Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02039:Olfr1502'

184639

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr1502

Ensembl Gene

ENSMUSG00000056858

Gene Name

olfactory receptor 1502

Synonyms

GA_x6K02T2RE5P-4193992-4194942, MOR211-1

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.095) question?

Stock #

IGL02039

Quality Score

Status

Chromosome

Chromosomal Location

13861795-13862745 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 13862719 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 309 (Q309*)

Ref Sequence

ENSEMBL: ENSMUSP00000073843 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074221]

Predicted Effect

probably null
Transcript: ENSMUST00000074221
AA Change: Q309*

SMART Domains

Protein: ENSMUSP00000073843
Gene: ENSMUSG00000056858
AA Change: Q309*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	7.1e-43	PFAM
Pfam:7tm_1	41	290	1.6e-17	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	A	11: 9,297,193	Y2313*	probably null	Het
Arhgef12	A	G	9: 42,972,267	I1323T	probably benign	Het
C87436	A	G	6: 86,453,695	M366V	probably benign	Het
Cep290	T	C	10: 100,514,602		probably null	Het
Cpsf3	T	C	12: 21,301,456	M326T	probably damaging	Het
Cpxm2	A	G	7: 132,047,753	V64A	probably damaging	Het
Csnka2ip	G	A	16: 64,478,594	S25F	probably damaging	Het
Cyfip1	T	C	7: 55,875,021	F168L	possibly damaging	Het
Dhx8	T	C	11: 101,764,027		probably null	Het
Dnah2	T	A	11: 69,499,212	I736F	probably damaging	Het
Erf	T	C	7: 25,244,544	E454G	possibly damaging	Het
Flnc	T	C	6: 29,450,719	V1482A	probably benign	Het
Fmn1	T	C	2: 113,365,080	L375P	unknown	Het
Foxm1	T	C	6: 128,369,360	Y85H	probably damaging	Het
Frem3	A	G	8: 80,612,971	E631G	probably damaging	Het
Fsip1	T	C	2: 118,240,414	D265G	probably damaging	Het
Gprc5c	C	T	11: 114,864,486	Q330*	probably null	Het
Grin1	C	T	2: 25,305,342	V246M	probably damaging	Het
Ifitm3	C	A	7: 141,010,650		probably benign	Het
Igdcc3	G	A	9: 65,183,880	V648I	probably benign	Het
Ighv5-2	A	G	12: 113,578,594	I87T	probably benign	Het
Imp4	G	A	1: 34,443,768		probably null	Het
Ino80	T	C	2: 119,380,073	N1327D	probably damaging	Het
Kif5a	T	C	10: 127,233,867	I830V	possibly damaging	Het
Mgea5	A	T	19: 45,773,703	V237E	probably damaging	Het
Muc5b	A	G	7: 141,871,164	Y4696C	possibly damaging	Het
Nrl	T	C	14: 55,522,110	E120G	probably benign	Het
Nsmaf	T	A	4: 6,424,995		probably benign	Het
Nup35	T	C	2: 80,642,775	M64T	probably benign	Het
Nxpe2	T	A	9: 48,319,659	N470I	probably benign	Het
Olfr109	T	A	17: 37,466,449	I81N	possibly damaging	Het
Os9	G	A	10: 127,096,291	P604S	possibly damaging	Het
Pitpnm1	A	G	19: 4,105,032	T287A	probably benign	Het
Pkd2l2	G	T	18: 34,435,368		probably null	Het
Pola2	A	T	19: 5,948,469	I355N	probably damaging	Het
Pp2d1	T	A	17: 53,515,994	R15*	probably null	Het
Prpf40a	T	C	2: 53,144,803	D749G	probably damaging	Het
Rhoh	T	C	5: 65,892,638	S84P	probably damaging	Het
Slc12a7	T	C	13: 73,809,094		probably null	Het
Slc37a2	A	G	9: 37,233,684	I454T	probably damaging	Het
Smarca2	A	G	19: 26,716,137	D28G	probably damaging	Het
Socs4	T	C	14: 47,290,193	I195T	probably benign	Het
Svep1	A	G	4: 58,123,980		probably null	Het
Thbd	T	C	2: 148,406,542	T469A	probably benign	Het
Thoc5	T	C	11: 4,922,027		probably null	Het
Vmn1r173	G	T	7: 23,702,896	M185I	probably benign	Het
Vmn1r59	T	C	7: 5,454,381	S127G	probably benign	Het
Vmn2r6	T	C	3: 64,556,189	E408G	probably damaging	Het
Yars	A	T	4: 129,215,259	I428F	probably damaging	Het
Zglp1	T	C	9: 21,067,039	E14G	possibly damaging	Het

Other mutations in Olfr1502

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Olfr1502	APN	19	13861786	unclassified	probably benign
IGL01061:Olfr1502	APN	19	13862705	missense	possibly damaging	0.94
IGL01534:Olfr1502	APN	19	13861919	missense	probably damaging	1.00
IGL02017:Olfr1502	APN	19	13862231	missense	possibly damaging	0.58
IGL02173:Olfr1502	APN	19	13862014	missense	probably benign	0.00
IGL02219:Olfr1502	APN	19	13861823	missense	probably damaging	1.00
IGL02475:Olfr1502	APN	19	13862299	missense	probably damaging	1.00
IGL02604:Olfr1502	APN	19	13861806	missense	probably benign	0.01
R0012:Olfr1502	UTSW	19	13861823	missense	probably damaging	0.98
R0594:Olfr1502	UTSW	19	13862279	missense	probably benign	0.04
R2184:Olfr1502	UTSW	19	13862035	missense	probably benign	0.02
R2518:Olfr1502	UTSW	19	13862309	missense	probably damaging	1.00
R5541:Olfr1502	UTSW	19	13861964	missense	probably benign
R5587:Olfr1502	UTSW	19	13862576	missense	probably damaging	1.00
R6211:Olfr1502	UTSW	19	13862574	missense	probably benign	0.01
R6351:Olfr1502	UTSW	19	13861822	missense	probably benign	0.04
R7575:Olfr1502	UTSW	19	13862017	missense	probably damaging	1.00

Posted On

2014-05-07