Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01981:Usp32'

183474

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Usp32

Ensembl Gene

ENSMUSG00000000804

Gene Name

ubiquitin specific peptidase 32

Synonyms

6430526O11Rik, 2900074J03Rik

Accession Numbers

Is this an essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL01981

Quality Score

Status

Chromosome

Chromosomal Location

84984442-85140161 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 85036524 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 622 (M622T)

Ref Sequence

ENSEMBL: ENSMUSP00000103710 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108075] [ENSMUST00000172515]

Predicted Effect

probably benign
Transcript: ENSMUST00000108075
AA Change: M622T

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000103710
Gene: ENSMUSG00000000804
AA Change: M622T

Domain	Start	End	E-Value	Type
EFh	232	260	4.66e0	SMART
EFh	268	296	5.8e-1	SMART
Blast:EFh	318	346	5e-7	BLAST
DUSP	389	588	2.32e-16	SMART
Pfam:Ubiquitin_3	628	711	2.4e-9	PFAM
Pfam:UCH	733	1564	2.4e-83	PFAM
Pfam:UCH_1	1202	1547	2.9e-12	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000172515

SMART Domains

Protein: ENSMUSP00000133781
Gene: ENSMUSG00000000804

Domain	Start	End	E-Value	Type
Blast:DUSP	1	52	7e-30	BLAST
low complexity region	53	65	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000174602
AA Change: M100T

SMART Domains

Protein: ENSMUSP00000134476
Gene: ENSMUSG00000000804
AA Change: M100T

Domain	Start	End	E-Value	Type
Pfam:DUSP	1	65	6.5e-17	PFAM
Pfam:Ubiquitin_3	122	216	8e-10	PFAM
Pfam:UCH	238	257	1.2e-7	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921501E09Rik	C	T	17: 33,067,654	G58E	probably damaging	Het
Akt2	A	C	7: 27,638,074	D417A	probably benign	Het
Ap1b1	T	A	11: 5,019,336	S231T	possibly damaging	Het
Arhgap31	G	A	16: 38,601,573	T1377I	probably damaging	Het
Cdkl3	A	G	11: 52,005,069	T48A	probably benign	Het
Chd3	T	C	11: 69,360,675	Y510C	probably damaging	Het
Chml	A	G	1: 175,688,185	S57P	probably damaging	Het
Cpxm1	G	T	2: 130,394,140	C367*	probably null	Het
D930020B18Rik	A	G	10: 121,692,414	T428A	probably damaging	Het
Dnaja3	A	T	16: 4,701,169	I325F	probably damaging	Het
Erbb3	A	G	10: 128,571,650	V943A	probably benign	Het
Fam110b	A	G	4: 5,799,481	I300V	probably benign	Het
Fam193a	A	G	5: 34,431,193	E76G	probably damaging	Het
Fbxl3	G	A	14: 103,095,464	T26M	possibly damaging	Het
Furin	A	G	7: 80,392,899	L380P	probably damaging	Het
Fxr2	A	C	11: 69,650,502	I354L	possibly damaging	Het
Garnl3	G	T	2: 32,997,729	N756K	probably damaging	Het
Gimap1	A	G	6: 48,743,324	Y290C	probably damaging	Het
Gm11639	A	T	11: 104,721,432		probably benign	Het
Gm5592	G	A	7: 41,286,371	W99*	probably null	Het
Hexdc	G	T	11: 121,216,993	S183I	possibly damaging	Het
Hmg20a	C	T	9: 56,477,230	P95S	probably damaging	Het
Jhy	A	T	9: 40,895,546	I769N	probably damaging	Het
Lrrd1	G	T	5: 3,851,267	C524F	probably damaging	Het
Musk	C	A	4: 58,296,629	S76R	probably damaging	Het
Myom3	C	T	4: 135,785,849	R613*	probably null	Het
Naa16	T	A	14: 79,381,516	E172D	probably benign	Het
Obox6	A	T	7: 15,834,921	M10K	possibly damaging	Het
Olfr1039	A	T	2: 86,130,830	Y278N	probably benign	Het
Pam	C	T	1: 97,834,441	V700M	probably damaging	Het
Pkd1l2	C	A	8: 117,016,916	R1978L	probably benign	Het
Pkhd1	T	A	1: 20,523,567	T1441S	possibly damaging	Het
Plg	A	G	17: 12,403,047		probably benign	Het
Pot1a	A	G	6: 25,750,100	L521P	probably damaging	Het
Pramef17	G	A	4: 143,994,354	P6S	probably damaging	Het
Ptprj	A	T	2: 90,439,912	V1280E	probably damaging	Het
Rcbtb2	T	C	14: 73,164,782	S136P	possibly damaging	Het
Rtl1	C	T	12: 109,591,935	E1157K	possibly damaging	Het
Sell	G	A	1: 164,065,626	R137Q	probably benign	Het
Shisa9	A	T	16: 12,244,658	M248L	probably benign	Het
Spag17	A	G	3: 100,058,833	E1144G	probably benign	Het
Sphk2	G	T	7: 45,710,733	Q616K	probably benign	Het
Tecrl	T	C	5: 83,294,606	T207A	probably benign	Het
Ubr5	T	C	15: 37,996,598	T1885A	probably benign	Het
Usp24	T	C	4: 106,375,768		probably benign	Het
Vangl1	A	G	3: 102,184,291	F160L	probably damaging	Het
Vps13d	T	C	4: 145,086,747	S3289G	probably damaging	Het
Wdfy4	A	G	14: 33,133,716	F647S	probably damaging	Het
Wdhd1	A	G	14: 47,261,450	L509P	probably damaging	Het
Zcchc2	A	G	1: 106,027,499	E640G	probably damaging	Het
Zfp563	T	A	17: 33,105,409	I326N	probably benign	Het

