Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01982:Ugt2b37'

182728

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ugt2b37

Ensembl Gene

ENSMUSG00000057425

Gene Name

UDP glucuronosyltransferase 2 family, polypeptide B37

Synonyms

0610033E06Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

IGL01982

Quality Score

Status

Chromosome

Chromosomal Location

87388351-87402647 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 87390291 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Serine at position 385 (I385S)

Ref Sequence

ENSEMBL: ENSMUSP00000075255 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075858]

AlphaFold

Q8VCN3

Predicted Effect

probably damaging
Transcript: ENSMUST00000075858
AA Change: I385S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000075255
Gene: ENSMUSG00000057425
AA Change: I385S

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:UDPGT	24	527	5.5e-256	PFAM
Pfam:Glyco_tran_28_C	328	449	2.5e-9	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	A	C	1: 71,385,857 (GRCm39)	S254A	probably benign	Het
Abca7	T	G	10: 79,838,475 (GRCm39)	L583R	probably damaging	Het
Acp1	A	T	12: 30,961,491 (GRCm39)	L14H	possibly damaging	Het
Adar	A	G	3: 89,645,397 (GRCm39)	I3V	probably benign	Het
Adh4	C	T	3: 138,134,788 (GRCm39)		probably benign	Het
Aldh1l1	A	G	6: 90,536,845 (GRCm39)	I103V	probably benign	Het
Asic3	C	A	5: 24,622,719 (GRCm39)	T523N	probably benign	Het
Aspm	T	C	1: 139,419,326 (GRCm39)	V1732A	probably benign	Het
Atad3a	C	T	4: 155,838,384 (GRCm39)	R211Q	possibly damaging	Het
Bahcc1	A	G	11: 120,178,299 (GRCm39)	Y2286C	probably damaging	Het
BC034090	T	C	1: 155,099,078 (GRCm39)	E569G	probably damaging	Het
Bpifb3	A	G	2: 153,767,521 (GRCm39)	N237S	probably benign	Het
Bysl	C	A	17: 47,921,996 (GRCm39)		probably null	Het
C2cd6	T	C	1: 59,106,932 (GRCm39)		probably benign	Het
Ccdc141	A	G	2: 76,861,003 (GRCm39)	F925L	probably damaging	Het
Cdca2	A	T	14: 67,915,168 (GRCm39)	V697E	probably damaging	Het
Cers1	A	G	8: 70,776,081 (GRCm39)	D324G	probably damaging	Het
Ctsq	T	A	13: 61,186,732 (GRCm39)	I91F	probably benign	Het
Ctsq	C	T	13: 61,187,335 (GRCm39)	C11Y	probably benign	Het
Cyp11b1	T	C	15: 74,711,252 (GRCm39)	N142S	possibly damaging	Het
Cyp3a59	G	T	5: 146,041,545 (GRCm39)	S363I	probably benign	Het
Eps15l1	A	T	8: 73,132,919 (GRCm39)	D567E	probably benign	Het
Esf1	G	A	2: 140,006,448 (GRCm39)	A233V	probably benign	Het
Fras1	A	T	5: 96,887,107 (GRCm39)	I2630F	possibly damaging	Het
Fyb1	A	T	15: 6,609,658 (GRCm39)	E77V	probably null	Het
