Incidental Mutation 'IGL02036:Vmn1r173'
ID184521
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r173
Ensembl Gene ENSMUSG00000115021
Gene Namevomeronasal 1 receptor 173
SynonymsGm5892
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.524) question?
Stock #IGL02036
Quality Score
Status
Chromosome7
Chromosomal Location23700703-23711009 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 23702896 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Isoleucine at position 185 (M185I)
Ref Sequence ENSEMBL: ENSMUSP00000153884 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000174055] [ENSMUST00000226233] [ENSMUST00000227987]
Predicted Effect probably benign
Transcript: ENSMUST00000174055
AA Change: M185I

PolyPhen 2 Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000134645
Gene: ENSMUSG00000115021
AA Change: M185I

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
Pfam:V1R 43 301 5.3e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226233
AA Change: M185I

PolyPhen 2 Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)
Predicted Effect probably benign
Transcript: ENSMUST00000227987
AA Change: M185I

PolyPhen 2 Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530053A07Rik G A 7: 28,137,525 V290M possibly damaging Het
Cep290 T A 10: 100,558,100 C2056* probably null Het
Cyp2c38 T A 19: 39,460,316 D143V probably null Het
Ddx10 T C 9: 53,204,183 K617R probably benign Het
Dgat2l6 T A X: 100,545,593 I336N probably damaging Het
Dopey1 A G 9: 86,531,765 I1906M probably benign Het
Dpep3 T G 8: 105,973,785 T430P probably benign Het
Dph1 T C 11: 75,184,165 probably null Het
Epha7 T C 4: 28,950,509 S775P probably damaging Het
F5 A G 1: 164,183,002 probably benign Het
Hdx T A X: 111,659,867 T342S probably benign Het
Inpp4a T C 1: 37,377,569 probably benign Het
Itgad A G 7: 128,189,821 T515A possibly damaging Het
Kcnc2 T A 10: 112,455,926 S340T possibly damaging Het
Krba1 C T 6: 48,415,642 T830I possibly damaging Het
Lrch1 G A 14: 74,795,293 probably benign Het
Mag C T 7: 30,908,452 V295M probably damaging Het
Mmp16 T A 4: 18,093,371 D375E probably benign Het
Olfr1216 A G 2: 89,013,479 V195A probably benign Het
Olfr314 T C 11: 58,787,097 Y288H probably damaging Het
Olfr90 A G 17: 37,085,667 F166S probably damaging Het
Pcyox1l T C 18: 61,707,536 probably benign Het
Secisbp2l A G 2: 125,758,207 S403P probably benign Het
Sh3tc2 T A 18: 62,014,907 H1229Q probably benign Het
Svep1 A C 4: 58,088,245 W1735G possibly damaging Het
Tbxas1 T A 6: 39,021,157 C220S probably benign Het
Ywhag A G 5: 135,911,494 V82A probably benign Het
Other mutations in Vmn1r173
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01490:Vmn1r173 APN 7 23702707 missense probably benign 0.01
IGL01637:Vmn1r173 APN 7 23702948 missense probably damaging 0.96
IGL01878:Vmn1r173 APN 7 23702452 missense probably damaging 1.00
IGL02039:Vmn1r173 APN 7 23702896 missense probably benign 0.04
IGL02171:Vmn1r173 APN 7 23702896 missense probably benign 0.04
IGL02209:Vmn1r173 APN 7 23703161 missense probably benign 0.25
PIT4515001:Vmn1r173 UTSW 7 23702486 nonsense probably null
R0157:Vmn1r173 UTSW 7 23702397 missense probably damaging 0.99
R0226:Vmn1r173 UTSW 7 23703083 missense possibly damaging 0.65
R0482:Vmn1r173 UTSW 7 23702791 missense probably damaging 0.99
R0792:Vmn1r173 UTSW 7 23702735 missense probably benign 0.01
R1242:Vmn1r173 UTSW 7 23703225 missense probably damaging 1.00
R1390:Vmn1r173 UTSW 7 23702898 missense possibly damaging 0.82
R1641:Vmn1r173 UTSW 7 23703108 missense probably benign 0.06
R1867:Vmn1r173 UTSW 7 23703235 missense unknown
R2325:Vmn1r173 UTSW 7 23703112 nonsense probably null
R3863:Vmn1r173 UTSW 7 23702552 missense probably damaging 1.00
R4407:Vmn1r173 UTSW 7 23703016 missense probably damaging 1.00
R4717:Vmn1r173 UTSW 7 23703212 missense probably damaging 1.00
R4841:Vmn1r173 UTSW 7 23702936 missense probably damaging 1.00
R4842:Vmn1r173 UTSW 7 23702936 missense probably damaging 1.00
R5966:Vmn1r173 UTSW 7 23702687 missense probably benign 0.00
R6022:Vmn1r173 UTSW 7 23702835 missense probably benign 0.07
R6114:Vmn1r173 UTSW 7 23702829 missense possibly damaging 0.53
R6657:Vmn1r173 UTSW 7 23702895 missense probably damaging 0.98
R7165:Vmn1r173 UTSW 7 23702651 missense probably benign 0.00
R7195:Vmn1r173 UTSW 7 23702459 missense probably damaging 0.99
R7201:Vmn1r173 UTSW 7 23702158 start gained probably benign
R7533:Vmn1r173 UTSW 7 23702646 missense probably benign 0.05
R7951:Vmn1r173 UTSW 7 23703255 missense unknown
R8351:Vmn1r173 UTSW 7 23702532 nonsense probably null
R8374:Vmn1r173 UTSW 7 23702495 missense probably damaging 0.98
X0022:Vmn1r173 UTSW 7 23702587 missense probably benign 0.06
Posted On2014-05-07