Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02008:Zfp976'

183285

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp976

Ensembl Gene

ENSMUSG00000074158

Gene Name

zinc finger protein 976

Synonyms

9830147E19Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.111) question?

Stock #

IGL02008

Quality Score

Status

Chromosome

Chromosomal Location

42609526-42642588 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 42614232 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000141023 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098503] [ENSMUST00000187616]

AlphaFold

E9Q981

Predicted Effect

probably benign
Transcript: ENSMUST00000098503

SMART Domains

Protein: ENSMUSP00000096105
Gene: ENSMUSG00000074158

Domain	Start	End	E-Value	Type
KRAB	4	66	1.73e-18	SMART
ZnF_C2H2	131	153	7.78e-3	SMART
ZnF_C2H2	159	181	1.67e-2	SMART
ZnF_C2H2	187	209	5.9e-3	SMART
ZnF_C2H2	215	237	1.38e-3	SMART
ZnF_C2H2	243	265	8.94e-3	SMART
ZnF_C2H2	271	293	2.24e-3	SMART
ZnF_C2H2	299	321	1.03e-2	SMART
ZnF_C2H2	327	349	1.58e-3	SMART
ZnF_C2H2	355	377	7.9e-4	SMART
ZnF_C2H2	383	405	5.9e-3	SMART
ZnF_C2H2	411	433	2.57e-3	SMART
ZnF_C2H2	439	461	3.16e-3	SMART
ZnF_C2H2	467	489	1.26e-2	SMART
ZnF_C2H2	495	517	8.34e-3	SMART
ZnF_C2H2	523	545	3.63e-3	SMART
ZnF_C2H2	551	573	4.79e-3	SMART
ZnF_C2H2	579	601	9.73e-4	SMART
ZnF_C2H2	607	629	3.63e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000107994

