Incidental Mutation 'IGL01998:Or1j20'
ID 182938
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1j20
Ensembl Gene ENSMUSG00000053146
Gene Name olfactory receptor family 1 subfamily J member 20
Synonyms MOR136-10, GA_x6K02T2NLDC-33564136-33565083, Olfr352
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # IGL01998
Quality Score
Chromosome 2
Chromosomal Location 36759580-36760527 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 36759658 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 27 (N27D)
Ref Sequence ENSEMBL: ENSMUSP00000149568 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065416] [ENSMUST00000217325]
AlphaFold Q8VGJ9
Predicted Effect probably benign
Transcript: ENSMUST00000065416
AA Change: N27D

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000070758
Gene: ENSMUSG00000053146
AA Change: N27D

Pfam:7tm_4 34 311 1.4e-56 PFAM
Pfam:7TM_GPCR_Srsx 38 308 1.8e-7 PFAM
Pfam:7tm_1 44 293 1.2e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217325
AA Change: N27D

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arpc3 T C 5: 122,541,470 (GRCm39) C78R probably damaging Het
Atp6v0b A G 4: 117,743,263 (GRCm39) probably null Het
B3gnt8 A G 7: 25,328,203 (GRCm39) Y211C probably damaging Het
Birc6 T C 17: 74,886,880 (GRCm39) I736T probably benign Het
Bltp1 T C 3: 37,011,165 (GRCm39) S1788P possibly damaging Het
Bpifb9a T C 2: 154,110,120 (GRCm39) probably null Het
C3ar1 A T 6: 122,827,899 (GRCm39) M106K probably damaging Het
C9orf72 A T 4: 35,194,179 (GRCm39) D205E probably benign Het
Cab39l T A 14: 59,734,344 (GRCm39) L21Q probably damaging Het
Casp1 A T 9: 5,303,043 (GRCm39) I166F probably damaging Het
Cd180 A G 13: 102,841,722 (GRCm39) E256G probably damaging Het
Clca4a T C 3: 144,663,887 (GRCm39) T519A probably damaging Het
Clstn3 A T 6: 124,435,622 (GRCm39) L233Q probably damaging Het
Crlf3 G A 11: 79,948,845 (GRCm39) probably benign Het
Depdc5 T C 5: 33,102,495 (GRCm39) probably benign Het
Drc7 T A 8: 95,785,821 (GRCm39) C226S probably damaging Het
Epha5 T A 5: 84,232,593 (GRCm39) D807V probably damaging Het
Fat2 A G 11: 55,187,021 (GRCm39) L1275P probably benign Het
Fv1 T C 4: 147,953,784 (GRCm39) C117R possibly damaging Het
Ighg2b C A 12: 113,270,709 (GRCm39) M140I unknown Het
Klra5 A T 6: 129,883,676 (GRCm39) Y60* probably null Het
Lmtk2 C T 5: 144,112,883 (GRCm39) T1201I probably damaging Het
Ncapd2 A T 6: 125,150,078 (GRCm39) S917T probably benign Het
Ncapd2 A T 6: 125,146,896 (GRCm39) L1230H probably damaging Het
Nfx1 T A 4: 41,004,353 (GRCm39) I708N probably damaging Het
Notch2 A T 3: 98,050,422 (GRCm39) D1899V probably damaging Het
Npepl1 T A 2: 173,957,993 (GRCm39) probably benign Het
Nps T A 7: 134,870,481 (GRCm39) probably benign Het
Nrg1 T C 8: 32,408,162 (GRCm39) S24G probably damaging Het
Or2ag16 G A 7: 106,351,758 (GRCm39) T279M possibly damaging Het
Or2t48 A T 11: 58,420,403 (GRCm39) Y136* probably null Het
Or4k2 C A 14: 50,424,105 (GRCm39) V190L probably benign Het
Pigx G T 16: 31,903,428 (GRCm39) T211K probably benign Het
