Incidental Mutation 'IGL02019:Krt26'
ID 183895
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Krt26
Ensembl Gene ENSMUSG00000075570
Gene Name keratin 26
Synonyms 4732407F15Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # IGL02019
Quality Score
Status
Chromosome 11
Chromosomal Location 99219376-99228792 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 99224471 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glutamine at position 349 (R349Q)
Ref Sequence ENSEMBL: ENSMUSP00000098051 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100482]
AlphaFold Q3TRJ4
Predicted Effect probably benign
Transcript: ENSMUST00000100482
AA Change: R349Q

PolyPhen 2 Score 0.296 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000098051
Gene: ENSMUSG00000075570
AA Change: R349Q

DomainStartEndE-ValueType
low complexity region 40 65 N/A INTRINSIC
Filament 79 394 1.1e-132 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148770
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the keratin superfamily. This keratin protein is a type I keratin that is specific for the inner root sheath of the hair follicle. This gene exists in a cluster with other keratin genes on chromosome 17q21. [provided by RefSeq, Jul 2009]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930519G04Rik C T 5: 115,017,645 (GRCm39) A178V possibly damaging Het
Acad11 A G 9: 103,992,544 (GRCm39) I495M probably damaging Het
Adgrd1 T C 5: 129,192,202 (GRCm39) S91P probably benign Het
Agk A G 6: 40,353,160 (GRCm39) I175V probably damaging Het
Ascc3 A T 10: 50,566,235 (GRCm39) N727Y probably damaging Het
Atrnl1 A T 19: 57,680,195 (GRCm39) probably benign Het
B4galt3 G A 1: 171,099,362 (GRCm39) G42D probably damaging Het
Brd10 A T 19: 29,694,463 (GRCm39) S976T probably benign Het
Brip1 C T 11: 86,088,775 (GRCm39) C42Y possibly damaging Het
Camkk1 T C 11: 72,928,027 (GRCm39) F233L probably damaging Het
Cd300ld A T 11: 114,878,227 (GRCm39) M95K probably damaging Het
Cdv3 A G 9: 103,237,224 (GRCm39) probably benign Het
Cog3 G T 14: 75,968,044 (GRCm39) Q430K possibly damaging Het
D6Wsu163e G A 6: 126,932,184 (GRCm39) G308S probably damaging Het
Dnah2 A G 11: 69,365,111 (GRCm39) M1951T probably damaging Het
Elavl3 G A 9: 21,948,014 (GRCm39) T51I probably damaging Het
Eri2 A T 7: 119,385,303 (GRCm39) C399* probably null Het
Ezh2 A T 6: 47,528,835 (GRCm39) probably null Het
Fgd6 C A 10: 93,969,216 (GRCm39) T1161K probably damaging Het
Gbf1 A T 19: 46,267,731 (GRCm39) H1193L possibly damaging Het
Gbp2b T A 3: 142,312,751 (GRCm39) F378Y possibly damaging Het
Hectd2 G A 19: 36,592,916 (GRCm39) V694M possibly damaging Het
Hook1 T A 4: 95,910,434 (GRCm39) S683T probably benign Het
Ifi202b G A 1: 173,802,550 (GRCm39) R95C possibly damaging Het
Kdm8 G T 7: 125,051,658 (GRCm39) V84L probably damaging Het
Kifc3 G A 8: 95,834,168 (GRCm39) probably benign Het
Lrig1 G T 6: 94,593,410 (GRCm39) Q424K probably damaging Het
Lrriq1 A T 10: 103,014,661 (GRCm39) M1049K probably benign Het
Mcidas A G 13: 113,133,377 (GRCm39) N103D probably benign Het
Mdn1 T C 4: 32,749,948 (GRCm39) L4377S possibly damaging Het
Mrpl41 T C 2: 24,864,429 (GRCm39) D81G possibly damaging Het
Mug2 G A 6: 122,024,394 (GRCm39) V489I probably benign Het
P2rx5 G T 11: 73,058,803 (GRCm39) probably benign Het
Pfas A T 11: 68,884,289 (GRCm39) probably benign Het
