Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02048:Il31'

184994

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Il31

Ensembl Gene

ENSMUSG00000029437

Gene Name

interleukin 31

Synonyms

1700013B14Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02048

Quality Score

Status

Chromosome

Chromosomal Location

123618215-123620686 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 123618553 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 157 (V157M)

Ref Sequence

ENSEMBL: ENSMUSP00000142507 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031389] [ENSMUST00000198463] [ENSMUST00000198901]

AlphaFold

Q6EAL8

Predicted Effect

probably benign
Transcript: ENSMUST00000031389
AA Change: V141M

PolyPhen 2 Score 0.332 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000031389
Gene: ENSMUSG00000029437
AA Change: V141M

Domain	Start	End	E-Value	Type
Pfam:IL31	28	158	7.5e-54	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000198463
AA Change: V157M

PolyPhen 2 Score 0.683 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000142507
Gene: ENSMUSG00000029437
AA Change: V157M

Domain	Start	End	E-Value	Type
Pfam:IL31	40	179	1.7e-64	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000198901
AA Change: V78M

PolyPhen 2 Score 0.516 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000143125
Gene: ENSMUSG00000029437
AA Change: V78M

Domain	Start	End	E-Value	Type
Pfam:IL31	1	100	1.4e-46	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000199227

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca1	C	T	4: 53,069,831 (GRCm39)	D1288N	probably damaging	Het
Abcc1	T	C	16: 14,229,383 (GRCm39)	F372L	probably damaging	Het
Adcy2	G	T	13: 69,036,186 (GRCm39)	N158K	possibly damaging	Het
Apba1	A	G	19: 23,915,000 (GRCm39)		probably null	Het
Arap3	T	C	18: 38,130,032 (GRCm39)	E43G	possibly damaging	Het
Bet1	A	T	6: 4,082,456 (GRCm39)		probably null	Het
Blm	A	G	7: 80,152,709 (GRCm39)		probably benign	Het
Brinp1	T	C	4: 68,681,379 (GRCm39)	I384V	probably benign	Het
Cyp3a13	T	C	5: 137,917,257 (GRCm39)		probably benign	Het
Dlg5	A	T	14: 24,222,271 (GRCm39)	I480N	possibly damaging	Het
Exoc3l4	A	G	12: 111,394,917 (GRCm39)	K538R	probably benign	Het
Flna	G	T	X: 73,272,106 (GRCm39)	T2008K	probably benign	Het
Hc	T	A	2: 34,886,039 (GRCm39)	Q1388L	probably benign	Het
Ifitm1	T	C	7: 140,548,205 (GRCm39)	S13P	probably benign	Het
Il1rapl2	A	G	X: 137,690,398 (GRCm39)	I288V	probably benign	Het
N4bp2l1	A	G	5: 150,500,103 (GRCm39)		probably null	Het
Nell1	T	C	7: 49,869,355 (GRCm39)	I210T	probably damaging	Het
Or52b3	T	C	7: 102,204,090 (GRCm39)	Y200H	probably damaging	Het
Or7e176	T	A	9: 20,171,784 (GRCm39)	I216N	possibly damaging	Het
Phf1	A	G	17: 27,153,515 (GRCm39)		probably benign	Het
Phf10	G	A	17: 15,165,411 (GRCm39)	P482S	probably benign	Het
Ppp6r3	T	G	19: 3,523,848 (GRCm39)	M522L	possibly damaging	Het
Qtrt1	T	C	9: 21,328,651 (GRCm39)	L205P	probably damaging	Het
Vmn2r11	T	C	5: 109,202,658 (GRCm39)	I140V	probably benign	Het
Xylt2	C	T	11: 94,557,171 (GRCm39)	E107K	possibly damaging	Het
Zfp512b	A	T	2: 181,231,715 (GRCm39)	F155Y	possibly damaging	Het
Zfyve27	A	G	19: 42,174,296 (GRCm39)	D314G	probably damaging	Het

Other mutations in Il31

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R4308:Il31	UTSW	5	123,618,769 (GRCm39)	missense	probably damaging	0.96
R4622:Il31	UTSW	5	123,618,498 (GRCm39)	missense	probably damaging	0.99
R5147:Il31	UTSW	5	123,620,121 (GRCm39)	intron	probably benign
R5858:Il31	UTSW	5	123,618,637 (GRCm39)	missense	probably benign	0.01
Z1177:Il31	UTSW	5	123,618,768 (GRCm39)	nonsense	probably null
Z1177:Il31	UTSW	5	123,618,642 (GRCm39)	missense	probably benign	0.00

Posted On

2014-05-07