Predicted Effect

probably benign
Transcript: ENSMUST00000187616

SMART Domains

Protein: ENSMUSP00000141023
Gene: ENSMUSG00000074158

Domain	Start	End	E-Value	Type
KRAB	3	65	7.4e-21	SMART
ZnF_C2H2	130	152	3.2e-5	SMART
ZnF_C2H2	158	180	7.1e-5	SMART
ZnF_C2H2	186	208	2.4e-5	SMART
ZnF_C2H2	214	236	5.7e-6	SMART
ZnF_C2H2	242	264	3.8e-5	SMART
ZnF_C2H2	270	292	9.7e-6	SMART
ZnF_C2H2	298	320	4.2e-5	SMART
ZnF_C2H2	326	348	6.6e-6	SMART
ZnF_C2H2	354	376	3.3e-6	SMART
ZnF_C2H2	382	404	2.5e-5	SMART
ZnF_C2H2	410	432	1e-5	SMART
ZnF_C2H2	438	460	1.3e-5	SMART
ZnF_C2H2	466	488	5.2e-5	SMART
ZnF_C2H2	494	516	3.6e-5	SMART
ZnF_C2H2	522	544	1.6e-5	SMART
ZnF_C2H2	550	572	2e-5	SMART
ZnF_C2H2	578	600	4e-6	SMART
ZnF_C2H2	606	628	1.5e-5	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	A	G	3: 122,176,101 (GRCm38)	T2252A	probably benign	Het
Abcc2	C	T	19: 43,821,750 (GRCm38)		probably benign	Het
Abcf1	T	C	17: 35,962,062 (GRCm38)	E231G	probably benign	Het
Astn2	T	C	4: 66,059,153 (GRCm38)	Y379C	probably damaging	Het
Atp8b1	G	T	18: 64,538,695 (GRCm38)		probably benign	Het
Atr	T	A	9: 95,881,420 (GRCm38)		probably benign	Het
Bdp1	A	G	13: 100,023,827 (GRCm38)	S2349P	possibly damaging	Het
Bmp2	T	C	2: 133,560,966 (GRCm38)	S146P	probably damaging	Het
Cacna1c	T	C	6: 118,715,924 (GRCm38)	S218G	probably null	Het
Cand2	T	C	6: 115,803,638 (GRCm38)	V1161A	probably damaging	Het
Clec16a	T	C	16: 10,580,960 (GRCm38)	V330A	probably damaging	Het
Cpsf1	A	T	15: 76,603,091 (GRCm38)	V161D	probably damaging	Het
Ctsh	A	G	9: 90,061,547 (GRCm38)	Y75C	probably damaging	Het
Cyp26c1	T	A	19: 37,688,924 (GRCm38)	L267Q	probably damaging	Het
Cyp26c1	C	A	19: 37,688,923 (GRCm38)	L267M	probably damaging	Het
Cyp2c50	G	A	19: 40,091,099 (GRCm38)	W212*	probably null	Het
Dnah5	T	A	15: 28,343,552 (GRCm38)	M2366K	probably damaging	Het
Ermp1	A	G	19: 29,612,920 (GRCm38)	M794T	probably damaging	Het
F11	G	T	8: 45,250,095 (GRCm38)	S186Y	probably damaging	Het
Fam184b	A	T	5: 45,532,823 (GRCm38)	F815I	possibly damaging	Het
Fezf2	T	C	14: 12,343,705 (GRCm38)	I347V	probably benign	Het
Fip1l1	C	T	5: 74,545,423 (GRCm38)	T114I	possibly damaging	Het
Gbp7	A	C	3: 142,546,450 (GRCm38)	D598A	probably benign	Het
Gm1110	T	A	9: 26,883,230 (GRCm38)	D500V	probably benign	Het
Gm3248	T	A	14: 5,943,928 (GRCm38)	M99L	probably benign	Het
Gpi-ps	A	T	8: 5,639,896 (GRCm38)		noncoding transcript	Het
Hspa9	G	A	18: 34,947,975 (GRCm38)	R218*	probably null	Het
Ikbip	G	A	10: 91,093,257 (GRCm38)		probably null	Het
Kcnb2	C	T	1: 15,710,809 (GRCm38)	T635M	probably benign	Het
Krtap29-1	T	A	11: 99,978,279 (GRCm38)	I259F	possibly damaging	Het
Lnpep	T	C	17: 17,570,957 (GRCm38)	T442A	probably benign	Het
Mgat1	T	A	11: 49,260,735 (GRCm38)	I15N	probably damaging	Het
Nlrp9c	A	T	7: 26,385,151 (GRCm38)	S334R	probably benign	Het
Notch2	A	T	3: 98,147,296 (GRCm38)	D2425V	probably damaging	Het
Ntn1	C	T	11: 68,213,263 (GRCm38)	V520M	probably damaging	Het
Or10d1b	A	G	9: 39,702,253 (GRCm38)	V172A	probably damaging	Het
Or4p18	T	A	2: 88,402,077 (GRCm38)	T286S	possibly damaging	Het
Or5d39	A	T	2: 88,149,578 (GRCm38)	V147E	probably damaging	Het
Or6c3b	T	A	10: 129,692,018 (GRCm38)	T8S	probably benign	Het
Or8g55	A	T	9: 39,873,485 (GRCm38)	D70V	probably damaging	Het
Or8k39	A	C	2: 86,733,177 (GRCm38)	I145R	possibly damaging	Het
Osr2	A	G	15: 35,301,992 (GRCm38)	H246R	probably damaging	Het
Papolg	T	C	11: 23,879,898 (GRCm38)	R224G	probably damaging	Het
Pax6	T	A	2: 105,692,278 (GRCm38)		probably null	Het
Pcyox1	A	G	6: 86,392,268 (GRCm38)	V192A	probably benign	Het
Phf1	C	T	17: 26,935,286 (GRCm38)	A159V	possibly damaging	Het
Ppfia4	G	A	1: 134,332,391 (GRCm38)	R45W	probably damaging	Het
Psmb9	T	A	17: 34,183,679 (GRCm38)	K109M	probably damaging	Het
Ptprt	T	A	2: 161,927,673 (GRCm38)	Y424F	probably benign	Het
Ptrh2	A	G	11: 86,689,766 (GRCm38)	I70V	probably benign	Het
Rnf213	G	A	11: 119,418,309 (GRCm38)		probably benign	Het
Rom1	T	A	19: 8,928,004 (GRCm38)	I271F	probably benign	Het
Satb2	T	A	1: 56,796,793 (GRCm38)	D731V	possibly damaging	Het
Serpinb7	G	T	1: 107,448,129 (GRCm38)	G159V	possibly damaging	Het
Slit1	T	C	19: 41,646,140 (GRCm38)	I393V	probably damaging	Het
Spata20	T	A	11: 94,483,463 (GRCm38)	D327V	probably damaging	Het
Spata31e3	G	A	13: 50,246,685 (GRCm38)	P535L	probably benign	Het
Spmap2l	A	T	5: 77,060,758 (GRCm38)	I378L	probably benign	Het
Tbc1d32	G	T	10: 56,151,775 (GRCm38)	Q744K	possibly damaging	Het
Tmem108	G	T	9: 103,489,240 (GRCm38)	N517K	possibly damaging	Het
Trp63	T	A	16: 25,862,461 (GRCm38)	N160K	probably damaging	Het
Ttll5	T	C	12: 85,933,611 (GRCm38)	S119P	probably damaging	Het
Ubqln3	T	A	7: 104,142,316 (GRCm38)	Q189L	probably damaging	Het
Vwa5a	G	A	9: 38,737,776 (GRCm38)	R638H	probably benign	Het
Wdr3	A	G	3: 100,150,982 (GRCm38)	S436P	probably damaging	Het
Zfp975	A	T	7: 42,662,791 (GRCm38)	C133S	probably damaging	Het
Zmiz1	A	G	14: 25,656,879 (GRCm38)	M860V	probably damaging	Het
Zscan4d	T	C	7: 11,162,369 (GRCm38)	E358G	probably benign	Het

