Incidental Mutation 'IGL02000:Rwdd2b'
ID183028
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rwdd2b
Ensembl Gene ENSMUSG00000041079
Gene NameRWD domain containing 2B
SynonymsORF5
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02000
Quality Score
Status
Chromosome16
Chromosomal Location87433407-87440573 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) T to A at 87436940 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000156299 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039101] [ENSMUST00000039449] [ENSMUST00000232095]
Predicted Effect probably benign
Transcript: ENSMUST00000039101
SMART Domains Protein: ENSMUSP00000049168
Gene: ENSMUSG00000041079

DomainStartEndE-ValueType
RWD 12 136 3.17e-24 SMART
Pfam:DUF1115 162 284 1.6e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000039449
SMART Domains Protein: ENSMUSP00000038775
Gene: ENSMUSG00000052299

DomainStartEndE-ValueType
low complexity region 160 176 N/A INTRINSIC
low complexity region 400 410 N/A INTRINSIC
low complexity region 509 522 N/A INTRINSIC
low complexity region 553 569 N/A INTRINSIC
low complexity region 815 832 N/A INTRINSIC
low complexity region 1380 1392 N/A INTRINSIC
low complexity region 1427 1451 N/A INTRINSIC
RING 1716 1762 1.05e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152430
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231843
Predicted Effect probably benign
Transcript: ENSMUST00000232095
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arid5a T C 1: 36,319,497 F450S probably damaging Het
Astn1 C T 1: 158,674,614 R1133C probably damaging Het
Cd101 G A 3: 101,012,082 P568L probably benign Het
Cdkl4 T C 17: 80,543,763 E170G probably damaging Het
Chit1 A G 1: 134,146,675 E240G probably benign Het
Duox2 T C 2: 122,290,709 T741A probably benign Het
Eef2 T C 10: 81,180,011 V427A probably benign Het
Ewsr1 T C 11: 5,088,077 D105G probably damaging Het
Ftsj3 C T 11: 106,250,407 R629Q probably benign Het
Gm10406 C T 14: 7,009,867 G181E probably benign Het
Ilk A G 7: 105,741,169 H185R probably benign Het
Lamc1 A T 1: 153,240,433 C1001S probably damaging Het
Mcidas T C 13: 112,997,440 S153P probably benign Het
Mtcl1 T C 17: 66,354,190 E931G probably benign Het
Myo10 C T 15: 25,808,066 R1925C probably damaging Het
Notch3 A G 17: 32,122,742 V2012A probably damaging Het
Olfr809 C A 10: 129,776,069 H67N probably benign Het
Parp6 A G 9: 59,648,892 M542V probably benign Het
Rab27a G A 9: 73,084,972 G94D probably damaging Het
Ralgapb A G 2: 158,454,114 probably benign Het
Rassf4 T C 6: 116,645,972 E26G probably benign Het
Rnf166 C T 8: 122,467,222 D221N probably damaging Het
Rptn G T 3: 93,396,428 G356V probably benign Het
Scfd1 T A 12: 51,414,117 S337T probably benign Het
Sel1l3 T A 5: 53,145,493 D678V probably damaging Het
Sidt1 A T 16: 44,286,369 F233I probably damaging Het
Slc12a4 T C 8: 105,945,232 D917G probably damaging Het
Slc22a2 A T 17: 12,584,383 I35F possibly damaging Het
Smco1 A T 16: 32,273,933 T141S possibly damaging Het
Svs6 T C 2: 164,317,432 probably benign Het
Syne2 C T 12: 76,015,645 A4247V probably damaging Het
Tacc2 T A 7: 130,729,168 probably null Het
Tgm4 A T 9: 123,056,466 I358F probably damaging Het
Thnsl2 A G 6: 71,134,219 S222P probably damaging Het
Tmem25 G A 9: 44,798,271 R78* probably null Het
Ube2l6 T C 2: 84,809,162 probably benign Het
Usp10 T A 8: 119,948,741 Y63N possibly damaging Het
Vit A G 17: 78,605,486 I283V possibly damaging Het
Vmn1r214 G A 13: 23,035,100 V255I possibly damaging Het
Xpo1 A G 11: 23,296,003 R1038G probably damaging Het
Ybx1 T A 4: 119,282,312 N50I probably damaging Het
Zhx1 T C 15: 58,054,287 K188E probably damaging Het
Other mutations in Rwdd2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02351:Rwdd2b APN 16 87437448 missense probably benign 0.06
IGL02358:Rwdd2b APN 16 87437448 missense probably benign 0.06
R1022:Rwdd2b UTSW 16 87436850 missense probably damaging 1.00
R1024:Rwdd2b UTSW 16 87436850 missense probably damaging 1.00
R1086:Rwdd2b UTSW 16 87436558 unclassified probably benign
R1886:Rwdd2b UTSW 16 87437125 missense probably benign 0.08
R2359:Rwdd2b UTSW 16 87436921 missense probably benign 0.06
R4308:Rwdd2b UTSW 16 87436727 missense probably damaging 1.00
R4495:Rwdd2b UTSW 16 87434562 missense probably benign 0.00
R4680:Rwdd2b UTSW 16 87437062 critical splice donor site probably null
R4943:Rwdd2b UTSW 16 87434534 missense possibly damaging 0.54
R6260:Rwdd2b UTSW 16 87434468 missense probably damaging 1.00
R7622:Rwdd2b UTSW 16 87434612 missense probably benign 0.03
R7768:Rwdd2b UTSW 16 87436745 missense probably benign 0.01
R8100:Rwdd2b UTSW 16 87436621 missense possibly damaging 0.90
RF022:Rwdd2b UTSW 16 87436670 missense probably benign 0.01
Posted On2014-05-07