Incidental Mutation 'IGL01995:Or1e35'
ID 183649
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1e35
Ensembl Gene ENSMUSG00000062186
Gene Name olfactory receptor family 1 subfamily E member 35
Synonyms MOR135-10, GA_x6K02T2P1NL-4062605-4061667, Olfr395
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # IGL01995
Quality Score
Status
Chromosome 11
Chromosomal Location 73797378-73798316 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 73798261 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 19 (I19T)
Ref Sequence ENSEMBL: ENSMUSP00000149064 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072991] [ENSMUST00000215690]
AlphaFold Q8VGR3
Predicted Effect possibly damaging
Transcript: ENSMUST00000072991
AA Change: I19T

PolyPhen 2 Score 0.517 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000072756
Gene: ENSMUSG00000062186
AA Change: I19T

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
Pfam:7tm_4 31 309 6.2e-56 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.8e-8 PFAM
Pfam:7tm_1 41 290 3.7e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215690
AA Change: I19T

PolyPhen 2 Score 0.517 (Sensitivity: 0.88; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503E14Rik T C 14: 44,401,302 (GRCm39) probably benign Het
AI661453 C A 17: 47,779,442 (GRCm39) probably benign Het
Arhgap29 G A 3: 121,807,977 (GRCm39) V1052I probably benign Het
Arhgef17 A G 7: 100,577,862 (GRCm39) S1029P probably benign Het
Arpc5l T C 2: 38,898,226 (GRCm39) S7P probably damaging Het
Asf1b A G 8: 84,682,533 (GRCm39) I26V probably benign Het
Cep95 T C 11: 106,697,197 (GRCm39) L240P probably damaging Het
Cnmd A G 14: 79,879,508 (GRCm39) probably benign Het
Cntn3 T A 6: 102,180,846 (GRCm39) N783I probably damaging Het
Col6a2 C A 10: 76,440,676 (GRCm39) probably benign Het
Col9a2 T C 4: 120,907,607 (GRCm39) probably null Het
Cry2 T C 2: 92,254,977 (GRCm39) E126G probably benign Het
Cxcl15 T C 5: 90,942,467 (GRCm39) V13A possibly damaging Het
Dbr1 A G 9: 99,465,952 (GRCm39) D510G probably benign Het
Dct A G 14: 118,271,655 (GRCm39) F392L probably damaging Het
Dgkz A G 2: 91,764,395 (GRCm39) probably benign Het
Dhrs7b A G 11: 60,721,541 (GRCm39) I2V probably benign Het
Efnb3 A T 11: 69,447,730 (GRCm39) probably null Het
Fbf1 T A 11: 116,041,846 (GRCm39) R565S probably null Het
Gimap5 T C 6: 48,729,727 (GRCm39) I99T probably damaging Het
Gm9912 A G 3: 148,891,085 (GRCm39) L16P unknown Het
Gpr17 A G 18: 32,080,187 (GRCm39) L292P probably damaging Het
Hdac10 C T 15: 89,011,801 (GRCm39) V129M probably damaging Het
Mfap3l A G 8: 61,124,498 (GRCm39) I247V possibly damaging Het
Mtus1 A T 8: 41,537,457 (GRCm39) S86R probably damaging Het
Mylk3 A G 8: 86,085,890 (GRCm39) S55P possibly damaging Het
Nol6 A T 4: 41,118,567 (GRCm39) C745S probably damaging Het
Nudt13 A T 14: 20,356,385 (GRCm39) E103D probably damaging Het
Or10ag59 A G 2: 87,405,806 (GRCm39) Y126C probably damaging Het
Pdzk1 G T 3: 96,764,687 (GRCm39) A324S probably benign Het
Pofut2 T C 10: 77,096,515 (GRCm39) V80A possibly damaging Het