Pknox2 A G 9: 36,834,929 (GRCm39) L180P probably damaging Het
Psmd5 C A 2: 34,744,286 (GRCm39) C412F probably benign Het
Rbks T A 5: 31,817,361 (GRCm39) D136V probably damaging Het
Rgl1 A G 1: 152,404,220 (GRCm39) probably benign Het
Scube3 A G 17: 28,386,658 (GRCm39) D721G probably damaging Het
Snrnp200 T A 2: 127,074,825 (GRCm39) V1466D possibly damaging Het
Stambp A T 6: 83,529,013 (GRCm39) L344Q probably damaging Het
Tctn1 A T 5: 122,396,912 (GRCm39) I157N probably damaging Het
Top2b T A 14: 16,409,965 (GRCm38) D877E probably benign Het
Vmn1r78 G A 7: 11,886,634 (GRCm39) G82S probably damaging Het
Vnn1 T C 10: 23,779,449 (GRCm39) F453L possibly damaging Het
Wdr38 A T 2: 38,888,424 (GRCm39) N7I probably damaging Het
Other mutations in Krt26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00970:Krt26 APN 11 99,222,107 (GRCm39) missense probably benign 0.00
IGL02138:Krt26 APN 11 99,224,471 (GRCm39) missense probably benign 0.30
IGL02188:Krt26 APN 11 99,224,471 (GRCm39) missense probably benign 0.30
IGL02189:Krt26 APN 11 99,224,471 (GRCm39) missense probably benign 0.30
IGL02192:Krt26 APN 11 99,224,471 (GRCm39) missense probably benign 0.30
IGL02647:Krt26 APN 11 99,224,471 (GRCm39) missense probably benign 0.30
IGL02651:Krt26 APN 11 99,224,471 (GRCm39) missense probably benign 0.30
R0122:Krt26 UTSW 11 99,224,545 (GRCm39) nonsense probably null
R1842:Krt26 UTSW 11 99,224,352 (GRCm39) small deletion probably benign
R1843:Krt26 UTSW 11 99,224,352 (GRCm39) small deletion probably benign
R1923:Krt26 UTSW 11 99,224,352 (GRCm39) small deletion probably benign
R1924:Krt26 UTSW 11 99,224,352 (GRCm39) small deletion probably benign
R3872:Krt26 UTSW 11 99,225,570 (GRCm39) missense probably damaging 1.00
R3873:Krt26 UTSW 11 99,225,570 (GRCm39) missense probably damaging 1.00
R3874:Krt26 UTSW 11 99,225,570 (GRCm39) missense probably damaging 1.00
R3875:Krt26 UTSW 11 99,225,570 (GRCm39) missense probably damaging 1.00
R4014:Krt26 UTSW 11 99,226,128 (GRCm39) missense probably damaging 0.99
R4939:Krt26 UTSW 11 99,225,522 (GRCm39) missense probably benign 0.03
R5620:Krt26 UTSW 11 99,228,597 (GRCm39) missense possibly damaging 0.86
R6035:Krt26 UTSW 11 99,224,415 (GRCm39) missense probably benign 0.43
R6035:Krt26 UTSW 11 99,224,415 (GRCm39) missense probably benign 0.43
R6151:Krt26 UTSW 11 99,228,315 (GRCm39) missense probably benign 0.35
R6578:Krt26 UTSW 11 99,225,628 (GRCm39) missense probably damaging 1.00
R6626:Krt26 UTSW 11 99,220,528 (GRCm39) missense probably benign 0.28
R7413:Krt26 UTSW 11 99,225,887 (GRCm39) missense probably benign 0.25
R7557:Krt26 UTSW 11 99,225,567 (GRCm39) missense probably damaging 1.00
R7919:Krt26 UTSW 11 99,224,420 (GRCm39) missense probably damaging 1.00
R8051:Krt26 UTSW 11 99,228,672 (GRCm39) missense probably damaging 0.97
R8090:Krt26 UTSW 11 99,227,315 (GRCm39) missense probably benign 0.13
R8163:Krt26 UTSW 11 99,220,498 (GRCm39) missense probably benign 0.00
R8211:Krt26 UTSW 11 99,226,110 (GRCm39) missense probably damaging 0.98
R8480:Krt26 UTSW 11 99,228,426 (GRCm39) missense probably damaging 1.00
R9040:Krt26 UTSW 11 99,222,093 (GRCm39) missense probably benign 0.00
R9418:Krt26 UTSW 11 99,228,741 (GRCm39) start gained probably benign
Z1186:Krt26 UTSW 11 99,228,643 (GRCm39) missense probably damaging 0.99
Z1191:Krt26 UTSW 11 99,228,643 (GRCm39) missense probably damaging 0.99
Posted On 2014-05-07