Incidental Mutation 'IGL02028:Tmem215'
ID184284
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem215
Ensembl Gene ENSMUSG00000046593
Gene Nametransmembrane protein 215
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.087) question?
Stock #IGL02028
Quality Score
Status
Chromosome4
Chromosomal Location40472180-40477168 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 40473940 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Leucine at position 6 (I6L)
Ref Sequence ENSEMBL: ENSMUSP00000136595 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049655] [ENSMUST00000179526]
Predicted Effect possibly damaging
Transcript: ENSMUST00000049655
AA Change: I6L

PolyPhen 2 Score 0.755 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000052129
Gene: ENSMUSG00000046593
AA Change: I6L

DomainStartEndE-ValueType
transmembrane domain 13 32 N/A INTRINSIC
transmembrane domain 37 59 N/A INTRINSIC
low complexity region 168 179 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000179526
AA Change: I6L

PolyPhen 2 Score 0.755 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000136595
Gene: ENSMUSG00000046593
AA Change: I6L

DomainStartEndE-ValueType
Pfam:TMEM215 1 235 2.5e-117 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi2 A G 1: 60,434,283 Y53C probably damaging Het
Acacb T A 5: 114,166,015 D166E probably damaging Het
Akap8l T C 17: 32,338,521 probably null Het
Arl6ip5 A G 6: 97,229,650 Y97C probably damaging Het
Atad5 T A 11: 80,134,110 S1772R probably benign Het
Ccdc106 A G 7: 5,059,646 Q155R probably damaging Het
Ccdc33 T C 9: 58,076,578 N446S probably benign Het
Cd3eap T C 7: 19,357,078 K368R probably damaging Het
Cdh2 T C 18: 16,650,420 D84G probably benign Het
Cntn6 A G 6: 104,859,426 K918E probably damaging Het
Dock6 T C 9: 21,838,826 D521G probably damaging Het
Etv6 C T 6: 134,248,733 A309V probably benign Het
Ezh1 G T 11: 101,199,340 H529Q probably damaging Het
Figla T C 6: 86,017,363 L40P probably damaging Het
Gabra4 T A 5: 71,633,596 Q301L probably damaging Het
Glt1d1 G A 5: 127,706,920 V313M possibly damaging Het
Gm28778 T A 1: 53,317,961 I94K possibly damaging Het
Gm4847 T C 1: 166,642,196 K103E probably benign Het
Gne A G 4: 44,066,852 S23P probably damaging Het
Hipk2 A G 6: 38,818,756 C186R possibly damaging Het
Lrp1b C T 2: 41,511,452 V283I probably damaging Het
Mcm10 A T 2: 5,008,700 D40E possibly damaging Het
Morc2b T A 17: 33,137,413 I462F possibly damaging Het
Myh1 T A 11: 67,210,615 I711N probably damaging Het
Oit3 A G 10: 59,438,655 F108L probably damaging Het
Olfr1289 T C 2: 111,483,471 F14L probably benign Het
Olfr913 T A 9: 38,594,419 L66* probably null Het
Rbm19 A G 5: 120,120,236 D172G probably damaging Het
Ribc2 A G 15: 85,143,335 D339G possibly damaging Het
Rras2 C A 7: 114,060,362 V56L probably benign Het
Scn2a A G 2: 65,763,658 E1617G probably damaging Het
Slc13a1 T A 6: 24,118,031 M236L probably benign Het
Snrnp27 C T 6: 86,682,973 R13H unknown Het
Srgap2 T C 1: 131,296,435 K92E probably damaging Het
Suco T C 1: 161,856,859 K231E possibly damaging Het
Tll2 C A 19: 41,098,649 E588* probably null Het
Tnc A C 4: 63,966,672 probably benign Het
Tob1 G A 11: 94,214,226 G196D probably benign Het
Ubtfl1 T A 9: 18,409,553 Y126N possibly damaging Het
Uck1 G T 2: 32,258,137 Q192K probably damaging Het
Vdac3-ps1 A G 13: 18,030,884 noncoding transcript Het
Vmn1r88 C T 7: 13,177,792 S25L probably benign Het
Vmn2r109 T G 17: 20,541,080 I672L probably benign Het
Vmn2r23 T C 6: 123,741,860 F724S probably damaging Het
Vmn2r54 A T 7: 12,632,161 F282Y probably damaging Het
Vmn2r82 A T 10: 79,379,223 I347F probably benign Het
Wasf2 G A 4: 133,195,801 R474H probably damaging Het
Wdr60 C A 12: 116,256,061 R87L probably benign Het
Zmym5 T C 14: 56,804,160 H162R possibly damaging Het
Other mutations in Tmem215
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02380:Tmem215 APN 4 40474534 missense probably benign 0.19
IGL02826:Tmem215 APN 4 40474632 makesense probably null
R1531:Tmem215 UTSW 4 40473965 missense probably damaging 1.00
R4941:Tmem215 UTSW 4 40474520 missense probably damaging 0.97
R5636:Tmem215 UTSW 4 40474394 missense probably damaging 0.99
R6820:Tmem215 UTSW 4 40473926 start codon destroyed probably null 0.88
R7767:Tmem215 UTSW 4 40474042 missense possibly damaging 0.75
Posted On2014-05-07