Incidental Mutation 'IGL02001:Or55b10'
ID 183059
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or55b10
Ensembl Gene ENSMUSG00000044824
Gene Name olfactory receptor family 55 subfamily B member 10
Synonyms S50, GA_x6K02T2PBJ9-5216160-5215210, MOR42-1, Olfr545
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # IGL02001
Quality Score
Status
Chromosome 7
Chromosomal Location 102143030-102143980 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 102143746 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 79 (T79S)
Ref Sequence ENSEMBL: ENSMUSP00000150232 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058750] [ENSMUST00000216116]
AlphaFold Q9WU94
Predicted Effect probably benign
Transcript: ENSMUST00000058750
AA Change: T79S

PolyPhen 2 Score 0.310 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000052396
Gene: ENSMUSG00000044824
AA Change: T79S

DomainStartEndE-ValueType
Pfam:7tm_4 35 314 1.8e-73 PFAM
Pfam:7TM_GPCR_Srsx 39 311 4.3e-8 PFAM
Pfam:7tm_1 45 296 4.6e-15 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211697
AA Change: T79S
Predicted Effect probably benign
Transcript: ENSMUST00000216116
AA Change: T79S

PolyPhen 2 Score 0.310 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217464
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice carrying a knock-out allele display a normal pattern of axonal projections to a large subset of glomeruli in the dorsal-medial and anterior-medial olfactory bulb, but also show abnormal innervation of glomeruli at the caudal margins of the olfactorybulb. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530064D06Rik T C 17: 48,473,842 (GRCm39) N25S possibly damaging Het
Als2 A T 1: 59,219,347 (GRCm39) probably benign Het
Asah2 T A 19: 32,020,939 (GRCm39) K255* probably null Het
Bclaf1 A G 10: 20,198,762 (GRCm39) probably benign Het
Bpifb2 T C 2: 153,733,195 (GRCm39) probably benign Het
Cacna2d2 G A 9: 107,399,315 (GRCm39) V669I probably benign Het
Cep89 T A 7: 35,102,432 (GRCm39) probably benign Het
Chl1 T G 6: 103,619,017 (GRCm39) L29R possibly damaging Het
Defb2 T C 8: 22,333,353 (GRCm39) Y43H probably damaging Het
Disc1 A G 8: 125,977,781 (GRCm39) Y799C probably damaging Het
Egf G T 3: 129,510,417 (GRCm39) A34E probably damaging Het
Fat2 A T 11: 55,203,071 (GRCm39) M1K probably null Het
Gprin1 T C 13: 54,887,005 (GRCm39) E423G probably damaging Het
Kcnh6 T C 11: 105,918,375 (GRCm39) probably benign Het
Kcnt1 A G 2: 25,798,164 (GRCm39) E925G probably damaging Het
Kctd16 A T 18: 40,391,733 (GRCm39) K107I possibly damaging Het
Lrig1 T C 6: 94,584,305 (GRCm39) K913R probably benign Het
Marchf7 A G 2: 60,065,235 (GRCm39) T504A possibly damaging Het
Mrpl11 C T 19: 5,013,680 (GRCm39) R154* probably null Het
Nlrp4a T C 7: 26,149,394 (GRCm39) F334L probably benign Het
Or2z2 C T 11: 58,346,335 (GRCm39) V147M probably benign Het
Parp6 A G 9: 59,557,244 (GRCm39) T610A possibly damaging Het
Pcdhb15 T G 18: 37,607,091 (GRCm39) L108V probably benign Het
Pomgnt1 G T 4: 116,010,105 (GRCm39) E156* probably null Het
Psma2 T G 13: 14,798,192 (GRCm39) F105V possibly damaging Het
Rapgef4 A G 2: 72,055,396 (GRCm39) probably benign Het
Sclt1 A T 3: 41,636,156 (GRCm39) S282T possibly damaging Het
Semp2l2b A T 10: 21,943,176 (GRCm39) M268K probably benign Het
Serpina3f A G 12: 104,185,725 (GRCm39) Y310C probably damaging Het
Sh3pxd2a T C 19: 47,261,886 (GRCm39) K331R probably damaging Het
Tectb T C 19: 55,178,027 (GRCm39) F183L possibly damaging Het
Tgfbr1 A G 4: 47,403,388 (GRCm39) H327R probably damaging Het
Try10 T A 6: 41,333,523 (GRCm39) D89E probably benign Het
Ttn G A 2: 76,587,128 (GRCm39) S21623L probably damaging Het
Ttn A G 2: 76,612,282 (GRCm39) L15489P probably damaging Het
Vdac3-ps1 A G 13: 18,205,973 (GRCm39) noncoding transcript Het
Vmn2r69 T A 7: 85,056,434 (GRCm39) Q568L probably benign Het
Wdr36 T A 18: 32,985,941 (GRCm39) D548E probably damaging Het
Zfand4 T A 6: 116,250,613 (GRCm39) H14Q probably benign Het
Other mutations in Or55b10
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1732:Or55b10 UTSW 7 102,143,247 (GRCm39) missense probably damaging 1.00
R1927:Or55b10 UTSW 7 102,143,266 (GRCm39) missense possibly damaging 0.89
R2570:Or55b10 UTSW 7 102,143,106 (GRCm39) missense probably damaging 0.99
R4693:Or55b10 UTSW 7 102,143,659 (GRCm39) missense probably damaging 0.98
R5777:Or55b10 UTSW 7 102,143,178 (GRCm39) missense probably benign 0.01
R6481:Or55b10 UTSW 7 102,143,346 (GRCm39) missense probably damaging 0.97
R6597:Or55b10 UTSW 7 102,143,628 (GRCm39) missense probably damaging 1.00
R7562:Or55b10 UTSW 7 102,143,227 (GRCm39) missense possibly damaging 0.90
R7715:Or55b10 UTSW 7 102,143,668 (GRCm39) missense possibly damaging 0.91
R8027:Or55b10 UTSW 7 102,143,629 (GRCm39) missense probably damaging 0.98
R8238:Or55b10 UTSW 7 102,143,827 (GRCm39) missense possibly damaging 0.65
R9094:Or55b10 UTSW 7 102,143,568 (GRCm39) missense possibly damaging 0.71
R9320:Or55b10 UTSW 7 102,144,084 (GRCm39) start gained probably benign
R9427:Or55b10 UTSW 7 102,143,206 (GRCm39) missense probably benign 0.02
Posted On 2014-05-07