Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02002:Vmn2r118'

183080

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r118

Ensembl Gene

ENSMUSG00000091504

Gene Name

vomeronasal 2, receptor 118

Synonyms

EG383258, Vmn2r119, EG668547

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.137) question?

Stock #

IGL02002

Quality Score

Status

Chromosome

Chromosomal Location

55592341-55624672 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 55592619 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 762 (S762R)

Ref Sequence

ENSEMBL: ENSMUSP00000131128 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168440]

AlphaFold

E9Q1C1

Predicted Effect

probably damaging
Transcript: ENSMUST00000168440
AA Change: S762R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000131128
Gene: ENSMUSG00000091504
AA Change: S762R

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	142	470	4.6e-27	PFAM
Pfam:NCD3G	513	566	2.6e-20	PFAM
Pfam:7tm_3	599	834	5.9e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9530053A07Rik	A	T	7: 28,152,796	Y1248F	probably damaging	Het
Abcg5	G	T	17: 84,682,051	Y76*	probably null	Het
Acadsb	T	A	7: 131,428,529	V135E	probably damaging	Het
Acap1	A	G	11: 69,884,460	Y326H	probably damaging	Het
Actl11	T	A	9: 107,929,330	V284D	probably benign	Het
Adcy10	G	T	1: 165,521,843	D428Y	probably damaging	Het
Akap8	A	G	17: 32,309,496	C481R	probably damaging	Het
Amotl2	G	A	9: 102,725,117	A26T	probably damaging	Het
Apob	T	C	12: 7,994,822	V814A	probably benign	Het
Casp8ap2	T	A	4: 32,639,391	N148K	probably damaging	Het
Ccdc149	G	A	5: 52,406,079	T124M	probably damaging	Het
Cd320	A	G	17: 33,843,240		probably benign	Het
Clca4b	T	C	3: 144,932,433	T23A	probably benign	Het
Col22a1	A	G	15: 71,811,097		probably benign	Het
Col24a1	T	A	3: 145,356,944	F675I	possibly damaging	Het
Col6a3	A	G	1: 90,782,136		probably benign	Het
Dap3	A	T	3: 88,936,228	M19K	probably benign	Het
Dsg2	A	G	18: 20,579,176	D123G	probably damaging	Het
Dysf	T	A	6: 84,210,787		probably benign	Het
Erbb4	A	G	1: 68,080,726	S853P	probably damaging	Het
Fbn2	A	G	18: 58,114,553	M423T	probably benign	Het
Fgfr1	T	C	8: 25,555,711	Y112H	probably damaging	Het
Gbp7	G	A	3: 142,538,900	A203T	probably damaging	Het
Gon4l	C	T	3: 88,895,336	P1085S	possibly damaging	Het
Gsdma2	T	C	11: 98,650,974	F176L	probably damaging	Het
Haghl	A	G	17: 25,784,265	F131S	probably damaging	Het
Hmcn1	G	A	1: 150,615,298	P4167S	probably damaging	Het
Hscb	T	C	5: 110,830,954	N199D	probably benign	Het
Lmbr1l	T	A	15: 98,904,785	N428Y	probably damaging	Het
Mc2r	T	A	18: 68,407,434	M263L	probably benign	Het
Metap1	T	A	3: 138,462,389	T325S	probably damaging	Het
Mff	A	G	1: 82,741,975	R225G	probably damaging	Het
Naprt	A	T	15: 75,891,372	L474Q	probably damaging	Het
Nin	A	T	12: 70,062,699	Y155*	probably null	Het
Nrg3	A	T	14: 38,370,767	C612*	probably null	Het
Olfr170	T	C	16: 19,606,550	I39M	possibly damaging	Het
Olfr472	A	T	7: 107,903,290	D191V	possibly damaging	Het
Olfr781	T	A	10: 129,333,127	I82K	probably damaging	Het
Pdilt	A	T	7: 119,500,444	F200L	probably damaging	Het
Ppard	T	G	17: 28,298,903	F315C	probably damaging	Het
Ror1	T	A	4: 100,441,184	S585T	probably damaging	Het
Spdye4a	T	A	5: 143,225,705	I35F	possibly damaging	Het
Tenm2	T	C	11: 36,207,095	K442R	probably benign	Het
Tln2	A	G	9: 67,356,698	I553T	probably damaging	Het
Tmem269	T	A	4: 119,214,141	I26F	probably benign	Het
Tsen2	T	C	6: 115,559,607	V108A	probably benign	Het
Ttyh3	A	T	5: 140,629,483	D383E	probably damaging	Het
Usp13	T	C	3: 32,847,825	S102P	probably damaging	Het
Washc4	A	G	10: 83,579,543	N799S	possibly damaging	Het
Zcchc6	A	G	13: 59,782,096	S1042P	possibly damaging	Het
Zdhhc17	C	T	10: 110,967,689	V256I	probably benign	Het
Zfp51	T	A	17: 21,463,959	F279I	probably damaging	Het
Zzz3	A	G	3: 152,451,369	T223A	probably damaging	Het

