Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02021:Vmn2r105'

183963

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r105

Ensembl Gene

ENSMUSG00000091670

Gene Name

vomeronasal 2, receptor 105

Synonyms

EG627743

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02021

Quality Score

Status

Chromosome

Chromosomal Location

20208230-20234872 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 20227895 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Methionine at position 222 (I222M)

Ref Sequence

ENSEMBL: ENSMUSP00000129762 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167382]

AlphaFold

E9Q3A5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000167382
AA Change: I222M

PolyPhen 2 Score 0.485 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000129762
Gene: ENSMUSG00000091670
AA Change: I222M

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	85	469	6.5e-42	PFAM
Pfam:NCD3G	512	565	3.2e-21	PFAM
Pfam:7tm_3	598	833	2.5e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110002L01Rik	G	A	12: 3,407,890		probably benign	Het
Adam10	C	T	9: 70,743,909	T72I	possibly damaging	Het
Adam26b	T	A	8: 43,519,872	M698L	probably benign	Het
Ankrd27	A	T	7: 35,614,456	H404L	probably damaging	Het
Atp1a1	T	C	3: 101,594,208	S60G	probably benign	Het
Bcat1	T	C	6: 145,047,289		probably benign	Het
Cd177	G	A	7: 24,745,206	A650V	probably benign	Het
Cmya5	T	C	13: 93,094,549	N1344D	probably benign	Het
Ctsd	G	T	7: 142,385,476	L71I	probably damaging	Het
Dctn2	T	C	10: 127,275,057		probably null	Het
Ddr1	G	A	17: 35,683,480	A801V	probably damaging	Het
Duoxa1	A	G	2: 122,304,646	F251S	probably benign	Het
Fcho1	A	C	8: 71,721,275	S2A	probably benign	Het
Gm4861	T	C	3: 137,552,110		probably null	Het
Gm4922	C	A	10: 18,784,477	G166W	probably damaging	Het
Hic2	A	G	16: 17,258,753	E482G	probably benign	Het
Hoxa5	C	T	6: 52,202,657	R246K	probably damaging	Het
Ipo11	A	T	13: 106,857,237	F721I	probably damaging	Het
Lama1	A	T	17: 67,821,626	S2993C	probably damaging	Het
Lonp2	T	A	8: 86,708,971	S612T	probably benign	Het
Lpar5	T	G	6: 125,081,992	Y225*	probably null	Het
Map4k3	A	G	17: 80,609,826	Y574H	probably damaging	Het
Msantd4	A	G	9: 4,385,163	E296G	probably damaging	Het
Ncs1	A	G	2: 31,284,165	D109G	probably damaging	Het
Nnt	T	C	13: 119,336,247		probably benign	Het
Nr1h5	T	C	3: 102,947,742		probably benign	Het
Olfr1288	A	G	2: 111,479,480	D232G	probably benign	Het
Olfr704	A	T	7: 106,865,489	K170*	probably null	Het
Plk4	A	G	3: 40,810,708	D595G	probably damaging	Het
Rbm17	C	A	2: 11,595,438		probably benign	Het
Slc24a3	T	A	2: 145,518,916	I193N	probably damaging	Het
St5	T	C	7: 109,557,372	Y57C	probably damaging	Het
Stat5a	G	T	11: 100,883,889	V759F	probably damaging	Het
Tgfbi	T	A	13: 56,631,353	L463Q	probably damaging	Het
Tigar	G	T	6: 127,089,290	A95E	probably damaging	Het
Tph1	A	G	7: 46,656,997	I180T	possibly damaging	Het
Usp22	T	A	11: 61,154,499	Y517F	probably damaging	Het
Wapl	A	G	14: 34,722,336	I582V	probably benign	Het
Zfp217	A	G	2: 170,115,149	V643A	probably benign	Het

