Incidental Mutation 'IGL02044:Gm17727'
ID184887
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm17727
Ensembl Gene ENSMUSG00000090738
Gene Namepredicted gene, 17727
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #IGL02044
Quality Score
Status
Chromosome9
Chromosomal Location35776524-35778109 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 35776663 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Glutamic Acid at position 94 (K94E)
Ref Sequence ENSEMBL: ENSMUSP00000129553 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171898] [ENSMUST00000184431]
Predicted Effect probably benign
Transcript: ENSMUST00000171898
AA Change: K94E

PolyPhen 2 Score 0.189 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000129553
Gene: ENSMUSG00000090738
AA Change: K94E

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000184431
SMART Domains Protein: ENSMUSP00000139380
Gene: ENSMUSG00000098847

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
low complexity region 32 43 N/A INTRINSIC
low complexity region 64 81 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam8 T C 7: 139,982,822 D772G possibly damaging Het
Atp6v0a2 T A 5: 124,646,014 N267K probably benign Het
Cx3cl1 T A 8: 94,780,540 V391D probably damaging Het
Dscaml1 C T 9: 45,746,943 R1671* probably null Het
Dzip3 A T 16: 48,948,427 S443T possibly damaging Het
Hrh2 A T 13: 54,214,946 T314S probably benign Het
Ifi206 C T 1: 173,480,991 V480M probably benign Het
Krt84 A G 15: 101,528,496 Y368H probably damaging Het
Lama1 T C 17: 67,811,490 S2566P probably benign Het
Lyst T A 13: 13,712,846 F3087I probably damaging Het
Map3k19 A T 1: 127,823,505 L703H probably damaging Het
Olfr150 C T 9: 39,736,974 S53L possibly damaging Het
Olfr25 A G 9: 38,330,165 S193G probably benign Het
Pard6a A G 8: 105,703,019 D203G probably damaging Het
Pde8a T C 7: 81,317,449 probably null Het
Pdia6 C A 12: 17,283,226 T400K probably damaging Het
Pdzd8 A T 19: 59,315,292 V354D possibly damaging Het
Sec13 A G 6: 113,736,420 I39T probably damaging Het
Smyd3 C T 1: 178,972,279 S365N probably benign Het
Sorcs1 A G 19: 50,288,159 probably benign Het
Tjp2 T G 19: 24,120,840 Y486S probably damaging Het
Tlr13 T C X: 106,157,097 F147L probably damaging Het
Ulk2 T A 11: 61,781,639 N958Y probably damaging Het
Unk T A 11: 116,049,328 M169K probably damaging Het
Wdr27 T C 17: 14,901,769 Y625C possibly damaging Het
Other mutations in Gm17727
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Gm17727 APN 9 35776748 missense possibly damaging 0.73
IGL02352:Gm17727 APN 9 35777884 start codon destroyed probably null 0.04
IGL02359:Gm17727 APN 9 35777884 start codon destroyed probably null 0.04
R0827:Gm17727 UTSW 9 35777851 missense probably damaging 0.97
R1382:Gm17727 UTSW 9 35778094 start gained probably benign
R1591:Gm17727 UTSW 9 35776656 missense probably damaging 0.99
R1794:Gm17727 UTSW 9 35777122 missense probably benign 0.01
R5419:Gm17727 UTSW 9 35778111 unclassified probably null
R6110:Gm17727 UTSW 9 35777146 missense possibly damaging 0.90
R6379:Gm17727 UTSW 9 35778085 start gained probably benign
R6614:Gm17727 UTSW 9 35777125 missense probably damaging 0.99
R7698:Gm17727 UTSW 9 35777176 missense probably benign 0.27
R7833:Gm17727 UTSW 9 35777110 missense probably damaging 1.00
R7916:Gm17727 UTSW 9 35777110 missense probably damaging 1.00
Posted On2014-05-07