Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02019:Mug2'

183876

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mug2

Ensembl Gene

ENSMUSG00000030131

Gene Name

murinoglobulin 2

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL02019

Quality Score

Status

Chromosome

Chromosomal Location

122006761-122085965 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 122047435 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 489 (V489I)

Ref Sequence

ENSEMBL: ENSMUSP00000080469 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081777]

AlphaFold

P28666

Predicted Effect

probably benign
Transcript: ENSMUST00000081777
AA Change: V489I

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000080469
Gene: ENSMUSG00000030131
AA Change: V489I

Domain	Start	End	E-Value	Type
Pfam:A2M_N	128	221	3.5e-21	PFAM
A2M_N_2	449	599	1.05e-42	SMART
low complexity region	711	728	N/A	INTRINSIC
A2M	740	830	7.16e-36	SMART
Pfam:Thiol-ester_cl	963	992	1e-18	PFAM
low complexity region	994	1005	N/A	INTRINSIC
Pfam:A2M_comp	1012	1097	5.8e-34	PFAM
Pfam:A2M_comp	1093	1243	3e-47	PFAM
A2M_recep	1353	1440	1.85e-38	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930519G04Rik	C	T	5: 114,879,584 (GRCm38)	A178V	possibly damaging	Het
9930021J03Rik	A	T	19: 29,717,063 (GRCm38)	S976T	probably benign	Het
Acad11	A	G	9: 104,115,345 (GRCm38)	I495M	probably damaging	Het
Adgrd1	T	C	5: 129,115,138 (GRCm38)	S91P	probably benign	Het
Agk	A	G	6: 40,376,226 (GRCm38)	I175V	probably damaging	Het
Ascc3	A	T	10: 50,690,139 (GRCm38)	N727Y	probably damaging	Het
Atrnl1	A	T	19: 57,691,763 (GRCm38)		probably benign	Het
B4galt3	G	A	1: 171,271,792 (GRCm38)	G42D	probably damaging	Het
Brip1	C	T	11: 86,197,949 (GRCm38)	C42Y	possibly damaging	Het
Camkk1	T	C	11: 73,037,201 (GRCm38)	F233L	probably damaging	Het
Cd300ld	A	T	11: 114,987,401 (GRCm38)	M95K	probably damaging	Het
Cdv3	A	G	9: 103,360,025 (GRCm38)		probably benign	Het
Cog3	G	T	14: 75,730,604 (GRCm38)	Q430K	possibly damaging	Het
D6Wsu163e	G	A	6: 126,955,221 (GRCm38)	G308S	probably damaging	Het
Dnah2	A	G	11: 69,474,285 (GRCm38)	M1951T	probably damaging	Het
Elavl3	G	A	9: 22,036,718 (GRCm38)	T51I	probably damaging	Het
Eri2	A	T	7: 119,786,080 (GRCm38)	C399*	probably null	Het
Ezh2	A	T	6: 47,551,901 (GRCm38)		probably null	Het
Fgd6	C	A	10: 94,133,354 (GRCm38)	T1161K	probably damaging	Het
Gbf1	A	T	19: 46,279,292 (GRCm38)	H1193L	possibly damaging	Het
Gbp2b	T	A	3: 142,606,990 (GRCm38)	F378Y	possibly damaging	Het
Hectd2	G	A	19: 36,615,516 (GRCm38)	V694M	possibly damaging	Het
Hook1	T	A	4: 96,022,197 (GRCm38)	S683T	probably benign	Het
Ifi202b	G	A	1: 173,974,984 (GRCm38)	R95C	possibly damaging	Het
Kdm8	G	T	7: 125,452,486 (GRCm38)	V84L	probably damaging	Het
Kifc3	G	A	8: 95,107,540 (GRCm38)		probably benign	Het
Krt26	C	T	11: 99,333,645 (GRCm38)	R349Q	probably benign	Het
Lrig1	G	T	6: 94,616,429 (GRCm38)	Q424K	probably damaging	Het
Lrriq1	A	T	10: 103,178,800 (GRCm38)	M1049K	probably benign	Het
Mcidas	A	G	13: 112,996,843 (GRCm38)	N103D	probably benign	Het
Mdn1	T	C	4: 32,749,948 (GRCm38)	L4377S	possibly damaging	Het
Mrpl41	T	C	2: 24,974,417 (GRCm38)	D81G	possibly damaging	Het
P2rx5	G	T	11: 73,167,977 (GRCm38)		probably benign	Het
Pfas	A	T	11: 68,993,463 (GRCm38)		probably benign	Het
Pknox2	A	G	9: 36,923,633 (GRCm38)	L180P	probably damaging	Het
Psmd5	C	A	2: 34,854,274 (GRCm38)	C412F	probably benign	Het
Rbks	T	A	5: 31,660,017 (GRCm38)	D136V	probably damaging	Het
Rgl1	A	G	1: 152,528,469 (GRCm38)		probably benign	Het
Scube3	A	G	17: 28,167,684 (GRCm38)	D721G	probably damaging	Het
Snrnp200	T	A	2: 127,232,905 (GRCm38)	V1466D	possibly damaging	Het
Stambp	A	T	6: 83,552,031 (GRCm38)	L344Q	probably damaging	Het
Tctn1	A	T	5: 122,258,849 (GRCm38)	I157N	probably damaging	Het
Top2b	T	A	14: 16,409,965 (GRCm38)	D877E	probably benign	Het
Vmn1r78	G	A	7: 12,152,707 (GRCm38)	G82S	probably damaging	Het
Vnn1	T	C	10: 23,903,551 (GRCm38)	F453L	possibly damaging	Het
Wdr38	A	T	2: 38,998,412 (GRCm38)	N7I	probably damaging	Het