Other mutations in Zfp976

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00465:Zfp976	APN	7	42,613,685 (GRCm38)	missense	unknown
IGL01102:Zfp976	APN	7	42,613,909 (GRCm38)	nonsense	probably null
IGL01111:Zfp976	APN	7	42,616,287 (GRCm38)	missense	probably damaging	0.99
IGL01628:Zfp976	APN	7	42,612,511 (GRCm38)	missense	unknown
IGL02548:Zfp976	APN	7	42,612,529 (GRCm38)	missense	unknown
R0190:Zfp976	UTSW	7	42,642,524 (GRCm38)	start gained	probably benign
R0685:Zfp976	UTSW	7	42,613,717 (GRCm38)	missense	probably damaging	0.98
R1310:Zfp976	UTSW	7	42,613,186 (GRCm38)	missense	probably damaging	1.00
R1353:Zfp976	UTSW	7	42,616,018 (GRCm38)	missense	probably damaging	0.99
R1447:Zfp976	UTSW	7	42,612,599 (GRCm38)	missense	possibly damaging	0.79
R1569:Zfp976	UTSW	7	42,613,382 (GRCm38)	missense	probably damaging	1.00
R1702:Zfp976	UTSW	7	42,616,000 (GRCm38)	missense	possibly damaging	0.86
R1829:Zfp976	UTSW	7	42,616,311 (GRCm38)	missense	probably damaging	1.00
R1939:Zfp976	UTSW	7	42,613,681 (GRCm38)	missense	unknown
R1978:Zfp976	UTSW	7	42,613,841 (GRCm38)	missense	probably damaging	1.00
R1981:Zfp976	UTSW	7	42,613,622 (GRCm38)	missense	probably damaging	0.99
R2160:Zfp976	UTSW	7	42,613,930 (GRCm38)	missense	probably benign
R2192:Zfp976	UTSW	7	42,613,271 (GRCm38)	missense	probably damaging	1.00
R3121:Zfp976	UTSW	7	42,613,514 (GRCm38)	missense	probably damaging	1.00
R4210:Zfp976	UTSW	7	42,616,325 (GRCm38)	missense	probably damaging	0.99
R4724:Zfp976	UTSW	7	42,613,033 (GRCm38)	missense	possibly damaging	0.91
R4943:Zfp976	UTSW	7	42,612,422 (GRCm38)	unclassified	probably benign
R5047:Zfp976	UTSW	7	42,613,419 (GRCm38)	nonsense	probably null
R5071:Zfp976	UTSW	7	42,612,930 (GRCm38)	nonsense	probably null
R5125:Zfp976	UTSW	7	42,612,501 (GRCm38)	splice site	probably null
R5178:Zfp976	UTSW	7	42,612,501 (GRCm38)	splice site	probably null
R5305:Zfp976	UTSW	7	42,613,478 (GRCm38)	missense	probably benign	0.00
R5777:Zfp976	UTSW	7	42,614,080 (GRCm38)	missense	probably benign	0.00
R6153:Zfp976	UTSW	7	42,614,186 (GRCm38)	missense	probably damaging	0.99
R6694:Zfp976	UTSW	7	42,614,186 (GRCm38)	missense	probably damaging	0.99
R7226:Zfp976	UTSW	7	42,613,260 (GRCm38)	nonsense	probably null
R7479:Zfp976	UTSW	7	42,613,179 (GRCm38)	missense	probably benign	0.01
R7561:Zfp976	UTSW	7	42,616,277 (GRCm38)	missense	probably damaging	1.00
R8178:Zfp976	UTSW	7	42,613,535 (GRCm38)	missense	probably benign	0.03
R8261:Zfp976	UTSW	7	42,612,701 (GRCm38)	missense	unknown
R8715:Zfp976	UTSW	7	42,613,445 (GRCm38)	missense	possibly damaging	0.89
R8921:Zfp976	UTSW	7	42,613,151 (GRCm38)	missense	possibly damaging	0.57
R9168:Zfp976	UTSW	7	42,613,587 (GRCm38)	nonsense	probably null
R9575:Zfp976	UTSW	7	42,612,617 (GRCm38)	missense	unknown
Z1088:Zfp976	UTSW	7	42,612,760 (GRCm38)	missense	possibly damaging	0.71

Posted On

2014-05-07