Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01982:Ly75'

182754

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ly75

Ensembl Gene

ENSMUSG00000026980

Gene Name

lymphocyte antigen 75

Synonyms

DEC-205, CD205

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01982

Quality Score

Status

Chromosome

Chromosomal Location

60292103-60383303 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 60311764 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 1334 (Y1334C)

Ref Sequence

ENSEMBL: ENSMUSP00000108152 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028362] [ENSMUST00000112533]

AlphaFold

Q60767

Predicted Effect

probably damaging
Transcript: ENSMUST00000028362
AA Change: Y1334C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000028362
Gene: ENSMUSG00000026980
AA Change: Y1334C

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
RICIN	33	146	2.63e-17	SMART
FN2	162	209	1.22e-23	SMART
CLECT	216	341	7.36e-32	SMART
CLECT	361	486	9.28e-29	SMART
CLECT	501	624	1.11e-17	SMART
CLECT	643	791	1.93e-26	SMART
CLECT	811	932	7.94e-2	SMART
CLECT	952	1091	5.81e-21	SMART
CLECT	1104	1222	1.04e-22	SMART
CLECT	1240	1382	3.48e-10	SMART
CLECT	1395	1513	9.59e-22	SMART
CLECT	1530	1661	7.79e-22	SMART
transmembrane domain	1670	1692	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000112533
AA Change: Y1334C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000108152
Gene: ENSMUSG00000026980
AA Change: Y1334C

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
RICIN	33	146	2.63e-17	SMART
FN2	162	209	1.22e-23	SMART
CLECT	216	341	7.36e-32	SMART
CLECT	361	486	9.28e-29	SMART
CLECT	501	624	1.11e-17	SMART
CLECT	643	791	1.93e-26	SMART
CLECT	811	932	7.94e-2	SMART
CLECT	952	1091	5.81e-21	SMART
CLECT	1104	1222	1.04e-22	SMART
CLECT	1240	1382	3.48e-10	SMART
CLECT	1395	1513	9.59e-22	SMART
CLECT	1530	1661	7.79e-22	SMART
transmembrane domain	1670	1692	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele display abnormalities in CD8-positive T cell morphology and cytotoxic T cell physiology. [provided by MGI curators]

Allele List at MGI

All alleles(7) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(5)

