Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01994:Vmn2r58'

183592

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r58

Ensembl Gene

ENSMUSG00000090383

Gene Name

vomeronasal 2, receptor 58

Synonyms

EG628422

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.280) question?

Stock #

IGL01994

Quality Score

Status

Chromosome

Chromosomal Location

41486305-41522094 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 41486394 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 834 (Y834H)

Ref Sequence

ENSEMBL: ENSMUSP00000126966 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171671]

AlphaFold

K7N6V2

Predicted Effect

probably damaging
Transcript: ENSMUST00000171671
AA Change: Y834H

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000126966
Gene: ENSMUSG00000090383
AA Change: Y834H

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	471	8e-43	PFAM
Pfam:NCD3G	514	567	1.8e-23	PFAM
Pfam:7tm_3	597	835	2.9e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actn2	A	T	13: 12,305,563 (GRCm39)	Y418N	probably benign	Het
Adam15	T	C	3: 89,248,812 (GRCm39)		probably benign	Het
Adam32	C	A	8: 25,392,812 (GRCm39)		probably benign	Het
Adamts12	T	A	15: 11,345,680 (GRCm39)	C1574S	probably damaging	Het
Adck1	T	C	12: 88,397,926 (GRCm39)	S187P	possibly damaging	Het
Atp13a3	A	G	16: 30,156,336 (GRCm39)	V949A	possibly damaging	Het
Atxn3	T	C	12: 101,908,439 (GRCm39)	T138A	probably benign	Het
Atxn7l2	C	T	3: 108,110,859 (GRCm39)	R559Q	probably damaging	Het
Bicra	G	T	7: 15,706,741 (GRCm39)	S1233R	possibly damaging	Het
Cacybp	G	T	1: 160,034,206 (GRCm39)	N101K	probably damaging	Het
Cops7b	T	C	1: 86,528,828 (GRCm39)	L185P	probably damaging	Het
Cttnbp2	T	C	6: 18,420,814 (GRCm39)	D899G	possibly damaging	Het
Cyp4f37	C	T	17: 32,844,150 (GRCm39)	R85*	probably null	Het
Dnah3	T	G	7: 119,550,437 (GRCm39)	N3294T	possibly damaging	Het
Elmo1	T	A	13: 20,526,634 (GRCm39)	Y395N	probably damaging	Het
Fam234b	T	A	6: 135,202,203 (GRCm39)	Y308*	probably null	Het
Fam43a	A	G	16: 30,419,481 (GRCm39)	K22E	probably damaging	Het
Fcer2a	T	C	8: 3,738,302 (GRCm39)	N123D	possibly damaging	Het
Gm11595	A	G	11: 99,663,027 (GRCm39)	C218R	unknown	Het
Gria4	T	C	9: 4,537,726 (GRCm39)	Y194C	probably damaging	Het
Grin2d	T	C	7: 45,507,396 (GRCm39)	E435G	probably damaging	Het
Hectd1	T	C	12: 51,844,725 (GRCm39)	E506G	probably damaging	Het
Htt	G	A	5: 34,989,948 (GRCm39)	S1160N	possibly damaging	Het
Ift140	A	G	17: 25,267,417 (GRCm39)	E605G	probably damaging	Het
Il17re	T	C	6: 113,445,411 (GRCm39)	V374A	probably benign	Het
Ippk	A	G	13: 49,612,093 (GRCm39)	Q439R	possibly damaging	Het
Itgam	G	A	7: 127,700,899 (GRCm39)	V530M	probably damaging	Het
Kirrel3	A	G	9: 34,931,429 (GRCm39)	H47R	possibly damaging	Het
Klk1b24	A	T	7: 43,841,057 (GRCm39)	I162F	probably damaging	Het
Lama1	A	T	17: 68,059,434 (GRCm39)	T606S	probably benign	Het
Lama2	C	T	10: 27,343,199 (GRCm39)		probably null	Het
Lrp2	A	G	2: 69,313,945 (GRCm39)	I2262T	probably benign	Het
Mamdc4	A	T	2: 25,458,546 (GRCm39)	I317N	possibly damaging	Het
Mtmr3	G	T	11: 4,437,938 (GRCm39)	H839N	probably benign	Het
Ncr1	G	T	7: 4,344,253 (GRCm39)	V177F	probably benign	Het
Nop58	T	C	1: 59,743,242 (GRCm39)	S219P	probably damaging	Het
Nrg3	T	C	14: 38,734,043 (GRCm39)	Y281C	probably damaging	Het
Nsf	A	G	11: 103,819,608 (GRCm39)	S54P	probably damaging	Het
Or56b6	A	T	7: 104,925,153 (GRCm39)		noncoding transcript	Het
Or6k8-ps1	T	A	1: 173,979,102 (GRCm39)	S7T	probably benign	Het
Plxnc1	T	C	10: 94,685,801 (GRCm39)	K730R	probably damaging	Het
Polr2g	A	T	19: 8,771,740 (GRCm39)		probably benign	Het
Rps13	A	G	7: 115,932,925 (GRCm39)		probably benign	Het
Scgb2b7	A	G	7: 31,403,409 (GRCm39)	I99T	probably benign	Het
Slc22a27	G	T	19: 7,887,108 (GRCm39)	H260Q	possibly damaging	Het
Spata18	G	T	5: 73,814,944 (GRCm39)		probably null	Het
Tns2	A	G	15: 102,019,814 (GRCm39)	E560G	possibly damaging	Het
Trbv16	T	C	6: 41,128,715 (GRCm39)		probably benign	Het
Ubr3	T	A	2: 69,851,520 (GRCm39)	I1829N	probably damaging	Het
Vcl	C	T	14: 21,053,311 (GRCm39)	T442I	probably damaging	Het
Vmn2r102	T	A	17: 19,880,731 (GRCm39)	I24N	probably benign	Het
Vmn2r114	T	C	17: 23,529,451 (GRCm39)	D217G	probably damaging	Het
Zdhhc8	G	T	16: 18,045,636 (GRCm39)		probably benign	Het

