Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02034:Gpr45'

184447

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr45

Ensembl Gene

ENSMUSG00000041907

Gene Name

G protein-coupled receptor 45

Synonyms

PSP24alpha, 9230112G11Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.156) question?

Stock #

IGL02034

Quality Score

Status

Chromosome

Chromosomal Location

42952872-43035456 bp(+) (GRCm38)

Type of Mutation

makesense

DNA Base Change (assembly)

T to C at 43033318 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Glutamine at position 374 (*374Q)

Ref Sequence

ENSEMBL: ENSMUSP00000135986 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000114761] [ENSMUST00000179766]

AlphaFold

Q9EQQ4

Predicted Effect

probably null
Transcript: ENSMUST00000114761
AA Change: *374Q

SMART Domains

Protein: ENSMUSP00000110409
Gene: ENSMUSG00000041907
AA Change: *374Q

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	42	188	5.5e-9	PFAM
Pfam:7TM_GPCR_Srsx	45	340	1.9e-7	PFAM
Pfam:7tm_1	51	325	2.4e-52	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158463

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000179655

SMART Domains

Protein: ENSMUSP00000136725
Gene: ENSMUSG00000096364

Domain	Start	End	E-Value	Type
low complexity region	90	102	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000179766
AA Change: *374Q

SMART Domains

Protein: ENSMUSP00000135986
Gene: ENSMUSG00000041907
AA Change: *374Q

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	42	189	7.1e-9	PFAM
Pfam:7TM_GPCR_Srsx	45	340	1.9e-7	PFAM
Pfam:7tm_1	51	325	2.1e-51	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9930021J03Rik	A	G	19: 29,716,859	S1745P	possibly damaging	Het
Bcor	A	G	X: 12,039,259	S1556P	possibly damaging	Het
Ccdc6	T	A	10: 70,169,148	I241N	probably benign	Het
Cd81	T	C	7: 143,066,249	I48T	probably damaging	Het
Cfap52	A	G	11: 67,946,292		probably null	Het
Cfap54	T	C	10: 93,061,485	M264V	probably damaging	Het
Cmya5	G	A	13: 93,084,535		probably benign	Het
Csn2	A	G	5: 87,696,082		probably benign	Het
Cyfip1	G	A	7: 55,898,353	R567Q	probably damaging	Het
Ehbp1	A	G	11: 22,285,486		probably null	Het
Ermp1	G	A	19: 29,645,959		probably benign	Het
Erv3	C	T	2: 131,856,014	V142I	possibly damaging	Het
Fzd2	A	G	11: 102,604,904	N58S	probably damaging	Het
Gcm2	G	A	13: 41,105,793	R67C	probably damaging	Het
Gm17019	A	G	5: 15,030,252	I182T	possibly damaging	Het
Haus8	T	C	8: 71,255,558	N165S	probably damaging	Het
Hoxd4	T	A	2: 74,728,406	L191Q	probably damaging	Het
I830077J02Rik	A	G	3: 105,927,249		probably benign	Het
Lpl	T	C	8: 68,880,772	L7P	possibly damaging	Het
Lrp1b	T	A	2: 41,268,370	K1612*	probably null	Het
Myh14	G	T	7: 44,616,293	A1546D	possibly damaging	Het
Nbea	A	G	3: 55,968,156	S1698P	probably damaging	Het
Olfr1217	C	T	2: 89,023,671	V111M	probably benign	Het
Olfr470	G	A	7: 107,845,178	T185I	probably benign	Het
Olfr676	C	A	7: 105,035,390	T64N	probably benign	Het
Olfr9	A	T	10: 128,990,701	Q263L	probably benign	Het
Otog	A	T	7: 46,295,993	K40*	probably null	Het
Rgma	C	A	7: 73,417,433	H145Q	probably damaging	Het
Rpgrip1l	A	T	8: 91,251,148		probably null	Het
Ssxb2	T	A	X: 8,458,504		probably benign	Het
Tmem175	C	T	5: 108,642,136	T118I	probably damaging	Het
Wdhd1	A	G	14: 47,261,351	V542A	probably benign	Het
Zfp977	G	A	7: 42,580,712	P130S	probably damaging	Het

Other mutations in Gpr45

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00508:Gpr45	APN	1	43032292	missense	possibly damaging	0.77
IGL01528:Gpr45	APN	1	43033223	missense	probably benign	0.00
IGL01833:Gpr45	APN	1	43032242	missense	probably benign
IGL02230:Gpr45	APN	1	43032656	missense	probably damaging	1.00
IGL02279:Gpr45	APN	1	43032838	missense	probably damaging	0.96
IGL02394:Gpr45	APN	1	43030112	intron	probably benign
IGL02795:Gpr45	APN	1	43032493	missense	possibly damaging	0.82
IGL02902:Gpr45	APN	1	43033211	missense	possibly damaging	0.67
IGL03017:Gpr45	APN	1	43032356	missense	possibly damaging	0.95
expansive	UTSW	1	43032838	missense	probably damaging	0.96
extensive	UTSW	1	43033058	missense	probably damaging	1.00
omnipresent	UTSW	1	43032374	missense	probably damaging	1.00
R0368:Gpr45	UTSW	1	43033016	missense	probably damaging	1.00
R2964:Gpr45	UTSW	1	43032508	missense	possibly damaging	0.87
R2965:Gpr45	UTSW	1	43032508	missense	possibly damaging	0.87
R2966:Gpr45	UTSW	1	43032508	missense	possibly damaging	0.87
R4551:Gpr45	UTSW	1	43032790	missense	probably benign	0.00
R4681:Gpr45	UTSW	1	43032908	missense	probably benign	0.00
R4821:Gpr45	UTSW	1	43030453	intron	probably benign
R4966:Gpr45	UTSW	1	43033120	missense	probably benign	0.00
R5054:Gpr45	UTSW	1	43032649	missense	probably benign	0.38
R5319:Gpr45	UTSW	1	43032838	missense	probably damaging	0.96
R5667:Gpr45	UTSW	1	43033058	missense	probably damaging	1.00
R5671:Gpr45	UTSW	1	43033058	missense	probably damaging	1.00
R7250:Gpr45	UTSW	1	43032371	missense	probably damaging	1.00
R8117:Gpr45	UTSW	1	43033315	missense	probably damaging	1.00
R8393:Gpr45	UTSW	1	43032235	missense	probably benign	0.00
R8752:Gpr45	UTSW	1	43032682	missense	possibly damaging	0.94
R8927:Gpr45	UTSW	1	43033154	missense	probably damaging	0.98
R8928:Gpr45	UTSW	1	43033154	missense	probably damaging	0.98
R9316:Gpr45	UTSW	1	43032374	missense	probably damaging	1.00

Posted On

2014-05-07