Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01981:Naa16'

183496

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Naa16

Ensembl Gene

ENSMUSG00000022020

Gene Name

N(alpha)-acetyltransferase 16, NatA auxiliary subunit

Synonyms

Narg1l, 1300019C06Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.099) question?

Stock #

IGL01981

Quality Score

Status

Chromosome

Chromosomal Location

79325269-79390778 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 79381516 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Aspartic acid at position 172 (E172D)

Ref Sequence

ENSEMBL: ENSMUSP00000022597 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022597] [ENSMUST00000163486] [ENSMUST00000169500]

Predicted Effect

probably benign
Transcript: ENSMUST00000022597
AA Change: E172D

PolyPhen 2 Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000022597
Gene: ENSMUSG00000022020
AA Change: E172D

Domain	Start	End	E-Value	Type
TPR	46	79	2.99e1	SMART
TPR	80	113	2.98e-3	SMART
Blast:TPR	224	257	1e-10	BLAST
TPR	374	407	9.96e0	SMART
TPR	408	441	7.47e0	SMART
low complexity region	616	633	N/A	INTRINSIC
Blast:TPR	672	705	3e-12	BLAST
low complexity region	830	841	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000163486
AA Change: E138D

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000131268
Gene: ENSMUSG00000022020
AA Change: E138D

Domain	Start	End	E-Value	Type
TPR	12	45	2.99e1	SMART
TPR	46	79	2.98e-3	SMART
Blast:TPR	190	223	3e-10	BLAST
TPR	340	373	9.96e0	SMART
TPR	374	407	7.47e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000165337

Predicted Effect

probably benign
Transcript: ENSMUST00000169500

SMART Domains

Protein: ENSMUSP00000127298
Gene: ENSMUSG00000022020

Domain	Start	End	E-Value	Type
PDB:4KVO\|D	1	46	1e-6	PDB

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921501E09Rik	C	T	17: 33,067,654	G58E	probably damaging	Het
Akt2	A	C	7: 27,638,074	D417A	probably benign	Het
Ap1b1	T	A	11: 5,019,336	S231T	possibly damaging	Het
Arhgap31	G	A	16: 38,601,573	T1377I	probably damaging	Het
Cdkl3	A	G	11: 52,005,069	T48A	probably benign	Het
Chd3	T	C	11: 69,360,675	Y510C	probably damaging	Het
Chml	A	G	1: 175,688,185	S57P	probably damaging	Het
Cpxm1	G	T	2: 130,394,140	C367*	probably null	Het
D930020B18Rik	A	G	10: 121,692,414	T428A	probably damaging	Het
Dnaja3	A	T	16: 4,701,169	I325F	probably damaging	Het
Erbb3	A	G	10: 128,571,650	V943A	probably benign	Het
Fam110b	A	G	4: 5,799,481	I300V	probably benign	Het
Fam193a	A	G	5: 34,431,193	E76G	probably damaging	Het
Fbxl3	G	A	14: 103,095,464	T26M	possibly damaging	Het
Furin	A	G	7: 80,392,899	L380P	probably damaging	Het
Fxr2	A	C	11: 69,650,502	I354L	possibly damaging	Het
Garnl3	G	T	2: 32,997,729	N756K	probably damaging	Het
Gimap1	A	G	6: 48,743,324	Y290C	probably damaging	Het
Gm11639	A	T	11: 104,721,432		probably benign	Het
Gm5592	G	A	7: 41,286,371	W99*	probably null	Het
Hexdc	G	T	11: 121,216,993	S183I	possibly damaging	Het
Hmg20a	C	T	9: 56,477,230	P95S	probably damaging	Het
Jhy	A	T	9: 40,895,546	I769N	probably damaging	Het
Lrrd1	G	T	5: 3,851,267	C524F	probably damaging	Het
Musk	C	A	4: 58,296,629	S76R	probably damaging	Het
Myom3	C	T	4: 135,785,849	R613*	probably null	Het
Obox6	A	T	7: 15,834,921	M10K	possibly damaging	Het
Olfr1039	A	T	2: 86,130,830	Y278N	probably benign	Het
Pam	C	T	1: 97,834,441	V700M	probably damaging	Het
Pkd1l2	C	A	8: 117,016,916	R1978L	probably benign	Het
Pkhd1	T	A	1: 20,523,567	T1441S	possibly damaging	Het
Plg	A	G	17: 12,403,047		probably benign	Het
Pot1a	A	G	6: 25,750,100	L521P	probably damaging	Het
Pramef17	G	A	4: 143,994,354	P6S	probably damaging	Het
Ptprj	A	T	2: 90,439,912	V1280E	probably damaging	Het
Rcbtb2	T	C	14: 73,164,782	S136P	possibly damaging	Het
Rtl1	C	T	12: 109,591,935	E1157K	possibly damaging	Het
Sell	G	A	1: 164,065,626	R137Q	probably benign	Het
Shisa9	A	T	16: 12,244,658	M248L	probably benign	Het
Spag17	A	G	3: 100,058,833	E1144G	probably benign	Het
Sphk2	G	T	7: 45,710,733	Q616K	probably benign	Het
Tecrl	T	C	5: 83,294,606	T207A	probably benign	Het
Ubr5	T	C	15: 37,996,598	T1885A	probably benign	Het
Usp24	T	C	4: 106,375,768		probably benign	Het
Usp32	A	G	11: 85,036,524	M622T	probably benign	Het
Vangl1	A	G	3: 102,184,291	F160L	probably damaging	Het
Vps13d	T	C	4: 145,086,747	S3289G	probably damaging	Het
Wdfy4	A	G	14: 33,133,716	F647S	probably damaging	Het
Wdhd1	A	G	14: 47,261,450	L509P	probably damaging	Het
Zcchc2	A	G	1: 106,027,499	E640G	probably damaging	Het
Zfp563	T	A	17: 33,105,409	I326N	probably benign	Het

