Incidental Mutation 'IGL01995:Cxcl15'
ID183653
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cxcl15
Ensembl Gene ENSMUSG00000029375
Gene Namechemokine (C-X-C motif) ligand 15
Synonymsweche, lungkine, Scyb15, Il8
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01995
Quality Score
Status
Chromosome5
Chromosomal Location90794534-90803067 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 90794608 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 13 (V13A)
Ref Sequence ENSEMBL: ENSMUSP00000031322 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031322]
Predicted Effect possibly damaging
Transcript: ENSMUST00000031322
AA Change: V13A

PolyPhen 2 Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000031322
Gene: ENSMUSG00000029375
AA Change: V13A

DomainStartEndE-ValueType
SCY 27 88 2.97e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175341
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted null mutation are viable and fertile but display reduced host defense against the pulmonary pathogen Klebsiella pneumoniae. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503E14Rik T C 14: 44,163,845 probably benign Het
AI661453 C A 17: 47,468,517 probably benign Het
Arhgap29 G A 3: 122,014,328 V1052I probably benign Het
Arhgef17 A G 7: 100,928,655 S1029P probably benign Het
Arpc5l T C 2: 39,008,214 S7P probably damaging Het
Asf1b A G 8: 83,955,904 I26V probably benign Het
Cep95 T C 11: 106,806,371 L240P probably damaging Het
Cnmd A G 14: 79,642,068 probably benign Het
Cntn3 T A 6: 102,203,885 N783I probably damaging Het
Col6a2 C A 10: 76,604,842 probably benign Het
Col9a2 T C 4: 121,050,410 probably null Het
Cry2 T C 2: 92,424,632 E126G probably benign Het
Dbr1 A G 9: 99,583,899 D510G probably benign Het
Dct A G 14: 118,034,243 F392L probably damaging Het
Dgkz A G 2: 91,934,050 probably benign Het
Dhrs7b A G 11: 60,830,715 I2V probably benign Het
Efnb3 A T 11: 69,556,904 probably null Het
Fbf1 T A 11: 116,151,020 R565S probably null Het
Gimap5 T C 6: 48,752,793 I99T probably damaging Het
Gm9912 A G 3: 149,185,449 L16P unknown Het
Gpr17 A G 18: 31,947,134 L292P probably damaging Het
Hdac10 C T 15: 89,127,598 V129M probably damaging Het
Mfap3l A G 8: 60,671,464 I247V possibly damaging Het
Mtus1 A T 8: 41,084,420 S86R probably damaging Het
Mylk3 A G 8: 85,359,261 S55P possibly damaging Het
Nol6 A T 4: 41,118,567 C745S probably damaging Het
Nudt13 A T 14: 20,306,317 E103D probably damaging Het
Olfr1129 A G 2: 87,575,462 Y126C probably damaging Het
Olfr395 A G 11: 73,907,435 I19T possibly damaging Het
Pdzk1 G T 3: 96,857,371 A324S probably benign Het
Pofut2 T C 10: 77,260,681 V80A possibly damaging Het
Rasip1 A G 7: 45,636,816 D821G probably damaging Het
Rnf10 T A 5: 115,251,102 K273* probably null Het
Slc4a9 A G 18: 36,539,775 M811V possibly damaging Het
Smchd1 T C 17: 71,444,020 D301G probably damaging Het
Tm9sf2 A T 14: 122,143,471 T159S probably benign Het
Tom1l1 G A 11: 90,649,861 P327S probably damaging Het
Trim3 A G 7: 105,618,482 probably benign Het
Trpm6 A C 19: 18,830,327 probably benign Het
Ttc13 A C 8: 124,688,882 L245R probably damaging Het
Txnrd1 T A 10: 82,877,284 V60E probably damaging Het
Ung T A 5: 114,136,386 D173E probably benign Het
Zbtb5 A G 4: 44,995,294 V30A probably damaging Het
Other mutations in Cxcl15
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0511:Cxcl15 UTSW 5 90798038 splice site probably benign
R0735:Cxcl15 UTSW 5 90801294 missense probably benign 0.01
R1709:Cxcl15 UTSW 5 90801416 missense unknown
R1758:Cxcl15 UTSW 5 90801464 missense unknown
R3768:Cxcl15 UTSW 5 90801444 missense unknown
R4950:Cxcl15 UTSW 5 90795245 missense possibly damaging 0.93
R5168:Cxcl15 UTSW 5 90795283 missense probably damaging 1.00
R5938:Cxcl15 UTSW 5 90801366 missense unknown
R6479:Cxcl15 UTSW 5 90795245 missense possibly damaging 0.93
R6557:Cxcl15 UTSW 5 90794566 start gained probably benign
X0064:Cxcl15 UTSW 5 90801341 missense unknown
Posted On2014-05-07