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921501E09Rik	T	G	17: 33,066,315 (GRCm38)	E504D	probably benign	Het
Abca12	A	C	1: 71,346,698 (GRCm38)	S254A	probably benign	Het
Abca7	T	G	10: 80,002,641 (GRCm38)	L583R	probably damaging	Het
Acp1	A	T	12: 30,911,492 (GRCm38)	L14H	possibly damaging	Het
Adar	A	G	3: 89,738,090 (GRCm38)	I3V	probably benign	Het
Adh4	C	T	3: 138,429,027 (GRCm38)		probably benign	Het
Aldh1l1	A	G	6: 90,559,863 (GRCm38)	I103V	probably benign	Het
Asic3	C	A	5: 24,417,721 (GRCm38)	T523N	probably benign	Het
Aspm	T	C	1: 139,491,588 (GRCm38)	V1732A	probably benign	Het
Atad3a	C	T	4: 155,753,927 (GRCm38)	R211Q	possibly damaging	Het
Bahcc1	A	G	11: 120,287,473 (GRCm38)	Y2286C	probably damaging	Het
BC034090	T	C	1: 155,223,332 (GRCm38)	E569G	probably damaging	Het
Bpifb3	A	G	2: 153,925,601 (GRCm38)	N237S	probably benign	Het
Bysl	C	A	17: 47,611,071 (GRCm38)		probably null	Het
C2cd6	T	C	1: 59,067,773 (GRCm38)		probably benign	Het
Ccdc141	A	G	2: 77,030,659 (GRCm38)	F925L	probably damaging	Het
Cdca2	A	T	14: 67,677,719 (GRCm38)	V697E	probably damaging	Het
Cers1	A	G	8: 70,323,431 (GRCm38)	D324G	probably damaging	Het
Ctsq	C	T	13: 61,039,521 (GRCm38)	C11Y	probably benign	Het
Ctsq	T	A	13: 61,038,918 (GRCm38)	I91F	probably benign	Het
Cyp11b1	T	C	15: 74,839,403 (GRCm38)	N142S	possibly damaging	Het
Cyp3a59	G	T	5: 146,104,735 (GRCm38)	S363I	probably benign	Het
Eps15l1	A	T	8: 72,379,075 (GRCm38)	D567E	probably benign	Het
Esf1	G	A	2: 140,164,528 (GRCm38)	A233V	probably benign	Het
Fras1	A	T	5: 96,739,248 (GRCm38)	I2630F	possibly damaging	Het
Fyb	A	T	15: 6,580,177 (GRCm38)	E77V	probably null	Het
Gjb6	C	A	14: 57,124,573 (GRCm38)	W77L	probably damaging	Het
Gm21983	A	G	7: 27,180,278 (GRCm38)	V88A	possibly damaging	Het
Gm8247	A	G	14: 44,585,631 (GRCm38)	T52A	probably damaging	Het
Gpr108	T	C	17: 57,237,877 (GRCm38)	K329E	probably damaging	Het
Gpr141	T	A	13: 19,751,738 (GRCm38)	H289L	probably benign	Het
Ilvbl	T	C	10: 78,579,022 (GRCm38)	Y240H	probably damaging	Het
Kntc1	G	A	5: 123,809,096 (GRCm38)	A1868T	probably benign	Het
Lrmda	A	C	14: 22,584,482 (GRCm38)	N112T	probably damaging	Het
Macc1	C	A	12: 119,445,634 (GRCm38)	P46T	probably benign	Het
Madd	A	T	2: 91,175,707 (GRCm38)	F381Y	probably damaging	Het
Map3k20	C	T	2: 72,298,333 (GRCm38)	Q38*	probably null	Het
Mcm4	A	T	16: 15,630,420 (GRCm38)	D424E	possibly damaging	Het
Micu1	T	A	10: 59,863,278 (GRCm38)	M463K	possibly damaging	Het
Mkrn2os	A	G	6: 115,585,531 (GRCm38)	L157P	probably damaging	Het
Nectin2	A	G	7: 19,717,562 (GRCm38)	S516P	probably damaging	Het
Nme5	T	A	18: 34,569,875 (GRCm38)	D120V	probably damaging	Het
Npy4r	T	C	14: 34,147,325 (GRCm38)	N2S	possibly damaging	Het
Nup107	A	T	10: 117,759,340 (GRCm38)		probably benign	Het
Omd	T	C	13: 49,589,497 (GRCm38)	Y8H	possibly damaging	Het
Ppp1r15a	T	C	7: 45,524,379 (GRCm38)		probably benign	Het
Ppp2ca	T	C	11: 52,099,064 (GRCm38)	F6L	probably benign	Het
Rab1a	T	C	11: 20,224,717 (GRCm38)	S97P	probably benign	Het
Ranbp3l	G	A	15: 9,058,746 (GRCm38)	G359R	probably damaging	Het
Rnf213	A	T	11: 119,443,268 (GRCm38)	H3101L	probably damaging	Het
Slc27a4	T	C	2: 29,812,615 (GRCm38)	F509S	probably damaging	Het
Slco4a1	T	C	2: 180,473,153 (GRCm38)	V623A	probably benign	Het
Spg20	T	A	3: 55,128,490 (GRCm38)		probably null	Het
Sptan1	A	G	2: 30,019,968 (GRCm38)	D1780G	probably damaging	Het
Tgm7	G	T	2: 121,093,625 (GRCm38)	Y605*	probably null	Het
Tmem106b	T	C	6: 13,071,969 (GRCm38)		probably benign	Het
Trak2	G	A	1: 58,926,655 (GRCm38)	A120V	possibly damaging	Het
Trappc8	G	A	18: 20,874,712 (GRCm38)		probably benign	Het
Trim66	T	C	7: 109,458,763 (GRCm38)	T973A	probably benign	Het
Ttyh3	C	A	5: 140,636,074 (GRCm38)		probably benign	Het
Ugt2b37	A	C	5: 87,242,432 (GRCm38)	I385S	probably damaging	Het
Usf3	A	G	16: 44,218,817 (GRCm38)	N1220S	possibly damaging	Het
Utrn	A	T	10: 12,748,029 (GRCm38)	I155N	probably damaging	Het
Vps13b	C	T	15: 35,438,904 (GRCm38)	Q377*	probably null	Het
Washc2	A	T	6: 116,236,189 (GRCm38)	E570D	probably benign	Het
Wscd1	T	C	11: 71,766,873 (GRCm38)	V168A	possibly damaging	Het
Zfp386	T	A	12: 116,059,168 (GRCm38)	C169S	probably benign	Het

