Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01998:Or2ag16'

182940

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or2ag16

Ensembl Gene

ENSMUSG00000059087

Gene Name

olfactory receptor family 2 subfamily AG member 16

Synonyms

MOR283-3, GA_x6K02T2PBJ9-9130754-9129519, Olfr698

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.091) question?

Stock #

IGL01998

Quality Score

Status

Chromosome

Chromosomal Location

106351658-106352593 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 106351758 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Methionine at position 279 (T279M)

Ref Sequence

ENSEMBL: ENSMUSP00000149305 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074981] [ENSMUST00000214306] [ENSMUST00000216255]

AlphaFold

Q7TRN4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000074981
AA Change: T279M

PolyPhen 2 Score 0.628 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000074509
Gene: ENSMUSG00000059087
AA Change: T279M

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	9.4e-50	PFAM
Pfam:7TM_GPCR_Srsx	35	305	9.8e-8	PFAM
Pfam:7tm_1	41	290	4.1e-24	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000214306
AA Change: T279M

PolyPhen 2 Score 0.628 (Sensitivity: 0.87; Specificity: 0.91)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215892

Predicted Effect

possibly damaging
Transcript: ENSMUST00000216255
AA Change: T279M

PolyPhen 2 Score 0.628 (Sensitivity: 0.87; Specificity: 0.91)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arpc3	T	C	5: 122,541,470 (GRCm39)	C78R	probably damaging	Het
Atp6v0b	A	G	4: 117,743,263 (GRCm39)		probably null	Het
B3gnt8	A	G	7: 25,328,203 (GRCm39)	Y211C	probably damaging	Het
Birc6	T	C	17: 74,886,880 (GRCm39)	I736T	probably benign	Het
Bltp1	T	C	3: 37,011,165 (GRCm39)	S1788P	possibly damaging	Het
Bpifb9a	T	C	2: 154,110,120 (GRCm39)		probably null	Het
C3ar1	A	T	6: 122,827,899 (GRCm39)	M106K	probably damaging	Het
C9orf72	A	T	4: 35,194,179 (GRCm39)	D205E	probably benign	Het
Cab39l	T	A	14: 59,734,344 (GRCm39)	L21Q	probably damaging	Het
Casp1	A	T	9: 5,303,043 (GRCm39)	I166F	probably damaging	Het
Cd180	A	G	13: 102,841,722 (GRCm39)	E256G	probably damaging	Het
Clca4a	T	C	3: 144,663,887 (GRCm39)	T519A	probably damaging	Het
Clstn3	A	T	6: 124,435,622 (GRCm39)	L233Q	probably damaging	Het
Crlf3	G	A	11: 79,948,845 (GRCm39)		probably benign	Het
Depdc5	T	C	5: 33,102,495 (GRCm39)		probably benign	Het
Drc7	T	A	8: 95,785,821 (GRCm39)	C226S	probably damaging	Het
Epha5	T	A	5: 84,232,593 (GRCm39)	D807V	probably damaging	Het
Fat2	A	G	11: 55,187,021 (GRCm39)	L1275P	probably benign	Het
Fv1	T	C	4: 147,953,784 (GRCm39)	C117R	possibly damaging	Het
Ighg2b	C	A	12: 113,270,709 (GRCm39)	M140I	unknown	Het
Klra5	A	T	6: 129,883,676 (GRCm39)	Y60*	probably null	Het
Lmtk2	C	T	5: 144,112,883 (GRCm39)	T1201I	probably damaging	Het
Ncapd2	A	T	6: 125,150,078 (GRCm39)	S917T	probably benign	Het
Ncapd2	A	T	6: 125,146,896 (GRCm39)	L1230H	probably damaging	Het
Nfx1	T	A	4: 41,004,353 (GRCm39)	I708N	probably damaging	Het
Notch2	A	T	3: 98,050,422 (GRCm39)	D1899V	probably damaging	Het
Npepl1	T	A	2: 173,957,993 (GRCm39)		probably benign	Het
Nps	T	A	7: 134,870,481 (GRCm39)		probably benign	Het
Nrg1	T	C	8: 32,408,162 (GRCm39)	S24G	probably damaging	Het
Or1j20	A	G	2: 36,759,658 (GRCm39)	N27D	probably benign	Het
Or2t48	A	T	11: 58,420,403 (GRCm39)	Y136*	probably null	Het
Or4k2	C	A	14: 50,424,105 (GRCm39)	V190L	probably benign	Het
Pigx	G	T	16: 31,903,428 (GRCm39)	T211K	probably benign	Het
Pink1	A	G	4: 138,048,053 (GRCm39)	I223T	probably damaging	Het
Plat	G	A	8: 23,257,163 (GRCm39)	A15T	probably benign	Het
Ptges2	G	A	2: 32,291,542 (GRCm39)	A310T	possibly damaging	Het
Rsl1d1	A	G	16: 11,012,509 (GRCm39)	S306P	possibly damaging	Het
Rxfp1	T	C	3: 79,567,403 (GRCm39)	K316E	probably benign	Het
Scn10a	A	G	9: 119,438,742 (GRCm39)	I1708T	probably damaging	Het
Sdk2	A	T	11: 113,729,358 (GRCm39)	F1073Y	probably damaging	Het
Sp100	A	G	1: 85,594,650 (GRCm39)	D170G	probably benign	Het
Spock1	A	T	13: 57,583,994 (GRCm39)		probably benign	Het
Strbp	A	G	2: 37,515,297 (GRCm39)	L243P	probably damaging	Het
Tex55	A	T	16: 38,648,586 (GRCm39)	D174E	probably benign	Het
Tgm5	T	A	2: 120,882,920 (GRCm39)	T446S	probably damaging	Het
Tmem59l	C	T	8: 70,937,431 (GRCm39)	V239I	probably benign	Het
Trav8-1	A	T	14: 53,707,662 (GRCm39)	T101S	probably benign	Het
Triml1	T	C	8: 43,594,350 (GRCm39)	D27G	probably damaging	Het
Vmn2r54	T	C	7: 12,349,227 (GRCm39)	E785G	probably benign	Het
Vps13c	A	G	9: 67,862,350 (GRCm39)		probably null	Het
Wwp2	C	T	8: 108,276,153 (GRCm39)	R64C	probably damaging	Het
Zfp608	T	C	18: 55,024,890 (GRCm39)	H1460R	probably damaging	Het