Other mutations in Vmn2r105

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01433:Vmn2r105	APN	17	20228555	missense	probably benign	0.01
IGL01909:Vmn2r105	APN	17	20224656	missense	probably damaging	1.00
IGL01925:Vmn2r105	APN	17	20208711	missense	possibly damaging	0.94
IGL02828:Vmn2r105	APN	17	20209083	missense	possibly damaging	0.80
IGL02838:Vmn2r105	APN	17	20227585	missense	probably damaging	1.00
IGL03343:Vmn2r105	APN	17	20226369	nonsense	probably null
R0096:Vmn2r105	UTSW	17	20227479	missense	possibly damaging	0.49
R0096:Vmn2r105	UTSW	17	20227479	missense	possibly damaging	0.49
R0212:Vmn2r105	UTSW	17	20208565	missense	possibly damaging	0.90
R0268:Vmn2r105	UTSW	17	20208676	missense	probably benign	0.18
R0271:Vmn2r105	UTSW	17	20234703	missense	probably damaging	0.96
R0613:Vmn2r105	UTSW	17	20208316	missense	probably damaging	1.00
R0765:Vmn2r105	UTSW	17	20227711	missense	probably benign	0.20
R0765:Vmn2r105	UTSW	17	20227857	missense	probably damaging	0.98
R1162:Vmn2r105	UTSW	17	20227711	missense	probably benign	0.20
R1263:Vmn2r105	UTSW	17	20208322	missense	probably damaging	1.00
R1363:Vmn2r105	UTSW	17	20208670	missense	probably benign	0.00
R1464:Vmn2r105	UTSW	17	20228742	splice site	probably benign
R2029:Vmn2r105	UTSW	17	20224578	missense	probably damaging	0.99
R2420:Vmn2r105	UTSW	17	20227835	missense	probably benign	0.15
R2421:Vmn2r105	UTSW	17	20227835	missense	probably benign	0.15
R2422:Vmn2r105	UTSW	17	20227835	missense	probably benign	0.15
R2570:Vmn2r105	UTSW	17	20227323	missense	probably damaging	1.00
R3847:Vmn2r105	UTSW	17	20208690	missense	possibly damaging	0.85
R3848:Vmn2r105	UTSW	17	20208690	missense	possibly damaging	0.85
R4030:Vmn2r105	UTSW	17	20208754	missense	probably damaging	0.99
R4275:Vmn2r105	UTSW	17	20228640	missense	probably damaging	1.00
R4551:Vmn2r105	UTSW	17	20226351	missense	probably benign
R4801:Vmn2r105	UTSW	17	20227294	missense	probably benign	0.00
R4802:Vmn2r105	UTSW	17	20227294	missense	probably benign	0.00
R4816:Vmn2r105	UTSW	17	20208691	missense	probably benign	0.27
R4929:Vmn2r105	UTSW	17	20228018	missense	probably benign	0.44
R5022:Vmn2r105	UTSW	17	20208414	missense	probably damaging	0.99
R5475:Vmn2r105	UTSW	17	20234782	missense	probably benign
R5576:Vmn2r105	UTSW	17	20224574	critical splice donor site	probably null
R5795:Vmn2r105	UTSW	17	20228736	missense	probably benign	0.00
R5895:Vmn2r105	UTSW	17	20228667	missense	probably benign	0.10
R6017:Vmn2r105	UTSW	17	20208627	missense	probably damaging	0.97
R6210:Vmn2r105	UTSW	17	20228496	missense	probably damaging	1.00
R6491:Vmn2r105	UTSW	17	20227730	nonsense	probably null
R6542:Vmn2r105	UTSW	17	20228541	missense	probably benign	0.03
R6729:Vmn2r105	UTSW	17	20208343	missense	probably damaging	0.99
R7020:Vmn2r105	UTSW	17	20209074	missense	probably damaging	1.00
R7033:Vmn2r105	UTSW	17	20208612	missense	probably damaging	0.97
R7488:Vmn2r105	UTSW	17	20208783	missense	probably damaging	1.00
R7491:Vmn2r105	UTSW	17	20228565	missense	probably benign	0.02
R7555:Vmn2r105	UTSW	17	20227675	missense	probably damaging	0.98
R7863:Vmn2r105	UTSW	17	20208675	missense	probably benign	0.18
R8137:Vmn2r105	UTSW	17	20234704	missense	probably benign	0.02
R8166:Vmn2r105	UTSW	17	20208642	missense	probably benign	0.07
R8186:Vmn2r105	UTSW	17	20224618	nonsense	probably null
R8214:Vmn2r105	UTSW	17	20228513	missense	probably benign	0.02
R8497:Vmn2r105	UTSW	17	20234872	start codon destroyed	probably null	0.75
R8850:Vmn2r105	UTSW	17	20208610	missense	probably damaging	1.00
R8880:Vmn2r105	UTSW	17	20208967	missense	probably damaging	0.99
R9272:Vmn2r105	UTSW	17	20227423	missense	probably damaging	1.00
R9506:Vmn2r105	UTSW	17	20209142	missense	probably benign	0.00
R9549:Vmn2r105	UTSW	17	20227761	missense	probably benign	0.12

Posted On

2014-05-07