Other mutations in Ly75

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00561:Ly75	APN	2	60,376,077 (GRCm38)	missense	probably damaging	1.00
IGL01072:Ly75	APN	2	60,354,496 (GRCm38)	missense	probably damaging	1.00
IGL01409:Ly75	APN	2	60,321,692 (GRCm38)	splice site	probably null
IGL01432:Ly75	APN	2	60,376,007 (GRCm38)	missense	probably damaging	1.00
IGL01626:Ly75	APN	2	60,301,015 (GRCm38)	missense	probably benign	0.13
IGL01690:Ly75	APN	2	60,338,311 (GRCm38)	missense	probably damaging	1.00
IGL01862:Ly75	APN	2	60,299,172 (GRCm38)	missense	probably damaging	1.00
IGL02075:Ly75	APN	2	60,352,356 (GRCm38)	missense	probably damaging	0.99
IGL02338:Ly75	APN	2	60,354,452 (GRCm38)	missense	probably benign	0.04
IGL02364:Ly75	APN	2	60,358,507 (GRCm38)	missense	probably damaging	1.00
IGL02456:Ly75	APN	2	60,293,781 (GRCm38)	missense	probably benign	0.09
IGL02474:Ly75	APN	2	60,383,182 (GRCm38)	missense	probably null	1.00
IGL02608:Ly75	APN	2	60,321,900 (GRCm38)	missense	probably benign	0.41
IGL02986:Ly75	APN	2	60,308,191 (GRCm38)	missense	probably damaging	1.00
IGL03015:Ly75	APN	2	60,376,160 (GRCm38)	missense	probably damaging	1.00
IGL03049:Ly75	APN	2	60,352,070 (GRCm38)	missense	probably damaging	0.99
euphues	UTSW	2	60,299,045 (GRCm38)	critical splice donor site	probably null
four_score	UTSW	2	60,311,771 (GRCm38)	missense	possibly damaging	0.75
lyly	UTSW	2	60,327,873 (GRCm38)	missense	possibly damaging	0.49
Witty	UTSW	2	60,354,500 (GRCm38)	missense	probably damaging	1.00
D605:Ly75	UTSW	2	60,352,352 (GRCm38)	critical splice donor site	probably null
R0046:Ly75	UTSW	2	60,339,457 (GRCm38)	intron	probably benign
R0055:Ly75	UTSW	2	60,321,918 (GRCm38)	missense	probably benign	0.01
R0055:Ly75	UTSW	2	60,321,918 (GRCm38)	missense	probably benign	0.01
R0071:Ly75	UTSW	2	60,321,819 (GRCm38)	missense	probably benign	0.01
R0071:Ly75	UTSW	2	60,321,819 (GRCm38)	missense	probably benign	0.01
R0285:Ly75	UTSW	2	60,318,319 (GRCm38)	missense	probably damaging	1.00
R0387:Ly75	UTSW	2	60,306,404 (GRCm38)	missense	probably benign	0.20
R0492:Ly75	UTSW	2	60,308,276 (GRCm38)	missense	probably damaging	1.00
R0688:Ly75	UTSW	2	60,316,221 (GRCm38)	missense	probably benign	0.41
R1367:Ly75	UTSW	2	60,293,758 (GRCm38)	splice site	probably null
R1463:Ly75	UTSW	2	60,368,757 (GRCm38)	critical splice donor site	probably null
R1581:Ly75	UTSW	2	60,327,893 (GRCm38)	missense	probably damaging	1.00
R1663:Ly75	UTSW	2	60,314,234 (GRCm38)	missense	probably damaging	1.00
R1818:Ly75	UTSW	2	60,311,777 (GRCm38)	missense	probably damaging	1.00
R1881:Ly75	UTSW	2	60,349,940 (GRCm38)	missense	probably benign	0.00
R2244:Ly75	UTSW	2	60,349,913 (GRCm38)	missense	probably benign	0.01
R2905:Ly75	UTSW	2	60,334,554 (GRCm38)	missense	probably benign	0.00
R3967:Ly75	UTSW	2	60,327,873 (GRCm38)	missense	possibly damaging	0.49
R3968:Ly75	UTSW	2	60,327,873 (GRCm38)	missense	possibly damaging	0.49
R4039:Ly75	UTSW	2	60,352,995 (GRCm38)	missense	probably damaging	1.00
R4406:Ly75	UTSW	2	60,354,550 (GRCm38)	missense	probably damaging	1.00
R4526:Ly75	UTSW	2	60,330,773 (GRCm38)	missense	probably benign	0.09
R4647:Ly75	UTSW	2	60,308,278 (GRCm38)	missense	probably damaging	1.00
R4795:Ly75	UTSW	2	60,349,940 (GRCm38)	missense	probably benign	0.00
R4796:Ly75	UTSW	2	60,349,940 (GRCm38)	missense	probably benign	0.00
R4962:Ly75	UTSW	2	60,352,125 (GRCm38)	missense	probably damaging	1.00
R4979:Ly75	UTSW	2	60,375,894 (GRCm38)	missense	probably damaging	1.00
