Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02027:Htr1f'

184216

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Htr1f

Ensembl Gene

ENSMUSG00000050783

Gene Name

5-hydroxytryptamine (serotonin) receptor 1F

Synonyms

Htr1eb

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02027

Quality Score

Status

Chromosome

Chromosomal Location

64924729-65105854 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 64926321 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 203 (K203*)

Ref Sequence

ENSEMBL: ENSMUSP00000063136 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063076]

AlphaFold

Q02284

Predicted Effect

probably null
Transcript: ENSMUST00000063076
AA Change: K203*

SMART Domains

Protein: ENSMUSP00000063136
Gene: ENSMUSG00000050783
AA Change: K203*

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	32	230	4.8e-7	PFAM
Pfam:7TM_GPCR_Srsx	34	362	2.4e-10	PFAM
Pfam:7tm_1	40	347	4.1e-74	PFAM
Pfam:7TM_GPCR_Srv	54	249	5.2e-7	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for disruptions in this gene display decreased temperature sensitivity and physiological abnormalities in nerve fibers. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adipor1	A	G	1: 134,431,185 (GRCm38)	T312A	probably benign	Het
Begain	T	G	12: 109,034,309 (GRCm38)	K384Q	possibly damaging	Het
C2cd6	T	C	1: 59,060,604 (GRCm38)	I393V	probably benign	Het
Catsperz	A	G	19: 6,925,296 (GRCm38)	V5A	probably benign	Het
Cbx1	T	A	11: 96,801,489 (GRCm38)	F67L	probably damaging	Het
Cerkl	T	C	2: 79,341,286 (GRCm38)		probably benign	Het
Ctgf	A	G	10: 24,596,409 (GRCm38)	S117G	probably damaging	Het
Cubn	G	T	2: 13,287,594 (GRCm38)	D3259E	probably damaging	Het
Cyp2u1	A	G	3: 131,297,951 (GRCm38)	Y307H	probably damaging	Het
Dcaf6	A	C	1: 165,424,341 (GRCm38)	D71E	probably damaging	Het
Dclk3	A	T	9: 111,467,843 (GRCm38)	K152*	probably null	Het
Fcgbp	G	A	7: 28,075,204 (GRCm38)	D68N	probably damaging	Het
Gm6576	A	G	15: 27,025,866 (GRCm38)		noncoding transcript	Het
Has2	T	C	15: 56,668,171 (GRCm38)	T383A	probably damaging	Het
Il1f9	A	T	2: 24,192,785 (GRCm38)	I191L	probably benign	Het
Iqgap3	T	C	3: 88,087,342 (GRCm38)	I116T	possibly damaging	Het
Itga1	C	T	13: 114,990,055 (GRCm38)		probably null	Het
Kif5b	T	C	18: 6,209,089 (GRCm38)	D891G	possibly damaging	Het
Krt74	T	C	15: 101,756,794 (GRCm38)		noncoding transcript	Het
Lama3	A	G	18: 12,516,513 (GRCm38)	K1776E	probably damaging	Het
Lats1	T	C	10: 7,712,948 (GRCm38)	S1110P	probably benign	Het
Lipo3	T	A	19: 33,580,519 (GRCm38)	K158*	probably null	Het
Lrrc9	T	A	12: 72,470,334 (GRCm38)		probably benign	Het
Met	A	G	6: 17,563,727 (GRCm38)		probably benign	Het
Mmp13	A	G	9: 7,272,955 (GRCm38)	Y105C	probably damaging	Het
Mtus1	T	C	8: 40,993,601 (GRCm38)	E1151G	probably damaging	Het
Nov	T	C	15: 54,747,934 (GRCm38)	V155A	probably damaging	Het
Nptx1	T	C	11: 119,544,596 (GRCm38)	D298G	possibly damaging	Het
Pdlim1	T	C	19: 40,243,466 (GRCm38)	N156S	probably benign	Het
Pdzk1	A	G	3: 96,854,673 (GRCm38)		probably benign	Het
Pex5	A	G	6: 124,398,888 (GRCm38)	S448P	probably benign	Het
Polr3e	G	T	7: 120,930,963 (GRCm38)	R124L	probably damaging	Het
Ppp2r2c	C	T	5: 36,952,472 (GRCm38)	R392C	probably damaging	Het
Prpf4b	T	C	13: 34,889,571 (GRCm38)	I543T	probably benign	Het
Prr27	A	G	5: 87,843,443 (GRCm38)	S305G	possibly damaging	Het
Repin1	A	G	6: 48,596,473 (GRCm38)	H56R	probably damaging	Het
Ryr2	A	T	13: 11,597,112 (GRCm38)	L408H	probably damaging	Het
Sbf2	T	A	7: 110,461,141 (GRCm38)	Q205H	probably damaging	Het
Sgo2b	G	A	8: 63,926,829 (GRCm38)	P990S	probably benign	Het
Slc33a1	G	T	3: 63,948,141 (GRCm38)	P361Q	probably damaging	Het
Tmem98	T	C	11: 80,815,657 (GRCm38)		probably benign	Het
Ttc25	C	T	11: 100,569,902 (GRCm38)	T495M	probably damaging	Het
Vmn1r16	T	C	6: 57,323,059 (GRCm38)	T193A	possibly damaging	Het
Vmn1r5	T	A	6: 56,985,655 (GRCm38)	I105K	probably damaging	Het
Zfp473	A	T	7: 44,738,038 (GRCm38)		probably benign	Het

