Incidental Mutation 'IGL02021:Olfr704'
ID183956
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr704
Ensembl Gene ENSMUSG00000073900
Gene Nameolfactory receptor 704
SynonymsGA_x6K02T2PBJ9-9247095-9248042, MOR283-12P
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock #IGL02021
Quality Score
Status
Chromosome7
Chromosomal Location106863185-106870921 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 106865489 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Stop codon at position 170 (K170*)
Ref Sequence ENSEMBL: ENSMUSP00000095745 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080925] [ENSMUST00000098141]
Predicted Effect probably null
Transcript: ENSMUST00000080925
AA Change: K170*
SMART Domains Protein: ENSMUSP00000079726
Gene: ENSMUSG00000073900
AA Change: K170*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.1e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 1.5e-7 PFAM
Pfam:7tm_1 41 290 1.5e-21 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000098141
AA Change: K170*
SMART Domains Protein: ENSMUSP00000095745
Gene: ENSMUSG00000073900
AA Change: K170*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.4e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 7.5e-7 PFAM
Pfam:7tm_1 41 290 1.7e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217164
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217204
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002L01Rik G A 12: 3,407,890 probably benign Het
Adam10 C T 9: 70,743,909 T72I possibly damaging Het
Adam26b T A 8: 43,519,872 M698L probably benign Het
Ankrd27 A T 7: 35,614,456 H404L probably damaging Het
Atp1a1 T C 3: 101,594,208 S60G probably benign Het
Bcat1 T C 6: 145,047,289 probably benign Het
Cd177 G A 7: 24,745,206 A650V probably benign Het
Cmya5 T C 13: 93,094,549 N1344D probably benign Het
Ctsd G T 7: 142,385,476 L71I probably damaging Het
Dctn2 T C 10: 127,275,057 probably null Het
Ddr1 G A 17: 35,683,480 A801V probably damaging Het
Duoxa1 A G 2: 122,304,646 F251S probably benign Het
Fcho1 A C 8: 71,721,275 S2A probably benign Het
Gm4861 T C 3: 137,552,110 probably null Het
Gm4922 C A 10: 18,784,477 G166W probably damaging Het
Hic2 A G 16: 17,258,753 E482G probably benign Het
Hoxa5 C T 6: 52,202,657 R246K probably damaging Het
Ipo11 A T 13: 106,857,237 F721I probably damaging Het
Lama1 A T 17: 67,821,626 S2993C probably damaging Het
Lonp2 T A 8: 86,708,971 S612T probably benign Het
Lpar5 T G 6: 125,081,992 Y225* probably null Het
Map4k3 A G 17: 80,609,826 Y574H probably damaging Het
Msantd4 A G 9: 4,385,163 E296G probably damaging Het
Ncs1 A G 2: 31,284,165 D109G probably damaging Het
Nnt T C 13: 119,336,247 probably benign Het
Nr1h5 T C 3: 102,947,742 probably benign Het
Olfr1288 A G 2: 111,479,480 D232G probably benign Het
Plk4 A G 3: 40,810,708 D595G probably damaging Het
Rbm17 C A 2: 11,595,438 probably benign Het
Slc24a3 T A 2: 145,518,916 I193N probably damaging Het
St5 T C 7: 109,557,372 Y57C probably damaging Het
Stat5a G T 11: 100,883,889 V759F probably damaging Het
Tgfbi T A 13: 56,631,353 L463Q probably damaging Het
Tigar G T 6: 127,089,290 A95E probably damaging Het
Tph1 A G 7: 46,656,997 I180T possibly damaging Het
Usp22 T A 11: 61,154,499 Y517F probably damaging Het
Vmn2r105 A C 17: 20,227,895 I222M possibly damaging Het
Wapl A G 14: 34,722,336 I582V probably benign Het
Zfp217 A G 2: 170,115,149 V643A probably benign Het
Other mutations in Olfr704
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01294:Olfr704 APN 7 106865763 missense probably damaging 0.99
IGL01543:Olfr704 APN 7 106865918 missense probably benign 0.00
R5055:Olfr704 UTSW 7 106865730 missense probably damaging 0.98
R5106:Olfr704 UTSW 7 106865388 missense probably damaging 1.00
Z1177:Olfr704 UTSW 7 106864988 missense probably benign
Posted On2014-05-07