Incidental Mutation 'IGL01996:Dpep3'
ID 182926
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dpep3
Ensembl Gene ENSMUSG00000031898
Gene Name dipeptidase 3
Synonyms MBD-3, 1700018F16Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # IGL01996
Quality Score
Status
Chromosome 8
Chromosomal Location 105973513-105979429 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 105974726 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 397 (N397S)
Ref Sequence ENSEMBL: ENSMUSP00000034371 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034371]
AlphaFold Q9DA79
Predicted Effect probably damaging
Transcript: ENSMUST00000034371
AA Change: N397S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000034371
Gene: ENSMUSG00000031898
AA Change: N397S

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
Pfam:Peptidase_M19 83 404 1.2e-110 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212917
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family. Alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110009E18Rik T C 1: 120,150,700 V29A possibly damaging Het
Adarb1 A G 10: 77,322,217 L132P probably damaging Het
Afg3l1 T G 8: 123,501,894 M733R probably damaging Het
Aox1 C T 1: 58,082,066 R899C probably benign Het
Arhgap44 T A 11: 65,005,496 probably benign Het
Asns T C 6: 7,682,378 D189G possibly damaging Het
Brap A G 5: 121,678,847 probably benign Het
Ccdc138 T A 10: 58,562,030 L564H probably damaging Het
Ccdc167 A G 17: 29,705,487 probably null Het
Ccdc178 A G 18: 22,097,756 Y353H probably damaging Het
Clca3b A T 3: 144,849,163 S41R probably benign Het
Eif1 T C 11: 100,321,000 I83T probably benign Het
Enah A T 1: 181,956,505 W80R unknown Het
F2rl1 C T 13: 95,513,924 C150Y probably damaging Het
Fbxw24 T C 9: 109,605,372 R387G possibly damaging Het
Fsd1l A G 4: 53,647,760 T68A probably benign Het
Greb1 T C 12: 16,690,845 K1412R possibly damaging Het
Grin2b T C 6: 135,732,586 S1321G probably damaging Het
Hist1h4j G A 13: 21,735,138 G15S unknown Het
Itgb7 C T 15: 102,217,977 G508D probably damaging Het
Kcnq3 A G 15: 66,023,696 I333T probably damaging Het
Knl1 A G 2: 119,104,061 D2115G probably damaging Het
Lmtk3 G A 7: 45,793,447 probably null Het
Lrpprc A G 17: 84,773,270 Y176H probably benign Het
Mier1 T C 4: 103,127,276 S22P possibly damaging Het
Mme A T 3: 63,343,549 N337I probably benign Het
Mthfd1 A G 12: 76,303,905 Y687C probably damaging Het
Nrp2 T C 1: 62,749,260 M373T probably damaging Het
Nudcd1 A T 15: 44,405,961 F101Y probably benign Het
Nup133 T A 8: 123,946,595 I66L probably benign Het
Olfr1406 T C 1: 173,183,727 T236A probably benign Het
Olfr378 T A 11: 73,425,968 N5I probably damaging Het
Olfr736 T G 14: 50,393,659 M301R probably damaging Het
Osbpl5 A G 7: 143,707,344 probably null Het
Paqr8 T C 1: 20,935,404 F261L probably damaging Het
Plxna2 A G 1: 194,799,776 E1452G probably damaging Het
Polh T C 17: 46,173,001 D446G probably benign Het
Psg19 A T 7: 18,790,061 M353K possibly damaging Het
Sap25 T C 5: 137,641,818 probably null Het
Sap30l C T 11: 57,809,951 R144* probably null Het
Sema6b C T 17: 56,131,157 V144M probably damaging Het
Sfmbt2 T C 2: 10,440,026 Y228H probably benign Het
Shank2 A G 7: 144,411,493 D946G probably damaging Het
Slc11a1 T A 1: 74,376,806 L52Q possibly damaging Het
Sptlc3 T C 2: 139,581,504 probably benign Het
Tgfb1i1 T C 7: 128,249,292 probably benign Het
Tifa T C 3: 127,796,580 probably benign Het
Tomm40l C T 1: 171,219,655 V265M possibly damaging Het
Trim45 C A 3: 100,928,109 Y469* probably null Het
Ttc21a G T 9: 119,958,116 A730S probably damaging Het
Vmn1r18 A T 6: 57,390,016 D184E possibly damaging Het
Vmn2r120 A T 17: 57,525,222 I189N possibly damaging Het
Other mutations in Dpep3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00158:Dpep3 APN 8 105979147 missense probably benign 0.22
IGL01078:Dpep3 APN 8 105978228 missense probably damaging 1.00
IGL01543:Dpep3 APN 8 105976182 missense probably damaging 1.00
IGL02036:Dpep3 APN 8 105973785 missense probably benign
R0422:Dpep3 UTSW 8 105976118 critical splice donor site probably null
R0627:Dpep3 UTSW 8 105978731 missense possibly damaging 0.56
R0747:Dpep3 UTSW 8 105977386 missense probably benign 0.12
R1116:Dpep3 UTSW 8 105978829 missense probably damaging 0.98
R1711:Dpep3 UTSW 8 105973693 missense probably benign 0.01
R2085:Dpep3 UTSW 8 105974714 missense probably damaging 1.00
R4385:Dpep3 UTSW 8 105978186 missense probably damaging 1.00
R4860:Dpep3 UTSW 8 105976189 missense probably benign 0.34
R4860:Dpep3 UTSW 8 105976189 missense probably benign 0.34
R5784:Dpep3 UTSW 8 105978743 missense probably benign 0.03
R6658:Dpep3 UTSW 8 105979096 missense probably benign
R6893:Dpep3 UTSW 8 105973842 missense probably benign
R7536:Dpep3 UTSW 8 105977400 missense probably damaging 1.00
R9213:Dpep3 UTSW 8 105973613 missense probably benign 0.15
R9528:Dpep3 UTSW 8 105977619 missense probably benign 0.01
R9766:Dpep3 UTSW 8 105978737 missense probably damaging 1.00
Posted On 2014-05-07