Incidental Mutation 'IGL02045:Or4d10b'
ID 184894
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or4d10b
Ensembl Gene ENSMUSG00000067528
Gene Name olfactory receptor family 4 subfamily D member 10B
Synonyms GA_x6K02T2RE5P-2418550-2417609, MOR239-2, Olfr1424
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # IGL02045
Quality Score
Status
Chromosome 19
Chromosomal Location 12036173-12037114 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 12036253 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 288 (T288A)
Ref Sequence ENSEMBL: ENSMUSP00000146552 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087830] [ENSMUST00000207681]
AlphaFold Q8VFV1
Predicted Effect possibly damaging
Transcript: ENSMUST00000087830
AA Change: T288A

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000085132
Gene: ENSMUSG00000067528
AA Change: T288A

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 2.4e-47 PFAM
Pfam:7tm_1 41 306 2.8e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000207681
AA Change: T288A

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb C A 5: 114,378,721 (GRCm39) H2044Q possibly damaging Het
Ankrd12 A T 17: 66,293,244 (GRCm39) S730T probably benign Het
Ano9 A T 7: 140,682,382 (GRCm39) N655K probably benign Het
Ap1ar A T 3: 127,609,298 (GRCm39) Y108N probably damaging Het
Asap3 A G 4: 135,954,752 (GRCm39) I55V probably benign Het
Barx2 T C 9: 31,770,094 (GRCm39) T145A probably damaging Het
Camta1 T C 4: 151,158,442 (GRCm39) probably null Het
Ces2e C T 8: 105,657,290 (GRCm39) probably benign Het
Cflar T C 1: 58,791,903 (GRCm39) I405T probably benign Het
Cibar2 T A 8: 120,896,461 (GRCm39) K174* probably null Het
Cyp51 A G 5: 4,133,247 (GRCm39) S464P probably damaging Het
Ermard G A 17: 15,271,826 (GRCm39) probably benign Het
Glb1l2 T C 9: 26,707,841 (GRCm39) T49A probably benign Het
Gls A G 1: 52,258,674 (GRCm39) V198A probably benign Het
Heatr5b A T 17: 79,115,855 (GRCm39) I867N probably damaging Het
Ighv1-14 A T 12: 114,610,334 (GRCm39) noncoding transcript Het
Iqsec1 T C 6: 90,641,051 (GRCm39) K1022E probably damaging Het
Myo10 A G 15: 25,726,574 (GRCm39) T299A probably benign Het
Nr2e3 A T 9: 59,856,291 (GRCm39) M82K probably benign Het
Ntpcr A G 8: 126,472,191 (GRCm39) probably benign Het
Or1e26 A G 11: 73,480,058 (GRCm39) C169R probably damaging Het
Or52s6 A G 7: 103,092,159 (GRCm39) L57P probably damaging Het
Or5p80 A G 7: 108,229,739 (GRCm39) D180G probably damaging Het
Or6c70 A T 10: 129,710,091 (GRCm39) D178E probably benign Het
Prkcb A G 7: 122,189,390 (GRCm39) D506G probably damaging Het
Rasgef1a A G 6: 118,066,404 (GRCm39) I470V probably benign Het
Rbm27 A G 18: 42,452,978 (GRCm39) E514G possibly damaging Het
Rgs22 G A 15: 36,013,300 (GRCm39) A1048V probably benign Het
Secisbp2l A G 2: 125,617,498 (GRCm39) F60L possibly damaging Het
Six4 T C 12: 73,155,429 (GRCm39) S505G probably benign Het
Skint1 T A 4: 111,882,727 (GRCm39) V257E possibly damaging Het
Smad9 A G 3: 54,693,593 (GRCm39) N174S possibly damaging Het
Smc2 A G 4: 52,462,914 (GRCm39) N635D probably benign Het
Stradb T A 1: 59,028,937 (GRCm39) I135N probably damaging Het
Syt12 T C 19: 4,497,762 (GRCm39) T407A probably damaging Het
Tmc8 T A 11: 117,677,346 (GRCm39) I322N probably damaging Het
Tnip1 A C 11: 54,802,365 (GRCm39) *648G probably null Het
Ttc3 T C 16: 94,210,540 (GRCm39) probably benign Het
Other mutations in Or4d10b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02095:Or4d10b APN 19 12,036,913 (GRCm39) missense probably benign 0.00
IGL02743:Or4d10b APN 19 12,036,811 (GRCm39) missense probably damaging 1.00
IGL02745:Or4d10b APN 19 12,036,565 (GRCm39) missense probably benign 0.05
R0834:Or4d10b UTSW 19 12,036,979 (GRCm39) missense probably benign 0.00
R1474:Or4d10b UTSW 19 12,036,844 (GRCm39) missense probably benign 0.30
R5590:Or4d10b UTSW 19 12,036,642 (GRCm39) missense probably benign 0.01
R6386:Or4d10b UTSW 19 12,036,920 (GRCm39) missense probably damaging 0.98
R6864:Or4d10b UTSW 19 12,036,777 (GRCm39) missense probably damaging 1.00
R8207:Or4d10b UTSW 19 12,036,222 (GRCm39) missense possibly damaging 0.94
R8213:Or4d10b UTSW 19 12,036,456 (GRCm39) missense probably benign 0.32
R9284:Or4d10b UTSW 19 12,036,273 (GRCm39) missense probably damaging 0.98
R9773:Or4d10b UTSW 19 12,036,939 (GRCm39) missense possibly damaging 0.94
Z1088:Or4d10b UTSW 19 12,036,493 (GRCm39) missense probably benign 0.03
Posted On 2014-05-07