Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02041:Vmn2r108'

184743

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r108

Ensembl Gene

ENSMUSG00000091805

Gene Name

vomeronasal 2, receptor 108

Synonyms

EG627805

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL02041

Quality Score

Status

Chromosome

Chromosomal Location

20682635-20701498 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 20683398 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Glutamic Acid at position 602 (V602E)

Ref Sequence

ENSEMBL: ENSMUSP00000130373 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167314]

AlphaFold

E9PYS0

Predicted Effect

probably damaging
Transcript: ENSMUST00000167314
AA Change: V602E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: V602E

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	6e-33	PFAM
Pfam:NCD3G	510	563	9.2e-22	PFAM
Pfam:7tm_3	593	831	2.2e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc2	A	T	19: 43,772,674 (GRCm39)	Q28L	probably damaging	Het
Abtb3	G	A	10: 85,223,418 (GRCm39)	D76N	unknown	Het
Afg1l	A	G	10: 42,330,376 (GRCm39)	V97A	probably damaging	Het
Akap6	A	C	12: 53,187,436 (GRCm39)	S1617R	probably damaging	Het
Aldh1a3	T	C	7: 66,057,579 (GRCm39)	N285D	probably damaging	Het
Arhgap20	A	T	9: 51,757,490 (GRCm39)	N494I	possibly damaging	Het
Atg9a	G	T	1: 75,159,748 (GRCm39)	Q712K	possibly damaging	Het
Cdcp2	G	A	4: 106,964,386 (GRCm39)		probably benign	Het
Cds2	T	A	2: 132,136,363 (GRCm39)	I84N	possibly damaging	Het
Clcn3	T	C	8: 61,376,187 (GRCm39)	I596V	probably damaging	Het
Ctxn1	A	G	8: 4,308,514 (GRCm39)	L39P	probably damaging	Het
Efhb	A	T	17: 53,733,287 (GRCm39)	V528D	probably damaging	Het
Fmod	T	G	1: 133,968,001 (GRCm39)	S14A	probably benign	Het
Foxh1	A	G	15: 76,553,120 (GRCm39)	F198S	probably damaging	Het
Gcc2	A	G	10: 58,105,103 (GRCm39)	E77G	probably damaging	Het
Gm5420	G	T	10: 21,566,933 (GRCm39)		noncoding transcript	Het
Gm6434	T	G	7: 25,581,655 (GRCm39)		noncoding transcript	Het
Il1b	A	T	2: 129,211,662 (GRCm39)	N19K	possibly damaging	Het
Lama2	T	A	10: 26,860,322 (GRCm39)	D3055V	probably damaging	Het
Lcn3	G	A	2: 25,655,636 (GRCm39)	V18I	probably benign	Het
Lpcat2	A	G	8: 93,644,809 (GRCm39)	S533G	probably benign	Het
Map4k2	G	A	19: 6,401,348 (GRCm39)	R606Q	probably benign	Het
Mtnr1b	T	C	9: 15,774,589 (GRCm39)	T157A	probably benign	Het
Myo15a	G	A	11: 60,397,689 (GRCm39)	E2705K	probably damaging	Het
Ncf2	A	G	1: 152,711,871 (GRCm39)		probably benign	Het
Nfkbil1	G	A	17: 35,439,934 (GRCm39)	T193M	probably benign	Het
Nmi	T	G	2: 51,850,641 (GRCm39)	K9T	possibly damaging	Het
Or2d4	T	C	7: 106,543,320 (GRCm39)	D296G	possibly damaging	Het
Or5p69	T	C	7: 107,966,742 (GRCm39)	F15S	probably damaging	Het
Or6c6c	A	G	10: 129,541,104 (GRCm39)	D119G	probably damaging	Het
Osbpl7	T	A	11: 96,951,334 (GRCm39)	C502S	probably benign	Het
Pex5	A	T	6: 124,382,240 (GRCm39)		probably benign	Het
Pkhd1l1	T	A	15: 44,356,452 (GRCm39)		probably null	Het
Prmt3	C	T	7: 49,478,711 (GRCm39)	T424M	possibly damaging	Het
Rapgef4	G	A	2: 72,029,140 (GRCm39)	G404D	probably damaging	Het
Rbm5	C	T	9: 107,633,045 (GRCm39)		probably benign	Het
Rfc2	T	A	5: 134,623,098 (GRCm39)	F238L	probably benign	Het
Rsl1	A	G	13: 67,324,612 (GRCm39)	E46G	probably damaging	Het
Sall1	A	G	8: 89,758,097 (GRCm39)	F669S	probably damaging	Het
Sipa1l2	A	G	8: 126,218,558 (GRCm39)	S260P	probably benign	Het
Slc26a8	A	G	17: 28,861,225 (GRCm39)	Y820H	probably damaging	Het
Tas2r115	A	G	6: 132,714,430 (GRCm39)	F174L	probably benign	Het
Terb1	A	C	8: 105,221,746 (GRCm39)	C185G	probably damaging	Het
Vmn2r58	T	A	7: 41,514,703 (GRCm39)	I89F	probably damaging	Het
Vps13b	G	T	15: 35,423,391 (GRCm39)	R237L	probably damaging	Het
Zfp865	T	C	7: 5,034,372 (GRCm39)	S786P	probably benign	Het

