795:Or6c6	UTSW	10	129,187,194 (GRCm39)	missense	probably damaging	0.99
R9224:Or6c6	UTSW	10	129,186,450 (GRCm39)	missense	probably benign
R9375:Or6c6	UTSW	10	129,186,989 (GRCm39)	missense	probably damaging	1.00
R9478:Or6c6	UTSW	10	129,186,960 (GRCm39)	missense	possibly damaging	0.70
X0027:Or6c6	UTSW	10	129,187,202 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07