Incidental Mutation 'IGL02023:Decr2'
ID184033
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Decr2
Ensembl Gene ENSMUSG00000036775
Gene Name2-4-dienoyl-Coenzyme A reductase 2, peroxisomal
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02023
Quality Score
Status
Chromosome17
Chromosomal Location26081211-26090329 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 26087380 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 94 (M94K)
Ref Sequence ENSEMBL: ENSMUSP00000045621 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025007] [ENSMUST00000040907]
Predicted Effect probably benign
Transcript: ENSMUST00000025007
SMART Domains Protein: ENSMUSP00000025007
Gene: ENSMUSG00000024177

DomainStartEndE-ValueType
NDK 36 173 4.09e-83 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000040907
AA Change: M94K

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000045621
Gene: ENSMUSG00000036775
AA Change: M94K

DomainStartEndE-ValueType
Blast:NDK 1 28 5e-9 BLAST
Pfam:adh_short 29 224 3.6e-44 PFAM
Pfam:KR 30 208 3.8e-11 PFAM
Pfam:adh_short_C2 35 271 6.4e-30 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123056
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134696
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137672
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150534
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a T C 11: 110,063,116 K833E probably benign Het
Adam29 T C 8: 55,872,484 I312V probably benign Het
Adcy8 T A 15: 64,822,220 I403F probably damaging Het
Ahcyl1 A T 3: 107,667,694 N444K probably damaging Het
Ang4 T C 14: 51,764,054 probably benign Het
Atf6b T C 17: 34,651,867 V401A possibly damaging Het
Atp7a A T X: 106,094,982 I604F probably damaging Het
Cd151 T C 7: 141,470,457 Y202H probably damaging Het
Cd99l2 A T X: 71,449,946 N64K possibly damaging Het
Cog7 C T 7: 121,943,777 probably null Het
Ddx58 A G 4: 40,216,487 Y504H possibly damaging Het
Dock11 A T X: 35,968,769 H188L probably benign Het
Dscam T C 16: 96,801,197 S682G probably benign Het
Fam126b G A 1: 58,530,115 A435V possibly damaging Het
Gja3 G T 14: 57,035,679 P412Q probably damaging Het
Glrb T C 3: 80,850,955 N333D probably benign Het
Gm11639 A T 11: 104,721,432 probably benign Het
Gpr65 T A 12: 98,275,868 V260D probably benign Het
Hormad1 A G 3: 95,578,293 E264G possibly damaging Het
Hsph1 T C 5: 149,633,859 R46G probably damaging Het
Iars A G 13: 49,688,249 Y71C probably damaging Het
Lsg1 T C 16: 30,585,676 H35R probably damaging Het
Mfge8 C T 7: 79,145,237 probably benign Het
Mgat4c T A 10: 102,378,184 Y9* probably null Het
Mpdz A T 4: 81,329,529 I1074N probably damaging Het
Muc19 T C 15: 91,888,259 noncoding transcript Het
Nbea A T 3: 55,681,016 M2434K probably damaging Het
Ncoa2 A G 1: 13,174,854 L540P probably damaging Het
Nhsl2 A G X: 102,078,252 R554G probably damaging Het
Npdc1 T A 2: 25,408,020 probably benign Het
Olfr171 A T 16: 19,624,408 S231T probably benign Het
Osbpl10 T A 9: 115,226,722 V654D probably damaging Het
Plxna1 C A 6: 89,357,332 G105V possibly damaging Het
Pnmal2 T C 7: 16,945,691 V200A probably damaging Het
Ppard A G 17: 28,298,897 H313R probably benign Het
Rasgrp4 T C 7: 29,138,910 L103P probably damaging Het
Ripk4 A T 16: 97,755,231 L104Q probably damaging Het
Setd2 T C 9: 110,594,636 V2253A probably benign Het
Setdb2 A G 14: 59,431,158 S43P probably damaging Het
Stab2 C A 10: 86,871,831 G1742V possibly damaging Het
Timm23 A G 14: 32,193,847 probably benign Het
Ttn T C 2: 76,785,655 N14902S possibly damaging Het
Ush2a A G 1: 188,733,514 T2760A probably benign Het
Vmn2r25 T C 6: 123,839,429 N398D probably damaging Het
Other mutations in Decr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01657:Decr2 APN 17 26082952 missense probably damaging 1.00
R0003:Decr2 UTSW 17 26083053 missense probably benign 0.00
R0003:Decr2 UTSW 17 26083053 missense probably benign 0.00
R1583:Decr2 UTSW 17 26083024 missense probably damaging 0.99
R1588:Decr2 UTSW 17 26083028 missense possibly damaging 0.91
R1903:Decr2 UTSW 17 26087413 missense probably damaging 0.99
R1968:Decr2 UTSW 17 26083079 missense probably benign 0.00
R2269:Decr2 UTSW 17 26083884 missense probably benign 0.03
R4758:Decr2 UTSW 17 26088940 missense probably damaging 0.96
R5021:Decr2 UTSW 17 26083006 missense probably damaging 1.00
R5174:Decr2 UTSW 17 26087469 splice site probably null
R6608:Decr2 UTSW 17 26083884 missense probably benign 0.30
R6661:Decr2 UTSW 17 26083587 missense possibly damaging 0.53
R8036:Decr2 UTSW 17 26082988 missense probably damaging 0.97
Posted On2014-05-07