Other mutations in Mug2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00708:Mug2	APN	6	122,047,487 (GRCm38)	missense	possibly damaging	0.83
IGL00957:Mug2	APN	6	122,040,654 (GRCm38)	missense	probably damaging	0.99
IGL01314:Mug2	APN	6	122,081,279 (GRCm38)	missense	possibly damaging	0.62
IGL01338:Mug2	APN	6	122,049,628 (GRCm38)	splice site	probably benign
IGL01477:Mug2	APN	6	122,081,684 (GRCm38)	splice site	probably benign
IGL01926:Mug2	APN	6	122,036,104 (GRCm38)	splice site	probably benign
IGL02305:Mug2	APN	6	122,036,056 (GRCm38)	missense	probably benign
IGL02310:Mug2	APN	6	122,059,123 (GRCm38)	splice site	probably benign
IGL02484:Mug2	APN	6	122,072,753 (GRCm38)	missense	probably damaging	1.00
IGL02516:Mug2	APN	6	122,070,843 (GRCm38)	missense	probably damaging	1.00
IGL02531:Mug2	APN	6	122,072,771 (GRCm38)	missense	probably damaging	1.00
IGL02666:Mug2	APN	6	122,081,326 (GRCm38)	missense	probably damaging	1.00
IGL02936:Mug2	APN	6	122,081,387 (GRCm38)	critical splice donor site	probably null
R0114:Mug2	UTSW	6	122,040,648 (GRCm38)	missense	probably damaging	1.00
R0119:Mug2	UTSW	6	122,036,063 (GRCm38)	missense	probably benign	0.00
R0123:Mug2	UTSW	6	122,074,714 (GRCm38)	missense	possibly damaging	0.89
R0144:Mug2	UTSW	6	122,071,011 (GRCm38)	splice site	probably benign
R0225:Mug2	UTSW	6	122,074,714 (GRCm38)	missense	possibly damaging	0.89
R0514:Mug2	UTSW	6	122,081,599 (GRCm38)	missense	probably damaging	1.00
R0763:Mug2	UTSW	6	122,075,294 (GRCm38)	missense	probably benign
R0959:Mug2	UTSW	6	122,085,495 (GRCm38)	missense	probably benign	0.33
R1104:Mug2	UTSW	6	122,059,055 (GRCm38)	missense	probably benign
R1239:Mug2	UTSW	6	122,081,678 (GRCm38)	splice site	probably benign
R1318:Mug2	UTSW	6	122,077,402 (GRCm38)	missense	probably damaging	1.00
R1460:Mug2	UTSW	6	122,040,533 (GRCm38)	splice site	probably benign
R1706:Mug2	UTSW	6	122,036,232 (GRCm38)	splice site	probably benign
R1761:Mug2	UTSW	6	122,074,705 (GRCm38)	missense	probably benign	0.20
R1901:Mug2	UTSW	6	122,071,842 (GRCm38)	missense	probably benign	0.02
R1913:Mug2	UTSW	6	122,070,870 (GRCm38)	missense	probably damaging	1.00
R1943:Mug2	UTSW	6	122,079,639 (GRCm38)	missense	probably benign
