Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01996:Vmn2r120'

182909

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r120

Ensembl Gene

ENSMUSG00000090655

Gene Name

vomeronasal 2, receptor 120

Synonyms

EG224916

Accession Numbers

Genbank: NM_001104591; MGI: 3644483

Essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

IGL01996

Quality Score

Status

Chromosome

Chromosomal Location

57508783-57545314 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 57525222 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 189 (I189N)

Ref Sequence

ENSEMBL: ENSMUSP00000129296 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165781]

AlphaFold

A0A3Q4EG79

Predicted Effect

possibly damaging
Transcript: ENSMUST00000165781
AA Change: I189N

PolyPhen 2 Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000129296
Gene: ENSMUSG00000090655
AA Change: I189N

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	80	474	5.9e-42	PFAM
Pfam:NCD3G	517	570	7.5e-22	PFAM
Pfam:7tm_3	598	836	1.3e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3110009E18Rik	T	C	1: 120,150,700	V29A	possibly damaging	Het
Adarb1	A	G	10: 77,322,217	L132P	probably damaging	Het
Afg3l1	T	G	8: 123,501,894	M733R	probably damaging	Het
Aox1	C	T	1: 58,082,066	R899C	probably benign	Het
Arhgap44	T	A	11: 65,005,496		probably benign	Het
Asns	T	C	6: 7,682,378	D189G	possibly damaging	Het
Brap	A	G	5: 121,678,847		probably benign	Het
Ccdc138	T	A	10: 58,562,030	L564H	probably damaging	Het
Ccdc167	A	G	17: 29,705,487		probably null	Het
Ccdc178	A	G	18: 22,097,756	Y353H	probably damaging	Het
Clca3b	A	T	3: 144,849,163	S41R	probably benign	Het
Dpep3	T	C	8: 105,974,726	N397S	probably damaging	Het
Eif1	T	C	11: 100,321,000	I83T	probably benign	Het
Enah	A	T	1: 181,956,505	W80R	unknown	Het
F2rl1	C	T	13: 95,513,924	C150Y	probably damaging	Het
Fbxw24	T	C	9: 109,605,372	R387G	possibly damaging	Het
Fsd1l	A	G	4: 53,647,760	T68A	probably benign	Het
Greb1	T	C	12: 16,690,845	K1412R	possibly damaging	Het
Grin2b	T	C	6: 135,732,586	S1321G	probably damaging	Het
Hist1h4j	G	A	13: 21,735,138	G15S	unknown	Het
Itgb7	C	T	15: 102,217,977	G508D	probably damaging	Het
Kcnq3	A	G	15: 66,023,696	I333T	probably damaging	Het
Knl1	A	G	2: 119,104,061	D2115G	probably damaging	Het
Lmtk3	G	A	7: 45,793,447		probably null	Het
Lrpprc	A	G	17: 84,773,270	Y176H	probably benign	Het
Mier1	T	C	4: 103,127,276	S22P	possibly damaging	Het
Mme	A	T	3: 63,343,549	N337I	probably benign	Het
Mthfd1	A	G	12: 76,303,905	Y687C	probably damaging	Het
Nrp2	T	C	1: 62,749,260	M373T	probably damaging	Het
Nudcd1	A	T	15: 44,405,961	F101Y	probably benign	Het
Nup133	T	A	8: 123,946,595	I66L	probably benign	Het
Olfr1406	T	C	1: 173,183,727	T236A	probably benign	Het
Olfr378	T	A	11: 73,425,968	N5I	probably damaging	Het
Olfr736	T	G	14: 50,393,659	M301R	probably damaging	Het
Osbpl5	A	G	7: 143,707,344		probably null	Het
Paqr8	T	C	1: 20,935,404	F261L	probably damaging	Het
Plxna2	A	G	1: 194,799,776	E1452G	probably damaging	Het
Polh	T	C	17: 46,173,001	D446G	probably benign	Het
Psg19	A	T	7: 18,790,061	M353K	possibly damaging	Het
Sap25	T	C	5: 137,641,818		probably null	Het
Sap30l	C	T	11: 57,809,951	R144*	probably null	Het
Sema6b	C	T	17: 56,131,157	V144M	probably damaging	Het
Sfmbt2	T	C	2: 10,440,026	Y228H	probably benign	Het
Shank2	A	G	7: 144,411,493	D946G	probably damaging	Het
Slc11a1	T	A	1: 74,376,806	L52Q	possibly damaging	Het
Sptlc3	T	C	2: 139,581,504		probably benign	Het
Tgfb1i1	T	C	7: 128,249,292		probably benign	Het
Tifa	T	C	3: 127,796,580		probably benign	Het
Tomm40l	C	T	1: 171,219,655	V265M	possibly damaging	Het
Trim45	C	A	3: 100,928,109	Y469*	probably null	Het
Ttc21a	G	T	9: 119,958,116	A730S	probably damaging	Het
Vmn1r18	A	T	6: 57,390,016	D184E	possibly damaging	Het

