Incidental Mutation 'IGL02043:Gm4841'
ID184835
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm4841
Ensembl Gene ENSMUSG00000068606
Gene Namepredicted gene 4841
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #IGL02043
Quality Score
Status
Chromosome18
Chromosomal Location60268301-60273267 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 60270965 bp
ZygosityHeterozygous
Amino Acid Change Serine to Alanine at position 19 (S19A)
Ref Sequence ENSEMBL: ENSMUSP00000087727 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090260]
Predicted Effect probably benign
Transcript: ENSMUST00000090260
AA Change: S19A

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000087727
Gene: ENSMUSG00000068606
AA Change: S19A

DomainStartEndE-ValueType
Pfam:IIGP 36 409 1.2e-129 PFAM
Pfam:MMR_HSR1 72 185 2.2e-11 PFAM
Pfam:Roc 72 188 1.9e-8 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610037L13Rik T G 4: 107,894,868 probably benign Het
Atp1b2 T C 11: 69,605,276 T33A probably benign Het
Brd2 A T 17: 34,112,616 probably benign Het
Carmil1 T C 13: 24,024,316 probably benign Het
Cdh9 A T 15: 16,856,232 D786V probably damaging Het
Cep128 A C 12: 91,266,730 probably benign Het
Cep85 T C 4: 134,155,727 T284A probably benign Het
Chrna1 C T 2: 73,568,106 E330K probably benign Het
Clec2l T C 6: 38,676,850 Y104H probably damaging Het
Clybl G T 14: 122,379,252 K226N probably damaging Het
Cmip T A 8: 117,445,328 D467E probably benign Het
Cpne3 A T 4: 19,543,340 probably null Het
Crisp4 A G 1: 18,134,100 V46A probably damaging Het
Csnk2a1 T C 2: 152,274,150 Y261H probably damaging Het
Cul5 C A 9: 53,658,673 G86V probably benign Het
Depdc7 T C 2: 104,730,281 T123A probably benign Het
Edem2 T C 2: 155,705,741 T384A probably damaging Het
F8 C T X: 75,332,641 M377I probably benign Het
Fan1 T A 7: 64,371,619 probably null Het
Fez2 T C 17: 78,381,622 D366G probably damaging Het
Gm4862 T A 3: 139,128,635 noncoding transcript Het
Hk3 T A 13: 55,015,095 Q44L probably damaging Het
Irgm1 C A 11: 48,866,815 L56F probably damaging Het
Ldlr A G 9: 21,733,499 T108A probably benign Het
Lgr4 T A 2: 110,011,290 M516K probably damaging Het
Lrp1b T C 2: 40,697,525 N3906S probably null Het
Lrrtm4 A G 6: 80,021,862 N86D possibly damaging Het
Map3k2 A G 18: 32,207,534 D198G probably damaging Het
Mapkapk3 C T 9: 107,262,422 probably null Het
Mvp A T 7: 126,993,618 Y374N probably damaging Het
Myo3a T C 2: 22,399,965 S711P probably benign Het
Myom3 A G 4: 135,770,675 K189E probably damaging Het
Naip1 T A 13: 100,426,796 K620N probably benign Het
Nlrp10 T C 7: 108,925,502 E257G probably damaging Het
Nptn T G 9: 58,640,729 M139R possibly damaging Het
Nrk T G X: 138,988,795 M1105R possibly damaging Het
Olfr357 T A 2: 36,997,465 Y218* probably null Het
Olfr519 A T 7: 108,893,839 C189* probably null Het
Olfr963 T G 9: 39,669,078 V7G probably damaging Het
Pcdhb16 A G 18: 37,479,195 T403A probably benign Het
Pcyt1b A G X: 93,702,116 E50G possibly damaging Het
Pigg C T 5: 108,344,324 T892I probably damaging Het
Ppig T G 2: 69,735,983 probably null Het
Prr12 A G 7: 45,050,005 probably benign Het
Slc5a5 G T 8: 70,892,429 A78E possibly damaging Het
Slc7a2 T G 8: 40,911,058 M436R probably benign Het
Sp7 T A 15: 102,359,255 M39L probably benign Het
Spag8 T A 4: 43,653,134 probably benign Het
Svep1 A G 4: 58,068,556 S3077P probably benign Het
Tmem30a A T 9: 79,774,089 probably benign Het
Tmem63a C T 1: 180,972,788 T714I probably benign Het
Trank1 T C 9: 111,363,960 L535P probably damaging Het
Tuba8 A C 6: 121,220,511 N44T probably benign Het
Wnk1 A G 6: 119,949,078 probably benign Het
Zfp654 A T 16: 64,785,028 I396K probably benign Het
Other mutations in Gm4841
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01102:Gm4841 APN 18 60270052 missense probably damaging 1.00
IGL02751:Gm4841 APN 18 60271021 utr 5 prime probably benign
R0277:Gm4841 UTSW 18 60270646 missense possibly damaging 0.83
R0323:Gm4841 UTSW 18 60270646 missense possibly damaging 0.83
R0616:Gm4841 UTSW 18 60270937 missense probably benign 0.00
R0882:Gm4841 UTSW 18 60269780 missense possibly damaging 0.92
R1778:Gm4841 UTSW 18 60270948 nonsense probably null
R2035:Gm4841 UTSW 18 60269857 missense probably benign 0.29
R2513:Gm4841 UTSW 18 60270905 missense probably damaging 1.00
R4242:Gm4841 UTSW 18 60270683 missense probably benign 0.05
R4295:Gm4841 UTSW 18 60270190 missense probably benign 0.01
R4574:Gm4841 UTSW 18 60269926 missense probably benign 0.02
R4720:Gm4841 UTSW 18 60270063 missense probably benign 0.00
R5273:Gm4841 UTSW 18 60270743 missense probably benign 0.00
R5314:Gm4841 UTSW 18 60270292 missense probably benign 0.13
R5378:Gm4841 UTSW 18 60271041 critical splice acceptor site probably null
R5902:Gm4841 UTSW 18 60270796 missense probably damaging 1.00
R5908:Gm4841 UTSW 18 60270434 missense possibly damaging 0.89
R6361:Gm4841 UTSW 18 60270760 missense probably damaging 1.00
R6677:Gm4841 UTSW 18 60270580 missense probably damaging 1.00
Posted On2014-05-07