Incidental Mutation 'IGL02006:Olfr225'
ID183178
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr225
Ensembl Gene ENSMUSG00000044061
Gene Nameolfactory receptor 225
SynonymsGA_x6K02T0073K-490-1545, MOR256-51
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.070) question?
Stock #IGL02006
Quality Score
Status
Chromosome11
Chromosomal Location59612966-59613882 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 59613159 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 65 (L65P)
Ref Sequence ENSEMBL: ENSMUSP00000149203 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055276] [ENSMUST00000213169]
Predicted Effect probably damaging
Transcript: ENSMUST00000055276
AA Change: L65P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000051482
Gene: ENSMUSG00000044061
AA Change: L65P

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 6.6e-47 PFAM
Pfam:7tm_1 40 289 4.3e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213169
AA Change: L65P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl1 G A 4: 86,199,345 G182S probably damaging Het
Akr1b7 A T 6: 34,415,450 N66I probably benign Het
Arrdc3 T A 13: 80,883,774 I42N probably damaging Het
Atp6v0d2 G T 4: 19,878,325 A316E probably damaging Het
Atp8a2 A G 14: 59,857,048 V847A possibly damaging Het
Ccdc171 A G 4: 83,795,242 N1173D possibly damaging Het
Crb2 A C 2: 37,786,463 D152A probably damaging Het
Ecm1 T C 3: 95,734,244 E559G probably damaging Het
Ephb1 A G 9: 102,194,772 probably null Het
Fndc11 C A 2: 181,222,091 R230S probably damaging Het
Frem1 A G 4: 82,992,800 probably null Het
Fyco1 G A 9: 123,829,831 Q427* probably null Het
Gm17541 A G 12: 4,689,619 probably benign Het
Gm5431 C T 11: 48,888,503 V809M probably damaging Het
Gm7293 A G 9: 51,622,743 noncoding transcript Het
Ift52 T C 2: 163,023,369 S47P probably benign Het
Iqcf6 A G 9: 106,627,311 D58G probably benign Het
Itm2b T C 14: 73,363,048 probably benign Het
Jakmip1 T C 5: 37,120,987 I536T probably damaging Het
Kcnh1 T G 1: 192,191,015 M3R possibly damaging Het
Kcnh5 G T 12: 74,897,548 P976T probably damaging Het
Layn G A 9: 51,057,291 probably benign Het
Lrrc37a T A 11: 103,456,491 Q3126L probably damaging Het
Meioc A T 11: 102,674,266 D180V probably damaging Het
Myo15 T A 11: 60,511,128 C3066S probably damaging Het
Nbeal1 T C 1: 60,272,259 probably null Het
Negr1 T C 3: 157,016,173 probably benign Het
Nek1 T A 8: 61,104,192 N940K probably benign Het
Nfkbib A T 7: 28,766,242 probably null Het
Nol4 T A 18: 22,921,918 T152S probably damaging Het
Oas3 G T 5: 120,769,235 R446S probably benign Het
Olfr457 A G 6: 42,472,091 V29A probably benign Het
Oosp3 C T 19: 11,699,420 L48F probably damaging Het
Pik3ap1 C A 19: 41,302,593 W500L probably benign Het
Ppih A G 4: 119,311,582 probably benign Het
Slc7a15 T C 12: 8,535,508 probably null Het
Srl T C 16: 4,497,286 E164G probably benign Het
Tbx10 C A 19: 3,998,186 T237K probably damaging Het
Trove2 G T 1: 143,760,346 probably benign Het
Vwa5b2 T C 16: 20,597,093 V392A probably damaging Het
Wfdc5 A T 2: 164,182,563 probably benign Het
Xirp2 T C 2: 67,511,962 F1516L possibly damaging Het
Znfx1 A G 2: 167,055,763 C414R probably damaging Het
Other mutations in Olfr225
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00090:Olfr225 APN 11 59613321 missense possibly damaging 0.86
IGL01835:Olfr225 APN 11 59613339 missense probably damaging 0.99
IGL03195:Olfr225 APN 11 59613803 missense probably damaging 1.00
R0148:Olfr225 UTSW 11 59613494 missense probably damaging 1.00
R0831:Olfr225 UTSW 11 59613654 missense possibly damaging 0.70
R1924:Olfr225 UTSW 11 59613123 missense possibly damaging 0.58
R2184:Olfr225 UTSW 11 59613138 missense probably damaging 1.00
R5772:Olfr225 UTSW 11 59613886 missense probably benign
R6986:Olfr225 UTSW 11 59614098 missense possibly damaging 0.53
R7405:Olfr225 UTSW 11 59614073 missense possibly damaging 0.53
R7755:Olfr225 UTSW 11 59613641 missense probably damaging 0.97
R7851:Olfr225 UTSW 11 59613963 missense probably benign 0.33
R7934:Olfr225 UTSW 11 59613963 missense probably benign 0.33
Z1177:Olfr225 UTSW 11 59613572 missense probably damaging 1.00
Posted On2014-05-07