Other mutations in Usp32

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00529:Usp32	APN	11	84994426	missense	probably damaging	1.00
IGL00701:Usp32	APN	11	85059125	splice site	probably null
IGL00848:Usp32	APN	11	85051181	splice site	probably benign
IGL00934:Usp32	APN	11	85007076	missense	probably damaging	1.00
IGL01019:Usp32	APN	11	85039265	missense	probably damaging	0.97
IGL01302:Usp32	APN	11	84988482	missense	probably benign	0.05
IGL01444:Usp32	APN	11	85059164	missense	probably damaging	0.97
IGL01575:Usp32	APN	11	85022802	missense	probably damaging	1.00
IGL02118:Usp32	APN	11	85032177	nonsense	probably null
IGL02159:Usp32	APN	11	85005802	splice site	probably null
IGL02227:Usp32	APN	11	84986481	missense	probably damaging	1.00
IGL02363:Usp32	APN	11	85044787	missense	probably benign	0.01
IGL02524:Usp32	APN	11	85010011	nonsense	probably null
IGL02613:Usp32	APN	11	85040070	missense	probably damaging	0.99
IGL02720:Usp32	APN	11	85006991	critical splice donor site	probably null
IGL02738:Usp32	APN	11	85083806	missense	probably damaging	1.00
IGL02929:Usp32	APN	11	84988372	missense	probably benign	0.01
IGL03303:Usp32	APN	11	85022832	missense	probably damaging	1.00
BB010:Usp32	UTSW	11	85007059	missense	probably damaging	1.00
BB020:Usp32	UTSW	11	85007059	missense	probably damaging	1.00
PIT4812001:Usp32	UTSW	11	85010074	missense	probably damaging	1.00
R0026:Usp32	UTSW	11	85032074	missense	possibly damaging	0.48
R0295:Usp32	UTSW	11	85053692	missense	probably damaging	0.98
R1320:Usp32	UTSW	11	85017793	missense	probably damaging	0.98
R1712:Usp32	UTSW	11	85042580	missense	probably benign	0.12
R1922:Usp32	UTSW	11	85007004	nonsense	probably null
R1973:Usp32	UTSW	11	85103931	missense	probably benign	0.09
R2010:Usp32	UTSW	11	85040004	missense	probably damaging	0.98
R2082:Usp32	UTSW	11	85030512	missense	probably damaging	0.99
R2355:Usp32	UTSW	11	85005909	missense	probably benign	0.34
R3147:Usp32	UTSW	11	85029087	missense	probably damaging	1.00
R3160:Usp32	UTSW	11	85025536	missense	probably damaging	0.97
R3162:Usp32	UTSW	11	85025536	missense	probably damaging	0.97
R3716:Usp32	UTSW	11	85042563	missense	probably damaging	1.00
R3816:Usp32	UTSW	11	84994384	critical splice donor site	probably null
R3870:Usp32	UTSW	11	85007055	nonsense	probably null
R3871:Usp32	UTSW	11	85081156	missense	probably null	0.81
R4041:Usp32	UTSW	11	85017739	missense	probably benign	0.40
R4079:Usp32	UTSW	11	85039229	missense	probably damaging	0.98