Pink1 A G 4: 138,048,053 (GRCm39) I223T probably damaging Het
Plat G A 8: 23,257,163 (GRCm39) A15T probably benign Het
Ptges2 G A 2: 32,291,542 (GRCm39) A310T possibly damaging Het
Rsl1d1 A G 16: 11,012,509 (GRCm39) S306P possibly damaging Het
Rxfp1 T C 3: 79,567,403 (GRCm39) K316E probably benign Het
Scn10a A G 9: 119,438,742 (GRCm39) I1708T probably damaging Het
Sdk2 A T 11: 113,729,358 (GRCm39) F1073Y probably damaging Het
Sp100 A G 1: 85,594,650 (GRCm39) D170G probably benign Het
Spock1 A T 13: 57,583,994 (GRCm39) probably benign Het
Strbp A G 2: 37,515,297 (GRCm39) L243P probably damaging Het
Tex55 A T 16: 38,648,586 (GRCm39) D174E probably benign Het
Tgm5 T A 2: 120,882,920 (GRCm39) T446S probably damaging Het
Tmem59l C T 8: 70,937,431 (GRCm39) V239I probably benign Het
Trav8-1 A T 14: 53,707,662 (GRCm39) T101S probably benign Het
Triml1 T C 8: 43,594,350 (GRCm39) D27G probably damaging Het
Vmn2r54 T C 7: 12,349,227 (GRCm39) E785G probably benign Het
Vps13c A G 9: 67,862,350 (GRCm39) probably null Het
Wwp2 C T 8: 108,276,153 (GRCm39) R64C probably damaging Het
Zfp608 T C 18: 55,024,890 (GRCm39) H1460R probably damaging Het
Other mutations in Or1j20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00899:Or1j20 APN 2 36,760,222 (GRCm39) missense probably benign 0.01
IGL01538:Or1j20 APN 2 36,760,532 (GRCm39) utr 3 prime probably benign
IGL01716:Or1j20 APN 2 36,759,679 (GRCm39) missense probably benign 0.11
IGL01735:Or1j20 APN 2 36,759,698 (GRCm39) missense possibly damaging 0.95
IGL02820:Or1j20 APN 2 36,759,871 (GRCm39) missense probably benign 0.01
IGL03267:Or1j20 APN 2 36,760,513 (GRCm39) missense probably benign 0.00
IGL03306:Or1j20 APN 2 36,760,537 (GRCm39) utr 3 prime probably benign
R0013:Or1j20 UTSW 2 36,760,172 (GRCm39) missense probably damaging 1.00
R0081:Or1j20 UTSW 2 36,760,022 (GRCm39) missense possibly damaging 0.58
R0421:Or1j20 UTSW 2 36,759,653 (GRCm39) missense possibly damaging 0.89
R1613:Or1j20 UTSW 2 36,760,405 (GRCm39) missense possibly damaging 0.91
R1842:Or1j20 UTSW 2 36,759,601 (GRCm39) missense probably damaging 1.00
R2698:Or1j20 UTSW 2 36,760,208 (GRCm39) missense possibly damaging 0.94
R4463:Or1j20 UTSW 2 36,760,205 (GRCm39) missense probably benign 0.31
R4993:Or1j20 UTSW 2 36,760,000 (GRCm39) missense probably benign 0.30
R5553:Or1j20 UTSW 2 36,760,477 (GRCm39) missense probably benign 0.00
R5666:Or1j20 UTSW 2 36,760,401 (GRCm39) missense probably benign 0.11
R5934:Or1j20 UTSW 2 36,760,280 (GRCm39) missense probably benign 0.34
R6290:Or1j20 UTSW 2 36,760,448 (GRCm39) missense probably damaging 1.00
R6312:Or1j20 UTSW 2 36,760,477 (GRCm39) missense probably benign 0.02
R7358:Or1j20 UTSW 2 36,759,890 (GRCm39) missense probably benign
R8383:Or1j20 UTSW 2 36,760,343 (GRCm39) missense probably damaging 1.00
R8392:Or1j20 UTSW 2 36,760,352 (GRCm39) missense probably damaging 1.00
R8967:Or1j20 UTSW 2 36,760,066 (GRCm39) missense probably damaging 1.00
R9311:Or1j20 UTSW 2 36,760,405 (GRCm39) missense probably damaging 1.00
X0022:Or1j20 UTSW 2 36,760,289 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07