Rasip1 A G 7: 45,286,240 (GRCm39) D821G probably damaging Het
Rnf10 T A 5: 115,389,161 (GRCm39) K273* probably null Het
Slc4a9 A G 18: 36,672,828 (GRCm39) M811V possibly damaging Het
Smchd1 T C 17: 71,751,015 (GRCm39) D301G probably damaging Het
Tm9sf2 A T 14: 122,380,883 (GRCm39) T159S probably benign Het
Tom1l1 G A 11: 90,540,687 (GRCm39) P327S probably damaging Het
Trim3 A G 7: 105,267,689 (GRCm39) probably benign Het
Trpm6 A C 19: 18,807,691 (GRCm39) probably benign Het
Ttc13 A C 8: 125,415,621 (GRCm39) L245R probably damaging Het
Txnrd1 T A 10: 82,713,118 (GRCm39) V60E probably damaging Het
Ung T A 5: 114,274,447 (GRCm39) D173E probably benign Het
Zbtb5 A G 4: 44,995,294 (GRCm39) V30A probably damaging Het
Other mutations in Or1e35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01288:Or1e35 APN 11 73,798,139 (GRCm39) missense probably damaging 1.00
IGL01618:Or1e35 APN 11 73,798,303 (GRCm39) missense probably damaging 1.00
IGL02494:Or1e35 APN 11 73,797,550 (GRCm39) missense possibly damaging 0.55
IGL02995:Or1e35 APN 11 73,798,045 (GRCm39) missense possibly damaging 0.90
IGL03256:Or1e35 APN 11 73,797,522 (GRCm39) missense probably benign 0.07
R0018:Or1e35 UTSW 11 73,797,452 (GRCm39) missense probably damaging 1.00
R0701:Or1e35 UTSW 11 73,797,655 (GRCm39) missense probably damaging 1.00
R0839:Or1e35 UTSW 11 73,798,138 (GRCm39) missense probably damaging 0.99
R1222:Or1e35 UTSW 11 73,798,240 (GRCm39) missense probably damaging 1.00
R1737:Or1e35 UTSW 11 73,797,911 (GRCm39) missense possibly damaging 0.69
R1819:Or1e35 UTSW 11 73,797,505 (GRCm39) missense probably benign 0.02
R2994:Or1e35 UTSW 11 73,797,541 (GRCm39) missense probably damaging 1.00
R3195:Or1e35 UTSW 11 73,797,484 (GRCm39) missense possibly damaging 0.91
R4622:Or1e35 UTSW 11 73,797,737 (GRCm39) missense possibly damaging 0.55
R4753:Or1e35 UTSW 11 73,797,677 (GRCm39) missense probably damaging 1.00
R5137:Or1e35 UTSW 11 73,797,452 (GRCm39) missense probably damaging 1.00
R5448:Or1e35 UTSW 11 73,797,437 (GRCm39) missense probably damaging 1.00
R5604:Or1e35 UTSW 11 73,797,853 (GRCm39) missense probably benign 0.02
R5748:Or1e35 UTSW 11 73,797,721 (GRCm39) missense probably damaging 0.98
R5899:Or1e35 UTSW 11 73,797,755 (GRCm39) missense probably damaging 1.00
R6156:Or1e35 UTSW 11 73,797,447 (GRCm39) nonsense probably null
R6388:Or1e35 UTSW 11 73,798,118 (GRCm39) missense probably damaging 1.00
R6572:Or1e35 UTSW 11 73,797,629 (GRCm39) missense possibly damaging 0.91
R7241:Or1e35 UTSW 11 73,798,058 (GRCm39) missense probably benign 0.05
R8870:Or1e35 UTSW 11 73,797,725 (GRCm39) missense probably benign 0.03
R9358:Or1e35 UTSW 11 73,797,451 (GRCm39) missense probably damaging 1.00
R9544:Or1e35 UTSW 11 73,797,637 (GRCm39) missense probably benign 0.14
R9645:Or1e35 UTSW 11 73,797,713 (GRCm39) missense probably benign
R9667:Or1e35 UTSW 11 73,798,097 (GRCm39) missense possibly damaging 0.83
R9707:Or1e35 UTSW 11 73,798,090 (GRCm39) missense possibly damaging 0.79
Z1177:Or1e35 UTSW 11 73,797,439 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07