Incidental Mutation 'IGL02034:Zfp977'
| ID |
184460 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp977
|
| Ensembl Gene |
ENSMUSG00000092335 |
| Gene Name |
zinc finger protein 977 |
| Synonyms |
Gm7221 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.248)
|
| Stock # |
IGL02034
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
42229207-42241971 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 42230136 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Serine
at position 130
(P130S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134517
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000173283]
[ENSMUST00000179470]
|
| AlphaFold |
L7N2E7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000173283
AA Change: P130S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000134517
Gene: ENSMUSG00000092335
AA Change: P130S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
3.82e-20 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
1.92e-2 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
5.99e-4 |
SMART |
|
ZnF_C2H2
|
215 |
237 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
243 |
265 |
7.15e-2 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
299 |
321 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
327 |
349 |
2.75e-3 |
SMART |
|
ZnF_C2H2
|
355 |
377 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
383 |
405 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
411 |
433 |
1.82e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000179470
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205775
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205970
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Bcor |
A |
G |
X: 11,905,498 (GRCm39) |
S1556P |
possibly damaging |
Het |
| Brd10 |
A |
G |
19: 29,694,259 (GRCm39) |
S1745P |
possibly damaging |
Het |
| Ccdc6 |
T |
A |
10: 70,004,978 (GRCm39) |
I241N |
probably benign |
Het |
| Cd81 |
T |
C |
7: 142,619,986 (GRCm39) |
I48T |
probably damaging |
Het |
| Cfap52 |
A |
G |
11: 67,837,118 (GRCm39) |
|
probably null |
Het |
| Cfap54 |
T |
C |
10: 92,897,347 (GRCm39) |
M264V |
probably damaging |
Het |
| Cmya5 |
G |
A |
13: 93,221,043 (GRCm39) |
|
probably benign |
Het |
| Csn2 |
A |
G |
5: 87,843,941 (GRCm39) |
|
probably benign |
Het |
| Cyfip1 |
G |
A |
7: 55,548,101 (GRCm39) |
R567Q |
probably damaging |
Het |
| Ehbp1 |
A |
G |
11: 22,235,486 (GRCm39) |
|
probably null |
Het |
| Ermp1 |
G |
A |
19: 29,623,359 (GRCm39) |
|
probably benign |
Het |
| Erv3 |
C |
T |
2: 131,697,934 (GRCm39) |
V142I |
possibly damaging |
Het |
| Fzd2 |
A |
G |
11: 102,495,730 (GRCm39) |
N58S |
probably damaging |
Het |
| Gcm2 |
G |
A |
13: 41,259,269 (GRCm39) |
R67C |
probably damaging |
Het |
| Gm17019 |
A |
G |
5: 15,080,266 (GRCm39) |
I182T |
possibly damaging |
Het |
| Gpr45 |
T |
C |
1: 43,072,478 (GRCm39) |
*374Q |
probably null |
Het |
| Haus8 |
T |
C |
8: 71,708,202 (GRCm39) |
N165S |
probably damaging |
Het |
| Hoxd4 |
T |
A |
2: 74,558,750 (GRCm39) |
L191Q |
probably damaging |
Het |
| I830077J02Rik |
A |
G |
3: 105,834,565 (GRCm39) |
|
probably benign |
Het |
| Lpl |
T |
C |
8: 69,333,424 (GRCm39) |
L7P |
possibly damaging |
Het |
| Lrp1b |
T |
A |
2: 41,158,382 (GRCm39) |
K1612* |
probably null |
Het |
| Myh14 |
G |
T |
7: 44,265,717 (GRCm39) |
A1546D |
possibly damaging |
Het |
| Nbea |
A |
G |
3: 55,875,577 (GRCm39) |
S1698P |
probably damaging |
Het |
| Or10p22 |
A |
T |
10: 128,826,570 (GRCm39) |
Q263L |
probably benign |
Het |
| Or4c112 |
C |
T |
2: 88,854,015 (GRCm39) |
V111M |
probably benign |
Het |
| Or52e7 |
C |
A |
7: 104,684,597 (GRCm39) |
T64N |
probably benign |
Het |
| Or5p51 |
G |
A |
7: 107,444,385 (GRCm39) |
T185I |
probably benign |
Het |
| Otog |
A |
T |
7: 45,945,417 (GRCm39) |
K40* |
probably null |
Het |
| Rgma |
C |
A |
7: 73,067,181 (GRCm39) |
H145Q |
probably damaging |
Het |
| Rpgrip1l |
A |
T |
8: 91,977,776 (GRCm39) |
|
probably null |
Het |
| Ssxb2 |
T |
A |
X: 8,324,743 (GRCm39) |
|
probably benign |
Het |
| Tmem175 |
C |
T |
5: 108,790,002 (GRCm39) |
T118I |
probably damaging |
Het |
| Wdhd1 |
A |
G |
14: 47,498,808 (GRCm39) |
V542A |
probably benign |
Het |
|
| Other mutations in Zfp977 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01350:Zfp977
|
APN |
7 |
42,230,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01541:Zfp977
|
APN |
7 |
42,230,156 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02678:Zfp977
|
APN |
7 |
42,232,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02684:Zfp977
|
APN |
7 |
42,232,439 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03178:Zfp977
|
APN |
7 |
42,232,072 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0707:Zfp977
|
UTSW |
7 |
42,229,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1640:Zfp977
|
UTSW |
7 |
42,229,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1668:Zfp977
|
UTSW |
7 |
42,230,070 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1993:Zfp977
|
UTSW |
7 |
42,229,409 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3151:Zfp977
|
UTSW |
7 |
42,229,870 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4587:Zfp977
|
UTSW |
7 |
42,229,614 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4678:Zfp977
|
UTSW |
7 |
42,229,437 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6073:Zfp977
|
UTSW |
7 |
42,230,165 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7054:Zfp977
|
UTSW |
7 |
42,229,786 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7436:Zfp977
|
UTSW |
7 |
42,229,884 (GRCm39) |
missense |
probably benign |
|
|
R7500:Zfp977
|
UTSW |
7 |
42,229,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8294:Zfp977
|
UTSW |
7 |
42,229,689 (GRCm39) |
missense |
probably benign |
|
|
R8418:Zfp977
|
UTSW |
7 |
42,229,410 (GRCm39) |
missense |
probably benign |
|
|
R8439:Zfp977
|
UTSW |
7 |
42,230,102 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8995:Zfp977
|
UTSW |
7 |
42,232,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9005:Zfp977
|
UTSW |
7 |
42,230,082 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9369:Zfp977
|
UTSW |
7 |
42,229,518 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0023:Zfp977
|
UTSW |
7 |
42,229,543 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2014-05-07 |
Incidental Mutation