Other mutations in Naa16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00551:Naa16	APN	14	79355729	missense	probably damaging	1.00
IGL01025:Naa16	APN	14	79384756	missense	probably damaging	1.00
IGL01155:Naa16	APN	14	79384715	missense	probably damaging	0.98
IGL01335:Naa16	APN	14	79345116	splice site	probably benign
IGL02230:Naa16	APN	14	79377361	splice site	probably benign
IGL02313:Naa16	APN	14	79384668	missense	probably damaging	1.00
IGL02418:Naa16	APN	14	79383366	missense	probably damaging	1.00
IGL02544:Naa16	APN	14	79335820	missense	probably damaging	1.00
IGL03051:Naa16	APN	14	79369082	missense	probably benign	0.01
IGL03064:Naa16	APN	14	79339628	missense	probably damaging	0.98
IGL03205:Naa16	APN	14	79356512	missense	possibly damaging	0.89
PIT4508001:Naa16	UTSW	14	79369087	missense	probably benign	0.15
R0651:Naa16	UTSW	14	79351392	missense	probably damaging	1.00
R1429:Naa16	UTSW	14	79359527	missense	probably benign	0.01
R1674:Naa16	UTSW	14	79387057	start codon destroyed	probably null	0.65
R1693:Naa16	UTSW	14	79351456	missense	probably damaging	1.00
R1874:Naa16	UTSW	14	79355743	missense	possibly damaging	0.62
R1992:Naa16	UTSW	14	79356491	missense	probably damaging	1.00
R2015:Naa16	UTSW	14	79345059	missense	probably damaging	1.00
R2391:Naa16	UTSW	14	79370049	missense	probably benign	0.16
R2847:Naa16	UTSW	14	79335883	missense	probably damaging	1.00
R2848:Naa16	UTSW	14	79335883	missense	probably damaging	1.00
R2877:Naa16	UTSW	14	79343298	missense	probably benign	0.00
R3884:Naa16	UTSW	14	79343262	missense	probably damaging	0.98
R4001:Naa16	UTSW	14	79343121	splice site	probably null
R4199:Naa16	UTSW	14	79355871	missense	probably damaging	1.00
R4638:Naa16	UTSW	14	79340033	splice site	probably null
R4676:Naa16	UTSW	14	79336348	unclassified	probably benign
R4690:Naa16	UTSW	14	79345057	missense	probably damaging	1.00
R4952:Naa16	UTSW	14	79345085	missense	probably damaging	1.00
R5087:Naa16	UTSW	14	79377415	missense	possibly damaging	0.68
R5104:Naa16	UTSW	14	79384700	nonsense	probably null
R5729:Naa16	UTSW	14	79355780	missense	probably damaging	1.00
R6178:Naa16	UTSW	14	79383340	missense	possibly damaging	0.93
R6960:Naa16	UTSW	14	79359471	missense	possibly damaging	0.65
R7794:Naa16	UTSW	14	79377494	missense	probably damaging	1.00
X0064:Naa16	UTSW	14	79351389	missense	probably damaging	1.00
Z1177:Naa16	UTSW	14	79344979	missense	probably damaging	1.00

Posted On

2014-05-07