R5072:Ly75	UTSW	2	60,375,963 (GRCm38)	missense	probably damaging	1.00
R5288:Ly75	UTSW	2	60,303,641 (GRCm38)	missense	probably damaging	1.00
R5373:Ly75	UTSW	2	60,311,771 (GRCm38)	missense	possibly damaging	0.75
R5374:Ly75	UTSW	2	60,311,771 (GRCm38)	missense	possibly damaging	0.75
R5384:Ly75	UTSW	2	60,334,487 (GRCm38)	nonsense	probably null
R5385:Ly75	UTSW	2	60,303,641 (GRCm38)	missense	probably damaging	1.00
R5395:Ly75	UTSW	2	60,365,111 (GRCm38)	missense	probably benign	0.41
R5531:Ly75	UTSW	2	60,365,145 (GRCm38)	missense	probably damaging	0.98
R5662:Ly75	UTSW	2	60,352,381 (GRCm38)	missense	probably damaging	1.00
R5667:Ly75	UTSW	2	60,308,311 (GRCm38)	missense	probably damaging	1.00
R5668:Ly75	UTSW	2	60,354,500 (GRCm38)	missense	probably damaging	1.00
R5671:Ly75	UTSW	2	60,308,311 (GRCm38)	missense	probably damaging	1.00
R5677:Ly75	UTSW	2	60,299,082 (GRCm38)	missense	probably benign	0.00
R5764:Ly75	UTSW	2	60,318,439 (GRCm38)	missense	probably benign
R5896:Ly75	UTSW	2	60,383,146 (GRCm38)	missense	probably benign
R6025:Ly75	UTSW	2	60,375,962 (GRCm38)	missense	probably damaging	1.00
R6113:Ly75	UTSW	2	60,368,873 (GRCm38)	missense	probably benign	0.04
R6448:Ly75	UTSW	2	60,299,045 (GRCm38)	critical splice donor site	probably null
R6601:Ly75	UTSW	2	60,318,376 (GRCm38)	missense	probably benign	0.11
R6745:Ly75	UTSW	2	60,308,179 (GRCm38)	missense	probably damaging	1.00
R6955:Ly75	UTSW	2	60,327,873 (GRCm38)	missense	possibly damaging	0.49
R6960:Ly75	UTSW	2	60,306,405 (GRCm38)	missense	probably benign
R7100:Ly75	UTSW	2	60,306,434 (GRCm38)	missense	probably benign
R7110:Ly75	UTSW	2	60,376,184 (GRCm38)	missense	probably benign	0.31
R7203:Ly75	UTSW	2	60,323,852 (GRCm38)	nonsense	probably null
R7291:Ly75	UTSW	2	60,329,993 (GRCm38)	missense	probably damaging	0.98
R7308:Ly75	UTSW	2	60,334,515 (GRCm38)	missense	probably benign	0.04
R7447:Ly75	UTSW	2	60,334,474 (GRCm38)	nonsense	probably null
R7512:Ly75	UTSW	2	60,334,563 (GRCm38)	missense	probably damaging	1.00
R7595:Ly75	UTSW	2	60,293,827 (GRCm38)	missense	probably benign	0.01
R7976:Ly75	UTSW	2	60,365,088 (GRCm38)	missense	probably damaging	1.00
R8005:Ly75	UTSW	2	60,332,934 (GRCm38)	missense	probably damaging	1.00
R8171:Ly75	UTSW	2	60,314,228 (GRCm38)	missense	possibly damaging	0.51
R8392:Ly75	UTSW	2	60,349,940 (GRCm38)	missense	probably benign	0.00
R8705:Ly75	UTSW	2	60,318,385 (GRCm38)	missense	probably damaging	0.98
R8714:Ly75	UTSW	2	60,334,485 (GRCm38)	missense	probably damaging	1.00
R8798:Ly75	UTSW	2	60,323,926 (GRCm38)	missense	probably benign	0.32
R8799:Ly75	UTSW	2	60,348,441 (GRCm38)	missense	probably damaging	1.00
R8834:Ly75	UTSW	2	60,331,089 (GRCm38)	missense	probably benign
R8990:Ly75	UTSW	2	60,358,559 (GRCm38)	missense	probably benign	0.10
R9015:Ly75	UTSW	2	60,316,098 (GRCm38)	missense	probably benign
R9547:Ly75	UTSW	2	60,330,725 (GRCm38)	critical splice donor site	probably null
R9628:Ly75	UTSW	2	60,327,941 (GRCm38)	missense	probably damaging	1.00
R9659:Ly75	UTSW	2	60,338,321 (GRCm38)	missense	probably damaging	1.00
R9660:Ly75	UTSW	2	60,323,840 (GRCm38)	missense	probably damaging	1.00
R9747:Ly75	UTSW	2	60,306,328 (GRCm38)	critical splice donor site	probably null
X0025:Ly75	UTSW	2	60,354,475 (GRCm38)	missense	probably damaging	1.00
Z1177:Ly75	UTSW	2	60,352,133 (GRCm38)	missense	possibly damaging	0.65
Z1177:Ly75	UTSW	2	60,350,004 (GRCm38)	nonsense	probably null

Posted On

2014-05-07