Gjb6	C	A	14: 57,362,030 (GRCm39)	W77L	probably damaging	Het
Gm21983	A	G	7: 26,879,703 (GRCm39)	V88A	possibly damaging	Het
Gm8247	A	G	14: 44,823,088 (GRCm39)	T52A	probably damaging	Het
Gpr108	T	C	17: 57,544,877 (GRCm39)	K329E	probably damaging	Het
Gpr141	T	A	13: 19,935,908 (GRCm39)	H289L	probably benign	Het
Ilvbl	T	C	10: 78,414,856 (GRCm39)	Y240H	probably damaging	Het
Kntc1	G	A	5: 123,947,159 (GRCm39)	A1868T	probably benign	Het
Lrmda	A	C	14: 22,634,550 (GRCm39)	N112T	probably damaging	Het
Ly75	T	C	2: 60,142,108 (GRCm39)	Y1334C	probably damaging	Het
Macc1	C	A	12: 119,409,369 (GRCm39)	P46T	probably benign	Het
Madd	A	T	2: 91,006,052 (GRCm39)	F381Y	probably damaging	Het
Map3k20	C	T	2: 72,128,677 (GRCm39)	Q38*	probably null	Het
Mcm4	A	T	16: 15,448,284 (GRCm39)	D424E	possibly damaging	Het
Micu1	T	A	10: 59,699,100 (GRCm39)	M463K	possibly damaging	Het
Mkrn2os	A	G	6: 115,562,492 (GRCm39)	L157P	probably damaging	Het
Nectin2	A	G	7: 19,451,487 (GRCm39)	S516P	probably damaging	Het
Nme5	T	A	18: 34,702,928 (GRCm39)	D120V	probably damaging	Het
Npy4r	T	C	14: 33,869,282 (GRCm39)	N2S	possibly damaging	Het
Nup107	A	T	10: 117,595,245 (GRCm39)		probably benign	Het
Omd	T	C	13: 49,742,973 (GRCm39)	Y8H	possibly damaging	Het
Phf8-ps	T	G	17: 33,285,289 (GRCm39)	E504D	probably benign	Het
Ppp1r15a	T	C	7: 45,173,803 (GRCm39)		probably benign	Het
Ppp2ca	T	C	11: 51,989,891 (GRCm39)	F6L	probably benign	Het
Rab1a	T	C	11: 20,174,717 (GRCm39)	S97P	probably benign	Het
Ranbp3l	G	A	15: 9,058,827 (GRCm39)	G359R	probably damaging	Het
Rnf213	A	T	11: 119,334,094 (GRCm39)	H3101L	probably damaging	Het
Slc27a4	T	C	2: 29,702,627 (GRCm39)	F509S	probably damaging	Het
Slco4a1	T	C	2: 180,114,946 (GRCm39)	V623A	probably benign	Het
Spart	T	A	3: 55,035,911 (GRCm39)		probably null	Het
Sptan1	A	G	2: 29,909,980 (GRCm39)	D1780G	probably damaging	Het
Tgm7	G	T	2: 120,924,106 (GRCm39)	Y605*	probably null	Het
Tmem106b	T	C	6: 13,071,968 (GRCm39)		probably benign	Het
Trak2	G	A	1: 58,965,814 (GRCm39)	A120V	possibly damaging	Het
Trappc8	G	A	18: 21,007,769 (GRCm39)		probably benign	Het
Trim66	T	C	7: 109,057,970 (GRCm39)	T973A	probably benign	Het
Ttyh3	C	A	5: 140,621,829 (GRCm39)		probably benign	Het
Usf3	A	G	16: 44,039,180 (GRCm39)	N1220S	possibly damaging	Het
Utrn	A	T	10: 12,623,773 (GRCm39)	I155N	probably damaging	Het
Vps13b	C	T	15: 35,439,050 (GRCm39)	Q377*	probably null	Het
Washc2	A	T	6: 116,213,150 (GRCm39)	E570D	probably benign	Het
Wscd1	T	C	11: 71,657,699 (GRCm39)	V168A	possibly damaging	Het
Zfp386	T	A	12: 116,022,788 (GRCm39)	C169S	probably benign	Het

