Incidental Mutation 'IGL01983:Hdac1-ps'
| ID |
183532 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Hdac1-ps
|
| Ensembl Gene |
ENSMUSG00000061062 |
| Gene Name |
histone deacetylase 1, pseudogene |
| Synonyms |
EG15181, Gm10093 |
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.908)
|
| Stock # |
IGL01983
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
78799011-78800454 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 78800282 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 424
(D424E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000078339
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079363]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000079363
AA Change: D424E
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000078339
Gene: ENSMUSG00000061062
AA Change: D424E
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Hist_deacetyl
|
18 |
320 |
3.2e-84 |
PFAM |
|
low complexity region
|
390 |
402 |
N/A |
INTRINSIC |
|
low complexity region
|
417 |
430 |
N/A |
INTRINSIC |
|
low complexity region
|
443 |
471 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acadl |
G |
A |
1: 66,880,783 (GRCm39) |
Q328* |
probably null |
Het |
| Alpk2 |
T |
C |
18: 65,483,753 (GRCm39) |
Y85C |
probably damaging |
Het |
| Arhgap31 |
C |
T |
16: 38,422,127 (GRCm39) |
R1313Q |
probably damaging |
Het |
| Chrnb1 |
G |
T |
11: 69,686,555 (GRCm39) |
R22S |
probably benign |
Het |
| Clec7a |
G |
A |
6: 129,442,539 (GRCm39) |
|
probably benign |
Het |
| Cyrib |
A |
G |
15: 63,809,236 (GRCm39) |
S251P |
probably benign |
Het |
| Epb41l5 |
A |
G |
1: 119,506,814 (GRCm39) |
|
probably benign |
Het |
| Hydin |
A |
C |
8: 111,241,527 (GRCm39) |
I2106L |
probably benign |
Het |
| Igkv3-5 |
T |
A |
6: 70,640,670 (GRCm39) |
D50E |
probably benign |
Het |
| Irf2bp1 |
G |
T |
7: 18,739,220 (GRCm39) |
A287S |
possibly damaging |
Het |
| Ldb3 |
G |
A |
14: 34,299,156 (GRCm39) |
S156L |
probably benign |
Het |
| Lnpep |
A |
T |
17: 17,751,440 (GRCm39) |
W942R |
probably damaging |
Het |
| Mst1r |
T |
A |
9: 107,794,475 (GRCm39) |
V1218D |
probably damaging |
Het |
| Naxd |
G |
T |
8: 11,560,218 (GRCm39) |
|
probably benign |
Het |
| Nol9 |
T |
C |
4: 152,130,494 (GRCm39) |
|
probably null |
Het |
| Nus1 |
T |
A |
10: 52,312,753 (GRCm39) |
L295Q |
probably damaging |
Het |
| Nxph2 |
A |
G |
2: 23,289,946 (GRCm39) |
I99M |
probably benign |
Het |
| Plekhg1 |
T |
A |
10: 3,895,904 (GRCm39) |
I432N |
probably damaging |
Het |
| Pon3 |
A |
G |
6: 5,240,974 (GRCm39) |
L69S |
probably damaging |
Het |
| Pram1 |
C |
A |
17: 33,859,835 (GRCm39) |
A134D |
probably damaging |
Het |
| Serpinb6c |
T |
A |
13: 34,081,317 (GRCm39) |
|
probably benign |
Het |
| Stk10 |
A |
T |
11: 32,539,460 (GRCm39) |
E280V |
probably benign |
Het |
| Tbc1d10c |
T |
A |
19: 4,240,708 (GRCm39) |
Q34L |
possibly damaging |
Het |
| Tnr |
G |
A |
1: 159,691,349 (GRCm39) |
V500I |
probably benign |
Het |
| Trim66 |
G |
A |
7: 109,057,458 (GRCm39) |
R992* |
probably null |
Het |
| Unc45b |
A |
G |
11: 82,827,687 (GRCm39) |
D728G |
probably benign |
Het |
| Usp13 |
A |
G |
3: 32,971,608 (GRCm39) |
D696G |
probably damaging |
Het |
| Utrn |
C |
T |
10: 12,545,525 (GRCm39) |
V1707I |
probably benign |
Het |
| Vmn2r96 |
A |
T |
17: 18,817,527 (GRCm39) |
H368L |
probably damaging |
Het |
| Xrn1 |
T |
C |
9: 95,855,421 (GRCm39) |
|
probably null |
Het |
| Zfhx3 |
C |
A |
8: 109,673,866 (GRCm39) |
L1639M |
probably damaging |
Het |
| Znfx1 |
A |
T |
2: 166,898,270 (GRCm39) |
V218E |
probably damaging |
Het |
|
| Other mutations in Hdac1-ps |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01936:Hdac1-ps
|
APN |
17 |
78,799,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02543:Hdac1-ps
|
APN |
17 |
78,799,303 (GRCm39) |
missense |
probably damaging |
0.97 |
|
buttress
|
UTSW |
17 |
78,800,343 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Chartre
|
UTSW |
17 |
78,799,969 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1174:Hdac1-ps
|
UTSW |
17 |
78,799,507 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1605:Hdac1-ps
|
UTSW |
17 |
78,799,537 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2416:Hdac1-ps
|
UTSW |
17 |
78,799,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2919:Hdac1-ps
|
UTSW |
17 |
78,800,275 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2920:Hdac1-ps
|
UTSW |
17 |
78,800,275 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3846:Hdac1-ps
|
UTSW |
17 |
78,800,401 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4544:Hdac1-ps
|
UTSW |
17 |
78,800,388 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4546:Hdac1-ps
|
UTSW |
17 |
78,800,388 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5223:Hdac1-ps
|
UTSW |
17 |
78,799,867 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5297:Hdac1-ps
|
UTSW |
17 |
78,800,187 (GRCm39) |
missense |
probably benign |
|
|
R6164:Hdac1-ps
|
UTSW |
17 |
78,799,716 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6568:Hdac1-ps
|
UTSW |
17 |
78,800,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6726:Hdac1-ps
|
UTSW |
17 |
78,800,287 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6901:Hdac1-ps
|
UTSW |
17 |
78,800,089 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6923:Hdac1-ps
|
UTSW |
17 |
78,800,343 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7838:Hdac1-ps
|
UTSW |
17 |
78,799,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8002:Hdac1-ps
|
UTSW |
17 |
78,799,716 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8728:Hdac1-ps
|
UTSW |
17 |
78,800,332 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8821:Hdac1-ps
|
UTSW |
17 |
78,799,969 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8920:Hdac1-ps
|
UTSW |
17 |
78,799,171 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9618:Hdac1-ps
|
UTSW |
17 |
78,799,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9649:Hdac1-ps
|
UTSW |
17 |
78,799,075 (GRCm39) |
missense |
probably benign |
0.03 |
|
X0060:Hdac1-ps
|
UTSW |
17 |
78,799,557 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Posted On |
2014-05-07 |
Incidental Mutation