Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02028:Vmn2r23'

184239

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r23

Ensembl Gene

ENSMUSG00000091620

Gene Name

vomeronasal 2, receptor 23

Synonyms

EG435916

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

IGL02028

Quality Score

Status

Chromosome

Chromosomal Location

123702821-123742291 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 123741860 bp

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 724 (F724S)

Ref Sequence

ENSEMBL: ENSMUSP00000126682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172391]

AlphaFold

E9PXI5

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158091

Predicted Effect

probably damaging
Transcript: ENSMUST00000172391
AA Change: F724S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: F724S

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	79	461	1.7e-31	PFAM
Pfam:NCD3G	513	566	1.2e-23	PFAM
Pfam:7tm_3	596	834	1.5e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abi2	A	G	1: 60,434,283	Y53C	probably damaging	Het
Acacb	T	A	5: 114,166,015	D166E	probably damaging	Het
Akap8l	T	C	17: 32,338,521		probably null	Het
Arl6ip5	A	G	6: 97,229,650	Y97C	probably damaging	Het
Atad5	T	A	11: 80,134,110	S1772R	probably benign	Het
Ccdc106	A	G	7: 5,059,646	Q155R	probably damaging	Het
Ccdc33	T	C	9: 58,076,578	N446S	probably benign	Het
Cd3eap	T	C	7: 19,357,078	K368R	probably damaging	Het
Cdh2	T	C	18: 16,650,420	D84G	probably benign	Het
Cntn6	A	G	6: 104,859,426	K918E	probably damaging	Het
Dock6	T	C	9: 21,838,826	D521G	probably damaging	Het
Etv6	C	T	6: 134,248,733	A309V	probably benign	Het
Ezh1	G	T	11: 101,199,340	H529Q	probably damaging	Het
Figla	T	C	6: 86,017,363	L40P	probably damaging	Het
Gabra4	T	A	5: 71,633,596	Q301L	probably damaging	Het
Glt1d1	G	A	5: 127,706,920	V313M	possibly damaging	Het
Gm28778	T	A	1: 53,317,961	I94K	possibly damaging	Het
Gm4847	T	C	1: 166,642,196	K103E	probably benign	Het
Gne	A	G	4: 44,066,852	S23P	probably damaging	Het
Hipk2	A	G	6: 38,818,756	C186R	possibly damaging	Het
Lrp1b	C	T	2: 41,511,452	V283I	probably damaging	Het
Mcm10	A	T	2: 5,008,700	D40E	possibly damaging	Het
Morc2b	T	A	17: 33,137,413	I462F	possibly damaging	Het
Myh1	T	A	11: 67,210,615	I711N	probably damaging	Het
Oit3	A	G	10: 59,438,655	F108L	probably damaging	Het
Olfr1289	T	C	2: 111,483,471	F14L	probably benign	Het
Olfr913	T	A	9: 38,594,419	L66*	probably null	Het
Rbm19	A	G	5: 120,120,236	D172G	probably damaging	Het
Ribc2	A	G	15: 85,143,335	D339G	possibly damaging	Het
Rras2	C	A	7: 114,060,362	V56L	probably benign	Het
Scn2a	A	G	2: 65,763,658	E1617G	probably damaging	Het
Slc13a1	T	A	6: 24,118,031	M236L	probably benign	Het
Snrnp27	C	T	6: 86,682,973	R13H	unknown	Het
Srgap2	T	C	1: 131,296,435	K92E	probably damaging	Het
Suco	T	C	1: 161,856,859	K231E	possibly damaging	Het
Tll2	C	A	19: 41,098,649	E588*	probably null	Het
Tmem215	A	T	4: 40,473,940	I6L	possibly damaging	Het
Tnc	A	C	4: 63,966,672		probably benign	Het
Tob1	G	A	11: 94,214,226	G196D	probably benign	Het
Ubtfl1	T	A	9: 18,409,553	Y126N	possibly damaging	Het
Uck1	G	T	2: 32,258,137	Q192K	probably damaging	Het
Vdac3-ps1	A	G	13: 18,030,884		noncoding transcript	Het
Vmn1r88	C	T	7: 13,177,792	S25L	probably benign	Het
Vmn2r109	T	G	17: 20,541,080	I672L	probably benign	Het
Vmn2r54	A	T	7: 12,632,161	F282Y	probably damaging	Het
Vmn2r82	A	T	10: 79,379,223	I347F	probably benign	Het
Wasf2	G	A	4: 133,195,801	R474H	probably damaging	Het
Wdr60	C	A	12: 116,256,061	R87L	probably benign	Het
Zmym5	T	C	14: 56,804,160	H162R	possibly damaging	Het