Other mutations in Vmn2r118

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Vmn2r118	APN	17	55592708	missense	probably damaging	1.00
IGL00976:Vmn2r118	APN	17	55593204	missense	probably damaging	1.00
IGL01419:Vmn2r118	APN	17	55593000	missense	probably benign	0.01
IGL01796:Vmn2r118	APN	17	55608585	missense	probably benign	0.30
IGL01799:Vmn2r118	APN	17	55592990	missense	probably damaging	1.00
IGL02075:Vmn2r118	APN	17	55610517	missense	probably benign	0.18
IGL02172:Vmn2r118	APN	17	55624598	missense	probably benign	0.00
IGL02529:Vmn2r118	APN	17	55610870	missense	possibly damaging	0.58
IGL02712:Vmn2r118	APN	17	55592655	missense	probably benign	0.21
IGL03096:Vmn2r118	APN	17	55607996	missense	probably damaging	1.00
R0306:Vmn2r118	UTSW	17	55608616	missense	possibly damaging	0.89
R0329:Vmn2r118	UTSW	17	55610717	missense	probably damaging	1.00
R0330:Vmn2r118	UTSW	17	55610717	missense	probably damaging	1.00
R0396:Vmn2r118	UTSW	17	55608643	missense	probably benign	0.00
R0411:Vmn2r118	UTSW	17	55611021	splice site	probably benign
R0513:Vmn2r118	UTSW	17	55610970	nonsense	probably null
R0627:Vmn2r118	UTSW	17	55610772	missense	probably benign	0.01
R0638:Vmn2r118	UTSW	17	55608466	missense	probably benign	0.03
R1328:Vmn2r118	UTSW	17	55608620	missense	probably benign	0.01
R1366:Vmn2r118	UTSW	17	55593237	nonsense	probably null
R1465:Vmn2r118	UTSW	17	55610935	missense	probably benign	0.33
R1465:Vmn2r118	UTSW	17	55610935	missense	probably benign	0.33
R1511:Vmn2r118	UTSW	17	55608496	nonsense	probably null
R1515:Vmn2r118	UTSW	17	55610643	missense	probably benign	0.25
R1550:Vmn2r118	UTSW	17	55608083	missense	probably damaging	1.00
R1779:Vmn2r118	UTSW	17	55611530	missense	probably benign	0.03
R1834:Vmn2r118	UTSW	17	55592456	missense	probably damaging	1.00
R1840:Vmn2r118	UTSW	17	55610406	nonsense	probably null
R1854:Vmn2r118	UTSW	17	55611556	missense	possibly damaging	0.57
R1967:Vmn2r118	UTSW	17	55592882	missense	probably damaging	1.00
R1976:Vmn2r118	UTSW	17	55592925	missense	probably damaging	1.00
R2308:Vmn2r118	UTSW	17	55624650	missense	probably benign	0.33
R3700:Vmn2r118	UTSW	17	55608421	missense	possibly damaging	0.68
R4334:Vmn2r118	UTSW	17	55610347	missense	possibly damaging	0.58
R4647:Vmn2r118	UTSW	17	55610665	missense	probably damaging	1.00
R4709:Vmn2r118	UTSW	17	55610860	missense	probably damaging	1.00
R4805:Vmn2r118	UTSW	17	55592581	missense	probably damaging	1.00
R4858:Vmn2r118	UTSW	17	55592894	missense	probably damaging	0.98
R5384:Vmn2r118	UTSW	17	55611565	missense	probably benign	0.00
R5385:Vmn2r118	UTSW	17	55611565	missense	probably benign	0.00
R5664:Vmn2r118	UTSW	17	55592765	missense	possibly damaging	0.46
R5740:Vmn2r118	UTSW	17	55593103	missense	probably benign	0.00
R5927:Vmn2r118	UTSW	17	55624494	missense	probably benign	0.04
R6143:Vmn2r118	UTSW	17	55592871	missense	possibly damaging	0.92
R6513:Vmn2r118	UTSW	17	55608093	missense	probably damaging	1.00
R6573:Vmn2r118	UTSW	17	55592996	missense	probably damaging	1.00
R6760:Vmn2r118	UTSW	17	55592714	missense	possibly damaging	0.92
R6794:Vmn2r118	UTSW	17	55592348	missense	possibly damaging	0.48
R6929:Vmn2r118	UTSW	17	55610440	missense	probably benign	0.01
R7201:Vmn2r118	UTSW	17	55608496	nonsense	probably null
R7539:Vmn2r118	UTSW	17	55592853	missense	probably damaging	0.98
R7836:Vmn2r118	UTSW	17	55593242	missense	probably damaging	0.99
R8179:Vmn2r118	UTSW	17	55608484	missense	probably benign	0.36
R8248:Vmn2r118	UTSW	17	55610936	missense	probably benign	0.18
R8347:Vmn2r118	UTSW	17	55610423	missense	possibly damaging	0.94
R8415:Vmn2r118	UTSW	17	55608057	missense	probably benign	0.08
R8428:Vmn2r118	UTSW	17	55608642	missense	probably benign	0.33
R8917:Vmn2r118	UTSW	17	55610216	missense	possibly damaging	0.82
R8993:Vmn2r118	UTSW	17	55610835	missense	possibly damaging	0.72
R9038:Vmn2r118	UTSW	17	55611649	missense	probably damaging	1.00
R9155:Vmn2r118	UTSW	17	55610207	missense	probably null	0.83
R9603:Vmn2r118	UTSW	17	55592837	missense	probably damaging	1.00
R9742:Vmn2r118	UTSW	17	55611009	missense	probably damaging	0.98
R9749:Vmn2r118	UTSW	17	55608415	critical splice donor site	probably null
R9792:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
R9793:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
R9795:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
X0022:Vmn2r118	UTSW	17	55593218	missense	probably damaging	1.00
Z1176:Vmn2r118	UTSW	17	55610655	nonsense	probably null

Posted On

2014-05-07