Incidental Mutation 'IGL02019:Kifc3'
ID 183916
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Kifc3
Ensembl Gene ENSMUSG00000031788
Gene Name kinesin family member C3
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02019
Quality Score
Status
Chromosome 8
Chromosomal Location 95826456-95929440 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to A at 95834168 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000148425 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034240] [ENSMUST00000169353] [ENSMUST00000169748] [ENSMUST00000212424] [ENSMUST00000212787] [ENSMUST00000213004] [ENSMUST00000212968]
AlphaFold O35231
Predicted Effect probably benign
Transcript: ENSMUST00000034240
SMART Domains Protein: ENSMUSP00000034240
Gene: ENSMUSG00000031788

DomainStartEndE-ValueType
low complexity region 33 46 N/A INTRINSIC
coiled coil region 100 360 N/A INTRINSIC
coiled coil region 393 430 N/A INTRINSIC
KISc 441 774 3.15e-158 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000169353
SMART Domains Protein: ENSMUSP00000127427
Gene: ENSMUSG00000031788

DomainStartEndE-ValueType
coiled coil region 33 223 N/A INTRINSIC
coiled coil region 256 293 N/A INTRINSIC
KISc 304 637 3.15e-158 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000169748
SMART Domains Protein: ENSMUSP00000126784
Gene: ENSMUSG00000031788

