Incidental Mutation 'IGL02002:Olfr781'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr781
Ensembl Gene ENSMUSG00000095138
Gene Nameolfactory receptor 781
SynonymsGA_x6K02T2PULF-11013616-11014551, MOR114-6
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL02002
Quality Score
Chromosomal Location129328854-129333844 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 129333127 bp
Amino Acid Change Isoleucine to Lysine at position 82 (I82K)
Ref Sequence ENSEMBL: ENSMUSP00000145356 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075613] [ENSMUST00000204108]
Predicted Effect probably damaging
Transcript: ENSMUST00000075613
AA Change: I82K

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000075041
Gene: ENSMUSG00000095138
AA Change: I82K

Pfam:7tm_4 28 305 1.6e-44 PFAM
Pfam:7tm_1 38 287 5e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000204108
AA Change: I82K

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000145356
Gene: ENSMUSG00000095138
AA Change: I82K

Pfam:7tm_4 28 305 1.6e-44 PFAM
Pfam:7tm_1 38 287 5e-24 PFAM
Meta Mutation Damage Score 0.5990 question?
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530053A07Rik A T 7: 28,152,796 Y1248F probably damaging Het
Abcg5 G T 17: 84,682,051 Y76* probably null Het
Acadsb T A 7: 131,428,529 V135E probably damaging Het
Acap1 A G 11: 69,884,460 Y326H probably damaging Het
Actl11 T A 9: 107,929,330 V284D probably benign Het
Adcy10 G T 1: 165,521,843 D428Y probably damaging Het
Akap8 A G 17: 32,309,496 C481R probably damaging Het
Amotl2 G A 9: 102,725,117 A26T probably damaging Het
Apob T C 12: 7,994,822 V814A probably benign Het
Casp8ap2 T A 4: 32,639,391 N148K probably damaging Het
Ccdc149 G A 5: 52,406,079 T124M probably damaging Het
Cd320 A G 17: 33,843,240 probably benign Het
Clca4b T C 3: 144,932,433 T23A probably benign Het
Col22a1 A G 15: 71,811,097 probably benign Het
Col24a1 T A 3: 145,356,944 F675I possibly damaging Het
Col6a3 A G 1: 90,782,136 probably benign Het
Dap3 A T 3: 88,936,228 M19K probably benign Het
Dsg2 A G 18: 20,579,176 D123G probably damaging Het
Dysf T A 6: 84,210,787 probably benign Het
Erbb4 A G 1: 68,080,726 S853P probably damaging Het
Fbn2 A G 18: 58,114,553 M423T probably benign Het
Fgfr1 T C 8: 25,555,711 Y112H probably damaging Het
Gbp7 G A 3: 142,538,900 A203T probably damaging Het
Gon4l C T 3: 88,895,336 P1085S possibly damaging Het
Gsdma2 T C 11: 98,650,974 F176L probably damaging Het
Haghl A G 17: 25,784,265 F131S probably damaging Het
Hmcn1 G A 1: 150,615,298 P4167S probably damaging Het
Hscb T C 5: 110,830,954 N199D probably benign Het
Lmbr1l T A 15: 98,904,785 N428Y probably damaging Het
Mc2r T A 18: 68,407,434 M263L probably benign Het
Metap1 T A 3: 138,462,389 T325S probably damaging Het
Mff A G 1: 82,741,975 R225G probably damaging Het
Naprt A T 15: 75,891,372 L474Q probably damaging Het
Nin A T 12: 70,062,699 Y155* probably null Het
Nrg3 A T 14: 38,370,767 C612* probably null Het
Olfr170 T C 16: 19,606,550 I39M possibly damaging Het
Olfr472 A T 7: 107,903,290 D191V possibly damaging Het
Pdilt A T 7: 119,500,444 F200L probably damaging Het
Ppard T G 17: 28,298,903 F315C probably damaging Het
Ror1 T A 4: 100,441,184 S585T probably damaging Het
Spdye4a T A 5: 143,225,705 I35F possibly damaging Het
Tenm2 T C 11: 36,207,095 K442R probably benign Het
Tln2 A G 9: 67,356,698 I553T probably damaging Het
Tmem269 T A 4: 119,214,141 I26F probably benign Het
Tsen2 T C 6: 115,559,607 V108A probably benign Het
Ttyh3 A T 5: 140,629,483 D383E probably damaging Het
Usp13 T C 3: 32,847,825 S102P probably damaging Het
Vmn2r118 T G 17: 55,592,619 S762R probably damaging Het
Washc4 A G 10: 83,579,543 N799S possibly damaging Het
Zcchc6 A G 13: 59,782,096 S1042P possibly damaging Het
Zdhhc17 C T 10: 110,967,689 V256I probably benign Het
Zfp51 T A 17: 21,463,959 F279I probably damaging Het
Zzz3 A G 3: 152,451,369 T223A probably damaging Het
Other mutations in Olfr781
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01121:Olfr781 APN 10 129332935 missense probably benign
IGL01636:Olfr781 APN 10 129332883 start codon destroyed probably damaging 0.96
IGL01744:Olfr781 APN 10 129333457 missense probably benign 0.05
IGL01867:Olfr781 APN 10 129333363 missense probably damaging 1.00
IGL02423:Olfr781 APN 10 129333528 missense probably benign 0.00
R2036:Olfr781 UTSW 10 129333672 missense probably benign 0.43
R2099:Olfr781 UTSW 10 129333283 missense probably damaging 0.96
R2273:Olfr781 UTSW 10 129333457 missense probably benign 0.05
R2274:Olfr781 UTSW 10 129333457 missense probably benign 0.05
R3841:Olfr781 UTSW 10 129333333 missense probably benign 0.00
R4585:Olfr781 UTSW 10 129333273 missense probably benign 0.08
R4586:Olfr781 UTSW 10 129333273 missense probably benign 0.08
R5522:Olfr781 UTSW 10 129332929 missense probably damaging 0.98
R6052:Olfr781 UTSW 10 129333202 missense possibly damaging 0.91
R6414:Olfr781 UTSW 10 129333709 missense probably benign 0.23
R6468:Olfr781 UTSW 10 129333711 missense possibly damaging 0.91
R6647:Olfr781 UTSW 10 129333164 nonsense probably null
R8099:Olfr781 UTSW 10 129333127 missense probably damaging 0.99
T0975:Olfr781 UTSW 10 129333445 missense probably benign 0.31
Posted On2014-05-07