Other mutations in Vmn2r120

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01335:Vmn2r120	APN	17	57525732	missense	possibly damaging	0.86
IGL01346:Vmn2r120	APN	17	57545232	missense	probably benign	0.11
IGL02503:Vmn2r120	APN	17	57509385	missense	probably benign	0.40
IGL02582:Vmn2r120	APN	17	57524724	missense	probably damaging	0.99
IGL02747:Vmn2r120	APN	17	57524719	missense	probably benign	0.19
IGL02896:Vmn2r120	APN	17	57509008	missense	probably damaging	1.00
IGL03139:Vmn2r120	APN	17	57524742	missense	probably benign	0.39
IGL03342:Vmn2r120	APN	17	57509372	missense	probably benign	0.03
A4554:Vmn2r120	UTSW	17	57525715	missense	probably benign	0.01
R0207:Vmn2r120	UTSW	17	57525052	missense	probably benign	0.17
R0472:Vmn2r120	UTSW	17	57524518	missense	probably benign	0.03
R0517:Vmn2r120	UTSW	17	57508949	missense	probably damaging	1.00
R1109:Vmn2r120	UTSW	17	57525829	missense	probably benign	0.09
R1316:Vmn2r120	UTSW	17	57525939	missense	probably benign	0.28
R1543:Vmn2r120	UTSW	17	57522374	missense	probably benign	0.09
R1795:Vmn2r120	UTSW	17	57525038	missense	probably benign	0.35
R1850:Vmn2r120	UTSW	17	57525826	missense	probably benign	0.19
R1920:Vmn2r120	UTSW	17	57524839	missense	probably benign	0.01
R1921:Vmn2r120	UTSW	17	57524839	missense	probably benign	0.01
R1922:Vmn2r120	UTSW	17	57524839	missense	probably benign	0.01
R2063:Vmn2r120	UTSW	17	57524553	missense	possibly damaging	0.88
R2064:Vmn2r120	UTSW	17	57524553	missense	possibly damaging	0.88
R2065:Vmn2r120	UTSW	17	57524553	missense	possibly damaging	0.88
R2067:Vmn2r120	UTSW	17	57524553	missense	possibly damaging	0.88
R2286:Vmn2r120	UTSW	17	57508958	missense	probably damaging	1.00
R2291:Vmn2r120	UTSW	17	57509479	missense	probably damaging	1.00
R3416:Vmn2r120	UTSW	17	57509241	missense	possibly damaging	0.89
R3874:Vmn2r120	UTSW	17	57524954	missense	probably benign	0.40
R4023:Vmn2r120	UTSW	17	57536718	missense	possibly damaging	0.92
R4024:Vmn2r120	UTSW	17	57536718	missense	possibly damaging	0.92
R4348:Vmn2r120	UTSW	17	57522466	missense	possibly damaging	0.47
R4409:Vmn2r120	UTSW	17	57509477	missense	probably damaging	1.00
R4610:Vmn2r120	UTSW	17	57509120	missense	probably damaging	1.00
R4771:Vmn2r120	UTSW	17	57524887	missense	probably damaging	1.00
R4786:Vmn2r120	UTSW	17	57522048	missense	probably benign	0.14
R4927:Vmn2r120	UTSW	17	57509125	missense	probably damaging	1.00
R5285:Vmn2r120	UTSW	17	57536703	missense	probably damaging	1.00
R5566:Vmn2r120	UTSW	17	57545290	missense	possibly damaging	0.95
R5578:Vmn2r120	UTSW	17	57522514	missense	probably benign	0.01
R5643:Vmn2r120	UTSW	17	57524977	missense	probably benign	0.01
R5644:Vmn2r120	UTSW	17	57524977	missense	probably benign	0.01
R5781:Vmn2r120	UTSW	17	57524938	missense	probably benign	0.00
R6084:Vmn2r120	UTSW	17	57525721	missense	probably benign	0.15
R6120:Vmn2r120	UTSW	17	57525973	missense	probably benign	0.02
R6160:Vmn2r120	UTSW	17	57509418	missense	probably benign	0.03
R6248:Vmn2r120	UTSW	17	57545287	missense	probably benign	0.03
R6256:Vmn2r120	UTSW	17	57524700	nonsense	probably null
R6730:Vmn2r120	UTSW	17	57525012	missense	probably benign	0.03
R6821:Vmn2r120	UTSW	17	57536659	missense	probably benign	0.00
R6868:Vmn2r120	UTSW	17	57545218	missense	probably benign	0.00
R6880:Vmn2r120	UTSW	17	57509187	missense	probably damaging	1.00
R6986:Vmn2r120	UTSW	17	57509340	missense	probably damaging	1.00
R7276:Vmn2r120	UTSW	17	57524881	missense	probably benign	0.11
R7373:Vmn2r120	UTSW	17	57509406	missense	probably benign	0.35
R7653:Vmn2r120	UTSW	17	57509258	missense	possibly damaging	0.93
R7667:Vmn2r120	UTSW	17	57536657	missense	probably benign	0.04
R7775:Vmn2r120	UTSW	17	57525942	missense	probably damaging	1.00
R7778:Vmn2r120	UTSW	17	57525942	missense	probably damaging	1.00
R7797:Vmn2r120	UTSW	17	57508874	missense	probably damaging	1.00
R7824:Vmn2r120	UTSW	17	57525942	missense	probably damaging	1.00
R7902:Vmn2r120	UTSW	17	57509244	missense	possibly damaging	0.87
R7922:Vmn2r120	UTSW	17	57524683	missense	probably damaging	0.99
R8508:Vmn2r120	UTSW	17	57525843	missense	probably benign	0.03
R8847:Vmn2r120	UTSW	17	57509217	missense	probably benign	0.01
R8882:Vmn2r120	UTSW	17	57545229	missense	probably benign	0.01
R9134:Vmn2r120	UTSW	17	57525093	missense	probably damaging	1.00
R9161:Vmn2r120	UTSW	17	57524864	missense
R9336:Vmn2r120	UTSW	17	57525201	missense	possibly damaging	0.91
RF005:Vmn2r120	UTSW	17	57521991	missense	possibly damaging	0.65
Z1177:Vmn2r120	UTSW	17	57509245	missense	probably benign	0.00
Z1188:Vmn2r120	UTSW	17	57522436	missense	probably damaging	1.00

Posted On

2014-05-07