Incidental Mutation 'IGL01998:Olfr698'
ID 182940
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr698
Ensembl Gene ENSMUSG00000059087
Gene Name olfactory receptor 698
Synonyms MOR283-3, GA_x6K02T2PBJ9-9130754-9129519
Accession Numbers
Essential gene? Probably non essential (E-score: 0.095) question?
Stock # IGL01998
Quality Score
Status
Chromosome 7
Chromosomal Location 106749889-106755397 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 106752551 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 279 (T279M)
Ref Sequence ENSEMBL: ENSMUSP00000149305 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074981] [ENSMUST00000214306] [ENSMUST00000216255]
AlphaFold Q7TRN4
Predicted Effect possibly damaging
Transcript: ENSMUST00000074981
AA Change: T279M

PolyPhen 2 Score 0.628 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000074509
Gene: ENSMUSG00000059087
AA Change: T279M

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 9.4e-50 PFAM
Pfam:7TM_GPCR_Srsx 35 305 9.8e-8 PFAM
Pfam:7tm_1 41 290 4.1e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214306
AA Change: T279M

PolyPhen 2 Score 0.628 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215892
Predicted Effect possibly damaging
Transcript: ENSMUST00000216255
AA Change: T279M

PolyPhen 2 Score 0.628 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110043O21Rik A T 4: 35,194,179 D205E probably benign Het
4930435E12Rik A T 16: 38,828,224 D174E probably benign Het
4932438A13Rik T C 3: 36,957,016 S1788P possibly damaging Het
Arpc3 T C 5: 122,403,407 C78R probably damaging Het
Atp6v0b A G 4: 117,886,066 probably null Het
B3gnt8 A G 7: 25,628,778 Y211C probably damaging Het
Birc6 T C 17: 74,579,885 I736T probably benign Het
Bpifb9a T C 2: 154,268,200 probably null Het
C3ar1 A T 6: 122,850,940 M106K probably damaging Het
Cab39l T A 14: 59,496,895 L21Q probably damaging Het
Casp1 A T 9: 5,303,043 I166F probably damaging Het
Cd180 A G 13: 102,705,214 E256G probably damaging Het
Clca4a T C 3: 144,958,126 T519A probably damaging Het
Clstn3 A T 6: 124,458,663 L233Q probably damaging Het
Crlf3 G A 11: 80,058,019 probably benign Het
Depdc5 T C 5: 32,945,151 probably benign Het
Drc7 T A 8: 95,059,193 C226S probably damaging Het
Epha5 T A 5: 84,084,734 D807V probably damaging Het
Fat2 A G 11: 55,296,195 L1275P probably benign Het
Fv1 T C 4: 147,869,327 C117R possibly damaging Het
Ighg2b C A 12: 113,307,089 M140I unknown Het
Klra5 A T 6: 129,906,713 Y60* probably null Het
Lmtk2 C T 5: 144,176,065 T1201I probably damaging Het
Ncapd2 A T 6: 125,173,115 S917T probably benign Het
Ncapd2 A T 6: 125,169,933 L1230H probably damaging Het
Nfx1 T A 4: 41,004,353 I708N probably damaging Het
Notch2 A T 3: 98,143,106 D1899V probably damaging Het
Npepl1 T A 2: 174,116,200 probably benign Het
Nps T A 7: 135,268,752 probably benign Het
Nrg1 T C 8: 31,918,134 S24G probably damaging Het
Olfr330 A T 11: 58,529,577 Y136* probably null Het
Olfr352 A G 2: 36,869,646 N27D probably benign Het
Olfr730 C A 14: 50,186,648 V190L probably benign Het
Pigx G T 16: 32,084,610 T211K probably benign Het
Pink1 A G 4: 138,320,742 I223T probably damaging Het
Plat G A 8: 22,767,147 A15T probably benign Het
Ptges2 G A 2: 32,401,530 A310T possibly damaging Het
Rsl1d1 A G 16: 11,194,645 S306P possibly damaging Het
Rxfp1 T C 3: 79,660,096 K316E probably benign Het
Scn10a A G 9: 119,609,676 I1708T probably damaging Het
Sdk2 A T 11: 113,838,532 F1073Y probably damaging Het
Sp100 A G 1: 85,666,929 D170G probably benign Het
Spock1 A T 13: 57,436,181 probably benign Het
Strbp A G 2: 37,625,285 L243P probably damaging Het
Tgm5 T A 2: 121,052,439 T446S probably damaging Het
Tmem59l C T 8: 70,484,781 V239I probably benign Het
Trav8-1 A T 14: 53,470,205 T101S probably benign Het
Triml1 T C 8: 43,141,313 D27G probably damaging Het
Vmn2r54 T C 7: 12,615,300 E785G probably benign Het
Vps13c A G 9: 67,955,068 probably null Het
Wwp2 C T 8: 107,549,521 R64C probably damaging Het
Zfp608 T C 18: 54,891,818 H1460R probably damaging Het
Other mutations in Olfr698
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01373:Olfr698 APN 7 106752446 utr 3 prime probably benign
IGL01901:Olfr698 APN 7 106752545 missense possibly damaging 0.52
IGL01912:Olfr698 APN 7 106752992 missense probably damaging 1.00
IGL02640:Olfr698 APN 7 106753352 missense probably damaging 1.00
IGL03195:Olfr698 APN 7 106752773 missense probably benign
R0255:Olfr698 UTSW 7 106752989 missense probably benign 0.19
R1104:Olfr698 UTSW 7 106752782 missense probably benign 0.37
R1796:Olfr698 UTSW 7 106752549 missense probably benign 0.02
R1909:Olfr698 UTSW 7 106752995 missense probably benign 0.21
R4133:Olfr698 UTSW 7 106753079 missense probably damaging 0.98
R5194:Olfr698 UTSW 7 106753219 missense probably benign 0.15
R5389:Olfr698 UTSW 7 106753083 missense probably damaging 0.99
R5426:Olfr698 UTSW 7 106752566 missense probably benign
R6162:Olfr698 UTSW 7 106753020 missense probably damaging 1.00
R6463:Olfr698 UTSW 7 106752801 missense probably benign 0.23
R6643:Olfr698 UTSW 7 106752569 missense probably benign 0.41
R6831:Olfr698 UTSW 7 106752571 missense probably damaging 0.99
R6972:Olfr698 UTSW 7 106752699 missense possibly damaging 0.60
R7392:Olfr698 UTSW 7 106753382 missense possibly damaging 0.69
R7717:Olfr698 UTSW 7 106752636 missense possibly damaging 0.58
R7852:Olfr698 UTSW 7 106752638 missense probably damaging 0.98
R8073:Olfr698 UTSW 7 106752801 nonsense probably null
R8245:Olfr698 UTSW 7 106753167 missense probably benign 0.03
R8698:Olfr698 UTSW 7 106753364 missense probably benign 0.05
R9192:Olfr698 UTSW 7 106753223 missense probably damaging 1.00
R9333:Olfr698 UTSW 7 106752575 missense probably damaging 1.00
Posted On 2014-05-07