Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02006:Iqcf6'

183177

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Iqcf6

Ensembl Gene

ENSMUSG00000091129

Gene Name

IQ motif containing F6

Synonyms

100041096

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.140) question?

Stock #

IGL02006

Quality Score

Status

Chromosome

Chromosomal Location

106503800-106504874 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 106504510 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 58 (D58G)

Ref Sequence

ENSEMBL: ENSMUSP00000131823 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171091]

AlphaFold

G3UWF2

Predicted Effect

probably benign
Transcript: ENSMUST00000171091
AA Change: D58G

PolyPhen 2 Score 0.125 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000131823
Gene: ENSMUSG00000091129
AA Change: D58G

Domain	Start	End	E-Value	Type
IQ	35	57	2.06e-3	SMART
IQ	91	113	8.13e-2	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamtsl1	G	A	4: 86,117,582 (GRCm39)	G182S	probably damaging	Het
Akr1b7	A	T	6: 34,392,385 (GRCm39)	N66I	probably benign	Het
Arrdc3	T	A	13: 81,031,893 (GRCm39)	I42N	probably damaging	Het
Atp6v0d2	G	T	4: 19,878,325 (GRCm39)	A316E	probably damaging	Het
Atp8a2	A	G	14: 60,094,497 (GRCm39)	V847A	possibly damaging	Het
Ccdc171	A	G	4: 83,713,479 (GRCm39)	N1173D	possibly damaging	Het
Crb2	A	C	2: 37,676,475 (GRCm39)	D152A	probably damaging	Het
Ecm1	T	C	3: 95,641,557 (GRCm39)	E559G	probably damaging	Het
Ephb1	A	G	9: 102,071,971 (GRCm39)		probably null	Het
Fndc11	C	A	2: 180,863,884 (GRCm39)	R230S	probably damaging	Het
Frem1	A	G	4: 82,911,037 (GRCm39)		probably null	Het
Fyco1	G	A	9: 123,658,896 (GRCm39)	Q427*	probably null	Het
Gm17541	A	G	12: 4,739,619 (GRCm39)		probably benign	Het
Gm5431	C	T	11: 48,779,330 (GRCm39)	V809M	probably damaging	Het
Gm7293	A	G	9: 51,534,043 (GRCm39)		noncoding transcript	Het
Ift52	T	C	2: 162,865,289 (GRCm39)	S47P	probably benign	Het
Itm2b	T	C	14: 73,600,488 (GRCm39)		probably benign	Het
Jakmip1	T	C	5: 37,278,331 (GRCm39)	I536T	probably damaging	Het
Kcnh1	T	G	1: 191,873,323 (GRCm39)	M3R	possibly damaging	Het
Kcnh5	G	T	12: 74,944,322 (GRCm39)	P976T	probably damaging	Het
Layn	G	A	9: 50,968,591 (GRCm39)		probably benign	Het
Lrrc37a	T	A	11: 103,347,317 (GRCm39)	Q3126L	probably damaging	Het
Meioc	A	T	11: 102,565,092 (GRCm39)	D180V	probably damaging	Het
Myo15a	T	A	11: 60,401,954 (GRCm39)	C3066S	probably damaging	Het
Nbeal1	T	C	1: 60,311,418 (GRCm39)		probably null	Het
Negr1	T	C	3: 156,721,810 (GRCm39)		probably benign	Het
Nek1	T	A	8: 61,557,226 (GRCm39)	N940K	probably benign	Het
Nfkbib	A	T	7: 28,465,667 (GRCm39)		probably null	Het
Nol4	T	A	18: 23,054,975 (GRCm39)	T152S	probably damaging	Het
Oas3	G	T	5: 120,907,300 (GRCm39)	R446S	probably benign	Het
Oosp3	C	T	19: 11,676,784 (GRCm39)	L48F	probably damaging	Het
Or2r3	A	G	6: 42,449,025 (GRCm39)	V29A	probably benign	Het
Or2w25	T	C	11: 59,503,985 (GRCm39)	L65P	probably damaging	Het
Pik3ap1	C	A	19: 41,291,032 (GRCm39)	W500L	probably benign	Het
Ppih	A	G	4: 119,168,779 (GRCm39)		probably benign	Het
Ro60	G	T	1: 143,636,084 (GRCm39)		probably benign	Het
Slc7a15	T	C	12: 8,585,508 (GRCm39)		probably null	Het
Srl	T	C	16: 4,315,150 (GRCm39)	E164G	probably benign	Het
Tbx10	C	A	19: 4,048,186 (GRCm39)	T237K	probably damaging	Het
Vwa5b2	T	C	16: 20,415,843 (GRCm39)	V392A	probably damaging	Het
Wfdc5	A	T	2: 164,024,483 (GRCm39)		probably benign	Het
Xirp2	T	C	2: 67,342,306 (GRCm39)	F1516L	possibly damaging	Het
Znfx1	A	G	2: 166,897,683 (GRCm39)	C414R	probably damaging	Het

Other mutations in Iqcf6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01598:Iqcf6	APN	9	106,504,707 (GRCm39)	missense	probably benign
IGL02519:Iqcf6	APN	9	106,504,479 (GRCm39)	missense	probably damaging	1.00
R0925:Iqcf6	UTSW	9	106,504,500 (GRCm39)	missense	probably benign	0.00
R1493:Iqcf6	UTSW	9	106,504,641 (GRCm39)	missense	probably benign	0.00
R4686:Iqcf6	UTSW	9	106,504,543 (GRCm39)	missense	probably damaging	1.00
R6590:Iqcf6	UTSW	9	106,504,501 (GRCm39)	missense	possibly damaging	0.83
R6690:Iqcf6	UTSW	9	106,504,501 (GRCm39)	missense	possibly damaging	0.83
R7489:Iqcf6	UTSW	9	106,504,656 (GRCm39)	missense	probably benign	0.25
R8847:Iqcf6	UTSW	9	106,504,650 (GRCm39)	missense	probably damaging	1.00
R8867:Iqcf6	UTSW	9	106,504,698 (GRCm39)	missense	possibly damaging	0.73

Posted On

2014-05-07