Incidental Mutation 'IGL02016:Spata22'
ID183761
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Spata22
Ensembl Gene ENSMUSG00000112920
Gene Namespermatogenesis associated 22
SynonymsLOC380709
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02016
Quality Score
Status
Chromosome11
Chromosomal Location73329741-73346044 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 73336031 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 65 (N65S)
Ref Sequence ENSEMBL: ENSMUSP00000113799 (fasta)
Predicted Effect possibly damaging
Transcript: ENSMUST00000092926
AA Change: N65S

PolyPhen 2 Score 0.485 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000117445
AA Change: N65S

PolyPhen 2 Score 0.485 (Sensitivity: 0.88; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit male and female infertility associated with arrested meiosis in germ cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810024B03Rik C A 2: 127,186,955 G108V probably damaging Het
4931406P16Rik A G 7: 34,239,101 M791T possibly damaging Het
A2ml1 T C 6: 128,558,335 E804G probably damaging Het
Abcg4 G A 9: 44,287,350 T35M probably damaging Het
Acad9 A T 3: 36,088,486 probably null Het
Adgrv1 T C 13: 81,397,453 D5571G probably damaging Het
App T A 16: 85,056,521 D223V unknown Het
Arhgap30 A G 1: 171,407,747 E563G probably damaging Het
Atp6v1e2 A T 17: 86,944,394 V192D probably damaging Het
Atr G A 9: 95,927,175 V1969I probably benign Het
Bean1 T C 8: 104,210,918 L43S possibly damaging Het
Cand1 A G 10: 119,212,568 V436A probably damaging Het
Card6 T C 15: 5,108,256 I39V probably damaging Het
Ccdc73 A G 2: 104,975,616 T300A probably benign Het
Ccdc88c T C 12: 100,941,207 T962A possibly damaging Het
Chd6 G T 2: 160,983,678 L1169I probably damaging Het
Chrna7 A T 7: 63,103,835 V312E probably damaging Het
Dna2 A G 10: 62,960,412 N540S probably benign Het
Elavl2 T C 4: 91,260,935 E209G probably damaging Het
Elmo2 A G 2: 165,295,012 probably null Het
Fto A T 8: 91,666,406 R494* probably null Het
Gm13088 T A 4: 143,655,319 E269V possibly damaging Het
Gm9966 A T 7: 95,958,807 T112S unknown Het
Gtf3c1 A C 7: 125,668,039 I940S probably damaging Het
Hecw2 C A 1: 53,831,543 Q1426H possibly damaging Het
Iars2 A C 1: 185,303,306 L579R probably damaging Het
Ifih1 A C 2: 62,606,984 M537R probably benign Het
Kcnmb4 A G 10: 116,446,462 probably benign Het
Large2 A G 2: 92,369,543 V175A possibly damaging Het
Mad2l1bp A G 17: 46,153,502 probably benign Het
Muc20 A T 16: 32,797,352 F14Y possibly damaging Het
Myom2 A G 8: 15,125,195 E1258G probably benign Het
Olfr1066 A T 2: 86,455,497 M258K probably damaging Het
Parp1 A T 1: 180,598,951 probably null Het
Prkra A T 2: 76,643,309 probably null Het
Ror2 C T 13: 53,110,728 S764N probably damaging Het
Scd1 C T 19: 44,400,307 G235S probably benign Het
Sdk1 A G 5: 142,034,429 H654R possibly damaging Het
Sesn3 A G 9: 14,320,337 Y188C probably damaging Het
Slc26a4 T C 12: 31,535,667 M461V probably damaging Het
Slc28a2 A G 2: 122,455,341 I439V probably benign Het
Smc5 T A 19: 23,273,712 N36I probably benign Het
Smurf2 A G 11: 106,822,678 F745S probably damaging Het
Tanc1 A G 2: 59,843,590 T1680A probably benign Het
Tnxb G A 17: 34,672,275 V531M probably damaging Het
Trpm3 T G 19: 22,902,069 Y727* probably null Het
Tssk1 A T 16: 17,894,894 Y181F probably damaging Het
Ucp3 T A 7: 100,480,559 V136E probably damaging Het
Uqcrfs1 A C 13: 30,545,114 V45G probably benign Het
Uvrag A G 7: 99,099,442 I101T probably benign Het
Vmn1r206 A T 13: 22,620,164 L291Q probably damaging Het
Wnk2 T A 13: 49,056,905 I1813F probably damaging Het
Zbtb3 T A 19: 8,803,215 V64E probably damaging Het
Zeb2 A G 2: 44,988,874 I1115T possibly damaging Het
Zfp280b C T 10: 76,039,111 L275F possibly damaging Het
Other mutations in Spata22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02833:Spata22 APN 11 73343743 missense probably benign 0.00
R0147:Spata22 UTSW 11 73331153 start codon destroyed probably null 1.00
R0304:Spata22 UTSW 11 73340449 nonsense probably null
R1855:Spata22 UTSW 11 73340559 missense probably benign 0.00
R1967:Spata22 UTSW 11 73331127 unclassified probably benign
R2073:Spata22 UTSW 11 73336226 missense possibly damaging 0.81
R2087:Spata22 UTSW 11 73340253 missense probably benign 0.11
R2196:Spata22 UTSW 11 73345834 missense probably benign 0.04
R2256:Spata22 UTSW 11 73340475 missense possibly damaging 0.50
R2509:Spata22 UTSW 11 73345767 missense probably damaging 1.00
R2849:Spata22 UTSW 11 73353745 nonsense probably null
R2883:Spata22 UTSW 11 73344678 missense possibly damaging 0.47
R3236:Spata22 UTSW 11 73345887 missense probably damaging 1.00
R3237:Spata22 UTSW 11 73345887 missense probably damaging 1.00
R4560:Spata22 UTSW 11 73345759 missense probably damaging 1.00
R4755:Spata22 UTSW 11 73345756 missense probably damaging 1.00
R5171:Spata22 UTSW 11 73336208 missense probably damaging 1.00
R5893:Spata22 UTSW 11 73336247 nonsense probably null
R6401:Spata22 UTSW 11 73333354 missense probably damaging 1.00
R6493:Spata22 UTSW 11 73353746 makesense probably null
R6496:Spata22 UTSW 11 73340363 missense probably damaging 0.99
R6647:Spata22 UTSW 11 73354700 utr 3 prime probably null
R6838:Spata22 UTSW 11 73345933 missense probably benign
R7099:Spata22 UTSW 11 73340399 missense probably benign
R7396:Spata22 UTSW 11 73345876 missense probably damaging 0.98
R7453:Spata22 UTSW 11 73335990 intron probably null
R7748:Spata22 UTSW 11 73336254 missense probably null 0.99
Posted On2014-05-07