R2054:Mug2	UTSW	6	122,077,492 (GRCm38)	missense	probably damaging	1.00
R2060:Mug2	UTSW	6	122,079,612 (GRCm38)	missense	probably benign
R2420:Mug2	UTSW	6	122,083,460 (GRCm38)	missense	probably damaging	1.00
R2432:Mug2	UTSW	6	122,084,376 (GRCm38)	missense	possibly damaging	0.93
R2916:Mug2	UTSW	6	122,074,724 (GRCm38)	splice site	probably null
R2918:Mug2	UTSW	6	122,074,724 (GRCm38)	splice site	probably null
R3423:Mug2	UTSW	6	122,047,506 (GRCm38)	splice site	probably benign
R3834:Mug2	UTSW	6	122,049,787 (GRCm38)	critical splice donor site	probably null
R3902:Mug2	UTSW	6	122,075,567 (GRCm38)	missense	probably damaging	1.00
R3941:Mug2	UTSW	6	122,063,563 (GRCm38)	missense	probably benign
R4227:Mug2	UTSW	6	122,040,732 (GRCm38)	missense	probably benign	0.10
R4284:Mug2	UTSW	6	122,063,673 (GRCm38)	missense	probably benign	0.00
R4287:Mug2	UTSW	6	122,063,673 (GRCm38)	missense	probably benign	0.00
R4377:Mug2	UTSW	6	122,071,007 (GRCm38)	critical splice donor site	probably null
R4419:Mug2	UTSW	6	122,079,630 (GRCm38)	missense	probably damaging	1.00
R4498:Mug2	UTSW	6	122,082,752 (GRCm38)	missense	probably damaging	0.99
R4566:Mug2	UTSW	6	122,079,638 (GRCm38)	missense	probably benign	0.00
R4690:Mug2	UTSW	6	122,036,296 (GRCm38)	missense	probably benign
R4732:Mug2	UTSW	6	122,071,872 (GRCm38)	missense	probably damaging	0.99
R4733:Mug2	UTSW	6	122,071,872 (GRCm38)	missense	probably damaging	0.99
R4741:Mug2	UTSW	6	122,079,613 (GRCm38)	missense	probably benign
R4888:Mug2	UTSW	6	122,081,195 (GRCm38)	missense	probably damaging	1.00
R5199:Mug2	UTSW	6	122,040,660 (GRCm38)	missense	probably benign
R5347:Mug2	UTSW	6	122,081,592 (GRCm38)	missense	probably damaging	1.00
R5457:Mug2	UTSW	6	122,049,729 (GRCm38)	nonsense	probably null
R5495:Mug2	UTSW	6	122,079,650 (GRCm38)	missense	probably damaging	0.96
R5509:Mug2	UTSW	6	122,084,381 (GRCm38)	missense	possibly damaging	0.84
R6006:Mug2	UTSW	6	122,083,500 (GRCm38)	missense	probably null	0.98
R6180:Mug2	UTSW	6	122,079,606 (GRCm38)	missense	probably benign	0.01
R6184:Mug2	UTSW	6	122,037,046 (GRCm38)	missense	probably benign
R6199:Mug2	UTSW	6	122,047,439 (GRCm38)	missense	probably benign	0.05
R6262:Mug2	UTSW	6	122,075,255 (GRCm38)	missense	probably damaging	1.00
