Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02027:Dclk3'

184219

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dclk3

Ensembl Gene

ENSMUSG00000032500

Gene Name

doublecortin-like kinase 3

Synonyms

Click-I, -II related, Dcamkl3

Accession Numbers

Genbank: NM_172928; MGI: 3039580

Is this an essential gene?

Possibly non essential (E-score: 0.277) question?

Stock #

IGL02027

Quality Score

Status

Chromosome

Chromosomal Location

111439081-111489118 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 111467843 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 152 (K152*)

Ref Sequence

ENSEMBL: ENSMUSP00000107510 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000111879]

AlphaFold

Q8BWQ5

Predicted Effect

probably null
Transcript: ENSMUST00000111879
AA Change: K152*

SMART Domains

Protein: ENSMUSP00000107510
Gene: ENSMUSG00000032500
AA Change: K152*

Domain	Start	End	E-Value	Type
low complexity region	2	29	N/A	INTRINSIC
Pfam:DCX	115	177	2.9e-17	PFAM
low complexity region	200	218	N/A	INTRINSIC
low complexity region	267	277	N/A	INTRINSIC
low complexity region	479	496	N/A	INTRINSIC
S_TKc	514	771	1.63e-110	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This gene encodes a member of the protein kinase superfamily and the doublecortin family. Differently from the other two closely related family members (DCLK1 and DCLK2), the protein encoded by this gene contains only one N-terminal doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. The protein contains a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. [provided by RefSeq, Sep 2010]

Allele List at MGI

All alleles(3) : Targeted, other(2) Gene trapped(1)

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adipor1	A	G	1: 134,431,185	T312A	probably benign	Het
Begain	T	G	12: 109,034,309	K384Q	possibly damaging	Het
C2cd6	T	C	1: 59,060,604	I393V	probably benign	Het
Catsperz	A	G	19: 6,925,296	V5A	probably benign	Het
Cbx1	T	A	11: 96,801,489	F67L	probably damaging	Het
Cerkl	T	C	2: 79,341,286		probably benign	Het
Ctgf	A	G	10: 24,596,409	S117G	probably damaging	Het
Cubn	G	T	2: 13,287,594	D3259E	probably damaging	Het
Cyp2u1	A	G	3: 131,297,951	Y307H	probably damaging	Het
Dcaf6	A	C	1: 165,424,341	D71E	probably damaging	Het
Fcgbp	G	A	7: 28,075,204	D68N	probably damaging	Het
Gm6576	A	G	15: 27,025,866		noncoding transcript	Het
Has2	T	C	15: 56,668,171	T383A	probably damaging	Het
Htr1f	T	A	16: 64,926,321	K203*	probably null	Het
Il1f9	A	T	2: 24,192,785	I191L	probably benign	Het
Iqgap3	T	C	3: 88,087,342	I116T	possibly damaging	Het
Itga1	C	T	13: 114,990,055		probably null	Het
Kif5b	T	C	18: 6,209,089	D891G	possibly damaging	Het
Krt74	T	C	15: 101,756,794		noncoding transcript	Het
Lama3	A	G	18: 12,516,513	K1776E	probably damaging	Het
Lats1	T	C	10: 7,712,948	S1110P	probably benign	Het
Lipo3	T	A	19: 33,580,519	K158*	probably null	Het
Lrrc9	T	A	12: 72,470,334		probably benign	Het
Met	A	G	6: 17,563,727		probably benign	Het
Mmp13	A	G	9: 7,272,955	Y105C	probably damaging	Het
Mtus1	T	C	8: 40,993,601	E1151G	probably damaging	Het
Nov	T	C	15: 54,747,934	V155A	probably damaging	Het
Nptx1	T	C	11: 119,544,596	D298G	possibly damaging	Het
Pdlim1	T	C	19: 40,243,466	N156S	probably benign	Het
Pdzk1	A	G	3: 96,854,673		probably benign	Het
Pex5	A	G	6: 124,398,888	S448P	probably benign	Het
Polr3e	G	T	7: 120,930,963	R124L	probably damaging	Het
Ppp2r2c	C	T	5: 36,952,472	R392C	probably damaging	Het
Prpf4b	T	C	13: 34,889,571	I543T	probably benign	Het
Prr27	A	G	5: 87,843,443	S305G	possibly damaging	Het
Repin1	A	G	6: 48,596,473	H56R	probably damaging	Het
Ryr2	A	T	13: 11,597,112	L408H	probably damaging	Het
Sbf2	T	A	7: 110,461,141	Q205H	probably damaging	Het
Sgo2b	G	A	8: 63,926,829	P990S	probably benign	Het
Slc33a1	G	T	3: 63,948,141	P361Q	probably damaging	Het
Tmem98	T	C	11: 80,815,657		probably benign	Het
Ttc25	C	T	11: 100,569,902	T495M	probably damaging	Het
Vmn1r16	T	C	6: 57,323,059	T193A	possibly damaging	Het
Vmn1r5	T	A	6: 56,985,655	I105K	probably damaging	Het
Zfp473	A	T	7: 44,738,038		probably benign	Het