Other mutations in Or2ag16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01373:Or2ag16	APN	7	106,351,653 (GRCm39)	utr 3 prime	probably benign
IGL01901:Or2ag16	APN	7	106,351,752 (GRCm39)	missense	possibly damaging	0.52
IGL01912:Or2ag16	APN	7	106,352,199 (GRCm39)	missense	probably damaging	1.00
IGL02640:Or2ag16	APN	7	106,352,559 (GRCm39)	missense	probably damaging	1.00
IGL03195:Or2ag16	APN	7	106,351,980 (GRCm39)	missense	probably benign
R0255:Or2ag16	UTSW	7	106,352,196 (GRCm39)	missense	probably benign	0.19
R1104:Or2ag16	UTSW	7	106,351,989 (GRCm39)	missense	probably benign	0.37
R1796:Or2ag16	UTSW	7	106,351,756 (GRCm39)	missense	probably benign	0.02
R1909:Or2ag16	UTSW	7	106,352,202 (GRCm39)	missense	probably benign	0.21
R4133:Or2ag16	UTSW	7	106,352,286 (GRCm39)	missense	probably damaging	0.98
R5194:Or2ag16	UTSW	7	106,352,426 (GRCm39)	missense	probably benign	0.15
R5389:Or2ag16	UTSW	7	106,352,290 (GRCm39)	missense	probably damaging	0.99
R5426:Or2ag16	UTSW	7	106,351,773 (GRCm39)	missense	probably benign
R6162:Or2ag16	UTSW	7	106,352,227 (GRCm39)	missense	probably damaging	1.00
R6463:Or2ag16	UTSW	7	106,352,008 (GRCm39)	missense	probably benign	0.23
R6643:Or2ag16	UTSW	7	106,351,776 (GRCm39)	missense	probably benign	0.41
R6831:Or2ag16	UTSW	7	106,351,778 (GRCm39)	missense	probably damaging	0.99
R6972:Or2ag16	UTSW	7	106,351,906 (GRCm39)	missense	possibly damaging	0.60
R7392:Or2ag16	UTSW	7	106,352,589 (GRCm39)	missense	possibly damaging	0.69
R7717:Or2ag16	UTSW	7	106,351,843 (GRCm39)	missense	possibly damaging	0.58
R7852:Or2ag16	UTSW	7	106,351,845 (GRCm39)	missense	probably damaging	0.98
R8073:Or2ag16	UTSW	7	106,352,008 (GRCm39)	nonsense	probably null
R8245:Or2ag16	UTSW	7	106,352,374 (GRCm39)	missense	probably benign	0.03
R8698:Or2ag16	UTSW	7	106,352,571 (GRCm39)	missense	probably benign	0.05
R9192:Or2ag16	UTSW	7	106,352,430 (GRCm39)	missense	probably damaging	1.00
R9333:Or2ag16	UTSW	7	106,351,782 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07