Incidental Mutation 'IGL01998:Klra5'
ID 182937
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Klra5
Ensembl Gene ENSMUSG00000030173
Gene Name killer cell lectin-like receptor, subfamily A, member 5
Synonyms Ly49e
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01998
Quality Score
Status
Chromosome 6
Chromosomal Location 129898996-129917650 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 129906713 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 60 (Y60*)
Ref Sequence ENSEMBL: ENSMUSP00000126290 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000014683] [ENSMUST00000118060] [ENSMUST00000169901]
AlphaFold Q60652
Predicted Effect probably null
Transcript: ENSMUST00000014683
AA Change: Y150*
SMART Domains Protein: ENSMUSP00000014683
Gene: ENSMUSG00000030173
AA Change: Y150*

DomainStartEndE-ValueType
low complexity region 56 66 N/A INTRINSIC
Blast:CLECT 73 123 4e-9 BLAST
CLECT 143 258 3.66e-18 SMART
Predicted Effect probably null
Transcript: ENSMUST00000118060
AA Change: Y150*
SMART Domains Protein: ENSMUSP00000112795
Gene: ENSMUSG00000030173
AA Change: Y150*

DomainStartEndE-ValueType
low complexity region 56 66 N/A INTRINSIC
Blast:CLECT 73 123 4e-9 BLAST
CLECT 143 258 3.66e-18 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000167079
SMART Domains Protein: ENSMUSP00000125971
Gene: ENSMUSG00000030173

DomainStartEndE-ValueType
CLECT 53 168 3.66e-18 SMART
Predicted Effect probably null
Transcript: ENSMUST00000169901
AA Change: Y60*
SMART Domains Protein: ENSMUSP00000126290
Gene: ENSMUSG00000030173
AA Change: Y60*