R4332:Usp32	UTSW	11	85103978	missense	possibly damaging	0.79
R4396:Usp32	UTSW	11	85053975	missense	probably benign
R4580:Usp32	UTSW	11	85059127	critical splice donor site	probably null
R4620:Usp32	UTSW	11	85059127	critical splice donor site	probably null
R4744:Usp32	UTSW	11	84994393	missense	probably damaging	1.00
R4909:Usp32	UTSW	11	85055772	nonsense	probably null
R5056:Usp32	UTSW	11	85026795	missense	probably benign	0.07
R5111:Usp32	UTSW	11	85077331	missense	possibly damaging	0.95
R5213:Usp32	UTSW	11	85022259	missense	probably damaging	1.00
R5308:Usp32	UTSW	11	85017718	missense	probably benign	0.12
R5381:Usp32	UTSW	11	85059127	critical splice donor site	probably benign
R5538:Usp32	UTSW	11	85017786	missense	possibly damaging	0.65
R5659:Usp32	UTSW	11	85077414	missense	possibly damaging	0.94
R6006:Usp32	UTSW	11	84992451	critical splice donor site	probably null
R6011:Usp32	UTSW	11	85032097	missense	possibly damaging	0.70
R6029:Usp32	UTSW	11	85025582	missense	probably damaging	0.99
R6074:Usp32	UTSW	11	84994573	missense	probably benign	0.00
R6331:Usp32	UTSW	11	84986576	missense	possibly damaging	0.92
R6353:Usp32	UTSW	11	85022281	missense	probably benign
R6714:Usp32	UTSW	11	85026870	missense	probably damaging	0.99
R6778:Usp32	UTSW	11	85025686	missense	probably benign	0.00
R6988:Usp32	UTSW	11	85010143	missense	probably benign	0.35
R6992:Usp32	UTSW	11	85032088	missense	probably damaging	0.99
R7182:Usp32	UTSW	11	85040170	missense	probably benign	0.34
R7186:Usp32	UTSW	11	85051234	missense	probably benign	0.45
R7198:Usp32	UTSW	11	85022855	frame shift	probably null
R7201:Usp32	UTSW	11	85022855	frame shift	probably null
R7469:Usp32	UTSW	11	84988553	missense	possibly damaging	0.94
R7502:Usp32	UTSW	11	85022898	missense	possibly damaging	0.48
R7513:Usp32	UTSW	11	85027112	nonsense	probably null
R7629:Usp32	UTSW	11	85019855	frame shift	probably null
R7703:Usp32	UTSW	11	85077327	missense	probably damaging	0.99
R7741:Usp32	UTSW	11	84987281	missense	probably damaging	0.99
R7765:Usp32	UTSW	11	84994408	missense	probably damaging	1.00
R7933:Usp32	UTSW	11	85007059	missense	probably damaging	1.00
R7998:Usp32	UTSW	11	84994426	missense	probably damaging	1.00
R8292:Usp32	UTSW	11	85077401	missense	probably damaging	0.99
R8305:Usp32	UTSW	11	85032185	missense	possibly damaging	0.83
X0028:Usp32	UTSW	11	84992606	missense	probably benign	0.05
Z1177:Usp32	UTSW	11	84988612	nonsense	probably null

Posted On

2014-05-07