Other mutations in Vmn2r58

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00089:Vmn2r58	APN	7	41,513,854 (GRCm39)	missense	possibly damaging	0.53
IGL00924:Vmn2r58	APN	7	41,486,891 (GRCm39)	missense	probably damaging	1.00
IGL01291:Vmn2r58	APN	7	41,513,935 (GRCm39)	missense	probably benign	0.02
IGL01480:Vmn2r58	APN	7	41,514,116 (GRCm39)	missense	probably benign	0.01
IGL01551:Vmn2r58	APN	7	41,514,703 (GRCm39)	missense	probably damaging	0.97
IGL01591:Vmn2r58	APN	7	41,514,753 (GRCm39)	missense	probably benign	0.03
IGL01940:Vmn2r58	APN	7	41,487,071 (GRCm39)	missense	probably benign	0.00
IGL02041:Vmn2r58	APN	7	41,514,703 (GRCm39)	missense	probably damaging	0.97
IGL02222:Vmn2r58	APN	7	41,513,449 (GRCm39)	missense	possibly damaging	0.81
IGL02317:Vmn2r58	APN	7	41,486,765 (GRCm39)	missense	possibly damaging	0.89
IGL02614:Vmn2r58	APN	7	41,486,553 (GRCm39)	missense	probably damaging	1.00
IGL02673:Vmn2r58	APN	7	41,514,082 (GRCm39)	missense	possibly damaging	0.90
IGL03323:Vmn2r58	APN	7	41,511,295 (GRCm39)	missense	probably benign	0.06
IGL03337:Vmn2r58	APN	7	41,513,810 (GRCm39)	missense	possibly damaging	0.93
IGL03380:Vmn2r58	APN	7	41,513,874 (GRCm39)	missense	probably benign	0.00
ANU05:Vmn2r58	UTSW	7	41,513,935 (GRCm39)	missense	probably benign	0.02
R0138:Vmn2r58	UTSW	7	41,487,048 (GRCm39)	missense	probably damaging	1.00
R0141:Vmn2r58	UTSW	7	41,511,309 (GRCm39)	missense	probably benign	0.11
R0421:Vmn2r58	UTSW	7	41,514,628 (GRCm39)	missense	probably benign	0.02
R0604:Vmn2r58	UTSW	7	41,510,000 (GRCm39)	missense	possibly damaging	0.78
R0854:Vmn2r58	UTSW	7	41,486,562 (GRCm39)	missense	probably damaging	1.00
R1413:Vmn2r58	UTSW	7	41,513,387 (GRCm39)	missense	probably benign	0.01
R1441:Vmn2r58	UTSW	7	41,486,864 (GRCm39)	missense	probably damaging	1.00
R1678:Vmn2r58	UTSW	7	41,513,480 (GRCm39)	missense	probably benign	0.40
R1691:Vmn2r58	UTSW	7	41,486,913 (GRCm39)	missense	possibly damaging	0.95
R1699:Vmn2r58	UTSW	7	41,509,951 (GRCm39)	missense	probably benign
R1865:Vmn2r58	UTSW	7	41,486,682 (GRCm39)	missense	possibly damaging	0.95
R2008:Vmn2r58	UTSW	7	41,509,924 (GRCm39)	missense	probably damaging	1.00
R2036:Vmn2r58	UTSW	7	41,513,417 (GRCm39)	missense	probably benign
R2202:Vmn2r58	UTSW	7	41,513,594 (GRCm39)	missense	probably benign	0.07
R3787:Vmn2r58	UTSW	7	41,513,498 (GRCm39)	missense	probably benign	0.01
R3883:Vmn2r58	UTSW	7	41,513,914 (GRCm39)	nonsense	probably null
R3944:Vmn2r58	UTSW	7	41,513,885 (GRCm39)	missense	probably benign	0.03
R3949:Vmn2r58	UTSW	7	41,513,348 (GRCm39)	missense	probably benign	0.08
R4232:Vmn2r58	UTSW	7	41,487,011 (GRCm39)	missense	possibly damaging	0.91
R4409:Vmn2r58	UTSW	7	41,522,051 (GRCm39)	missense	possibly damaging	0.69
