Incidental Mutation 'IGL01998:Ighg2b'
ID 182944
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ighg2b
Ensembl Gene ENSMUSG00000076613
Gene Name immunoglobulin heavy constant gamma 2B
Synonyms IgG2b, gamma2b
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # IGL01998
Quality Score
Status
Chromosome 12
Chromosomal Location 113267934-113271553 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 113270709 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 140 (M140I)
Gene Model predicted gene model for transcript(s):
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000103418
AA Change: M140I
SMART Domains Protein: ENSMUSP00000100214
Gene: ENSMUSG00000076613
AA Change: M140I

DomainStartEndE-ValueType
IGc1 22 92 6.9e-16 SMART
low complexity region 108 121 N/A INTRINSIC
IG_like 145 220 4.02e-2 SMART
IGc1 251 324 1.64e-31 SMART
Predicted Effect unknown
Transcript: ENSMUST00000192188
AA Change: M140I
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arpc3 T C 5: 122,541,470 (GRCm39) C78R probably damaging Het
Atp6v0b A G 4: 117,743,263 (GRCm39) probably null Het
B3gnt8 A G 7: 25,328,203 (GRCm39) Y211C probably damaging Het
Birc6 T C 17: 74,886,880 (GRCm39) I736T probably benign Het
Bltp1 T C 3: 37,011,165 (GRCm39) S1788P possibly damaging Het
Bpifb9a T C 2: 154,110,120 (GRCm39) probably null Het
C3ar1 A T 6: 122,827,899 (GRCm39) M106K probably damaging Het
C9orf72 A T 4: 35,194,179 (GRCm39) D205E probably benign Het
Cab39l T A 14: 59,734,344 (GRCm39) L21Q probably damaging Het
Casp1 A T 9: 5,303,043 (GRCm39) I166F probably damaging Het
Cd180 A G 13: 102,841,722 (GRCm39) E256G probably damaging Het
Clca4a T C 3: 144,663,887 (GRCm39) T519A probably damaging Het
Clstn3 A T 6: 124,435,622 (GRCm39) L233Q probably damaging Het
Crlf3 G A 11: 79,948,845 (GRCm39) probably benign Het
Depdc5 T C 5: 33,102,495 (GRCm39) probably benign Het
Drc7 T A 8: 95,785,821 (GRCm39) C226S probably damaging Het
Epha5 T A 5: 84,232,593 (GRCm39) D807V probably damaging Het
Fat2 A G 11: 55,187,021 (GRCm39) L1275P probably benign Het
Fv1 T C 4: 147,953,784 (GRCm39) C117R possibly damaging Het
Klra5 A T 6: 129,883,676 (GRCm39) Y60* probably null Het
Lmtk2 C T 5: 144,112,883 (GRCm39) T1201I probably damaging Het
Ncapd2 A T 6: 125,150,078 (GRCm39) S917T probably benign Het
Ncapd2 A T 6: 125,146,896 (GRCm39) L1230H probably damaging Het
Nfx1 T A 4: 41,004,353 (GRCm39) I708N probably damaging Het
Notch2 A T 3: 98,050,422 (GRCm39) D1899V probably damaging Het
Npepl1 T A 2: 173,957,993 (GRCm39) probably benign Het
Nps T A 7: 134,870,481 (GRCm39) probably benign Het
Nrg1 T C 8: 32,408,162 (GRCm39) S24G probably damaging Het
Or1j20 A G 2: 36,759,658 (GRCm39) N27D probably benign Het
Or2ag16 G A 7: 106,351,758 (GRCm39) T279M possibly damaging Het
Or2t48 A T 11: 58,420,403 (GRCm39) Y136* probably null Het
Or4k2 C A 14: 50,424,105 (GRCm39) V190L probably benign Het
Pigx G T 16: 31,903,428 (GRCm39) T211K probably benign Het
