Incidental Mutation 'IGL02041:Ncf2'
| ID |
184772 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Ncf2
|
| Ensembl Gene |
ENSMUSG00000026480 |
| Gene Name |
neutrophil cytosolic factor 2 |
| Synonyms |
NADPH oxidase subunit (67kDa), Ncf-2, p67phox, NOXA2 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.087)
|
| Stock # |
IGL02041
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
1 |
| Chromosomal Location |
152675945-152712742 bp(+) (GRCm39) |
| Type of Mutation |
utr 3 prime |
| DNA Base Change (assembly) |
A to G
at 152711871 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140404
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027754]
[ENSMUST00000043560]
[ENSMUST00000073441]
[ENSMUST00000111836]
[ENSMUST00000186568]
|
| AlphaFold |
O70145 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000027754
|
| SMART Domains |
Protein: ENSMUSP00000027754
Gene: ENSMUSG00000026480
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
37 |
70 |
1.42e0 |
SMART |
|
TPR
|
71 |
104 |
3.58e-6 |
SMART |
|
TPR
|
121 |
154 |
1.05e1 |
SMART |
|
SH3
|
243 |
298 |
1.02e-13 |
SMART |
|
low complexity region
|
312 |
326 |
N/A |
INTRINSIC |
|
PB1
|
350 |
428 |
2.6e-10 |
SMART |
|
SH3
|
459 |
514 |
8.36e-19 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000043560
|
| SMART Domains |
Protein: ENSMUSP00000041241
Gene: ENSMUSG00000042772
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:EST1
|
63 |
177 |
3.4e-30 |
PFAM |
|
Pfam:EST1_DNA_bind
|
179 |
438 |
3.3e-64 |
PFAM |
|
low complexity region
|
457 |
465 |
N/A |
INTRINSIC |
|
low complexity region
|
615 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
682 |
710 |
N/A |
INTRINSIC |
|
low complexity region
|
711 |
729 |
N/A |
INTRINSIC |
|
low complexity region
|
874 |
898 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
922 |
N/A |
INTRINSIC |
|
low complexity region
|
931 |
947 |
N/A |
INTRINSIC |
|
low complexity region
|
1008 |
1034 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1140 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000073441
|
| SMART Domains |
Protein: ENSMUSP00000073144
Gene: ENSMUSG00000042772
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:EST1
|
52 |
172 |
2.3e-26 |
PFAM |
|
Pfam:EST1_DNA_bind
|
171 |
430 |
3.6e-66 |
PFAM |
|
low complexity region
|
449 |
457 |
N/A |
INTRINSIC |
|
low complexity region
|
653 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
748 |
N/A |
INTRINSIC |
|
low complexity region
|
749 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
919 |
935 |
N/A |
INTRINSIC |
|
low complexity region
|
996 |
1022 |
N/A |
INTRINSIC |
|
low complexity region
|
1114 |
1128 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111836
|
| SMART Domains |
Protein: ENSMUSP00000107467
Gene: ENSMUSG00000042772
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:EST1
|
52 |
172 |
2.3e-26 |
PFAM |
|
Pfam:EST1_DNA_bind
|
171 |
430 |
3.7e-66 |
PFAM |
|
low complexity region
|
449 |
457 |
N/A |
INTRINSIC |
|
low complexity region
|
607 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
674 |
702 |
N/A |
INTRINSIC |
|
low complexity region
|
703 |
721 |
N/A |
INTRINSIC |
|
low complexity region
|
866 |
890 |
N/A |
INTRINSIC |
|
low complexity region
|
898 |
914 |
N/A |
INTRINSIC |
|
low complexity region
|
923 |
939 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1026 |
N/A |
INTRINSIC |
|
low complexity region
|
1118 |
1132 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186568
