Incidental Mutation 'IGL02031:Serinc2'
ID184378
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Serinc2
Ensembl Gene ENSMUSG00000023232
Gene Nameserine incorporator 2
SynonymsFKSG84, 2310004K20Rik, TDE2, Tde2l
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.090) question?
Stock #IGL02031
Quality Score
Status
Chromosome4
Chromosomal Location130253495-130279205 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to T at 130264444 bp
ZygosityHeterozygous
Amino Acid Change Tryptophan to Stop codon at position 15 (W15*)
Ref Sequence ENSEMBL: ENSMUSP00000116586 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105996] [ENSMUST00000120126] [ENSMUST00000122374] [ENSMUST00000146478] [ENSMUST00000154846]
Predicted Effect probably null
Transcript: ENSMUST00000105996
AA Change: W70*
SMART Domains Protein: ENSMUSP00000101618
Gene: ENSMUSG00000023232
AA Change: W70*

DomainStartEndE-ValueType
Pfam:Serinc 15 449 4.1e-162 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000120126
AA Change: W79*
SMART Domains Protein: ENSMUSP00000113044
Gene: ENSMUSG00000023232
AA Change: W79*

DomainStartEndE-ValueType
Pfam:Serinc 25 457 1.4e-158 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000122374
AA Change: W15*
SMART Domains Protein: ENSMUSP00000112535
Gene: ENSMUSG00000023232
AA Change: W15*

DomainStartEndE-ValueType
Pfam:Serinc 1 394 2.9e-148 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000146478
AA Change: W15*
SMART Domains Protein: ENSMUSP00000115198
Gene: ENSMUSG00000023232
AA Change: W15*

DomainStartEndE-ValueType
Pfam:Serinc 1 148 1.9e-56 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000154846
AA Change: W15*
SMART Domains Protein: ENSMUSP00000116586
Gene: ENSMUSG00000023232
AA Change: W15*

DomainStartEndE-ValueType
Pfam:Serinc 1 82 3.3e-26 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik T C 15: 8,179,769 F230S probably damaging Het
4931408C20Rik A G 1: 26,685,023 Y359H probably damaging Het
Aipl1 T C 11: 72,030,202 probably benign Het
Akap11 T C 14: 78,513,813 D378G possibly damaging Het
Ankrd33b A T 15: 31,325,183 F129L probably damaging Het
Apob A G 12: 8,015,222 K4064E probably benign Het
Arhgef10l T C 4: 140,575,345 D506G probably damaging Het
Arid4b A C 13: 14,153,412 probably benign Het
Ccdc88c A T 12: 100,933,311 Y1263N probably damaging Het
Ckap5 T C 2: 91,612,772 L1697P possibly damaging Het
Cpxm1 C T 2: 130,393,681 V464M probably damaging Het
Dhrs7c A G 11: 67,815,889 E291G probably benign Het
Dst C A 1: 34,189,917 P1872H possibly damaging Het
G6pc2 G A 2: 69,222,991 A130T probably benign Het
Gm4847 A G 1: 166,635,009 V304A probably damaging Het
Gm8267 T C 14: 44,717,917 D155G possibly damaging Het
Kank1 G A 19: 25,410,702 V580I probably benign Het
Kcnh4 A G 11: 100,745,823 S757P probably damaging Het
Krt34 C A 11: 100,039,023 A216S possibly damaging Het
Mfhas1 A T 8: 35,589,372 I334F probably damaging Het
Mrgprb8 A G 7: 48,389,339 M253V probably benign Het
Olfr503 A T 7: 108,544,930 H133L probably benign Het
Pp2d1 T A 17: 53,508,440 T419S probably damaging Het
Pprc1 T A 19: 46,072,343 probably benign Het
Reln A G 5: 21,979,016 S1662P probably damaging Het
Sema7a G A 9: 57,955,140 E209K possibly damaging Het
Serpina3k A G 12: 104,345,266 T368A probably benign Het
Setd3 A T 12: 108,163,030 W54R probably damaging Het
Slc9c1 G A 16: 45,599,470 S1001N probably benign Het
Snapc3 A G 4: 83,417,976 D75G probably benign Het
Stard9 T C 2: 120,702,339 S333P probably benign Het
Utrn T C 10: 12,735,204 D469G probably damaging Het
Other mutations in Serinc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00913:Serinc2 APN 4 130264408 missense possibly damaging 0.88
IGL02551:Serinc2 APN 4 130260774 missense probably benign 0.01
R1455:Serinc2 UTSW 4 130264340 missense probably damaging 0.96
R1520:Serinc2 UTSW 4 130260750 missense probably benign 0.00
R2059:Serinc2 UTSW 4 130260785 missense probably damaging 1.00
R2869:Serinc2 UTSW 4 130265212 missense probably damaging 1.00
R2869:Serinc2 UTSW 4 130265212 missense probably damaging 1.00
R3160:Serinc2 UTSW 4 130260735 missense probably benign
R3162:Serinc2 UTSW 4 130260735 missense probably benign
R4497:Serinc2 UTSW 4 130254054 missense possibly damaging 0.67
R4735:Serinc2 UTSW 4 130263645 missense probably benign 0.13
R4987:Serinc2 UTSW 4 130263027 splice site probably null
R5569:Serinc2 UTSW 4 130278479 missense probably benign 0.17
R5681:Serinc2 UTSW 4 130265076 missense probably damaging 1.00
R5946:Serinc2 UTSW 4 130255521 missense possibly damaging 0.91
R6556:Serinc2 UTSW 4 130258271 missense probably damaging 1.00
R6898:Serinc2 UTSW 4 130255442 missense probably benign 0.13
R7264:Serinc2 UTSW 4 130258259 missense probably benign 0.00
R7526:Serinc2 UTSW 4 130258790 missense probably benign 0.03
R7835:Serinc2 UTSW 4 130275487 missense unknown
Z1176:Serinc2 UTSW 4 130253995 missense probably damaging 1.00
Posted On2014-05-07