Incidental Mutation 'IGL02023:Dock11'
ID184058
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dock11
Ensembl Gene ENSMUSG00000031093
Gene Namededicator of cytokinesis 11
SynonymsZizimin2, 5033414A21Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.194) question?
Stock #IGL02023
Quality Score
Status
ChromosomeX
Chromosomal Location35888832-36076562 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 35968769 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Leucine at position 188 (H188L)
Ref Sequence ENSEMBL: ENSMUSP00000110921 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033419] [ENSMUST00000115266]
Predicted Effect probably benign
Transcript: ENSMUST00000033419
AA Change: H372L

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000033419
Gene: ENSMUSG00000031093
AA Change: H372L

DomainStartEndE-ValueType
Pfam:DUF3398 52 145 4.2e-39 PFAM
PH 166 274 1.4e-17 SMART
Blast:PH 329 440 4e-58 BLAST
Pfam:DOCK-C2 636 827 2.4e-53 PFAM
low complexity region 1254 1270 N/A INTRINSIC
Pfam:DHR-2 1510 2029 7.3e-210 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115266
AA Change: H188L

PolyPhen 2 Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000110921
Gene: ENSMUSG00000031093
AA Change: H188L

DomainStartEndE-ValueType
PH 1 90 6.82e-7 SMART
Blast:PH 145 256 5e-58 BLAST
Pfam:DOCK-C2 451 644 1.3e-60 PFAM
low complexity region 1083 1099 N/A INTRINSIC
low complexity region 1521 1529 N/A INTRINSIC
Pfam:Ded_cyto 1681 1858 1.2e-68 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a T C 11: 110,063,116 K833E probably benign Het
Adam29 T C 8: 55,872,484 I312V probably benign Het
Adcy8 T A 15: 64,822,220 I403F probably damaging Het
Ahcyl1 A T 3: 107,667,694 N444K probably damaging Het
Ang4 T C 14: 51,764,054 probably benign Het
Atf6b T C 17: 34,651,867 V401A possibly damaging Het
Atp7a A T X: 106,094,982 I604F probably damaging Het
Cd151 T C 7: 141,470,457 Y202H probably damaging Het
Cd99l2 A T X: 71,449,946 N64K possibly damaging Het
Cog7 C T 7: 121,943,777 probably null Het
Ddx58 A G 4: 40,216,487 Y504H possibly damaging Het
Decr2 A T 17: 26,087,380 M94K probably benign Het
Dscam T C 16: 96,801,197 S682G probably benign Het
Fam126b G A 1: 58,530,115 A435V possibly damaging Het
Gja3 G T 14: 57,035,679 P412Q probably damaging Het
Glrb T C 3: 80,850,955 N333D probably benign Het
Gm11639 A T 11: 104,721,432 probably benign Het
Gpr65 T A 12: 98,275,868 V260D probably benign Het
Hormad1 A G 3: 95,578,293 E264G possibly damaging Het
Hsph1 T C 5: 149,633,859 R46G probably damaging Het
Iars A G 13: 49,688,249 Y71C probably damaging Het
Lsg1 T C 16: 30,585,676 H35R probably damaging Het
Mfge8 C T 7: 79,145,237 probably benign Het
Mgat4c T A 10: 102,378,184 Y9* probably null Het
Mpdz A T 4: 81,329,529 I1074N probably damaging Het
Muc19 T C 15: 91,888,259 noncoding transcript Het
Nbea A T 3: 55,681,016 M2434K probably damaging Het
Ncoa2 A G 1: 13,174,854 L540P probably damaging Het
Nhsl2 A G X: 102,078,252 R554G probably damaging Het
Npdc1 T A 2: 25,408,020 probably benign Het
Olfr171 A T 16: 19,624,408 S231T probably benign Het
Osbpl10 T A 9: 115,226,722 V654D probably damaging Het
Plxna1 C A 6: 89,357,332 G105V possibly damaging Het
Pnmal2 T C 7: 16,945,691 V200A probably damaging Het
Ppard A G 17: 28,298,897 H313R probably benign Het
Rasgrp4 T C 7: 29,138,910 L103P probably damaging Het
Ripk4 A T 16: 97,755,231 L104Q probably damaging Het
Setd2 T C 9: 110,594,636 V2253A probably benign Het
Setdb2 A G 14: 59,431,158 S43P probably damaging Het
Stab2 C A 10: 86,871,831 G1742V possibly damaging Het
Timm23 A G 14: 32,193,847 probably benign Het
Ttn T C 2: 76,785,655 N14902S possibly damaging Het
Ush2a A G 1: 188,733,514 T2760A probably benign Het
Vmn2r25 T C 6: 123,839,429 N398D probably damaging Het
Other mutations in Dock11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00536:Dock11 APN X 35994434 missense probably benign 0.15
IGL00650:Dock11 APN X 36006593 splice site probably benign
IGL00769:Dock11 APN X 36004062 missense possibly damaging 0.74
IGL00963:Dock11 APN X 36032382 missense possibly damaging 0.63
IGL01389:Dock11 APN X 35993048 missense probably benign 0.43
IGL01410:Dock11 APN X 36037643 missense probably damaging 1.00
IGL01519:Dock11 APN X 35963353 missense probably benign
IGL02253:Dock11 APN X 36041128 missense probably damaging 1.00
IGL02416:Dock11 APN X 36020086 missense probably damaging 0.97
IGL02583:Dock11 APN X 36006717 missense possibly damaging 0.48
IGL03014:Dock11 APN X 36047046 splice site probably benign
IGL03037:Dock11 APN X 36047046 splice site probably benign
IGL03065:Dock11 APN X 36047046 splice site probably benign
IGL03277:Dock11 APN X 36013950 missense probably benign 0.32
R0816:Dock11 UTSW X 36020035 missense probably damaging 1.00
R0819:Dock11 UTSW X 36020035 missense probably damaging 1.00
R0820:Dock11 UTSW X 36020035 missense probably damaging 1.00
R1430:Dock11 UTSW X 36069912 missense probably benign 0.00
R1512:Dock11 UTSW X 36020035 missense probably damaging 1.00
Z1088:Dock11 UTSW X 36002533 missense probably benign 0.01
Z1176:Dock11 UTSW X 35984848 missense possibly damaging 0.69
Posted On2014-05-07