|
| SMART Domains |
Protein: ENSMUSP00000140404
Gene: ENSMUSG00000026480
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
37 |
70 |
1.42e0 |
SMART |
|
TPR
|
71 |
104 |
3.58e-6 |
SMART |
|
TPR
|
121 |
154 |
1.05e1 |
SMART |
|
SH3
|
243 |
298 |
1.02e-13 |
SMART |
|
low complexity region
|
312 |
326 |
N/A |
INTRINSIC |
|
PB1
|
350 |
428 |
2.6e-10 |
SMART |
|
SH3
|
459 |
514 |
8.36e-19 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 46 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc2 |
A |
T |
19: 43,772,674 (GRCm39) |
Q28L |
probably damaging |
Het |
| Abtb3 |
G |
A |
10: 85,223,418 (GRCm39) |
D76N |
unknown |
Het |
| Afg1l |
A |
G |
10: 42,330,376 (GRCm39) |
V97A |
probably damaging |
Het |
| Akap6 |
A |
C |
12: 53,187,436 (GRCm39) |
S1617R |
probably damaging |
Het |
| Aldh1a3 |
T |
C |
7: 66,057,579 (GRCm39) |
N285D |
probably damaging |
Het |
| Arhgap20 |
A |
T |
9: 51,757,490 (GRCm39) |
N494I |
possibly damaging |
Het |
| Atg9a |
G |
T |
1: 75,159,748 (GRCm39) |
Q712K |
possibly damaging |
Het |
| Cdcp2 |
G |
A |
4: 106,964,386 (GRCm39) |
|
probably benign |
Het |
| Cds2 |
T |
A |
2: 132,136,363 (GRCm39) |
I84N |
possibly damaging |
Het |
| Clcn3 |
T |
C |
8: 61,376,187 (GRCm39) |
I596V |
probably damaging |
Het |
| Ctxn1 |
A |
G |
8: 4,308,514 (GRCm39) |
L39P |
probably damaging |
Het |
| Efhb |
A |
T |
17: 53,733,287 (GRCm39) |
V528D |
probably damaging |
Het |
| Fmod |
T |
G |
1: 133,968,001 (GRCm39) |
S14A |
probably benign |
Het |
| Foxh1 |
A |
G |
15: 76,553,120 (GRCm39) |
F198S |
probably damaging |
Het |
| Gcc2 |
A |
G |
10: 58,105,103 (GRCm39) |
E77G |
probably damaging |
Het |
| Gm5420 |
G |
T |
10: 21,566,933 (GRCm39) |
|
noncoding transcript |
Het |
| Gm6434 |
T |
G |
7: 25,581,655 (GRCm39) |
|
noncoding transcript |
Het |
| Il1b |
A |
T |
2: 129,211,662 (GRCm39) |
N19K |
possibly damaging |
Het |
| Lama2 |
T |
A |
10: 26,860,322 (GRCm39) |
D3055V |
probably damaging |
Het |
| Lcn3 |
G |
A |
2: 25,655,636 (GRCm39) |
V18I |
probably benign |
Het |
| Lpcat2 |
A |
G |
8: 93,644,809 (GRCm39) |
S533G |
probably benign |
Het |
| Map4k2 |
G |
A |
19: 6,401,348 (GRCm39) |
R606Q |
probably benign |
Het |
| Mtnr1b |
T |
C |
9: 15,774,589 (GRCm39) |
T157A |
probably benign |
Het |
| Myo15a |
G |
A |
11: 60,397,689 (GRCm39) |
E2705K |
probably damaging |
Het |
| Nfkbil1 |
G |
A |
17: 35,439,934 (GRCm39) |
T193M |
probably benign |
Het |
| Nmi |
T |
G |
2: 51,850,641 (GRCm39) |
K9T |
possibly damaging |
Het |
| Or2d4 |
T |
C |
7: 106,543,320 (GRCm39) |
D296G |
possibly damaging |
Het |
| Or5p69 |
T |
C |
7: 107,966,742 (GRCm39) |
F15S |
probably damaging |
Het |
| Or6c6c |
A |
G |
10: 129,541,104 (GRCm39) |
D119G |
probably damaging |
Het |
| Osbpl7 |
T |
A |
11: 96,951,334 (GRCm39) |
C502S |
probably benign |
Het |
| Pex5 |
A |
T |
6: 124,382,240 (GRCm39) |
|
probably benign |
Het |
| Pkhd1l1 |
T |
A |
15: 44,356,452 (GRCm39) |
|
probably null |
Het |
| Prmt3 |
C |
T |
7: 49,478,711 (GRCm39) |
T424M |
possibly damaging |
Het |
| Rapgef4 |
G |
A |
2: 72,029,140 (GRCm39) |
G404D |
probably damaging |
Het |
| Rbm5 |
C |
T |
9: 107,633,045 (GRCm39) |
|
probably benign |
Het |
| Rfc2 |
T |
A |
5: 134,623,098 (GRCm39) |
F238L |
probably benign |
Het |
| Rsl1 |
A |
G |
13: 67,324,612 (GRCm39) |
E46G |
probably damaging |
Het |
| Sall1 |
A |
G |
8: 89,758,097 (GRCm39) |
F669S |
probably damaging |
Het |
| Sipa1l2 |
A |
G |
8: 126,218,558 (GRCm39) |
S260P |