Other mutations in Htr1f

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00896:Htr1f	APN	16	64,926,106 (GRCm38)	missense	probably benign	0.00
IGL01134:Htr1f	APN	16	64,926,138 (GRCm38)	missense	probably benign	0.00
IGL01455:Htr1f	APN	16	64,926,022 (GRCm38)	missense	probably damaging	1.00
IGL01580:Htr1f	APN	16	64,925,835 (GRCm38)	nonsense	probably null
IGL01865:Htr1f	APN	16	64,925,919 (GRCm38)	missense	probably damaging	1.00
IGL02234:Htr1f	APN	16	64,926,067 (GRCm38)	missense	probably damaging	1.00
IGL02567:Htr1f	APN	16	64,926,248 (GRCm38)	missense	probably benign	0.45
R0035:Htr1f	UTSW	16	64,926,497 (GRCm38)	missense	probably damaging	1.00
R0131:Htr1f	UTSW	16	64,926,728 (GRCm38)	missense	probably damaging	1.00
R0131:Htr1f	UTSW	16	64,926,728 (GRCm38)	missense	probably damaging	1.00
R0132:Htr1f	UTSW	16	64,926,728 (GRCm38)	missense	probably damaging	1.00
R0193:Htr1f	UTSW	16	64,926,749 (GRCm38)	missense	probably damaging	1.00
R0523:Htr1f	UTSW	16	64,925,899 (GRCm38)	missense	probably damaging	1.00
R0722:Htr1f	UTSW	16	64,925,891 (GRCm38)	missense	probably damaging	0.99
R2055:Htr1f	UTSW	16	64,926,035 (GRCm38)	missense	probably damaging	1.00
R3418:Htr1f	UTSW	16	64,925,897 (GRCm38)	missense	probably damaging	1.00
R4090:Htr1f	UTSW	16	64,925,961 (GRCm38)	missense	probably benign	0.06
R4320:Htr1f	UTSW	16	64,926,687 (GRCm38)	missense	possibly damaging	0.87
R5037:Htr1f	UTSW	16	64,925,928 (GRCm38)	missense	probably damaging	1.00
R6004:Htr1f	UTSW	16	64,925,876 (GRCm38)	missense	probably damaging	1.00
R7383:Htr1f	UTSW	16	64,926,843 (GRCm38)	missense	probably benign	0.00
R7462:Htr1f	UTSW	16	64,926,020 (GRCm38)	missense	probably damaging	0.99
R7864:Htr1f	UTSW	16	64,926,794 (GRCm38)	missense	probably damaging	1.00
R8677:Htr1f	UTSW	16	64,926,051 (GRCm38)	missense	possibly damaging	0.69
R8816:Htr1f	UTSW	16	64,926,174 (GRCm38)	missense	probably benign	0.05
R8836:Htr1f	UTSW	16	64,926,833 (GRCm38)	missense	probably benign
R9106:Htr1f	UTSW	16	64,926,274 (GRCm38)	missense	probably damaging	1.00
R9155:Htr1f	UTSW	16	64,926,425 (GRCm38)	missense	probably benign	0.00
R9182:Htr1f	UTSW	16	64,926,462 (GRCm38)	missense	probably benign	0.03
R9244:Htr1f	UTSW	16	64,926,494 (GRCm38)	missense	probably benign	0.31
R9430:Htr1f	UTSW	16	64,926,468 (GRCm38)	missense	probably damaging	1.00
Z1176:Htr1f	UTSW	16	64,926,874 (GRCm38)	missense	probably benign
Z1176:Htr1f	UTSW	16	64,926,077 (GRCm38)	nonsense	probably null

Posted On

2014-05-07