Other mutations in Ugt2b37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00401:Ugt2b37	APN	5	87,390,340 (GRCm39)	missense	possibly damaging	0.90
IGL00567:Ugt2b37	APN	5	87,401,933 (GRCm39)	missense	probably damaging	1.00
IGL00787:Ugt2b37	APN	5	87,390,288 (GRCm39)	missense	probably benign	0.00
IGL01560:Ugt2b37	APN	5	87,399,698 (GRCm39)	missense	probably damaging	1.00
IGL01617:Ugt2b37	APN	5	87,399,738 (GRCm39)	missense	probably damaging	1.00
IGL02299:Ugt2b37	APN	5	87,390,174 (GRCm39)	missense	probably benign	0.00
IGL02323:Ugt2b37	APN	5	87,398,423 (GRCm39)	splice site	probably benign
IGL02326:Ugt2b37	APN	5	87,388,861 (GRCm39)	missense	probably benign	0.25
IGL02516:Ugt2b37	APN	5	87,388,741 (GRCm39)	missense	probably damaging	1.00
IGL03285:Ugt2b37	APN	5	87,388,734 (GRCm39)	missense	probably damaging	1.00
R0076:Ugt2b37	UTSW	5	87,402,080 (GRCm39)	missense	probably benign	0.31
R0141:Ugt2b37	UTSW	5	87,388,842 (GRCm39)	missense	probably damaging	1.00
R0312:Ugt2b37	UTSW	5	87,398,524 (GRCm39)	missense	probably damaging	1.00
R0359:Ugt2b37	UTSW	5	87,398,443 (GRCm39)	missense	probably benign	0.10
R0523:Ugt2b37	UTSW	5	87,399,691 (GRCm39)	missense	possibly damaging	0.91
R1938:Ugt2b37	UTSW	5	87,388,716 (GRCm39)	missense	probably damaging	1.00
R1962:Ugt2b37	UTSW	5	87,402,193 (GRCm39)	missense	probably damaging	1.00
R2496:Ugt2b37	UTSW	5	87,402,569 (GRCm39)	missense	probably damaging	0.97
R3704:Ugt2b37	UTSW	5	87,390,846 (GRCm39)	missense	possibly damaging	0.55
R4430:Ugt2b37	UTSW	5	87,401,951 (GRCm39)	missense	probably benign	0.00
R4825:Ugt2b37	UTSW	5	87,398,498 (GRCm39)	missense	possibly damaging	0.91
R5043:Ugt2b37	UTSW	5	87,399,719 (GRCm39)	nonsense	probably null
R5098:Ugt2b37	UTSW	5	87,390,812 (GRCm39)	missense	probably damaging	1.00
R5174:Ugt2b37	UTSW	5	87,399,739 (GRCm39)	missense	probably benign	0.00
R5522:Ugt2b37	UTSW	5	87,388,759 (GRCm39)	missense	probably benign	0.14
R5879:Ugt2b37	UTSW	5	87,402,265 (GRCm39)	missense	probably benign
R5999:Ugt2b37	UTSW	5	87,402,036 (GRCm39)	missense	probably benign	0.25
R6374:Ugt2b37	UTSW	5	87,390,279 (GRCm39)	missense	probably damaging	1.00
R6454:Ugt2b37	UTSW	5	87,388,836 (GRCm39)	missense	probably damaging	1.00
R6857:Ugt2b37	UTSW	5	87,388,705 (GRCm39)	missense	probably damaging	0.98
R6875:Ugt2b37	UTSW	5	87,390,288 (GRCm39)	missense	probably benign	0.00
R6916:Ugt2b37	UTSW	5	87,402,459 (GRCm39)	missense	probably benign	0.07
R7099:Ugt2b37	UTSW	5	87,388,848 (GRCm39)	missense	probably benign	0.00
R7239:Ugt2b37	UTSW	5	87,402,590 (GRCm39)	missense	probably benign
R7470:Ugt2b37	UTSW	5	87,401,971 (GRCm39)	missense	probably benign	0.24
R7810:Ugt2b37	UTSW	5	87,402,118 (GRCm39)	missense	probably damaging	1.00
R7841:Ugt2b37	UTSW	5	87,398,489 (GRCm39)	missense	probably benign	0.05
R7860:Ugt2b37	UTSW	5	87,402,189 (GRCm39)	missense	probably damaging	1.00
R7861:Ugt2b37	UTSW	5	87,390,299 (GRCm39)	nonsense	probably null
R8200:Ugt2b37	UTSW	5	87,388,750 (GRCm39)	nonsense	probably null
R8211:Ugt2b37	UTSW	5	87,390,235 (GRCm39)	missense	probably benign	0.07
R8282:Ugt2b37	UTSW	5	87,402,440 (GRCm39)	missense	probably benign	0.01
R8312:Ugt2b37	UTSW	5	87,390,799 (GRCm39)	missense	probably benign	0.15
R8520:Ugt2b37	UTSW	5	87,388,714 (GRCm39)	missense	probably benign	0.04
R8688:Ugt2b37	UTSW	5	87,390,240 (GRCm39)	missense	possibly damaging	0.52
R8695:Ugt2b37	UTSW	5	87,390,243 (GRCm39)	missense	probably benign	0.00
R8772:Ugt2b37	UTSW	5	87,402,345 (GRCm39)	missense	probably benign	0.00
R8839:Ugt2b37	UTSW	5	87,402,415 (GRCm39)	missense	probably damaging	1.00
R9087:Ugt2b37	UTSW	5	87,401,996 (GRCm39)	missense	probably benign	0.01
R9139:Ugt2b37	UTSW	5	87,399,636 (GRCm39)	missense	probably benign	0.09
R9424:Ugt2b37	UTSW	5	87,402,217 (GRCm39)	missense	probably damaging	0.99
R9432:Ugt2b37	UTSW	5	87,402,046 (GRCm39)	missense	probably damaging	0.97
R9498:Ugt2b37	UTSW	5	87,402,244 (GRCm39)	missense	probably benign	0.07
R9711:Ugt2b37	UTSW	5	87,402,532 (GRCm39)	missense	possibly damaging	0.85
R9718:Ugt2b37	UTSW	5	87,390,802 (GRCm39)	missense	probably benign	0.11
R9783:Ugt2b37	UTSW	5	87,388,840 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07