Other mutations in Dclk3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02125:Dclk3	APN	9	111469107	missense	probably damaging	1.00
IGL02547:Dclk3	APN	9	111469023	missense	probably damaging	1.00
IGL03393:Dclk3	APN	9	111488673	utr 3 prime	probably benign
G1citation:Dclk3	UTSW	9	111439337	missense	probably benign	0.03
IGL02984:Dclk3	UTSW	9	111488575	missense	probably damaging	1.00
R0109:Dclk3	UTSW	9	111467670	missense	possibly damaging	0.93
R0109:Dclk3	UTSW	9	111467670	missense	possibly damaging	0.93
R0238:Dclk3	UTSW	9	111482628	missense	probably damaging	0.99
R0238:Dclk3	UTSW	9	111482628	missense	probably damaging	0.99
R0432:Dclk3	UTSW	9	111484935	missense	probably damaging	1.00
R0440:Dclk3	UTSW	9	111469163	missense	probably damaging	1.00
R0530:Dclk3	UTSW	9	111482721	missense	probably damaging	1.00
R1024:Dclk3	UTSW	9	111469070	missense	possibly damaging	0.95
R1443:Dclk3	UTSW	9	111469020	missense	probably benign	0.01
R1474:Dclk3	UTSW	9	111469236	missense	probably benign	0.43
R1479:Dclk3	UTSW	9	111468546	missense	probably benign
R1482:Dclk3	UTSW	9	111467820	missense	possibly damaging	0.90
R1543:Dclk3	UTSW	9	111468054	missense	probably benign	0.04
R1552:Dclk3	UTSW	9	111488579	missense	probably damaging	1.00
R1559:Dclk3	UTSW	9	111469208	missense	probably damaging	1.00
R2011:Dclk3	UTSW	9	111468354	missense	probably benign	0.00
R2369:Dclk3	UTSW	9	111488542	missense	probably benign	0.16
R4111:Dclk3	UTSW	9	111469080	missense	probably damaging	0.99
R4510:Dclk3	UTSW	9	111467992	missense	probably benign	0.01
R4511:Dclk3	UTSW	9	111467992	missense	probably benign	0.01
R4592:Dclk3	UTSW	9	111467895	missense	probably damaging	1.00
R4604:Dclk3	UTSW	9	111469185	missense	probably damaging	1.00
R4857:Dclk3	UTSW	9	111468648	missense	probably benign
R4932:Dclk3	UTSW	9	111468042	missense	possibly damaging	0.56
R5045:Dclk3	UTSW	9	111467788	missense	probably damaging	0.99
R5233:Dclk3	UTSW	9	111468681	missense	probably benign
R5338:Dclk3	UTSW	9	111469059	missense	possibly damaging	0.95
R5463:Dclk3	UTSW	9	111469260	missense	probably benign	0.26
R6822:Dclk3	UTSW	9	111439337	missense	probably benign	0.03
R6995:Dclk3	UTSW	9	111467700	missense	possibly damaging	0.88
R7187:Dclk3	UTSW	9	111484996	missense	probably damaging	1.00
R7532:Dclk3	UTSW	9	111467528	missense	probably benign	0.03
R7534:Dclk3	UTSW	9	111468218	missense	probably benign
R7734:Dclk3	UTSW	9	111469095	missense	probably damaging	1.00
R8326:Dclk3	UTSW	9	111467534	missense	probably damaging	0.96
R8372:Dclk3	UTSW	9	111485013	missense	probably damaging	0.98
R8388:Dclk3	UTSW	9	111482745	missense	probably damaging	1.00
R8423:Dclk3	UTSW	9	111468719	missense	possibly damaging	0.93
R8493:Dclk3	UTSW	9	111468147	missense	probably benign	0.06
R9013:Dclk3	UTSW	9	111468498	missense	probably benign	0.31
R9114:Dclk3	UTSW	9	111488615	missense	probably benign	0.06
R9338:Dclk3	UTSW	9	111439305	missense	unknown
R9412:Dclk3	UTSW	9	111482751	critical splice donor site	probably null
X0020:Dclk3	UTSW	9	111485075	missense	probably damaging	1.00

Posted On

2014-05-07