probably benign |
Het |
| Slc26a8 |
A |
G |
17: 28,861,225 (GRCm39) |
Y820H |
probably damaging |
Het |
| Tas2r115 |
A |
G |
6: 132,714,430 (GRCm39) |
F174L |
probably benign |
Het |
| Terb1 |
A |
C |
8: 105,221,746 (GRCm39) |
C185G |
probably damaging |
Het |
| Vmn2r108 |
A |
T |
17: 20,683,398 (GRCm39) |
V602E |
probably damaging |
Het |
| Vmn2r58 |
T |
A |
7: 41,514,703 (GRCm39) |
I89F |
probably damaging |
Het |
| Vps13b |
G |
T |
15: 35,423,391 (GRCm39) |
R237L |
probably damaging |
Het |
| Zfp865 |
T |
C |
7: 5,034,372 (GRCm39) |
S786P |
probably benign |
Het |
|
| Other mutations in Ncf2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00572:Ncf2
|
APN |
1 |
152,683,925 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL00952:Ncf2
|
APN |
1 |
152,711,857 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01504:Ncf2
|
APN |
1 |
152,709,080 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01693:Ncf2
|
APN |
1 |
152,700,074 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02005:Ncf2
|
APN |
1 |
152,692,803 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL02327:Ncf2
|
APN |
1 |
152,692,744 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02366:Ncf2
|
APN |
1 |
152,710,824 (GRCm39) |
missense |
probably benign |
|
|
IGL02627:Ncf2
|
APN |
1 |
152,686,759 (GRCm39) |
splice site |
probably benign |
|
|
R0560:Ncf2
|
UTSW |
1 |
152,697,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1136:Ncf2
|
UTSW |
1 |
152,706,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1640:Ncf2
|
UTSW |
1 |
152,683,784 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R1673:Ncf2
|
UTSW |
1 |
152,706,230 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1836:Ncf2
|
UTSW |
1 |
152,683,822 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1873:Ncf2
|
UTSW |
1 |
152,701,661 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1940:Ncf2
|
UTSW |
1 |
152,709,815 (GRCm39) |
splice site |
probably benign |
|
|
R1967:Ncf2
|
UTSW |
1 |
152,706,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3405:Ncf2
|
UTSW |
1 |
152,701,698 (GRCm39) |
unclassified |
probably benign |
|
|
R3406:Ncf2
|
UTSW |
1 |
152,701,698 (GRCm39) |
unclassified |
probably benign |
|
|
R4501:Ncf2
|
UTSW |
1 |
152,710,784 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4503:Ncf2
|
UTSW |
1 |
152,709,529 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4563:Ncf2
|
UTSW |
1 |
152,683,976 (GRCm39) |
intron |
probably benign |
|
|
R5841:Ncf2
|
UTSW |
1 |
152,697,269 (GRCm39) |
splice site |
silent |
|
|
R6336:Ncf2
|
UTSW |
1 |
152,709,821 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6385:Ncf2
|
UTSW |
1 |
152,706,173 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6522:Ncf2
|
UTSW |
1 |
152,703,214 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6811:Ncf2
|
UTSW |
1 |
152,711,791 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7048:Ncf2
|
UTSW |
1 |
152,683,921 (GRCm39) |
missense |
probably benign |
|
|
R8224:Ncf2
|
UTSW |
1 |
152,706,144 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8256:Ncf2
|
UTSW |
1 |
152,692,851 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8863:Ncf2
|
UTSW |
1 |
152,711,864 (GRCm39) |
makesense |
probably null |
|
|
X0066:Ncf2
|
UTSW |
1 |
152,686,730 (GRCm39) |
start codon destroyed |
probably null |
0.27 |
|
Z1177:Ncf2
|
UTSW |
1 |
152,701,693 (GRCm39) |
critical splice donor site |
probably null |
|
|
| Posted On |
2014-05-07 |
Incidental Mutation