Other mutations in Vmn2r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Vmn2r23	APN	6	123729725	missense	possibly damaging	0.89
IGL01012:Vmn2r23	APN	6	123729596	missense	probably benign
IGL01073:Vmn2r23	APN	6	123712800	missense	possibly damaging	0.82
IGL01547:Vmn2r23	APN	6	123704424	missense	possibly damaging	0.88
IGL01571:Vmn2r23	APN	6	123704407	missense	probably damaging	1.00
IGL01950:Vmn2r23	APN	6	123741886	missense	possibly damaging	0.80
IGL02248:Vmn2r23	APN	6	123741744	missense	probably damaging	0.96
IGL02318:Vmn2r23	APN	6	123741836	missense	probably benign	0.10
IGL02649:Vmn2r23	APN	6	123704478	missense	probably benign
IGL02831:Vmn2r23	APN	6	123704385	missense	probably benign	0.22
IGL02832:Vmn2r23	APN	6	123704396	missense	probably benign	0.00
IGL02865:Vmn2r23	APN	6	123741619	missense	probably damaging	1.00
IGL02964:Vmn2r23	APN	6	123741782	missense	possibly damaging	0.93
IGL03347:Vmn2r23	APN	6	123704374	missense	probably benign	0.01
IGL03396:Vmn2r23	APN	6	123729626	missense	probably damaging	1.00
PIT4472001:Vmn2r23	UTSW	6	123712977	missense	possibly damaging	0.62
R0597:Vmn2r23	UTSW	6	123729721	missense	probably benign	0.08
R0677:Vmn2r23	UTSW	6	123713451	missense	probably benign	0.00
R0904:Vmn2r23	UTSW	6	123742135	missense	probably damaging	1.00
R1330:Vmn2r23	UTSW	6	123742004	missense	probably damaging	1.00
R1424:Vmn2r23	UTSW	6	123713270	nonsense	probably null
R1629:Vmn2r23	UTSW	6	123713427	missense	probably benign	0.05
R1842:Vmn2r23	UTSW	6	123729690	missense	possibly damaging	0.77
R1867:Vmn2r23	UTSW	6	123702915	missense	probably damaging	1.00
R1919:Vmn2r23	UTSW	6	123713010	missense	possibly damaging	0.94
R2087:Vmn2r23	UTSW	6	123741499	missense	probably benign	0.00
R2338:Vmn2r23	UTSW	6	123704425	missense	possibly damaging	0.88
R2568:Vmn2r23	UTSW	6	123742188	nonsense	probably null
R2867:Vmn2r23	UTSW	6	123713164	missense	possibly damaging	0.94
R2867:Vmn2r23	UTSW	6	123713164	missense	possibly damaging	0.94
R3500:Vmn2r23	UTSW	6	123713170	missense	possibly damaging	0.81
R3789:Vmn2r23	UTSW	6	123741389	missense	probably damaging	1.00
R4164:Vmn2r23	UTSW	6	123729738	missense	probably benign
R4506:Vmn2r23	UTSW	6	123702925	missense	probably damaging	1.00
R4652:Vmn2r23	UTSW	6	123741730	missense	probably damaging	1.00
R4697:Vmn2r23	UTSW	6	123741826	missense	probably damaging	1.00
R4840:Vmn2r23	UTSW	6	123713074	missense	probably damaging	1.00
R4983:Vmn2r23	UTSW	6	123733349	missense	probably damaging	1.00
R5276:Vmn2r23	UTSW	6	123712977	missense	possibly damaging	0.62
R5392:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R5528:Vmn2r23	UTSW	6	123713002	missense	probably damaging	1.00
R5529:Vmn2r23	UTSW	6	123713451	missense	probably benign	0.00
R5664:Vmn2r23	UTSW	6	123713074	missense	probably damaging	1.00
R5749:Vmn2r23	UTSW	6	123733273	missense	probably benign
R5761:Vmn2r23	UTSW	6	123712759	missense	probably benign	0.39
R5762:Vmn2r23	UTSW	6	123733393	missense	probably damaging	1.00
R5868:Vmn2r23	UTSW	6	123712942	missense	probably benign	0.12
R5935:Vmn2r23	UTSW	6	123741895	missense	possibly damaging	0.94
R6242:Vmn2r23	UTSW	6	123704400	missense	possibly damaging	0.82
R6416:Vmn2r23	UTSW	6	123712902	missense	probably damaging	1.00
R6524:Vmn2r23	UTSW	6	123713425	missense	probably damaging	1.00
R6576:Vmn2r23	UTSW	6	123733273	missense	probably benign
R6925:Vmn2r23	UTSW	6	123704553	missense	probably damaging	1.00
R7148:Vmn2r23	UTSW	6	123713022	missense	probably benign
R7215:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R7252:Vmn2r23	UTSW	6	123741581	missense	probably damaging	0.97
R7403:Vmn2r23	UTSW	6	123704579	missense	probably benign	0.01
R8015:Vmn2r23	UTSW	6	123704541	missense	probably benign	0.00
R8143:Vmn2r23	UTSW	6	123741353	missense	probably damaging	0.99
R8474:Vmn2r23	UTSW	6	123704640	missense	probably benign	0.36
R8520:Vmn2r23	UTSW	6	123741656	missense	probably damaging	0.99
R8679:Vmn2r23	UTSW	6	123713472	missense	probably damaging	0.99
R8713:Vmn2r23	UTSW	6	123703032	missense
R8966:Vmn2r23	UTSW	6	123742120	missense	possibly damaging	0.94
R9124:Vmn2r23	UTSW	6	123742079	missense	not run
RF018:Vmn2r23	UTSW	6	123713116	missense	probably benign	0.00
T0975:Vmn2r23	UTSW	6	123713161	missense	probably benign	0.00
Z1088:Vmn2r23	UTSW	6	123742108	missense	probably damaging	0.98
Z1177:Vmn2r23	UTSW	6	123729725	frame shift	probably null

Posted On

2014-05-07