Other mutations in Vmn2r108

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00903:Vmn2r108	APN	17	20,682,774 (GRCm39)	missense	probably damaging	0.98
IGL01143:Vmn2r108	APN	17	20,682,727 (GRCm39)	missense	possibly damaging	0.82
IGL01311:Vmn2r108	APN	17	20,682,939 (GRCm39)	nonsense	probably null
IGL01411:Vmn2r108	APN	17	20,691,282 (GRCm39)	missense	probably benign	0.01
IGL01414:Vmn2r108	APN	17	20,691,942 (GRCm39)	missense	probably benign	0.00
IGL01536:Vmn2r108	APN	17	20,683,543 (GRCm39)	missense	probably damaging	1.00
IGL01748:Vmn2r108	APN	17	20,683,476 (GRCm39)	missense	probably benign	0.03
IGL01769:Vmn2r108	APN	17	20,691,280 (GRCm39)	missense	probably benign	0.02
IGL02022:Vmn2r108	APN	17	20,691,987 (GRCm39)	missense	possibly damaging	0.77
IGL02049:Vmn2r108	APN	17	20,691,608 (GRCm39)	missense	probably benign	0.00
IGL02344:Vmn2r108	APN	17	20,689,405 (GRCm39)	missense	probably damaging	1.00
IGL02939:Vmn2r108	APN	17	20,691,545 (GRCm39)	missense	probably benign	0.05
IGL03202:Vmn2r108	APN	17	20,691,319 (GRCm39)	nonsense	probably null
PIT4498001:Vmn2r108	UTSW	17	20,683,279 (GRCm39)	missense	probably damaging	1.00
R0112:Vmn2r108	UTSW	17	20,691,897 (GRCm39)	missense	probably benign	0.07
R0505:Vmn2r108	UTSW	17	20,683,096 (GRCm39)	missense	possibly damaging	0.77
R0833:Vmn2r108	UTSW	17	20,691,721 (GRCm39)	missense	probably benign
R0836:Vmn2r108	UTSW	17	20,691,721 (GRCm39)	missense	probably benign
R0943:Vmn2r108	UTSW	17	20,691,397 (GRCm39)	nonsense	probably null
R1411:Vmn2r108	UTSW	17	20,683,107 (GRCm39)	missense	probably damaging	0.98
R1442:Vmn2r108	UTSW	17	20,692,623 (GRCm39)	nonsense	probably null
R1587:Vmn2r108	UTSW	17	20,692,383 (GRCm39)	missense	probably damaging	1.00
R1751:Vmn2r108	UTSW	17	20,682,786 (GRCm39)	missense	probably damaging	1.00
R1773:Vmn2r108	UTSW	17	20,689,335 (GRCm39)	missense	probably damaging	1.00
R2021:Vmn2r108	UTSW	17	20,691,252 (GRCm39)	missense	probably benign	0.00
R2159:Vmn2r108	UTSW	17	20,689,363 (GRCm39)	missense	probably benign	0.41
R2224:Vmn2r108	UTSW	17	20,701,295 (GRCm39)	nonsense	probably null
R2226:Vmn2r108	UTSW	17	20,701,295 (GRCm39)	nonsense	probably null
R2517:Vmn2r108	UTSW	17	20,692,577 (GRCm39)	missense	probably damaging	1.00
R3710:Vmn2r108	UTSW	17	20,682,932 (GRCm39)	missense	probably benign
R4470:Vmn2r108	UTSW	17	20,682,990 (GRCm39)	missense	probably damaging	1.00
R4686:Vmn2r108	UTSW	17	20,691,636 (GRCm39)	missense	probably damaging	0.99
R4729:Vmn2r108	UTSW	17	20,692,632 (GRCm39)	missense	probably damaging	0.99
R4799:Vmn2r108	UTSW	17	20,682,891 (GRCm39)	missense	probably damaging	1.00
R4993:Vmn2r108	UTSW	17	20,701,449 (GRCm39)	missense	probably benign	0.04
R5088:Vmn2r108	UTSW	17	20,690,454 (GRCm39)	missense	possibly damaging	0.46
R5213:Vmn2r108	UTSW	17	20,691,755 (GRCm39)	missense	probably benign	0.00