R6416:Mug2	UTSW	6	122,082,754 (GRCm38)	missense	probably damaging	1.00
R6548:Mug2	UTSW	6	122,047,442 (GRCm38)	missense	probably damaging	1.00
R6703:Mug2	UTSW	6	122,078,694 (GRCm38)	missense	probably benign	0.25
R7106:Mug2	UTSW	6	122,082,721 (GRCm38)	missense	probably damaging	1.00
R7131:Mug2	UTSW	6	122,075,247 (GRCm38)	missense	probably damaging	1.00
R7372:Mug2	UTSW	6	122,083,466 (GRCm38)	missense	possibly damaging	0.88
R7379:Mug2	UTSW	6	122,047,487 (GRCm38)	missense	possibly damaging	0.83
R7419:Mug2	UTSW	6	122,040,570 (GRCm38)	missense	possibly damaging	0.86
R7423:Mug2	UTSW	6	122,079,726 (GRCm38)	missense	probably benign	0.00
R7581:Mug2	UTSW	6	122,063,711 (GRCm38)	missense	probably damaging	1.00
R7582:Mug2	UTSW	6	122,079,644 (GRCm38)	missense	probably damaging	0.99
R7672:Mug2	UTSW	6	122,040,719 (GRCm38)	missense	probably benign	0.37
R7713:Mug2	UTSW	6	122,078,795 (GRCm38)	missense	possibly damaging	0.83
R7759:Mug2	UTSW	6	122,081,358 (GRCm38)	missense	probably damaging	1.00
R7834:Mug2	UTSW	6	122,036,282 (GRCm38)	missense	probably benign
R7850:Mug2	UTSW	6	122,075,211 (GRCm38)	missense	probably damaging	1.00
R8029:Mug2	UTSW	6	122,081,545 (GRCm38)	critical splice acceptor site	probably null
R8127:Mug2	UTSW	6	122,075,608 (GRCm38)	missense	probably benign	0.01
R8335:Mug2	UTSW	6	122,040,584 (GRCm38)	missense	probably benign
R8348:Mug2	UTSW	6	122,072,233 (GRCm38)	nonsense	probably null
R8557:Mug2	UTSW	6	122,063,701 (GRCm38)	missense	probably damaging	0.99
R8798:Mug2	UTSW	6	122,081,610 (GRCm38)	missense	probably damaging	1.00
R8823:Mug2	UTSW	6	122,063,689 (GRCm38)	missense	possibly damaging	0.89
R9029:Mug2	UTSW	6	122,084,369 (GRCm38)	missense	probably damaging	1.00
R9153:Mug2	UTSW	6	122,040,668 (GRCm38)	missense	possibly damaging	0.71
R9185:Mug2	UTSW	6	122,077,483 (GRCm38)	missense	probably benign	0.06
R9186:Mug2	UTSW	6	122,075,289 (GRCm38)	missense	probably damaging	0.99
R9418:Mug2	UTSW	6	122,040,741 (GRCm38)	missense	probably benign	0.00
R9464:Mug2	UTSW	6	122,051,731 (GRCm38)	missense	probably benign	0.01
R9622:Mug2	UTSW	6	122,051,792 (GRCm38)	missense	probably benign	0.29
Z1177:Mug2	UTSW	6	122,037,121 (GRCm38)	missense	probably damaging	1.00

Posted On

2014-05-07