R4411:Vmn2r58	UTSW	7	41,511,360 (GRCm39)	missense	possibly damaging	0.85
R4413:Vmn2r58	UTSW	7	41,511,360 (GRCm39)	missense	possibly damaging	0.85
R4600:Vmn2r58	UTSW	7	41,522,046 (GRCm39)	missense	probably benign	0.03
R4610:Vmn2r58	UTSW	7	41,487,117 (GRCm39)	missense	probably benign
R4646:Vmn2r58	UTSW	7	41,509,935 (GRCm39)	missense	probably damaging	0.96
R4793:Vmn2r58	UTSW	7	41,514,495 (GRCm39)	missense	probably damaging	0.99
R4870:Vmn2r58	UTSW	7	41,486,639 (GRCm39)	missense	possibly damaging	0.76
R4981:Vmn2r58	UTSW	7	41,486,885 (GRCm39)	missense	probably damaging	1.00
R4993:Vmn2r58	UTSW	7	41,487,176 (GRCm39)	missense	probably benign	0.00
R5024:Vmn2r58	UTSW	7	41,513,746 (GRCm39)	missense	probably damaging	0.99
R5064:Vmn2r58	UTSW	7	41,486,534 (GRCm39)	missense	probably damaging	0.99
R5330:Vmn2r58	UTSW	7	41,513,384 (GRCm39)	nonsense	probably null
R5526:Vmn2r58	UTSW	7	41,522,069 (GRCm39)	missense	probably benign	0.01
R5980:Vmn2r58	UTSW	7	41,514,480 (GRCm39)	missense	possibly damaging	0.81
R6163:Vmn2r58	UTSW	7	41,486,825 (GRCm39)	missense	probably benign	0.31
R6365:Vmn2r58	UTSW	7	41,513,607 (GRCm39)	missense	probably benign	0.42
R6567:Vmn2r58	UTSW	7	41,514,673 (GRCm39)	missense	probably benign	0.34
R6594:Vmn2r58	UTSW	7	41,486,535 (GRCm39)	missense	possibly damaging	0.69
R6980:Vmn2r58	UTSW	7	41,513,662 (GRCm39)	missense	possibly damaging	0.64
R7373:Vmn2r58	UTSW	7	41,487,212 (GRCm39)	missense	probably damaging	1.00
R7458:Vmn2r58	UTSW	7	41,487,123 (GRCm39)	missense	probably benign	0.06
R7630:Vmn2r58	UTSW	7	41,513,611 (GRCm39)	missense	probably damaging	0.99
R7807:Vmn2r58	UTSW	7	41,521,910 (GRCm39)	missense	probably benign	0.05
R8114:Vmn2r58	UTSW	7	41,511,392 (GRCm39)	missense	probably damaging	1.00
R8232:Vmn2r58	UTSW	7	41,514,076 (GRCm39)	missense	probably damaging	0.97
R8313:Vmn2r58	UTSW	7	41,521,952 (GRCm39)	missense	probably benign	0.01
R8412:Vmn2r58	UTSW	7	41,513,722 (GRCm39)	missense	probably benign	0.01
R8530:Vmn2r58	UTSW	7	41,513,576 (GRCm39)	missense	probably damaging	1.00
R8851:Vmn2r58	UTSW	7	41,487,219 (GRCm39)	missense	probably benign
R8881:Vmn2r58	UTSW	7	41,486,609 (GRCm39)	missense	probably benign	0.05
R8936:Vmn2r58	UTSW	7	41,513,981 (GRCm39)	missense
R9045:Vmn2r58	UTSW	7	41,487,087 (GRCm39)	missense	probably benign	0.00
R9166:Vmn2r58	UTSW	7	41,513,431 (GRCm39)	missense	probably damaging	1.00
R9706:Vmn2r58	UTSW	7	41,510,000 (GRCm39)	missense	probably damaging	0.99
RF006:Vmn2r58	UTSW	7	41,486,383 (GRCm39)	frame shift	probably null
RF027:Vmn2r58	UTSW	7	41,486,383 (GRCm39)	frame shift	probably null
Z1176:Vmn2r58	UTSW	7	41,513,789 (GRCm39)	missense	probably benign	0.01

Posted On

2014-05-07