Pink1 A G 4: 138,048,053 (GRCm39) I223T probably damaging Het
Plat G A 8: 23,257,163 (GRCm39) A15T probably benign Het
Ptges2 G A 2: 32,291,542 (GRCm39) A310T possibly damaging Het
Rsl1d1 A G 16: 11,012,509 (GRCm39) S306P possibly damaging Het
Rxfp1 T C 3: 79,567,403 (GRCm39) K316E probably benign Het
Scn10a A G 9: 119,438,742 (GRCm39) I1708T probably damaging Het
Sdk2 A T 11: 113,729,358 (GRCm39) F1073Y probably damaging Het
Sp100 A G 1: 85,594,650 (GRCm39) D170G probably benign Het
Spock1 A T 13: 57,583,994 (GRCm39) probably benign Het
Strbp A G 2: 37,515,297 (GRCm39) L243P probably damaging Het
Tex55 A T 16: 38,648,586 (GRCm39) D174E probably benign Het
Tgm5 T A 2: 120,882,920 (GRCm39) T446S probably damaging Het
Tmem59l C T 8: 70,937,431 (GRCm39) V239I probably benign Het
Trav8-1 A T 14: 53,707,662 (GRCm39) T101S probably benign Het
Triml1 T C 8: 43,594,350 (GRCm39) D27G probably damaging Het
Vmn2r54 T C 7: 12,349,227 (GRCm39) E785G probably benign Het
Vps13c A G 9: 67,862,350 (GRCm39) probably null Het
Wwp2 C T 8: 108,276,153 (GRCm39) R64C probably damaging Het
Zfp608 T C 18: 55,024,890 (GRCm39) H1460R probably damaging Het
Other mutations in Ighg2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01366:Ighg2b APN 12 113,270,656 (GRCm39) missense possibly damaging 0.79
IGL01837:Ighg2b APN 12 113,270,065 (GRCm39) missense unknown
IGL01973:Ighg2b APN 12 113,271,305 (GRCm39) missense unknown
IGL02147:Ighg2b APN 12 113,270,011 (GRCm39) makesense probably null
IGL02183:Ighg2b APN 12 113,271,449 (GRCm39) missense unknown
IGL03089:Ighg2b APN 12 113,270,298 (GRCm39) missense probably damaging 1.00
PIT4453001:Ighg2b UTSW 12 113,270,492 (GRCm39) missense unknown
R4199:Ighg2b UTSW 12 113,270,907 (GRCm39) missense probably damaging 0.96
R4459:Ighg2b UTSW 12 113,270,578 (GRCm39) missense unknown
R4577:Ighg2b UTSW 12 113,270,512 (GRCm39) missense unknown
R4589:Ighg2b UTSW 12 113,270,104 (GRCm39) missense unknown
R4807:Ighg2b UTSW 12 113,267,965 (GRCm39) unclassified probably benign
R4822:Ighg2b UTSW 12 113,270,011 (GRCm39) makesense probably null
R5424:Ighg2b UTSW 12 113,271,550 (GRCm39) missense unknown
R5641:Ighg2b UTSW 12 113,270,767 (GRCm39) missense unknown
R6297:Ighg2b UTSW 12 113,270,512 (GRCm39) missense unknown
R6701:Ighg2b UTSW 12 113,270,699 (GRCm39) missense unknown
R6703:Ighg2b UTSW 12 113,268,653 (GRCm39) unclassified probably benign
R6880:Ighg2b UTSW 12 113,270,726 (GRCm39) missense
R7342:Ighg2b UTSW 12 113,270,050 (GRCm39) missense
R7505:Ighg2b UTSW 12 113,268,600 (GRCm39) missense
R7908:Ighg2b UTSW 12 113,270,074 (GRCm39) missense
R8543:Ighg2b UTSW 12 113,270,552 (GRCm39) missense probably damaging 1.00
R8951:Ighg2b UTSW 12 113,270,926 (GRCm39) missense probably benign
R9237:Ighg2b UTSW 12 113,270,217 (GRCm39) missense
R9539:Ighg2b UTSW 12 113,270,498 (GRCm39) missense
R9789:Ighg2b UTSW 12 113,270,304 (GRCm39) missense
Posted On 2014-05-07