R5289:Vmn2r108	UTSW	17	20,691,866 (GRCm39)	missense	probably damaging	1.00
R5290:Vmn2r108	UTSW	17	20,691,665 (GRCm39)	missense	probably benign	0.00
R5713:Vmn2r108	UTSW	17	20,691,290 (GRCm39)	missense	probably damaging	1.00
R5753:Vmn2r108	UTSW	17	20,683,179 (GRCm39)	missense	probably damaging	0.99
R5792:Vmn2r108	UTSW	17	20,683,398 (GRCm39)	missense	probably damaging	0.99
R5798:Vmn2r108	UTSW	17	20,692,545 (GRCm39)	missense	probably benign	0.39
R5897:Vmn2r108	UTSW	17	20,691,580 (GRCm39)	missense	probably benign	0.01
R6018:Vmn2r108	UTSW	17	20,683,268 (GRCm39)	missense	possibly damaging	0.83
R6093:Vmn2r108	UTSW	17	20,701,402 (GRCm39)	missense	probably benign	0.00
R6156:Vmn2r108	UTSW	17	20,692,447 (GRCm39)	missense	probably benign	0.03
R6199:Vmn2r108	UTSW	17	20,682,644 (GRCm39)	missense	probably benign	0.01
R6259:Vmn2r108	UTSW	17	20,683,371 (GRCm39)	missense	possibly damaging	0.95
R6309:Vmn2r108	UTSW	17	20,691,660 (GRCm39)	missense	probably damaging	0.98
R6324:Vmn2r108	UTSW	17	20,691,977 (GRCm39)	nonsense	probably null
R6364:Vmn2r108	UTSW	17	20,691,260 (GRCm39)	missense	probably benign	0.00
R6446:Vmn2r108	UTSW	17	20,692,609 (GRCm39)	nonsense	probably null
R6541:Vmn2r108	UTSW	17	20,701,480 (GRCm39)	missense	probably benign	0.02
R7025:Vmn2r108	UTSW	17	20,691,345 (GRCm39)	missense	possibly damaging	0.67
R7063:Vmn2r108	UTSW	17	20,701,410 (GRCm39)	missense	probably damaging	1.00
R7092:Vmn2r108	UTSW	17	20,701,338 (GRCm39)	missense	probably benign	0.10
R7096:Vmn2r108	UTSW	17	20,682,762 (GRCm39)	missense	probably damaging	1.00
R7203:Vmn2r108	UTSW	17	20,683,038 (GRCm39)	missense	probably benign	0.12
R7458:Vmn2r108	UTSW	17	20,692,532 (GRCm39)	missense	probably benign	0.17
R7619:Vmn2r108	UTSW	17	20,692,457 (GRCm39)	missense	probably benign	0.02
R7841:Vmn2r108	UTSW	17	20,690,305 (GRCm39)	critical splice donor site	probably null
R7944:Vmn2r108	UTSW	17	20,691,890 (GRCm39)	missense	probably damaging	0.99
R8048:Vmn2r108	UTSW	17	20,691,762 (GRCm39)	missense	probably benign	0.29
R8213:Vmn2r108	UTSW	17	20,690,350 (GRCm39)	missense	probably benign	0.03
R8218:Vmn2r108	UTSW	17	20,683,465 (GRCm39)	missense	probably damaging	1.00
R8507:Vmn2r108	UTSW	17	20,683,195 (GRCm39)	nonsense	probably null
R8708:Vmn2r108	UTSW	17	20,682,687 (GRCm39)	missense	probably damaging	0.98
R8845:Vmn2r108	UTSW	17	20,691,361 (GRCm39)	missense	probably benign	0.03
R9030:Vmn2r108	UTSW	17	20,690,312 (GRCm39)	missense	probably benign	0.01
R9226:Vmn2r108	UTSW	17	20,691,330 (GRCm39)	missense	probably benign
R9278:Vmn2r108	UTSW	17	20,692,561 (GRCm39)	missense	probably benign	0.11
X0022:Vmn2r108	UTSW	17	20,691,371 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r108	UTSW	17	20,691,375 (GRCm39)	missense	probably benign	0.01
Z1177:Vmn2r108	UTSW	17	20,691,219 (GRCm39)	missense	probably damaging	0.99

Posted On

2014-05-07