Incidental Mutation 'IGL02045:Ntpcr'
ID 184927
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ntpcr
Ensembl Gene ENSMUSG00000031851
Gene Name nucleoside-triphosphatase, cancer-related
Synonyms 2310079N02Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # IGL02045
Quality Score
Status
Chromosome 8
Chromosomal Location 126456724-126474974 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 126472191 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000115996 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034313] [ENSMUST00000143504] [ENSMUST00000152189]
AlphaFold Q9CQA9
Predicted Effect probably benign
Transcript: ENSMUST00000034313
SMART Domains Protein: ENSMUSP00000034313
Gene: ENSMUSG00000031851

DomainStartEndE-ValueType
AAA 1 170 2.61e-6 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138656
Predicted Effect probably benign
Transcript: ENSMUST00000143504
SMART Domains Protein: ENSMUSP00000121271
Gene: ENSMUSG00000031851

DomainStartEndE-ValueType
Pfam:NTPase_1 56 145 5.4e-27 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146055
Predicted Effect probably benign
Transcript: ENSMUST00000152189
SMART Domains Protein: ENSMUSP00000115996
Gene: ENSMUSG00000031851

DomainStartEndE-ValueType
Pfam:NTPase_1 6 178 3.2e-63 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a non-specific nucleoside triphosphatase that is slow-acting in vitro. This gene is overexpressed in many tumor tissues, and while it is not essential for the cell, overexpression is cytotoxic. However, the cytotoxicity is not related to its triphosphatase activity. [provided by RefSeq, Jul 2016]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb C A 5: 114,378,721 (GRCm39) H2044Q possibly damaging Het
Ankrd12 A T 17: 66,293,244 (GRCm39) S730T probably benign Het
Ano9 A T 7: 140,682,382 (GRCm39) N655K probably benign Het
Ap1ar A T 3: 127,609,298 (GRCm39) Y108N probably damaging Het
Asap3 A G 4: 135,954,752 (GRCm39) I55V probably benign Het
Barx2 T C 9: 31,770,094 (GRCm39) T145A probably damaging Het
Camta1 T C 4: 151,158,442 (GRCm39) probably null Het
Ces2e C T 8: 105,657,290 (GRCm39) probably benign Het
Cflar T C 1: 58,791,903 (GRCm39) I405T probably benign Het
Cibar2 T A 8: 120,896,461 (GRCm39) K174* probably null Het
Cyp51 A G 5: 4,133,247 (GRCm39) S464P probably damaging Het
Ermard G A 17: 15,271,826 (GRCm39) probably benign Het
Glb1l2 T C 9: 26,707,841 (GRCm39) T49A probably benign Het
Gls A G 1: 52,258,674 (GRCm39) V198A probably benign Het
Heatr5b A T 17: 79,115,855 (GRCm39) I867N probably damaging Het
Ighv1-14 A T 12: 114,610,334 (GRCm39) noncoding transcript Het
Iqsec1 T C 6: 90,641,051 (GRCm39) K1022E probably damaging Het
Myo10 A G 15: 25,726,574 (GRCm39) T299A probably benign Het
Nr2e3 A T 9: 59,856,291 (GRCm39) M82K probably benign Het
Or1e26 A G 11: 73,480,058 (GRCm39) C169R probably damaging Het
Or4d10b T C 19: 12,036,253 (GRCm39) T288A possibly damaging Het
Or52s6 A G 7: 103,092,159 (GRCm39) L57P probably damaging Het
Or5p80 A G 7: 108,229,739 (GRCm39) D180G probably damaging Het
Or6c70 A T 10: 129,710,091 (GRCm39) D178E probably benign Het
Prkcb A G 7: 122,189,390 (GRCm39) D506G probably damaging Het
Rasgef1a A G 6: 118,066,404 (GRCm39) I470V probably benign Het
Rbm27 A G 18: 42,452,978 (GRCm39) E514G possibly damaging Het
Rgs22 G A 15: 36,013,300 (GRCm39) A1048V probably benign Het
Secisbp2l A G 2: 125,617,498 (GRCm39) F60L possibly damaging Het
Six4 T C 12: 73,155,429 (GRCm39) S505G probably benign Het
Skint1 T A 4: 111,882,727 (GRCm39) V257E possibly damaging Het
Smad9 A G 3: 54,693,593 (GRCm39) N174S possibly damaging Het
Smc2 A G 4: 52,462,914 (GRCm39) N635D probably benign Het
Stradb T A 1: 59,028,937 (GRCm39) I135N probably damaging Het
Syt12 T C 19: 4,497,762 (GRCm39) T407A probably damaging Het
Tmc8 T A 11: 117,677,346 (GRCm39) I322N probably damaging Het
Tnip1 A C 11: 54,802,365 (GRCm39) *648G probably null Het
Ttc3 T C 16: 94,210,540 (GRCm39) probably benign Het
Other mutations in Ntpcr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00971:Ntpcr APN 8 126,474,501 (GRCm39) missense probably damaging 0.98
IGL01582:Ntpcr APN 8 126,471,981 (GRCm39) missense probably benign 0.11
IGL01862:Ntpcr APN 8 126,462,837 (GRCm39) missense probably benign 0.14
IGL02077:Ntpcr APN 8 126,464,107 (GRCm39) nonsense probably null
R0491:Ntpcr UTSW 8 126,464,093 (GRCm39) nonsense probably null
R0988:Ntpcr UTSW 8 126,464,170 (GRCm39) splice site probably benign
R1781:Ntpcr UTSW 8 126,472,141 (GRCm39) missense probably damaging 1.00
R2412:Ntpcr UTSW 8 126,472,144 (GRCm39) missense probably damaging 1.00
R3838:Ntpcr UTSW 8 126,464,111 (GRCm39) missense probably damaging 1.00
R4453:Ntpcr UTSW 8 126,462,929 (GRCm39) missense probably benign 0.14
R6126:Ntpcr UTSW 8 126,462,626 (GRCm39) critical splice donor site probably null
R6440:Ntpcr UTSW 8 126,471,981 (GRCm39) missense probably damaging 0.97
R6463:Ntpcr UTSW 8 126,462,843 (GRCm39) missense probably benign 0.02
R7102:Ntpcr UTSW 8 126,456,794 (GRCm39) missense unknown
R7910:Ntpcr UTSW 8 126,474,483 (GRCm39) missense probably benign
R8230:Ntpcr UTSW 8 126,464,159 (GRCm39) critical splice donor site probably null
R8732:Ntpcr UTSW 8 126,472,074 (GRCm39) missense probably benign
R8876:Ntpcr UTSW 8 126,464,785 (GRCm39) intron probably benign
X0024:Ntpcr UTSW 8 126,472,165 (GRCm39) missense probably damaging 0.99
X0025:Ntpcr UTSW 8 126,472,054 (GRCm39) missense probably damaging 1.00
Z1177:Ntpcr UTSW 8 126,472,023 (GRCm39) frame shift probably null
Posted On 2014-05-07