Incidental Mutation 'IGL02030:Fut10'
| ID |
184330 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Fut10
|
| Ensembl Gene |
ENSMUSG00000046152 |
| Gene Name |
fucosyltransferase 10 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
IGL02030
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
8 |
| Chromosomal Location |
31677359-31751766 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 31726006 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 254
(Q254*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124437
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000066173]
[ENSMUST00000110527]
[ENSMUST00000161502]
[ENSMUST00000161788]
|
| AlphaFold |
Q5F2L2 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000066173
AA Change: Q254*
|
| SMART Domains |
Protein: ENSMUSP00000069816
Gene: ENSMUSG00000046152
AA Change: Q254*
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
9 |
31 |
N/A |
INTRINSIC |
|
Pfam:Glyco_tran_10_N
|
79 |
184 |
5e-13 |
PFAM |
|
Pfam:Glyco_transf_10
|
209 |
410 |
7.9e-38 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110527
|
| SMART Domains |
Protein: ENSMUSP00000106156
Gene: ENSMUSG00000046152
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Glyco_transf_10
|
7 |
134 |
3e-9 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000161502
AA Change: Q254*
|
| SMART Domains |
Protein: ENSMUSP00000125265
Gene: ENSMUSG00000046152
AA Change: Q254*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Glyco_transf_10
|
7 |
412 |
4.1e-92 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000161788
AA Change: Q254*
|
| SMART Domains |
Protein: ENSMUSP00000124437
Gene: ENSMUSG00000046152
AA Change: Q254*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Glyco_transf_10
|
7 |
411 |
1.3e-92 |
PFAM |
|
low complexity region
|
418 |
429 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162162
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 27 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam26a |
T |
C |
8: 44,021,894 (GRCm39) |
D532G |
probably benign |
Het |
| Adam29 |
C |
T |
8: 56,325,157 (GRCm39) |
M432I |
probably benign |
Het |
| Cbs |
A |
G |
17: 31,844,463 (GRCm39) |
|
probably null |
Het |
| Ccer1 |
A |
G |
10: 97,529,472 (GRCm39) |
Y45C |
unknown |
Het |
| Clu |
G |
A |
14: 66,213,240 (GRCm39) |
G209S |
probably benign |
Het |
| Ddx17 |
T |
C |
15: 79,414,577 (GRCm39) |
D530G |
probably benign |
Het |
| Ddx4 |
T |
C |
13: 112,761,311 (GRCm39) |
|
probably benign |
Het |
| Fry |
C |
T |
5: 150,395,083 (GRCm39) |
|
probably benign |
Het |
| Gucy2e |
A |
G |
11: 69,114,642 (GRCm39) |
F1002S |
probably damaging |
Het |
| Hsd3b6 |
T |
C |
3: 98,713,489 (GRCm39) |
Y270C |
probably benign |
Het |
| Jup |
A |
G |
11: 100,267,817 (GRCm39) |
I502T |
probably damaging |
Het |
| Lrrc71 |
T |
A |
3: 87,652,531 (GRCm39) |
|
probably null |
Het |
| Mei1 |
T |
C |
15: 81,999,944 (GRCm39) |
V1127A |
probably benign |
Het |
| Ncstn |
A |
T |
1: 171,900,024 (GRCm39) |
|
probably benign |
Het |
| Nin |
T |
C |
12: 70,092,042 (GRCm39) |
R756G |
probably damaging |
Het |
| Notch2 |
C |
A |
3: 98,006,737 (GRCm39) |
|
probably null |
Het |
| Oacyl |
T |
C |
18: 65,870,981 (GRCm39) |
V394A |
probably damaging |
Het |
| Or1j19 |
A |
G |
2: 36,677,410 (GRCm39) |
Y291C |
probably damaging |
Het |
| Or5b21 |
T |
C |
19: 12,839,799 (GRCm39) |
F220S |
probably benign |
Het |
| Or6b13 |
A |
G |
7: 139,782,545 (GRCm39) |
I46T |
probably damaging |
Het |
| Parn |
A |
G |
16: 13,482,514 (GRCm39) |
|
probably null |
Het |
| Rspo3 |
T |
G |
10: 29,376,044 (GRCm39) |
E173A |
probably damaging |
Het |
| Rusc2 |
T |
A |
4: 43,416,095 (GRCm39) |
V467E |
possibly damaging |
Het |
| Sema7a |
G |
A |
9: 57,862,423 (GRCm39) |
E209K |
possibly damaging |
Het |
| Uchl4 |
T |
C |
9: 64,142,911 (GRCm39) |
S131P |
probably benign |
Het |
| Usp54 |
T |
C |
14: 20,616,014 (GRCm39) |
I769V |
probably benign |
Het |
| Xirp2 |
T |
C |
2: 67,339,325 (GRCm39) |
M522T |
probably benign |
Het |
|
| Other mutations in Fut10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00336:Fut10
|
APN |
8 |
31,685,319 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL00566:Fut10
|
APN |
8 |
31,725,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00858:Fut10
|
APN |
8 |
31,725,733 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL00861:Fut10
|
APN |
8 |
31,725,733 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL00862:Fut10
|
APN |
8 |
31,725,733 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01916:Fut10
|
APN |
8 |
31,725,734 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02318:Fut10
|
APN |
8 |
31,726,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02354:Fut10
|
APN |
8 |
31,691,398 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02361:Fut10
|
APN |
8 |
31,691,398 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02932:Fut10
|
APN |
8 |
31,749,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03345:Fut10
|
APN |
8 |
31,750,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0234:Fut10
|
UTSW |
8 |
31,726,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0234:Fut10
|
UTSW |
8 |
31,726,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1728:Fut10
|
UTSW |
8 |
31,691,418 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1729:Fut10
|
UTSW |
8 |
31,691,418 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1845:Fut10
|
UTSW |
8 |
31,726,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2173:Fut10
|
UTSW |
8 |
31,726,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2518:Fut10
|
UTSW |
8 |
31,726,495 (GRCm39) |
missense |
probably benign |
0.19 |
|
R3692:Fut10
|
UTSW |
8 |
31,726,048 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4449:Fut10
|
UTSW |
8 |
31,726,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5015:Fut10
|
UTSW |
8 |
31,726,148 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5942:Fut10
|
UTSW |
8 |
31,691,485 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6497:Fut10
|
UTSW |
8 |
31,726,278 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7566:Fut10
|
UTSW |
8 |
31,749,950 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7645:Fut10
|
UTSW |
8 |
31,726,232 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8127:Fut10
|
UTSW |
8 |
31,684,999 (GRCm39) |
start gained |
probably benign |
|
|
R8241:Fut10
|
UTSW |
8 |
31,750,034 (GRCm39) |
nonsense |
probably null |
|
|
R8899:Fut10
|
UTSW |
8 |
31,726,514 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9314:Fut10
|
UTSW |
8 |
31,691,504 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Posted On |
2014-05-07 |
Incidental Mutation