DomainStartEndE-ValueType
CLECT 53 168 3.66e-18 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal NK and T cell morphology and function. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110043O21Rik A T 4: 35,194,179 D205E probably benign Het
4930435E12Rik A T 16: 38,828,224 D174E probably benign Het
4932438A13Rik T C 3: 36,957,016 S1788P possibly damaging Het
Arpc3 T C 5: 122,403,407 C78R probably damaging Het
Atp6v0b A G 4: 117,886,066 probably null Het
B3gnt8 A G 7: 25,628,778 Y211C probably damaging Het
Birc6 T C 17: 74,579,885 I736T probably benign Het
Bpifb9a T C 2: 154,268,200 probably null Het
C3ar1 A T 6: 122,850,940 M106K probably damaging Het
Cab39l T A 14: 59,496,895 L21Q probably damaging Het
Casp1 A T 9: 5,303,043 I166F probably damaging Het
Cd180 A G 13: 102,705,214 E256G probably damaging Het
Clca4a T C 3: 144,958,126 T519A probably damaging Het
Clstn3 A T 6: 124,458,663 L233Q probably damaging Het
Crlf3 G A 11: 80,058,019 probably benign Het
Depdc5 T C 5: 32,945,151 probably benign Het
Drc7 T A 8: 95,059,193 C226S probably damaging Het
Epha5 T A 5: 84,084,734 D807V probably damaging Het
Fat2 A G 11: 55,296,195 L1275P probably benign Het
Fv1 T C 4: 147,869,327 C117R possibly damaging Het
Ighg2b C A 12: 113,307,089 M140I unknown Het
Lmtk2 C T 5: 144,176,065 T1201I probably damaging Het
Ncapd2 A T 6: 125,169,933 L1230H probably damaging Het
Ncapd2 A T 6: 125,173,115 S917T probably benign Het
Nfx1 T A 4: 41,004,353 I708N probably damaging Het
Notch2 A T 3: 98,143,106 D1899V probably damaging Het
Npepl1 T A 2: 174,116,200 probably benign Het
Nps T A 7: 135,268,752 probably benign Het
Nrg1 T C 8: 31,918,134 S24G probably damaging Het
Olfr330 A T 11: 58,529,577 Y136* probably null Het
Olfr352 A G 2: 36,869,646 N27D probably benign Het
Olfr698 G A 7: 106,752,551 T279M possibly damaging Het
Olfr730 C A 14: 50,186,648 V190L probably benign Het
Pigx G T 16: 32,084,610 T211K probably benign Het
Pink1 A G 4: 138,320,742 I223T probably damaging Het
Plat G A 8: 22,767,147 A15T probably benign Het
Ptges2 G A 2: 32,401,530 A310T possibly damaging Het
Rsl1d1 A G 16: 11,194,645 S306P possibly damaging Het
Rxfp1 T C 3: 79,660,096 K316E probably benign Het
Scn10a A G 9: 119,609,676 I1708T probably damaging Het
Sdk2 A T 11: 113,838,532 F1073Y probably damaging Het
Sp100 A G 1: 85,666,929 D170G probably benign Het
Spock1 A T 13: 57,436,181 probably benign Het
Strbp A G 2: 37,625,285 L243P probably damaging Het
Tgm5 T A 2: 121,052,439 T446S probably damaging Het
Tmem59l C T 8: 70,484,781 V239I probably benign Het
Trav8-1 A T 14: 53,470,205 T101S probably benign Het
Triml1 T C 8: 43,141,313 D27G probably damaging Het
Vmn2r54 T C 7: 12,615,300 E785G probably benign Het
Vps13c A G 9: 67,955,068 probably null Het
Wwp2 C T 8: 107,549,521 R64C probably damaging Het
Zfp608 T C 18: 54,891,818 H1460R probably damaging Het
Other mutations in Klra5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00838:Klra5 APN 6 129911359 missense possibly damaging 0.63
IGL00972:Klra5 APN 6 129906605 missense probably damaging 1.00
IGL01770:Klra5 APN 6 129906664 missense probably damaging 1.00
IGL01978:Klra5 APN 6 129911430 missense probably benign 0.32
IGL02103:Klra5 APN 6 129911344 splice site probably null
IGL02995:Klra5 APN 6 129906614 missense possibly damaging 0.46
IGL03036:Klra5 APN 6 129908867 missense probably damaging 0.99
R0314:Klra5 UTSW 6 129903590 missense probably damaging 1.00
R0378:Klra5 UTSW 6 129906614 missense possibly damaging 0.46
R0646:Klra5 UTSW 6 129903564 missense probably damaging 1.00
R0731:Klra5 UTSW 6 129908796 missense possibly damaging 0.88
R1552:Klra5 UTSW 6 129909885 missense probably damaging 0.97
R1572:Klra5 UTSW 6 129906622 missense probably damaging 1.00
R1807:Klra5 UTSW 6 129899420 missense probably benign 0.00
R4451:Klra5 UTSW 6 129908834 nonsense probably null
R4619:Klra5 UTSW 6 129908813 missense probably benign 0.05
R4647:Klra5 UTSW 6 129899376 missense probably damaging 0.99
R5019:Klra5 UTSW 6 129899389 missense probably benign
R5364:Klra5 UTSW 6 129899353 missense probably benign
R6724:Klra5 UTSW 6 129906680 missense probably benign 0.29
R6925:Klra5 UTSW 6 129911457 missense probably benign 0.41
R7834:Klra5 UTSW 6 129899290 critical splice donor site probably null
R8855:Klra5 UTSW 6 129903570 missense probably damaging 1.00
R8866:Klra5 UTSW 6 129903570 missense probably damaging 1.00
R9144:Klra5 UTSW 6 129909948 missense probably benign 0.16
R9145:Klra5 UTSW 6 129909948 missense probably benign 0.16
R9148:Klra5 UTSW 6 129909948 missense probably benign 0.16
R9440:Klra5 UTSW 6 129906723 missense possibly damaging 0.95
R9452:Klra5 UTSW 6 129906723 missense possibly damaging 0.95
R9453:Klra5 UTSW 6 129906723 missense possibly damaging 0.95
R9454:Klra5 UTSW 6 129906723 missense possibly damaging 0.95
R9469:Klra5 UTSW 6 129906723 missense possibly damaging 0.95
R9471:Klra5 UTSW 6 129906723 missense possibly damaging 0.95
R9615:Klra5 UTSW 6 129906723 missense possibly damaging 0.95
R9627:Klra5 UTSW 6 129906738 missense probably benign 0.03
Z1176:Klra5 UTSW 6 129911452 missense not run
Posted On 2014-05-07