DomainStartEndE-ValueType
coiled coil region 34 324 N/A INTRINSIC
coiled coil region 357 394 N/A INTRINSIC
KISc 405 728 3.11e-148 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211854
Predicted Effect probably benign
Transcript: ENSMUST00000212424
Predicted Effect probably benign
Transcript: ENSMUST00000212787
Predicted Effect probably benign
Transcript: ENSMUST00000213004
Predicted Effect probably benign
Transcript: ENSMUST00000212968
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mice homozygous for this targeted mutation are viable, fertile, and appear phenotypically indistinguishable from wild-type littermates. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930519G04Rik C T 5: 115,017,645 (GRCm39) A178V possibly damaging Het
Acad11 A G 9: 103,992,544 (GRCm39) I495M probably damaging Het
Adgrd1 T C 5: 129,192,202 (GRCm39) S91P probably benign Het
Agk A G 6: 40,353,160 (GRCm39) I175V probably damaging Het
Ascc3 A T 10: 50,566,235 (GRCm39) N727Y probably damaging Het
Atrnl1 A T 19: 57,680,195 (GRCm39) probably benign Het
B4galt3 G A 1: 171,099,362 (GRCm39) G42D probably damaging Het
Brd10 A T 19: 29,694,463 (GRCm39) S976T probably benign Het
Brip1 C T 11: 86,088,775 (GRCm39) C42Y possibly damaging Het
Camkk1 T C 11: 72,928,027 (GRCm39) F233L probably damaging Het
Cd300ld A T 11: 114,878,227 (GRCm39) M95K probably damaging Het
Cdv3 A G 9: 103,237,224 (GRCm39) probably benign Het
Cog3 G T 14: 75,968,044 (GRCm39) Q430K possibly damaging Het
D6Wsu163e G A 6: 126,932,184 (GRCm39) G308S probably damaging Het
Dnah2 A G 11: 69,365,111 (GRCm39) M1951T probably damaging Het
Elavl3 G A 9: 21,948,014 (GRCm39) T51I probably damaging Het
Eri2 A T 7: 119,385,303 (GRCm39) C399* probably null Het
Ezh2 A T 6: 47,528,835 (GRCm39) probably null Het
Fgd6 C A 10: 93,969,216 (GRCm39) T1161K probably damaging Het
Gbf1 A T 19: 46,267,731 (GRCm39) H1193L possibly damaging Het
Gbp2b T A 3: 142,312,751 (GRCm39) F378Y possibly damaging Het
Hectd2 G A 19: 36,592,916 (GRCm39) V694M possibly damaging Het
Hook1 T A 4: 95,910,434 (GRCm39) S683T probably benign Het
Ifi202b G A 1: 173,802,550 (GRCm39) R95C possibly damaging Het
Kdm8 G T 7: 125,051,658 (GRCm39) V84L probably damaging Het
Krt26 C T 11: 99,224,471 (GRCm39) R349Q probably benign Het
Lrig1 G T 6: 94,593,410 (GRCm39) Q424K probably damaging Het
Lrriq1 A T 10: 103,014,661 (GRCm39) M1049K probably benign Het
Mcidas A G 13: 113,133,377 (GRCm39) N103D probably benign Het
Mdn1 T C 4: 32,749,948 (GRCm39) L4377S possibly damaging Het
Mrpl41 T C 2: 24,864,429 (GRCm39) D81G possibly damaging Het
Mug2 G A 6: 122,024,394 (GRCm39) V489I probably benign Het
P2rx5 G T 11: 73,058,803 (GRCm39) probably benign Het
Pfas A T 11: 68,884,289 (GRCm39) probably benign Het
Pknox2 A G 9: 36,834,929 (GRCm39) L180P probably damaging Het
Psmd5 C A 2: 34,744,286 (GRCm39) C412F probably benign Het
Rbks T A 5: 31,817,361 (GRCm39) D136V probably damaging Het
Rgl1 A G 1: 152,404,220 (GRCm39) probably benign Het
Scube3 A G 17: 28,386,658 (GRCm39) D721G probably damaging Het
Snrnp200 T A 2: 127,074,825 (GRCm39) V1466D possibly damaging Het
Stambp A T 6: 83,529,013 (GRCm39) L344Q probably damaging Het
Tctn1 A T 5: 122,396,912 (GRCm39) I157N probably damaging Het
Top2b T A 14: 16,409,965 (GRCm38) D877E probably benign Het
Vmn1r78 G A 7: 11,886,634 (GRCm39) G82S probably damaging Het
Vnn1 T C 10: 23,779,449 (GRCm39) F453L possibly damaging Het
Wdr38 A T 2: 38,888,424 (GRCm39) N7I probably damaging Het
Other mutations in Kifc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00720:Kifc3 APN 8 95,864,644 (GRCm39) missense probably damaging 1.00
IGL01904:Kifc3 APN 8 95,864,585 (GRCm39) missense possibly damaging 0.81
IGL02090:Kifc3 APN 8 95,829,108 (GRCm39) missense probably damaging 1.00
IGL02355:Kifc3 APN 8 95,836,507 (GRCm39) missense probably damaging 1.00
IGL02362:Kifc3 APN 8 95,836,507 (GRCm39) missense probably damaging 1.00
IGL02620:Kifc3 APN 8 95,836,582 (GRCm39) missense probably damaging 0.98
IGL02720:Kifc3 APN 8 95,834,993 (GRCm39) missense probably benign 0.00
IGL03030:Kifc3 APN 8 95,829,040 (GRCm39) missense probably damaging 1.00
IGL03327:Kifc3 APN 8 95,835,060 (GRCm39) missense probably damaging 1.00
IGL03390:Kifc3 APN 8 95,835,241 (GRCm39) missense probably damaging 1.00
R0233:Kifc3 UTSW 8 95,828,100 (GRCm39) splice site probably null
R0281:Kifc3 UTSW 8 95,830,088 (GRCm39) missense probably damaging 1.00
R0302:Kifc3 UTSW 8 95,830,098 (GRCm39) missense possibly damaging 0.50
R0619:Kifc3 UTSW 8 95,829,293 (GRCm39) missense probably benign 0.13
R0731:Kifc3 UTSW 8 95,832,361 (GRCm39) missense probably damaging 1.00
R1017:Kifc3 UTSW 8 95,832,413 (GRCm39) missense probably damaging 0.99
R1147:Kifc3 UTSW 8 95,864,546 (GRCm39) missense probably damaging 1.00
R1147:Kifc3 UTSW 8 95,864,546 (GRCm39) missense probably damaging 1.00
R1257:Kifc3 UTSW 8 95,832,400 (GRCm39) missense probably damaging 0.98
R1472:Kifc3 UTSW 8 95,864,541 (GRCm39) critical splice donor site probably null
R1480:Kifc3 UTSW 8 95,836,515 (GRCm39) missense probably damaging 1.00
R1553:Kifc3 UTSW 8 95,833,170 (GRCm39) missense possibly damaging 0.67
R2071:Kifc3 UTSW 8 95,834,981 (GRCm39) critical splice donor site probably null
R2115:Kifc3 UTSW 8 95,835,341 (GRCm39) missense probably damaging 1.00
R3703:Kifc3 UTSW 8 95,830,656 (GRCm39) splice site probably benign
R3704:Kifc3 UTSW 8 95,830,656 (GRCm39) splice site probably benign
R3705:Kifc3 UTSW 8 95,830,656 (GRCm39) splice site probably benign
R4223:Kifc3 UTSW 8 95,836,610 (GRCm39) missense probably damaging 0.96
R4463:Kifc3 UTSW 8 95,828,744 (GRCm39) missense probably damaging 1.00
R4508:Kifc3 UTSW 8 95,834,048 (GRCm39) splice site probably null
R4980:Kifc3 UTSW 8 95,853,177 (GRCm39) missense probably benign
R5032:Kifc3 UTSW 8 95,829,354 (GRCm39) missense probably damaging 1.00
R5068:Kifc3 UTSW 8 95,836,844 (GRCm39) missense possibly damaging 0.54
R5421:Kifc3 UTSW 8 95,836,473 (GRCm39) missense probably damaging 0.99
R5556:Kifc3 UTSW 8 95,835,087 (GRCm39) nonsense probably null
R6845:Kifc3 UTSW 8 95,835,307 (GRCm39) missense probably benign 0.28
R7136:Kifc3 UTSW 8 95,830,077 (GRCm39) missense probably benign 0.10
R7196:Kifc3 UTSW 8 95,833,239 (GRCm39) missense probably benign 0.02
R7404:Kifc3 UTSW 8 95,830,092 (GRCm39) missense probably benign 0.02
R7441:Kifc3 UTSW 8 95,864,615 (GRCm39) missense probably benign 0.00
R7784:Kifc3 UTSW 8 95,837,320 (GRCm39) critical splice donor site probably null
R7861:Kifc3 UTSW 8 95,834,165 (GRCm39) critical splice acceptor site probably null
R8440:Kifc3 UTSW 8 95,836,422 (GRCm39) missense possibly damaging 0.89
R8754:Kifc3 UTSW 8 95,829,024 (GRCm39) missense probably damaging 1.00
R8983:Kifc3 UTSW 8 95,833,104 (GRCm39) missense probably damaging 1.00
R9035:Kifc3 UTSW 8 95,853,195 (GRCm39) missense possibly damaging 0.52
R9149:Kifc3 UTSW 8 95,853,317 (GRCm39) missense probably benign
R9464:Kifc3 UTSW 8 95,830,622 (GRCm39) missense possibly damaging 0.61
R9589:Kifc3 UTSW 8 95,861,372 (GRCm39) missense possibly damaging 0.87
X0023:Kifc3 UTSW 8 95,835,926 (GRCm39) missense probably benign 0.00
Posted On 2014-05-07