Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02026:Olfr114'

184190

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr114

Ensembl Gene

ENSMUSG00000062629

Gene Name

olfactory receptor 114

Synonyms

MOR218-10, GA_x6K02T2PSCP-2049802-2048870

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL02026

Quality Score

Status

Chromosome

Chromosomal Location

37589233-37592743 bp(-) (GRCm38)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

A to G at 37589407 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000149735 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076914] [ENSMUST00000214871] [ENSMUST00000216249]

Predicted Effect

probably benign
Transcript: ENSMUST00000076914

SMART Domains

Protein: ENSMUSP00000076181
Gene: ENSMUSG00000062629

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	2e-43	PFAM
Pfam:7TM_GPCR_Srsx	35	305	3.7e-6	PFAM
Pfam:7tm_1	41	290	3e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214871

Predicted Effect

probably benign
Transcript: ENSMUST00000216249

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamdec1	A	T	14: 68,571,802	V237E	possibly damaging	Het
Amh	T	C	10: 80,805,408	L54P	probably damaging	Het
Aoc3	T	C	11: 101,337,595	S743P	probably benign	Het
Arhgap23	T	A	11: 97,451,581	W19R	probably damaging	Het
Atm	C	T	9: 53,442,417		probably null	Het
BC100530	C	A	16: 36,367,486	V6F	possibly damaging	Het
Ccdc47	T	C	11: 106,205,027	E281G	probably damaging	Het
Col7a1	A	C	9: 108,968,029	K1650N	probably damaging	Het
Evi2b	T	C	11: 79,515,787	S321G	probably damaging	Het
Fancm	T	G	12: 65,105,734	V988G	probably benign	Het
Gbp2	A	G	3: 142,633,480	Y431C	probably damaging	Het
Gclc	T	C	9: 77,792,060	V530A	probably benign	Het
Gm4985	T	G	X: 23,957,994	H314P	probably damaging	Het
Gm5885	T	C	6: 133,531,328		noncoding transcript	Het
Hlcs	A	T	16: 94,134,705	I576N	probably damaging	Het
Hnrnpul1	A	T	7: 25,745,162	F240L	probably damaging	Het
Itgb6	C	A	2: 60,628,066	V448F	possibly damaging	Het
Lama1	A	G	17: 67,809,292	T2385A	possibly damaging	Het
Lamc2	C	T	1: 153,144,736		probably benign	Het
Lrrc32	C	T	7: 98,499,560	R516C	probably benign	Het
Lrrtm3	T	C	10: 64,088,452	N312S	probably damaging	Het
Ltbp4	G	A	7: 27,327,417	R468*	probably null	Het
Man1a	T	C	10: 54,014,473	E373G	probably damaging	Het
Myo1h	A	T	5: 114,323,444	Q250L	probably null	Het
Myo9a	T	C	9: 59,905,962	V2077A	probably damaging	Het
Otud5	C	T	X: 7,871,993		probably benign	Het
Pcsk1	A	G	13: 75,112,653	S332G	probably benign	Het
Pde8b	A	G	13: 95,034,361	V549A	probably damaging	Het
Pgap1	A	T	1: 54,494,819	M645K	probably benign	Het
Pm20d1	A	T	1: 131,801,759	R175*	probably null	Het
Polr2b	A	G	5: 77,332,252	N585S	probably benign	Het
Recql	T	A	6: 142,366,668	K41*	probably null	Het
Sccpdh	A	T	1: 179,678,069	H138L	possibly damaging	Het
Sec31a	A	T	5: 100,369,626	S951T	probably benign	Het
Slc44a4	A	T	17: 34,921,856		probably benign	Het
Tchhl1	G	T	3: 93,470,555	A189S	probably damaging	Het
Tdrd12	G	A	7: 35,504,233		probably benign	Het
Trbv12-1	A	G	6: 41,113,994	D100G	probably damaging	Het
Ttll13	T	A	7: 80,260,379	S757T	probably benign	Het
Vipas39	T	A	12: 87,251,709		probably benign	Het
Vmn1r64	G	A	7: 5,883,650	P298L	possibly damaging	Het
Vmn1r81	A	G	7: 12,260,505	S59P	probably damaging	Het
Vsx1	A	T	2: 150,688,527	V145D	probably benign	Het
Wdfy4	T	A	14: 33,093,300	N1586I	probably damaging	Het
Zan	T	A	5: 137,405,464		probably benign	Het
Zfp318	C	T	17: 46,396,810	R265*	probably null	Het
Zzef1	T	A	11: 72,881,338	M1707K	probably benign	Het

Other mutations in Olfr114

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01534:Olfr114	APN	17	37590072	missense	possibly damaging	0.93
IGL01624:Olfr114	APN	17	37589925	missense	probably benign	0.00
IGL02608:Olfr114	APN	17	37590219	missense	probably damaging	1.00
IGL02632:Olfr114	APN	17	37590341	missense	probably benign	0.00
IGL02990:Olfr114	APN	17	37589668	missense	probably benign	0.00
R0114:Olfr114	UTSW	17	37589415	makesense	probably null
R1156:Olfr114	UTSW	17	37589517	missense	possibly damaging	0.93
R1366:Olfr114	UTSW	17	37589764	missense	probably benign	0.03
R3413:Olfr114	UTSW	17	37589696	missense	probably benign	0.00
R3701:Olfr114	UTSW	17	37589826	nonsense	probably null
R6122:Olfr114	UTSW	17	37589926	missense	probably benign	0.12
R6639:Olfr114	UTSW	17	37589931	missense	probably damaging	1.00
R7066:Olfr114	UTSW	17	37590143	missense	probably damaging	1.00
R7316:Olfr114	UTSW	17	37590135	missense	probably damaging	0.99
R8340:Olfr114	UTSW	17	37590143	missense	probably damaging	1.00
R8483:Olfr114	UTSW	17	37589975	missense	possibly damaging	0.52
R8555:Olfr114	UTSW	17	37589649	missense	possibly damaging	0.95

Posted On

2014-05-07